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Interventions are needed to support patient–provider decision-making for DCIS: a scoping review

Purpose Prognostic and treatment uncertainty make ductal carcinoma in situ (DCIS) complex to manage. The purpose of this study was to describe research that evaluated DCIS communication experiences, needs and interventions among DCIS patients or physicians. Methods MEDLINE, EMBASE, CINAHL and The Cochrane Library were searched from inception to February 2017. English language ...

Investigation on the morphological and optical evolution of bimetallic Pd-Ag nanoparticles on sapphire (0001) by the systematic control of composition, annealing temperature and time

Multi-metallic alloy nanoparticles (NPs) can offer additional opportunities for modifying the electronic, optical and catalytic properties by the control of composition, configuration and size of individual nanostructures that are consisted of more than single element. In this paper, the fabrication of bimetallic Pd-Ag NPs is systematically demonstrated via the solid state ...

The influence of POSS nanoparticles on selected thermal properties of polyurethane-based hybrids

Organic–inorganic hybrid materials, prepared via chemical synthesis route or physical blending of functionalized nanofillers within polymer matrix, have gained an increased attention in the recent years. Polyhedral oligomeric silsesquioxane (POSS) nanoparticles, due to their nanometer size and functionalization possibilities, are applied as effective modifiers—both chemical and ...

Reliability of plasma polar metabolite concentrations in a large-scale cohort study using capillary electrophoresis-mass spectrometry

Background Cohort studies with metabolomics data are becoming more widespread, however, large-scale studies involving 10,000s of participants are still limited, especially in Asian populations. Therefore, we started the Tsuruoka Metabolomics Cohort Study enrolling 11,002 community-dwelling adults in Japan, and using capillary electrophoresis-mass spectrometry (CE-MS) and liquid ...

Identification and expression analyses of WRKY genes reveal their involvement in growth and abiotic stress response in watermelon (Citrullus lanatus)

Despite identification of WRKY family genes in numerous plant species, a little is known about WRKY genes in watermelon, one of the most economically important fruit crops around the world. Here, we identified a total of 63 putative WRKY genes in watermelon and classified them into three major groups (I-III) and five subgroups (IIa-IIe) in group II. The structure analysis indicated ...

Survival benefit associated with metformin use in inoperable non-small cell lung cancer patients with diabetes: A population-based retrospective cohort study

Objective To evaluate the effects of metformin use on the survival of inoperable non-small cell lung cancer (NSCLC) patients with diabetes using the Taiwanese National Health Insurance Research Database. Research design and methods In total, 7,620 patients were eligible in this study, among them, 3,578 patients were metformin users and 4,042 were non-users. Propensity score ...

Influence of Organisational Resources on Performance of ISO Certified Organisations in Kenya

This study aimed at examining the influence of organisational resources on organisational performance of International Organisation for Standardization (ISO) certified organisations in Kenya. The study was based on Total Quality Management (TQM) theory. A cross-sectional research survey design was adopted. Primary data was collected from a sample of 282 ISO certified organisations ...

Targeting DNA repair with PNKP inhibition sensitizes radioresistant prostate cancer cells to high LET radiation

High linear energy transfer (LET) radiation or heavy ion such as carbon ion radiation is used as a method for advanced radiotherapy in the treatment of cancer. It has many advantages over the conventional photon based radiotherapy using Co-60 gamma or high energy X-rays from a Linear Accelerator. However, charged particle therapy is very costly. One way to reduce the cost as well ...

The Drosophila CLAMP protein associates with diverse proteins on chromatin

Gaining new insights into gene regulation involves an in-depth understanding of protein-protein interactions on chromatin. A powerful model for studying mechanisms of gene regulation is dosage compensation, a process that targets the X-chromosome to equalize gene expression between XY males and XX females. We previously identified a zinc finger protein in Drosophila melanogaster ...

A portable optical reader and wall projector towards enumeration of bio-conjugated beads or cells

Measurement of the height of a packed column of cells or beads, which can be direclty related to the number of cells or beads present in a chamber, is an important step in a number of diagnostic assays. For example, haematocrit measurements may rapidly identify anemia or polycthemia. Recently, user-friendly and cost-efficient Lab-on-a-Chip devices have been developed towards ...

Positron emission tomography-magnetic resonance imaging (PET-MRI) for response assessment after radiation therapy of cervical carcinoma: a pilot study

Background Advanced stage cervical cancer is primarily treated by radiotherapy. Local tumor control is a prerequisite for cure. Imaging after treatment is controversial. Positron emission tomography (PET) combined with computer tomography (PET-CT) shows great promise for detecting metastases. On the other hand, magnetic resonance imaging (MRI) is superior in depicting anatomical ...

Crystal structures of H-2Db in complex with the LCMV-derived peptides GP92 and GP392 explain pleiotropic effects of glycosylation on antigen presentation and immunogenicity

Post-translational modifications significantly broaden the epitope repertoire for major histocompatibility class I complexes (MHC-I) and may allow viruses to escape immune recognition. Lymphocytic choriomeningitis virus (LCMV) infection of H-2b mice generates CD8+ CTL responses directed towards several MHC-I-restricted epitopes including the peptides GP92 (CSANNSHHYI) and GP392 ...

The dynamics of pico-sized and bloom-forming cyanobacteria in large water bodies in the Mekong River Basin

In the face of plans for increased construction of dams and reservoirs in the Mekong River Basin, it is critically important to better understand the primary-producer community of phytoplankton, especially the warm-water cyanobacteria. This is because these algae can serve as the primary source of carbon for higher trophic levels, including fishes, but can also form harmful blooms, ...

Author Correction: A Dynamic Approach to Risk Factors for Maternal Corporal Punishment in Early to Middle Childhood

The original version of this article unfortunately contained a mistake. In the second sentence of the Abstract section the word “Fragile” was missing. It should read as “Archival data from Fragile Families and Child Wellbeing Study…”

Regge-like relation and a universal description of heavy–light systems

Using the Regge-like formula \((M-m_Q)^2=\pi \sigma L\) between hadron mass M and angular momentum L with a heavy quark mass \(m_Q\) and a string tension \(\sigma \), we analyze all the heavy–light systems, i.e., \(D/D_s/B/B_s\) mesons and charmed and bottom baryons. Numerical plots are obtained for all the heavy–light mesons of experimental data whose slope becomes nearly equal to ...

A CuNi/C Nanosheet Array Based on a Metal–Organic Framework Derivate as a Supersensitive Non-Enzymatic Glucose Sensor

Bimetal catalysts are good alternatives for non-enzymatic glucose sensors owing to their low cost, high activity, good conductivity, and ease of fabrication. In the present study, a self-supported CuNi/C electrode prepared by electrodepositing Cu nanoparticles on a Ni-based metal–organic framework (MOF) derivate was used as a non-enzymatic glucose sensor. The porous construction ...

The Incidence of Injury in Amateur Male Rugby Union: A Systematic Review and Meta-Analysis

Background Rugby union is a physically demanding, full-contact team sport that has gained worldwide popularity. The incidence of injury in rugby union has been widely reported in the literature. While comprehensive injury surveillance and prevention programmes have been implemented within the professional game, there is a need for similar strategies in the amateur game. Despite ...

Rising up: Fertility trends in Egypt before and after the revolution

In 2014, Egypt’s Demographic and Health Survey (EDHS) documented an increase in the total fertility rate (TFR) to 3.5, up from a low of 3.0 recorded by the 2008 EDHS. The increase has been anecdotally attributed to the social upheaval following Egypt’s January 2011 revolution, but little is known about when fertility first began to increase and among which sub-groups of women. ...

Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis

Prevalence of multiple sclerosis varies with geographic latitude. We hypothesized that this fact might be partially associated with the influence of latitude on circadian rhythm and consequently that genetic variability of key circadian rhythm regulators, ARNTL and CLOCK genes, might contribute to the risk for multiple sclerosis. Our aim was to analyse selected polymorphisms of ...

Mg-doped ZnO films prepared by chemical bath deposition

A simple, low-temperature route for the chemical bath deposition of Mg-doped ZnO films, based on low-cost, abundant and non-toxic materials was developed. The film growth mechanism, the resulting morphology and texture were investigated in detail by scanning electron microscopy and X-ray diffraction measurements. It was found that substantial film growth is only possible in a ...

Environment for integration of distributed heterogeneous computing systems

Connecting multiple and heterogeneous hardware devices to solve problems raises some challenges, especially in terms of interoperability and communications management. A distributed solution may offer many advantages, like easy use of dispersed resources in a network and potential increase in processing power and data transfer speed. However, integrating devices from different ...