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Deleterious Effects of Intermittent Recombinant Parathyroid Hormone on Cartilage Formation in a Rabbit Microfracture Model: a Preliminary Study

Intermittent parathyroid hormone administration can enhance fracture healing in an animal model. Despite the success of exogenous parathyroid hormone on fracture healing and spine fusion, few studies have examined the role of parathyroid hormone on cartilage formation. We determined the effects of intermittent parathyroid hormone on cartilage formation in a rabbit microfracture...

Do Ceramic Femoral Heads Reduce Taper Fretting Corrosion in Hip Arthroplasty? A Retrieval Study

Background Previous studies regarding modular head-neck taper corrosion were largely based on cobalt chrome (CoCr) alloy femoral heads. Less is known about head-neck taper corrosion with ceramic femoral heads. Questions/purposes We asked (1) whether ceramic heads resulted in less taper corrosion than CoCr heads; (2) what device and patient factors influence taper fretting...

Prospective multicenter evaluation of rapid, gated SPECT myocardial perfusion upright imaging

Jamshid Maddahi jmaddahi@mednet FACC Ricardo Mendez John J. Mahmarian Gregory Thomas Hetal Babla MS Chuanyong Bai Samia Arram BS Peter Maffetone CNMT Richard Conwell BS Background. A novel three

Existence of the rdl mutant alleles among the anopheles malaria vector in Indonesia

Background The gamma-aminobutyric acid (GABA) receptor-chloride channel complex is known to be the target site of dieldrin, a cyclodiene insecticide. GABA-receptors, with a naturally occurring amino acid substitution, A302S/G in the putative ion-channel lining region, confer resistance to cyclodiene insecticides that includes aldrin, chlordane, dieldrin, heptachlor, endrin and...

The Impact of Language Barriers on Documentation of Informed Consent at a Hospital with On-Site Interpreter Services

BACKGROUND Informed consent is legally and ethically required before invasive non-emergent procedures. Language barriers make obtaining informed consent more complex. OBJECTIVE Determine the impact of language barriers on documentation of informed consent among patients in a teaching hospital with on-site interpreter services. DESIGN Matched retrospective chart review study...

Osteosarcoma of the Proximal Tibia: Limb-Sparing Resection and Reconstruction with a Modular Segmental Proximal Tibia Tumor Prosthesis

A limb-sparing resection was performed for osteosarcoma of the proximal tibia in a young patient. A special modular segmental proximal tibial endoprosthesis that includes a hinged total knee component was used for reconstruction. A medial gastrocnemius rotational flap was utilized to reconstruct the extensor mechanism of the knee. The muscle flap aids in covering the prosthesis...

Cancer Cachexia: Traditional Therapies and Novel Molecular Mechanism-Based Approaches to Treatment

Nagi B. Kumar FADA 0 Aslam Kazi Tiffany Smith BS Theresa Crocker MS Daohai Yu Richard R. Reich Kiran Reddy Sally Hastings Martine Exterman Lodovico Balducci Kyle Dalton BS Gerold Bepler 0 Department

Ki-67 expression is predictive of prognosis in patients with stage I/II extranodal NK/T-cell lymphoma, nasal type

Background: Localized extranodal natural killer (NK)/T-cell lymphoma, nasal type, commonly has a low or low–intermediate risk of the international prognostic index (IPI), so the IPI has shown inconsistency in predicting prognosis. Thus, we analyzed Ki-67 expression and proposed a new prognostic model including Ki-67 expression for stage I/II extranodal NK/T-cell lymphoma...

Ki-67 expression is predictive of prognosis in patients with stage I/II extranodal NK/T-cell lymphoma, nasal type

expression in peripheral T-cell lymphoma: a proposed clinical-pathologic prognostic score . J Clin Oncol 2006 ; 24 : 2472 - 2479 . 14. Kim SJ , Kim BS , Choi CW et al. Treatment outcome of front-line systemic

Platelet-activating factor receptor (PAF-R)-dependent pathways control tumour growth and tumour response to chemotherapy

Background Phagocytosis of apoptotic cells by macrophages induces a suppressor phenotype. Previous data from our group suggested that this occurs via Platelet-activating factor receptor (PAF-R)-mediated pathways. In the present study, we investigated the impact of apoptotic cell inoculation or induction by a chemotherapeutic agent (dacarbazine, DTIC) on tumour growth...

Utility of multispectral imaging for nuclear classification of routine clinical histopathology imagery

. Boucheron LE , Harvey NR , Manjunath BS : Utility of multispectral imaging for analysis of routine clinical histopathology imagery . 2006 . Presented at the 2006 Workshop on Multiscale Biological Imaging

Model based dynamics analysis in live cell microtubule images

Background The dynamic growing and shortening behaviors of microtubules are central to the fundamental roles played by microtubules in essentially all eukaryotic cells. Traditionally, microtubule behavior is quantified by manually tracking individual microtubules in time-lapse images under various experimental conditions. Manual analysis is laborious, approximate, and often...

Catechol-o-Methyltransferase Enzyme Activity and Protein Expression in Human Prefrontal Cortex across the Postnatal Lifespan

-- 31 . Bearden CE , Jawad AF , Lynch DR , Sokol S , Kanes SJ , McDonald-McGinn DM , Saitta SC , Harris SE , Moss E , Wang PP , Zackai E , Emanuel BS , Simon TJ . 2004 . Effects of a functional COMT ... positron emission tomography study . Neurosci Lett . 364 : 159 -- 163 . Chen J , Lipska BK , Halim N , Ma QD , Matsumoto M , Melhem S , Kolachana BS , Hyde TM , Herman MM , Apud J , Egan MF , Kleinman JE

Primary Small-bowel Non-Hodgkin's Lymphoma: A Study of Clinical Features, Pathology, Management and Prognosis

The records of 34 patients diagnosed with primary small bowel non-Hodgkin's lymphoma during a 10-year period between January 1996 and December 2005, including 27 cases for which complete follow-up records were available, were studied. Abdominal pain (70.6% of patients) was the main presenting symptom, followed by intestinal obstruction (38.2%). The most common primary site was...

Erratum to: Routine Rapid HIV Screening in Six Community Health Centers Serving Populations at Risk

Bernstein BS 0 Kathleen McNamara RN 0 0 National Association of Community Health Centers , Bethesda, MD , USA 1 Center for AIDS Prevention Studies, University of California , San Francisco, CA , USA - T

First report of multiple lineages of dengue viruses type 1 in Rio de Janeiro, Brazil

Background In Brazil dengue has been a major public health problem since DENV-1 introduction and spread in 1986. After a low or silent co-circulation, DENV-1 re-emerged in 2009 causing a major epidemic in the country in 2010 and 2011. In this study, the phylogeny of DENV-1 strains isolated in RJ after its first introduction in 1986 and after its emergence in 2009 and 2010 was...