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Synthesis and characterization of bionanoparticle—Silica composites and mesoporous silica with large pores

A sol-gel process has been developed to incorporate bionanoparticles, such as turnip yellow mosaic virus, cowpea mosaic virus, tobacco mosaic virus, and ferritin into silica, while maintaining the integrity and morphology of the particles. The structures of the resulting materials were characterized by transmission electron microscopy, small angle X-ray scattering, and N2...

Identification and expression profile of a putative basement membrane protein gene in the midgut of Helicoverpa armigera

amount of isopropanol in PBS without RH-2485 was injected. Authors' contributions Jia-Lin Wang carried out immunoblotting. Xiao-Juan Jiang performed Northern blot. Qian Wang completed immunohistochemistry

Hemoglobinopathy: Molecular Epidemiological Characteristics and Health Effects on Hakka People in the Meizhou Region, Southern China

Background Hemoglobinopathies are the most common inherited diseases in southern China. However, there have been only a few epidemiological studies of hemoglobinopathies in Guangdong province. Materials and Methods Peripheral blood samples were collected from 15299 “healthy” unrelated subjects of dominantly ethnic Hakka in the Meizhou region, on which hemoglobin electrophoresis...

Landscape Composition and Spatial Prediction of Alveolar Echinococcosis in Southern Ningxia, China

Background Alveolar echinococcosis (AE) presents a serious public health challenge within China. Mass screening ultrasound surveys can detect pre-symptomatic AE, but targeting areas identified from hospital records is inefficient regarding AE. Prediction of undetected or emerging hotspots would increase detection rates. Voles and lemmings of the subfamily Arvicolinae are...

c-Fms-mediated differentiation and priming of monocyte lineage cells play a central role in autoimmune arthritis

Introduction Tyrosine kinases are key mediators of multiple signaling pathways implicated in rheumatoid arthritis (RA). We previously demonstrated that imatinib mesylate--a Food and Drug Administration (FDA)-approved, antineoplastic drug that potently inhibits the tyrosine kinases Abl, c-Kit, platelet-derived growth factor receptor (PDGFR), and c-Fms--ameliorates murine...

SOCIOECONOMIC AND BEHAVIOR RISK FACTORS OF HUMAN ALVEOLAR ECHINOCOCCOSIS IN TIBETAN COMMUNITIES IN SICHUAN, PEOPLE’S REPUBLIC OF CHINA

0 Organization Collaborating Centre on Prevention and Treatment of Human Echinococcosis, SERF Research Unit, Universit e de Franche-Comt e , 25030 Besanon, France 1 QIAN WANG, JIAMIN QIU, WEN YANG ... Program), and the Sichuan Provincial Health Department. Qian Wang was supported by a PhD grant from the French Embassy, French Ministry of Foreign Affairs, in Beijing, Peoples Republic of China.

Design and synthesis of boronic-acid-labeled thymidine triphosphate for incorporation into DNA

The boronic acid moiety is a versatile functional group useful in carbohydrate recognition, glycoprotein pull-down, inhibition of hydrolytic enzymes and boron neutron capture therapy. The incorporation of the boronic-acid group into DNA could lead to molecules of various biological functions. We have successfully synthesized a boronic acid-labeled thymidine triphosphate (B-TTP...

Small Molecule, Non-Peptide p75NTR Ligands Inhibit Aβ-Induced Neurodegeneration and Synaptic Impairment

The p75 neurotrophin receptor (p75NTR) is expressed by neurons particularly vulnerable in Alzheimer's disease (AD). We tested the hypothesis that non-peptide, small molecule p75NTR ligands found to promote survival signaling might prevent Aβ-induced degeneration and synaptic dysfunction. These ligands inhibited Aβ-induced neuritic dystrophy, death of cultured neurons and A...

Activation of the hedgehog pathway in human hepatocellular carcinomas

Liver cancers, the majority of which are hepatocellular carcinomas (HCCs), rank as the fourth in cancer mortality worldwide and are the most rapidly increasing type of cancer in the United States. However, the molecular mechanisms underlying HCC development are not well understood. Activation of the hedgehog pathway is shown to be involved in several types of gastrointestinal...