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Primary Infection with Zidovudine-Resistant Human Immunodeficiency Virus Type 1 Does Not Adversely Affect Outcome at 1 Year

Human immunodeficiency virus type 1 (HIV-1) variants with reduced in vitro sensitivity to zidovudine, conferred by specific mutations in the viral reverse transcriptase, emerge during prolonged therapy. Late-stage disease and declining CD4 cell count are associated with more rapid emergence of these resistant variants. Isolates of HIV-1 from seroconverters were screened for the ...

Visual comparison processes: Identity and similarity decisions

In the first experiment, in which two successively presented free-form visual patterns varied in their similarity to each other, subjects had to decide, in one condition, if the patterns were “identical” and in two other conditions if the patterns were “similar.” Qualitative individual differences in the effect of similarity on the time required to make a decision were found in the ...

Changes in Biologic Phenotype of Human Immunodeficiency Virus during Treatment of Patients with Didanosine

Progression to AIDS in patients harboring human immunodeficiency virus type 1 (HIV-1) isolates expressing a syncytium-inducing (SI) phenotype is faster than in those in whom the virus expresses a non-SI (NSI) phenotype. Zidovudine monotherapy does not appear to alter this outcome. To examine the role of didanosine (ddl) monotherapy in phenotype expression, HIV-1 isolates from 73 ...

Field independence/dependence, sex, and water levels

should be made to Sherman Ross, Department of Psychology, Howard University , Washington, D.C. 20059 2 JEROME H. BLUE, JOHN A. COOPER, and SHERMAN ROSS Howard University , Washington, D. C. 20059 3

Fequency-specific color adaptation in the human visual system

Following prolonged exposure to two vertical grating patterns differing in spatial frequency—one pattern illuminated in green light alternated with the other pattern illuminated in red light—human observers will sometimes report seeing desaturated complementary colors when presented with a neutrally illuminated test field consisting of adjacent halves of the two adapting gratings. ...

Clinical Efficacy of High-Dose Acyclovir in Patients with Human Immunodeficiency Virus Infection: A Meta-Analysis of Randomized Individual Patient Data

A meta-analysis of 8 randomized trials (1792 patients, 2947 patient-years of follow-up) showed that acyclovir (⩾3200 mg/day) offered a significant survival benefit (P = .006 by log-rank test) in human immunodeficiency virus (HIV) infection. The treatment effect did not vary significantly in patient subgroups of different CD4 cell counts, hemoglobin levels, age, race, and sex, and ...

The Properties and Subcellular Localization of Acid Phosphatases in the Colourless Alga, Polytomella Caeca

R. A. Cooper 0 I. D. Bowen 0 D. Lloyd 0 0 Departments of Microbiology and Zoology, University College , Newport Road, Cardiff, CFi 3NR, Wales The acid -nitrophenyl phosphatase of homogenates of ... . caeca is discussed in view of the inability to detect eleven other latent acid hydrolases in cell-free homogenates. THE PROPERTIES AND SUBCELLULAR ROSEMARY A. COOPER,* I. D. BOWENf AND D. LLOYD

Postoperative malignant hyperthermia: A case report

Canad. Anaesth. Soc. J. j. BELDAVS .l.D. C.R.C.P.  V. SMALL C.R.C.P. 0 D. A. COOPER ~I.D. C.R.C.P. ~"AND g. A. BRITT DIP.ANAES. F.R.C.P. 0 Department of Anaesthesia and Department of Internal

High-Dose Nevirapine in Previously Untreated Human Immunodeficiency Virus Type 1-Infected Persons Does Not Result in Sustained Suppression of Viral Replication

High-dose nevirapine treatment has been reported to confer sustained antiretroviral effects, despite a rapid development of resistance. The use of this strategy was evaluated in 20 previously untreated human immunodeficiency virus type 1 (HIV-1) p24 antigenemic persons with CD4 cell counts between 100 and 500/mm3. Treatment consisted of 400 mg of nevirapine, after a 2-week lead-in ...

Virologic and Immunologic Benefits of Initial Combination Therapy with Zidovudine and Zalcitabine or Didanosine Compared with Zidovudine Monotherapy

, Joep M. A. Lange, David A. Cooper , James Lavelle, Lewis Lefkowitz, Mark Moore, Brendan A. Larder, Marty St. Clair, Jan Willem Mulder, Ray McKinnis , Kevin N. Pennington 2 P. Richard Harrigan, Ian


PSEUDOPALISADING CELLS Daniel J. Brat, Lee A. Cooper, David A. Gutman, Candace S. Chisolm, Christina Appin, Jun Kong, Tahsin Kurc, Erwin G. Van Meir, Joel H. Saltz, and Carlos S. Moreno; Emory University, Atlanta