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Internal Carotid Artery Stenosis and Collateral Recruitment in Stroke Patients

Purpose Leptomeningeal collaterals improve outcome in stroke patients. There is great individual variability in their extent. Internal carotid artery (ICA) stenosis may lead to more extensive recruitment of leptomeningeal collaterals. The purpose of this study was to evaluate the association of pre-existing ICA stenosis with leptomeningeal collateral filling visualized with ...

Study protocol on the role of intestinal microbiota in colorectal cancer treatment: a pathway to personalized medicine 2.0

Purpose Investigate in patients with metastatic and/or irresectable colorectal cancer treated with systemic treatment with capecitabine or TAS-102 whether:1. Intestinal microbiota composition can act as a predictor for response. 2. Intestinal microbiota composition changes during systemic treatment and its relation to chemotoxicity. Background Gut microbiota and host determinants ...

Long-term impacts of parental migration on Chinese children’s psychosocial well-being: mitigating and exacerbating factors

Purpose Prolonged separation from migrant parents raises concerns for the well-being of 60 million left behind children (LBC) in rural China. This study aimed to investigate the impact of current and previous parental migration on child psychosocial well-being, with a focus on emotional and behavioral outcomes, while considering factors in family care and support. Methods Children ...

Tests of the Stability of Chinese RhFe Resistance Thermometers at Low Temperatures

Rhodium–iron resistance thermometers are recommended as precise thermometers at temperatures below 25 K. The thermometers were developed at the National Physical Laboratory and produced by H. Tinsley and Co Ltd almost 50 years ago. Later, they were made by other companies and institutes as well, but despite this, the availability of the thermometers decreased and a new source of ...

Early stage breast cancer treatment and prognostic factors

Developments in early breast cancer presented at the 2016 San Antonio Breast Cancer Symposium included important studies on extending adjuvant endocrine therapy with aromatase inhibitors, the role of bisphosphonates, and evidence for molecular prognostic factors and circulating tumor cells in early stage breast cancer patients.

Allometry varies among related families of Norway spruce

Key message Slopes and intercepts of allometric equations for organs’ biomass varied among half-sib families of Norway spruce and between age categories in a family-dependent manner. Genetic variation should be accounted for when applying allometric analysis to mixtures of genetic groups. Context Genetic variation in relationships among plant biomass components was rarely addressed ...

Prevalence, predictors, and prognostic implications of residual impairment of functional capacity after transcatheter aortic valve implantation

Background Patients with degenerative aortic stenosis (AS) referred for transcatheter aortic valve implantation (TAVI) typically have advanced cardiac and vascular adverse remodeling and multiple comorbidities and, therefore, might not recover a normal functional capacity after valve replacement. We sought to investigate the prevalence, the predictors, and the prognostic impact of ...

Risk assessment of precipitation extremes in northern Xinjiang, China

This study was conducted using daily precipitation records gathered at 37 meteorological stations in northern Xinjiang, China, from 1961 to 2010. We used the extreme value theory model, generalized extreme value (GEV) and generalized Pareto distribution (GPD), statistical distribution function to fit outputs of precipitation extremes with different return periods to estimate risks ...

How can climate change and engineered water conveyance affect sediment dynamics in the San Francisco Bay-Delta system?

Suspended sediment concentration is an important estuarine health indicator. Estuarine ecosystems rely on the maintenance of habitat conditions, which are changing due to direct human impact and climate change. This study aims to evaluate the impact of climate change relative to engineering measures on estuarine fine sediment dynamics and sediment budgets. We use the highly ...

Duodenal Switch Is Superior to Gastric Bypass in Patients with Super Obesity when Evaluated with the Bariatric Analysis and Reporting Outcome System (BAROS)

Background It is not clear which bariatric procedure that gives the best outcome for patients with super obesity (body mass index [BMI] > 50 kg/m2). This study aims to compare outcomes in patients with super obesity after Roux-en-Y gastric bypass (RYGB) and duodenal switch (BPD/DS) using the Bariatric Analysis and Reporting Outcome System (BAROS) and a local questionnaire for ...

Active power measurement in arc welding and its role in heat transfer to the plate

A contemporary paper claimed that a method using the resistance of impedance (active power) for arc power calculation is more accurate than the conventional approach, with consequences on the actual heat transfer to the plate. However, despite the comprehensive reasoning, no heat-related results are shown in this intriguing paper to support the claim. Thus, the aim of this work was ...

Some of the earliest depictions of the human spine: a glimpse into European history

Introduction Drawings of the human form have a history almost as old as mankind itself. However, illustrations of the human spine as seen with the vertebral column were not seen until much later. This paper reviews some of the early European depictions of the human vertebral column from the twelfth (e.g., Fünfbilderserie “Bone-Man”: 1152 A.D.) and thirteenth (e.g., Ashmole 1292) ...

Malignancy estimation of Lung-RADS criteria for subsolid nodules on CT: accuracy of low and high risk spectrum when using NLST nodules

Purpose Lung-RADS proposes malignancy probabilities for categories 2 (<1%) and 4B (>15%). The purpose of this study was to quantify and compare malignancy rates for Lung-RADS 2 and 4B subsolid nodules (SSNs) on a nodule base. Methods We identified all baseline SSNs eligible for Lung-RADS 2 and 4B in the National Lung Screening Trial (NLST) database. Solid cores and nodule locations ...

Developing the Totality of Evidence for Biosimilars: Regulatory Considerations and Building Confidence for the Healthcare Community

Biosimilars are highly similar versions of approved branded biologics. Unlike generics, they are not exact replicas of reference products. Minor differences between biosimilars and reference products in some aspects are expected; likewise, biosimilar products will differ from each other. The objective of this review is to discuss the challenges associated with the development and ...

Heterologous expression of a Streptomyces cyaneus laccase for biomass modification applications

Laccases are used for the conversion of biomass into fermentable sugars but it is difficult to produce high yields of active laccases in heterologous expression systems. We overcame this challenge by expressing Streptomyces cyaneus CECT 3335 laccase in Escherichia coli (ScLac) and we achieved a yield of up to 104 mg L−1 following purification by one-step affinity chromatography. ...

Statistical analysis of arsenic contamination in drinking water in a city of Iran and its modeling using GIS

In this research, probable arsenic contamination in drinking water in the city of Ardabil was studied in 163 samples during four seasons. In each season, sampling was carried out randomly in the study area. Results were analyzed statistically applying SPSS 19 software, and the data was also modeled by Arc GIS 10.1 software. The maximum permissible arsenic concentration in drinking ...

Simple solution to the optimal deployment of cooperative nodes in two-dimensional TOA-based and AOA-based localization system

Cellular-based cooperative communication is a promising technique that allows cooperation among mobile devices not only to increase data throughput but also to improve localization services. For a certain number of cooperative nodes, the geometry plays a significant role in enhancing the accuracy of target. In this paper, a simple solution to the deployment of cooperative nodes ...

Using Metal-Multilayer-Dielectric Structure to Increase Sensitivity of Surface Plasmon Resonance Sensor

We propose using a specially designed metal-multilayer-dielectric structure deposited on glass substrate to enhance the evanescent field and improve the sensitivity of the surface plasmon resonance sensor. The proposed structure supports both hybrid plasmonic transverse magnetic modes and conventional waveguide transverse electric modes. We show numerically the significant ...

Isolated splenic tuberculosis with subsequent paradoxical deterioration: a case report

Background Isolated tuberculosis of the spleen has been described occasionally in literature, mostly in immunosuppressed individuals with various risk factors. Sequestration in the spleen makes such Mycobacterium tuberculosis infection difficult to diagnose. This report describes an extremely rare case of isolated splenic tuberculosis in an immunocompetent individual. Case ...

The Utrecht cohort for Multiple BREast cancer intervention studies and Long-term evaLuAtion (UMBRELLA): objectives, design, and baseline results

Purpose In oncology, RCTs are often beset by slow recruitment, limited generalizability, and strong preferences for interventions by patients and physicians. The cohort multiple randomized controlled trial (cmRCT) is an innovative design with the potential to overcome those challenges. In cmRCT, a prospective cohort serves as an infrastructure for multiple RCTs. We implemented ...

Starvation signals in yeast are integrated to coordinate metabolic reprogramming and stress response to ensure longevity

Studies on replicative and chronological aging in Saccharomyces cerevisiae have greatly advanced our understanding of how longevity is regulated in all eukaryotes. Chronological lifespan (CLS) of yeast is defined as the age-dependent viability of non-dividing cell populations. A number of nutrient sensing and signal transduction pathways (mainly TOR and PKA) have been shown to ...