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Impact of Therapeutic Immunization on HIV-1 Viremia after Discontinuation of Antiretroviral Therapy Initiated during Acute Infection

Habib, Georgia Theofan, David A. Cooper, and Luc Perrin, for the QUEST Study Group 2 Author affiliations and study group members are listed after the text. Royal Free Centre for HIV Medicine, Royal Free ... . Mazarin, B. Mouterde, R. El Habib. Data Safety Monitoring Board. M. Schechter (Canada), I. Weller (United Kingdom), R. Luethy (Switzerland), J. M. Molina (France). Core Group. S. Kinlochde Loes, D. A

A Sentencing Problem: How Far Is a Fall from Grace

Cleveland State Law Review H. H. A. Cooper 0 Court of Criminal Appeal Act, 1907, as modified by the Court of Criminal Appeal Act , 1964 1 Regina v. McConnach , The Times Law Report, 21st 2 Visiting Prof. of

Patterns of Viral Dynamics during Primary Human Immunodeficiency Virus Type 1 Infection

This study used curve-fitting techniques to detail the dynamics of human immunodeficiency virus (HIV)-1 and its relationship to circulating T lymphocyte changes in a cohort of 41 male patients (mean age 36 ± 7 years) infected with HIV-1. The following characteristics of viral kinetics were obtained: virus load peak, 6.35 ± 0.71 log10 RNA copies/mL at 12.2 ±7.1 days; virus load drop ...

LAB-IMMUNOLOGY RESEARCH

Epidemiological studies have highlighted associations between the regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) and reduced cancer risks in humans. Most NSAIDs function as cyclooxygenase-2 (COX-2) inhibitors that prevent production of prostaglandin E2 (PGE2). PGE2 induces myeloid-derived suppressor cells (MDSCs), and NSAIDs reduce vascular endothelial growth factor ...

Outpatient Continuous Intravenous Interleukin-2 or Subcutaneous, Polyethylene Glycol—Modified Interleukin-2 in Human Immunodeficiency Virus—Infected Patients: A Randomized, Controlled, Multicenter Study

The safety and activity of outpatient-based continuous intravenous interleukin-2 (CIV IL-2) or a slow-release, polyethylene glycol (PEG)—modified IL-2 were studied in human immunodeficiency virus (HlV)—infected persons with CD4 cell counts between 200 and 500/mm3. One hundred fifteen patients were randomized to antiretroviral therapy plus cyclical CIV IL-2 (n = 27), subcutaneous ...

Estimation of the potency of ORG 9426 using two different modes of nerve stimulation

The potency of ORG 9426, a new nondepolarising muscle relaxant, has been estimated using two different modes of nerve stimulation in patients anaesthetised with thiopentone, nitrous oxide-oxygen and intravenous fentanyl. The force of contraction of adductor pollicis was measured following a single twitch (ST) at 0.1 Hz or a train-of-four (TOF) mode of stimulation at 2 Hz every ten ...

Administration of Imiquimod, an Interferon Inducer, in Asymptomatic Human Immunodeficiency Virus—Infected Persons to Determine Safety and Biologic Response Modification

A phase I study to determine safety, maximum tolerated dose, and biologic response during multiple once-a-week administration of oral imiquimod, an immune response modifier, was conducted in 12 adults with early human immunodeficiency virus (HIV) infection. All completed the dose-escalation phase of weekly dosing at 100-mg increments and received at least one maintenance dose, 100 ...

A multiprocessor system for generating visual displays and controlling experiments

A laboratory is described that is based on an IMSAI 8080 microcomputer and an IMLAC graphics display system. Procedures for using the system are described and illustrated.

Severity and Prognosis of Acute Human Immunodeficiency Virus Type 1 Illness: A Dose-Response Relationship

This study examined the relationship between the severity of acute human immunodeficiency virus type 1 (HIV-1) illness and disease progression and death. The population included 218 patients with acute HIV-1 illness and 41 asymptomatic patients who underwent HIV-1 seroconversion; the patients were followed up prospectively. We analyzed progression to Centers for Disease Control and ...

Meta-Analysis of the INSIG2 Association with Obesity Including 74,345 Individuals: Does Heterogeneity of Estimates Relate to Study Design?

Kronenberg Vera Adamkova Sonia S. Anand Kristin Ardlie Heike Biebermann Peter Bjerregaard Heiner Boeing Claude Bouchard Marina Ciullo Jackie A. Cooper Dolores Corella Christian Dina James C. Engert Eva Fisher

Delivery of Legal Services to the Poor in the Twenty-First Century

Michael A. Cooper , Charles J. Ogletree, Robert F. Drinan, Elaine R. Jones, Margaret Fung, Bob Herbert, Deborah L. Rhode, Beverly M. Smith, William G. Paul, Charles Halpern , Kristen B. Glen & Robert E

Acute Human Immunodeficiency Virus Type 1 Disease as a Mononucleosis-Like Illness: Is the Diagnosis Too Restrictive?

The purpose of this study was to describe the frequency and duration of clinical features at the time of acute human immunodeficiency virus type 1 (HIV-1) disease in 218 patients with documented symptomatic primary HIV-1 infection. The mean duration of acute HIV-1 disease was 25.1 days (median, 20.0 days) and did not differ by gender, age, and risk factor. The frequency and mean ...

Fourier analyses: A mathematical and geometric explanation

Fourier analyses are used in electrophysiological research to reduce EEG data to an interpretable, analyzable form. This article outlines the mathematical similarities and differences between Fourier transforms and fast Fourier transforms. A geometric explanation of the application of fast Fourier transforms and a Fourier series to theta-band EEG data is also included in this ...

Automatization and perceptual restructuring performance across the menstrual cycle

The cognitive performance of undergraduate psychology women (n=49) and men (n=48) was assessed using standardized automatization and perceptual restructuring measures. Women were classified into five groups based on the phase of the menstrual cycle they were experiencing at the time of testing. Results showed that the automatization performance of women who were expecting to ...

Haemodynamic effects of rocuronium during fentanyl anaesthesia: comparison with vecuronium

Haemodynamic variables were measured following administration of rocuronium 0.6 mg· kg−1 or vecuronium 0.08 mg · kg−1 (approximately equivalent to 2 × ED95 doses) in patients anaesthetized with fentanyl 50 μg· kg−1 and scheduled to undergo elective coronary artery bypass grafting. There were increases in stroke volume index (+15%) and cardiac index (+11%), and a decrease in ...

Pooled Analysis of 3 Randomized, Controlled Trials of Interleukin-2 Therapy in Adult Human Immunodeficiency Virus Type 1 Disease

We collected human immunodeficiency virus (HIV) disease progression, survival, most recent CD4 cell count, and plasma HIV RNA levels from patients (n = 157) who participated in randomized clinical trials of interleukin (IL)–2 that commenced before 1995. Data were available for 155 (99%) patients. Statistical analyses were based on the intention-to-treat principle. Median follow-up ...

Discrimination learning after hippocampal lesions in 1-day-old rats

Hooded rat pups (N=26) received radio frequency lesions at 1 day of age. Ten were operated controls, nine received hippocampal ablations, and seven sustained lesions of the entorhinal area. The effects of the surgery were assessed using a left-right spatial discrimination test with the home cage and mother serving as reward. The results suggest that partial deefferentation of the ...