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Structure-Based High-Throughput Epitope Analysis of Hexon Proteins in B and C Species Human Adenoviruses (HAdVs)

Human adenoviruses (HAdVs) are the etiologic agent of many human infectious diseases. The existence of at least 54 different serotypes of HAdVs has resulted in difficulties in clinical diagnosis. Acute respiratory tract disease (ARD) caused by some serotypes from B and C species is particularly serious. Hexon, the main coat protein of HAdV, contains the major serotype-specific B...

Clinical features and risk factors for severe and critical pregnant women with 2009 pandemic H1N1 influenza infection in China

Peng-jun Zhang Xiao-li Li Bin Cao Shi-gui Yang 0 Li-rong Liang Li Gu Zhen Xu Ke Hu Hong-yuan Zhang Xi-xin Yan Wen-bao Huang Wei Chen Jing-xiao Zhang Lan-juan Li 0 Chen Wang 1 for for the National

High Prevalence of Macrolide Resistance in Mycoplasma pneumoniae Isolates from Adult and Adolescent Patients with Respiratory Tract Infection in China

The resistance rate of 67 Mycoplasma pneumoniae isolates from 356 ambulatory adult patients with respiratory tract infection was 69% (46 of 67). All 46 macrolide-resistant strains harbored point mutations in the 23S ribosomal RNA gene. Patients infected with macrolide-resistant M. pneumoniae required significantly longer durations of antibiotic therapy and had longer time to...

The association between serum adhesion molecules and outcome in acute spontaneous intracerebral hemorrhage

Introduction Serum concentrations of adhesion molecules may be connected to the pathogenesis of secondary brain injury after spontaneous intracerebral hemorrhage (ICH). This study posits the hypothesis that levels of adhesion molecules substantially increase after ICH and are decreased thereafter, and that they can predict treatment outcomes. Methods Two hundred and thirty-nine...

Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage

Human polynucleotide kinase/phosphatase (PNKP) is a dual specificity 5′-DNA kinase/3′-DNA phosphatase, with roles in base excision repair, DNA single-strand break repair and non-homologous end joining (NHEJ); yet precisely how PNKP functions in the repair of DNA double strand breaks (DSBs) remains unclear. We demonstrate that PNKP is phosphorylated by the DNA-dependent protein...

Pulmonary Embolism Incidence and Fatality Trends in Chinese Hospitals from 1997 to 2008: A Multicenter Registration Study

Background There has not been sufficient evidence to support the Asians being less susceptible to pulmonary embolism (PE) than other ethnicities, because the prevalence of PE/deep venous thrombosis (DVT) in different racial and ethnic groups has not been carefully studied until recently except in Caucasians. To test the hypothesis that the Chinese population has a lower risk for...

Knowledge-guided multi-scale independent component analysis for biomarker identification

Background Many statistical methods have been proposed to identify disease biomarkers from gene expression profiles. However, from gene expression profile data alone, statistical methods often fail to identify biologically meaningful biomarkers related to a specific disease under study. In this paper, we develop a novel strategy, namely knowledge-guided multi-scale independent...

Signal Regulatory Protein α Negatively Regulates β2 Integrin-Mediated Monocyte Adhesion, Transendothelial Migration and Phagocytosis

Background Signal regulate protein α (SIRPα) is involved in many functional aspects of monocytes. Here we investigate the role of SIRPα in regulating β2 integrin-mediated monocyte adhesion, transendothelial migration (TEM) and phagocytosis. Methodology/Principal Findings THP-1 monocytes/macropahges treated with advanced glycation end products (AGEs) resulted in a decrease of SIRP...

Area Disease Estimation Based on Sentinel Hospital Records

Qiao Sun Zhong-Jie Li Xiao-Zhou Li Sheng-Jie Lai Hong-Yan Chen Dao-Chen Wang Yang Yang, Fred Hutchinson Cancer Research Center, United States of America Background: Population health attributes (such as

Characteristics of stable chronic obstructive pulmonary disease patients in the pulmonology clinics of seven Asian cities

Silverman,13 Jae Seung Lee,1 Ting Yang,14 Yingxiang Lin,14 Chen Wang,14 Sang-Do Lee1  1Department of Pulmonary and Critical Care Medicine and Clinical Research Center for Chronic Obstructive Airway Diseases ... Hironi Makita 13 Edwin K Silverman 10 Jae Seung Lee 3 Ting Yang 11 Yingxiang Lin 11 Chen Wang 11 Sang-Do Lee 3 0 Department of Medicine, Khon Kaen University , Khon Kaen , Thailand 1 Department of

Clinical significance of Neutrophil gelatinase-associated lipocalin(NGAL) expression in primary rectal cancer

Background Emerging evidence has demonstrated that Neutrophil gelatinase-associated lipocalin (NGAL) is up-regulated in multiple malignancies, including oesophagus cancer, and plays a critical role in tumorigenesis and progression. However, till now, little is known about the role of NGAL in human rectal cancer. Its association with clinicopathologic characteristics and...

Efficacy and safety of 2-hour urokinase regime in acute pulmonary embolism: a randomized controlled trial

Thromboembolism(VTE) Study Group for their great contributions to this study. The members of the study group were as follows: Steering Committee--Chen Wang, Xiansheng Cheng, Xinzhi Weng, Weixuan Lu, Quanying He ... , Yiming Zhao, Binrong Ma, Nanshan Zhong; Independent Central Adjudication Committee--Xiansheng Cheng, Ruping Dai, Youmin Guo, Tie Wang, Weixuan Lu, Quanying He, Yiming Zhao, Chen Wang; Data and Coordinating

PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 Are Associated with Type 2 Diabetes in a Chinese Population

Background Recent advance in genetic studies added the confirmed susceptible loci for type 2 diabetes to eighteen. In this study, we attempt to analyze the independent and joint effect of variants from these loci on type 2 diabetes and clinical phenotypes related to glucose metabolism. Methods/Principal Findings Twenty-one single nucleotide polymorphisms (SNPs) from fourteen loci...

NEURO-ONCOLOGY IN DEVELOPING COUNTRIES

INTRODUCTION: Using ventricoluperitoneal shunt before the resection of pediatric posterior fossa brain tumors, presenting with hydrocephalus used to be common practice, but most centers now are abandoning this policy due to the complications associated with the shunt. MATERIAL AND METHODS: We report retrospectively on the short term outcome of posterior fossa brain tumour in...

CD44v4 Is a Major E-Selectin Ligand that Mediates Breast Cancer Cell Transendothelial Migration

BackgroundEndothelial E-selectin has been shown to play a pivotal role in mediating cell–cell interactions between breast cancer cells and endothelial monolayers during tumor cell metastasis. However, the counterreceptor for E-selectin and its role in mediating breast cancer cell transendothelial migration remain unknown.Methodology/Principal FindingsBy assessing migration of...

Epigenome-wide ovarian cancer analysis identifies a methylation profile differentiating clear-cell histology with epigenetic silencing of the HERG K+ channel

4 Devin C. Koestler 6 Brooke L. Fridley 5 Kimberly R. Kalli 2 Sebastian M. Armasu 4 Melissa C. Larson 4 Chen Wang 4 Stacey J. Winham 4 Robert A. Vierkant 4 David N. Rider 4 Matthew S. Block 0 Brandy

Abscisic acid regulates TSRF1-mediated resistance to Ralstonia solanacearum by modifying the expression of GCC box-containing genes in tobacco

Although recent studies have established a significant regulatory role for abscisic acid (ABA) and ethylene response factor (ERF) proteins in plant pathogen resistance, it is not clear whether and how ABA performs this role. Previously, it was reported that an ERF protein, TSRF1, activates the expression of GCC box-containing genes and significantly enhances the resistance to...

Bacterial brain abscess in patients with nasopharyngeal carcinoma following radiotherapy: microbiology, clinical features and therapeutic outcomes

Background This study aimed to analyze the clinical features, causative pathogens, neuro-imaging findings, and therapeutic outcomes of bacterial brain abscess in patients with nasopharyngeal carcinoma (NPC) following radiotherapy. Methods NPC patients with bacterial brain abscess were evaluated. Their clinical data were collected over a 22-year period. For comparison, the...

Aluminum nanoparticles enhance anticancer immune response induced by tumor cell vaccine

The application of nanomaterial in cancer treatment is promising and intriguing. Anti-tumor immunotherapy has the potential to significantly improve the prognosis of cancer treatment, though the efficacy of immunotherapy generally needs further improvement. One way to improve the efficacy is using immune adjuvants, but the adjuvants for anticancer immunotherapy have to be more...