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“The Necessary War: Canadians Fighting the Second World War 1939–1943, Volume One (Book Review)” by Tim Cook & “Fight to the Finish: Canadians in the Second World War 1944–1945, Volume Two (Book Review)” by Tim Cook

Review of The Necessary War: Canadians Fighting the Second World War 1939–1943, Volume One & Fight to the Finish: Canadians in the Second World War 1944–1945, Volume Two by Tim Cook.

Quantitative Testing of Prescriber Knowledge Regarding the Risks and Safe Use of Albiglutide

Background The risk of pancreatitis and potential risk of medullary thyroid carcinoma associated with glucagon-like peptide-1 receptor agonists prompted the US Food and Drug Administration to require a Risk Evaluation and Mitigation Strategy for albiglutide, including education for prescribers and subsequent assessment of their knowledge of the risks and safe use of albiglutide via ...

Online conformance checking: relating event streams to process models using prefix-alignments

Companies often specify the intended behaviour of their business processes in a process model. Conformance checking techniques allow us to assess to what degree such process models and corresponding process execution data correspond to one another. In recent years, alignments have proven extremely useful for calculating conformance checking statistics. Existing techniques to ...

Inferior immunogenicity and efficacy of respiratory syncytial virus fusion protein-based subunit vaccine candidates in aged versus young mice

Respiratory syncytial virus (RSV) is recognized as an important cause of lower and upper respiratory tract infections in older adults, and a successful vaccine would substantially lower morbidity and mortality in this age group. Recently, two vaccine candidates based on soluble purified glycoprotein F (RSV F), either alone or adjuvanted with glucopyranosyl lipid A formulated in a ...

Restrictive surgical approach to palliate angina in a patient with coronary three vessel disease and biventricular metastatic hepatocellular carcinoma

Metastatic cardiac tumors may cause different symptoms including angina, symptoms of heart failure and/or arrhythmia. In patients with concomitant coronary artery disease, it may be difficult to distinguish between angina caused by metastases to the heart, for example, by stealing perfusion from the coronary arteries, and angina caused by coronary stenosis. Identifying the origin ...

The effectiveness and cost-effectiveness of plant sterol or stanol-enriched functional foods as a primary prevention strategy for people with cardiovascular disease risk in England: a modeling study

This study appraises the effectiveness and cost-effectiveness of consumption of plant sterol-enriched margarine-type spreads for the prevention of cardiovascular disease (CVD) in people with hypercholesterolemia in England, compared to a normal diet. A nested Markov model was employed using the perspective of the British National Health Service (NHS). Effectiveness outcomes were ...

CUAHSI 2017 Conference Editor's Note

An introduction to the Open Water Volume 4, Issue 2.

Analysis of the relationship between prescribed dose and dosimetric advantage of real-time intraoperatively built custom-linked seeds in iodine-125 prostate brachytherapy

The purpose of this study was to investigate the differences in the dosimetric advantage of using intraoperatively built custom-linked (IBCL) seeds between permanent iodine-125 (I-125) seed implantation (PI) alone and PI followed by external-beam radiation therapy (EBRT) for prostate cancer. We reviewed the records of 62 patients with localized prostate cancer who received ...

Breathing new life into an old target: pulmonary disease drugs for Parkinson’s disease therapy

Increases in α-synuclein protein expression are suspected to increase the risk of the development of Parkinson’s disease (PD). A recent study has demonstrated that β2-adrenergic receptor (β2AR) agonists decrease histone acetylation in the α-synuclein gene and suppress transcription. Coupled with the anti-inflammatory effects that are associated with β2AR activation, this ...

Visual management of performance with PROMETHEE productivity analysis

Multi-criteria decision analysis has been used to solve many problems. Here we describe an adaptation of PROMETHEE for measuring productivity. The results of PROMETHEE productivity analysis are displayed graphically, permitting the user to distinguish easily between four types of action: efficient, effective, frugal and inefficient actions. The productivity graph can be used for ...

Congenital myopathies: clinical phenotypes and new diagnostic tools

Congenital myopathies are a group of genetic muscle disorders characterized clinically by hypotonia and weakness, usually from birth, and a static or slowly progressive clinical course. Historically, congenital myopathies have been classified on the basis of major morphological features seen on muscle biopsy. However, different genes have now been identified as associated with the ...

Where Are We Today In The International Fight Against Overseas Corruption: An Historical Perspective, And Two Problems Going Forward

The goal of my comments is to take a step back and begin with an historical perspective on the collective, international effort to fight corruption, and then to suggest two problems that effort faces today.

Plant organ cultures as masked mycotoxin biofactories: Deciphering the fate of zearalenone in micropropagated durum wheat roots and leaves

“Masked mycotoxins” senso strictu are conjugates of mycotoxins resulting from metabolic pathways activated by the interplay between pathogenic fungi and infected plants. Zearalenone, an estrogenic mycotoxin produced by Fusarium spp, was the first masked mycotoxin ever described in the literature, but its biotransformation has been studied to a lesser extent if compared to other ...

Two experts, three opinions: volatile organic compounds’ testing methods and regulative systems

As a result of the implementation of the CE-marking in the European Union, the testing method as defined in prEN 16516 is about to become the new volatile organic compounds (VOC) testing standard and replace a multitude of testing methods and regulative systems in Europe that assess the existence of VOC in building materials, including wood-based materials. The aim of this study ...

Optimizing and accelerating the assignation of lineages in Mycobacterium tuberculosis using novel alternative single-tube assays

The assignation of lineages in Mycobacterium tuberculosis (MTB) provides valuable information for evolutionary and phylogeographic studies and makes for more accurate knowledge of the distribution of this pathogen worldwide. Differences in virulence have also been found for certain lineages. MTB isolates were initially assigned to lineages based on data obtained from genotyping ...

Stability of linear EDF networks with resource sharing

We consider a linear real-time, multiresource network with generally distributed stochastic primitives and soft customer deadlines, in which some users require service from several shared resources simultaneously. We show that a strictly subcritical network of this type is stable under the preemptive Earliest Deadline First scheduling strategy. Our argument is direct, without using ...

Regulatory T cells induced by B cells: a novel subpopulation of regulatory T cells

Regulatory T cells play a crucial role in the homeostasis of the immune response. In addition to CD4+Foxp3+ regulatory T cells, several subsets of Foxp3- regulatory T cells, such as T helper 3 (Th3) cells and type 1 regulatory T (Tr1) cells, have been described in mice and human. Accumulating evidence shows that naïve B cells contribute to tolerance and are able to promote ...

The prognostic value of asymmetric dimethylarginine in patients with cardiac syndrome X

Background The pathophysiology of cardiac syndrome X is multifactorial and endothelial dysfunction has been implicated as important contributing factor. Asymmetric dimethylarginine (ADMA), characterized as a circulating endogenous inhibitor of nitric oxide synthase, may have been implicated as an important contributing factor for the development of endothelial dysfunction. In this ...

‘Better late than never’: the interplay between green technology and age for firm growth

This paper investigates the relationship between green/non-green technologies and firm growth. By combining the literature on eco-innovations, industrial organisation and entrepreneurial studies, we examine the dependence of this relationship on the pace at which firms grow and the age of the firm. From a dataset of 5498 manufacturing firms in Italy for the period of 2000–2008, ...