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What’s in a p? Reassessing best practices for conducting and reporting hypothesis-testing research

Social science research has recently been subject to considerable criticism regarding the validity and power of empirical tests published in leading journals, and business scholarship is no exception. Transparency and replicability of empirical findings are essential to build a cumulative body of scholarly knowledge. Yet current practices are under increased scrutiny to achieve ...

Socioenvironmental factors associated with heat and cold-related mortality in Vadu HDSS, western India: a population-based case-crossover study

Ambient temperatures (heat and cold) are associated with mortality, but limited research is available about groups most vulnerable to these effects in rural populations. We estimated the effects of heat and cold on daily mortality among different sociodemographic groups in the Vadu HDSS area, western India. We studied all deaths in the Vadu HDSS area during 2004–2013. A conditional ...

The Need for Restructuring the Disordered Science of Amorphous Drug Formulations

The alarming numbers of poorly soluble discovery compounds have centered the efforts towards finding strategies to improve the solubility. One of the attractive approaches to enhance solubility is via amorphization despite the stability issue associated with it. Although the number of amorphous-based research reports has increased tremendously after year 2000, little is known on ...

Characteristics of stepfamilies and maternal mental health compared with non-stepfamilies in Japan

Background Stepfamilies remain poorly understood in Japanese society, and the support needs of stepfamily mothers are unclear. This study aimed to identify characteristics of stepfamilies and maternal mental health as compared with non-stepfamilies in Japan to utilize as a primary resource for providing effective support through community-based health care for stepfamilies. Methods ...

The effects of Kanizsa contours on temporal integration and attention in rapid serial visual presentation

Performance in rapid serial visual presentation tasks has been shown to depend on the temporal integration of target stimuli when they are presented in direct succession. Temporal target integration produces a single, combined representation of visually compatible stimuli, which is comparatively easy to identify. It is currently unknown to what extent target compatibility affects ...

Dimension-6 operator analysis of the CLIC sensitivity to new physics

We estimate the possible accuracies of measurements at the proposed CLIC e + e − collider of Higgs and W + W − production at centre-of-mass energies up to 3 TeV, incorporating also Higgsstrahlung projections at higher energies that had not been consid-ered previously, and use them to explore the prospective CLIC sensitivities to decoupled new physics. We present the resulting ...

History of cosmic evolution with modified Gauss–Bonnet-dilatonic coupled term

Gauss–Bonnet-dilatonic coupling in four dimensions plays an important role to explain late-time cosmic evolution. However, this term is an outcome of the low energy string effective action and thus ought to be important in the early universe too. Unfortunately, a phase-space formulation of such a theory does not exist in the literature due to branching. We therefore consider a ...

Huwelijk beschermt tegen alcoholmisbruik

Dat gescheiden mensen gemiddeld meer drinken en zich vaker schuldig maken aan alcoholmisbruik is bekend. Toch bleven veel vragen over de precieze relatie tussen partnerscheiding en drankgebruik tot nog toe onbeantwoord.

Does Eligibility for Tertiary Education Affect Crime Rates? Quasi-Experimental Evidence

Objectives This paper estimates the effect of tertiary education eligibility on crime in Sweden. The hypothesis tested is that continuing to higher education decreases crime rates since it allows young people to escape inactivity and idleness, which are known to trigger crime. However, to qualify for tertiary education, individuals have to meet the eligibility requirements in ...

The Hokkaido Birth Cohort Study on Environment and Children’s Health: cohort profile—updated 2017

The Hokkaido Study on Environment and Children’s Health is an ongoing study consisting of two birth cohorts of different population sizes: the Sapporo cohort and the Hokkaido cohort. Our primary study goals are (1) to examine the effects of low-level environmental chemical exposures on birth outcomes, including birth defects and growth retardation; (2) to follow the development of ...

NAFLD as a Sexual Dimorphic Disease: Role of Gender and Reproductive Status in the Development and Progression of Nonalcoholic Fatty Liver Disease and Inherent Cardiovascular Risk

Nonalcoholic fatty liver disease (NAFLD) spans steatosis through nonalcoholic steatohepatis, cirrhosis, and hepatocellular carcinoma (HCC) associated with striking systemic features and excess cardiovascular and liver-related mortality. The pathogenesis of NAFLD is complex and multifactorial. Endocrine derangements are closely linked with dysmetabolic traits. For example, in animal ...

Reduced amygdala reactivity and impaired working memory during dissociation in borderline personality disorder

Affective hyper-reactivity and impaired cognitive control of emotional material are core features of borderline personality disorder (BPD). A high percentage of individuals with BPD experience stress-related dissociation, including emotional numbing and memory disruptions. So far little is known about how dissociation influences the neural processing of emotional material in the ...

Down Under: Freddy is dead

Als je dertienjarige zoon omkomt bij een auto-ongeluk waarbij jij de bestuurder was, hoe kom je dan met jezelf in het reine? Behandelaar Sandy wilde een cliënt van haar met me bespreken die dat had meegemaakt en ze nodigde me daarom uit voor een bakje koffie.

Talk and Tools: the best of both worlds in mobile user interfaces for E-coaching

In this paper, a user interface paradigm, called Talk-and-Tools, is presented for automated e-coaching. The paradigm is based on the idea that people interact in two ways with their environment: symbolically and physically. The main goal is to show how the paradigm can be applied in the design of interactive systems that offer an acceptable coaching process. As a proof of concept, ...

Structure based classification for bile salt export pump (BSEP) inhibitors using comparative structural modeling of human BSEP

The bile salt export pump (BSEP) actively transports conjugated monovalent bile acids from the hepatocytes into the bile. This facilitates the formation of micelles and promotes digestion and absorption of dietary fat. Inhibition of BSEP leads to decreased bile flow and accumulation of cytotoxic bile salts in the liver. A number of compounds have been identified to interact with ...

Using Participatory Action Research to Develop a Working Model That Enhances Psychiatric Nurses’ Professionalism: The Architecture of Stability

Ward rules in psychiatric care aim to promote safety for both patients and staff. Simultaneously, ward rules are associated with increased patient violence, leading to neither a safe work environment nor a safe caring environment. Although ward rules are routinely used, few studies have explicitly accounted for their impact. To describe the process of a team development project ...

When sex doesn’t sell to men: mortality salience, disgust and the appeal of products and advertisements featuring sexualized women

Although men typically hold favorable views of advertisements featuring female sexuality, from a Terror Management Theory perspective, this should be less the case when thoughts of human mortality are salient. Two experiments conducted in South Korea supported this hypothesis across a variety of products (e.g., perfume and vodka). Men became more negative towards advertisements ...

Classmate characteristics, class composition and children’s perceived classroom climate

Aim A beneficial classroom climate is vital for school achievements, health, well-being, and school satisfaction. However, there is little knowledge as to how the classmate characteristics and class composition are related to the level of a perceived messy and disorderly classroom climate and whether the estimated relationships vary between different groups of children. The aim of ...

Hh signaling in regeneration of the ischemic heart

Myocardial infarction (MI) is caused by the occlusion of a coronary artery due to underlying atherosclerosis complicated by localized thrombosis. The blockage of blood flow leads to cardiomyocyte (CM) death in the infarcted area. Adult mammalian cardiomyocytes have little capacity to proliferate in response to injury; however, some pathways active during embryogenesis and silent ...

Investigation of the change in soil fabric during cone penetration in silt using 2D measurements

Interpretation of CPTU testing in silt is non-trivial because of the partially drained conditions that are likely to occur during penetration. A better understanding of the pore pressure generation/dissipation is needed in order to obtain reliable design parameters. Following a previous study using X-ray computed tomography (micro-CT) with volumetric digital image correlation ...