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Anxiety and depression symptoms and migraine: a symptom-based approach research

Background Anxiety and mood disorders have been shown to be the most relevant psychiatric comorbidities associated with migraine, influencing its clinical course, treatment response, and clinical outcomes. Limited information is available on how specific anxiety and depression symptoms are related to migraine. Symptoms-based approach, a current trend in mental health research, may ...

Disrupted functional connectivity of periaqueductal gray subregions in episodic migraine

Background The periaqueductal gray (PAG) dysfunction was recognized in migraine, and the altered dysfunction of PAG subregions were not totally detected up to now. The aim of this study is to investigate the altered functional connectivity of PAG subregions in EM patients. Methods The brain structural images and resting state functional MR imaging (rs-fMRI) data were obtained from ...

The universe of ANA testing: a case for point-of-care ANA testing

Testing for total antinuclear antibodies (ANA) is a critical tool for diagnosis and management of autoimmune diseases at both the primary care and subspecialty settings. Repurposing of ANA from a test for lupus to a test for any autoimmune condition has driven the increase in ANA requests. Changes in ANA referral patterns include early or subclinical autoimmune disease detection in ...

Do general innovation policy tools fit all? Analysis of the regional impact of the Norwegian Skattefunn scheme

Background The paper examines the regional effects of a general innovation policy, i.e. a policy tool that does not target specific industries or subnational regions. General policy tools are an important part of the portfolio of innovation policy measures. However, there is a question over whether general tools are equally relevant for all types of firms, irrespective of their ...

Optimal nitrogen fertilization of boreal conifer forest

Background Forest fertilization offers a means to increase the production of renewable resources. Nitrogen is the most common fertilizer in boreal upland forests. There is plenty of research on the effect of nitrogen fertilization on volume growth, but less research on the optimal timing of fertilization and optimal management of fertilized stands. Methods This study used ...

Instrumental approach toward understanding nano-pollutants

Nano-pollutants (NPLTs) have recently raised global concerns due to their possible harmful impact on environment and human health. However, until date, information on the occurrence, fate and toxicity of NPLTs in environment is scant. The knowledge gap can be attributed to the lack of advanced and sophisticated methodologies for the precise detection and characterization of NPLTs ...

The micro-politics of small-scale fisheries governance in South Africa: a case study of community-based political representation as a form of brokerage

The right of small-scale fishers to participate in governance and management processes has been increasingly recognised by theorists and policy-makers over the last thirty years. Political representation is central to the realisation of the right to participation. In the context of small-scale fisheries, the first level of political representation is usually located within a ...

Perceptions of neighborhood environments and their association with overweight in children, adolescents, and caretakers in a medium-sized city in Brazil

Background Previous studies conducted in developed countries have suggested associations between perceptions of neighborhood characteristics and weight gain. However, there are few studies regarding the adult perception of the residential environment and overweight in children and adolescents in countries with low and medium income. The aim of the study was to assess the ...

Genome-wide Association Analysis Tracks Bacterial Leaf Blight Resistance Loci In Rice Diverse Germplasm

Background A range of resistance loci against different races of Xanthomonas oryzae pv. oryzae (Xoo), the pathogen causing bacterial blight (BB) disease of rice, have been discovered and characterized. Several have been deployed in modern varieties, however, due to rapid evolution of Xoo, a number have already become ineffective. The continuous “arms race” between Xoo and rice ...

Comparison of response patterns in different survey designs: a longitudinal panel with mixed-mode and online-only design

Background Increasing availability of the Internet allows using only online data collection for more epidemiological studies. We compare response patterns in a population-based health survey using two survey designs: mixed-mode (choice between paper-and-pencil and online questionnaires) and online-only design (without choice). Methods We used data from a longitudinal panel, the ...

Botulinum neurotoxin type A for the treatment of pain: not just in migraine and trigeminal neuralgia

Background Despite their huge epidemiological impact, primary headaches, trigeminal neuralgia and other chronic pain conditions still receive suboptimal medical approach, even in developed countries. The limited efficacy of current pain-killers and prophylactic treatments stands among the main reasons for this phenomenon. Botulinum neurotoxin (BoNT) represents a well-established ...

The FAST D protocol: a simple method to rule out traumatic vascular injuries of the lower extremities

Background The aim of this study is to assess the accuracy of a Fast Doppler protocol for the examination of an injured lower limb, namely 2-Point Fast Doppler (2PFD), in order to rapidly triage arterial lesions after penetrating trauma. Methods The presence of flow and the aspects of the Doppler waveform of the dorsalis pedis artery (DPA) and posterior tibial artery (PTA) of the ...

Data completion in building information management: electrical lines from range scans and photographs

Background The concept of building information management (BIM) is based on its holistic nature. This idea pays off, if all relevant information is fused into one consistent data set. As a consequence, the completeness of data is vital and the research question on how to complete data automatically remains open. Methods In this article we present a data completion technique based ...

Barriers and facilitators for BIM use among Swedish medium-sized contractors - “We wait until someone tells us to use it”

Background The pace of diffusion of BIM (Building Information Modelling) use is considered to increase with governmental initiatives in which public clients in countries like Finland, Singapore, United Kingdom, and Sweden begin requiring BIM as a part of the project delivery. Currently, larger contractor firms use BIM to a certain extent. However, BIM use by mid-sized contractor ...

Fatty acid composition of sprat (Sprattus sprattus) and herring (Clupea harengus) in the Baltic Sea as potential prey for salmon (Salmo salar)

Sprat (Sprattus sprattus) and small herring (Clupea harengus) are the dominant prey fish of Atlantic salmon (Salmo salar) in the Baltic Sea. If the fatty acid (FA) proportions of sprat and herring differ, the dietary history of ascending salmon could be determined from their FA profiles. Therefore, we investigated the FA composition of several age groups of whole sprat and small ...

Cystoid macular edema associated with preservative-free latanoprost after uncomplicated cataract surgery: case report and review of the literature

Background Cystoid macular edema associated with latanoprost administration has been reported in patients after complicated cataract surgery with coexisting risk factors. We present the first case of preservative free latanoprost associated cystoid macular edema that occurred many months after uncomplicated cataract surgery. Case presentation A 65-year old Caucasian female ...

Schizophrenia and substance use comorbidity: a genome-wide perspective

Dual diagnosis with substance use disorders (SUDs) consistently contributes to the premature mortality and increased disability observed in schizophrenia. Large genome-wide association studies are providing the information needed to investigate the genetic architecture of psychiatric disorders. Here, we discuss recent genetic investigations of dual diagnosis (i.e., schizophrenia ...

DNA double-strand breaks in human induced pluripotent stem cell reprogramming and long-term in vitro culturing

Background Human induced pluripotent stem cells (hiPSCs) play roles in both disease modelling and regenerative medicine. It is critical that the genomic integrity of the cells remains intact and that the DNA repair systems are fully functional. In this article, we focused on the detection of DNA double-strand breaks (DSBs) by phosphorylated histone H2AX (known as γH2AX) and ...

Optical fiber grating vibration sensor for vibration monitoring of hydraulic pump

In view of the existing electrical vibration monitoring traditional hydraulic pump vibration sensor, the high false alarm rate is susceptible to electromagnetic interference and is not easy to achieve long-term reliable monitoring, based on the design of a beam of the uniform strength structure of the fiber Bragg grating (FBG) vibration sensor. In this paper, based on the analysis ...

Construction of low-ethanol–wine yeasts through partial deletion of the Saccharomyces cerevisiae PDC2 gene

We propose an alternative GMO based strategy to obtain Saccharomyces cerevisiae mutant strains with a slight reduction in their ability to produce ethanol, but with a moderate impact on the yeast metabolism. Through homologous recombination, two truncated Pdc2p proteins Pdc2pΔ344 and Pdc2pΔ519 were obtained and transformed into haploid and diploid lab yeast strains. In the pdc2Δ344 ...