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A new method to evaluate temperature vs. pH activity profiles for biotechnological relevant enzymes

Glycoside hydrolases are important for various industrial and scientific applications. Determination of their temperature as well as pH optima and range is crucial to evaluate whether an enzyme is suitable for application in a biotechnological process. These basic characteristics of enzymes are generally determined by two separate measurements. However, these lead to a ...

A strongly selected mutation in the HIV-1 genome is independent of T cell responses and neutralizing antibodies

Mutations rapidly accumulate in the HIV-1 genome after infection. Some of those mutations are selected by host immune responses and often cause viral fitness losses. This study is to investigate whether strongly selected mutations that are not associated with immune responses result in fitness losses. Strongly selected mutations were identified by analyzing 5′-half HIV-1 genome ...

Customized microscale approach for optimizing two-phase bio-oxidations of alkanes with high reproducibility

Numerous challenges remain to achieve industrially competitive space–time yields for bio-oxidations. The ability to rapidly screen bioconversion reactions for characterization and optimization is of major importance in bioprocess development and biocatalyst selection; studies at conventional lab scale are time consuming and labor intensive with low experimental throughput. The ...

Behavioral testing of minipigs transgenic for the Huntington gene—A three-year observational study

Background Large animal models of Huntington’s disease (HD) may increase the reliability of translating preclinical findings to humans. Long live expectancy offers opportunities particularly for disease modifying approaches, but also challenges. The transgenic (tg) HD minipig model assessed in this study exhibits a high genetic homology with humans, similar body weight, and ...

The effect of electronic monitoring feedback on medication adherence and clinical outcomes: A systematic review

Objective This study aims to assess the efficacy of Electronic Monitoring Feedback (EMF) as an intervention to improve medication adherence (i.e. dose- or full adherence) and clinical outcomes in adult patients. Methods A systematic search was performed in Medline, EMBASE, PsycINFO and Web of Science and reported according to the PRISMA guidelines. Randomised controlled trials ...

Recurrence analysis of ant activity patterns

In this study, we used recurrence quantification analysis (RQA) and recurrence plots (RPs) to compare the movement activity of individual workers of three ant species, as well as a gregarious beetle species. RQA and RPs quantify the number and duration of recurrences of a dynamical system, including a detailed quantification of signals that could be stochastic, deterministic, or ...

Interpretation of Offshore Crustal Movements Following the 2011 Tohoku-Oki Earthquake by the Combined Effect of Afterslip and Viscoelastic Stress Relaxation

On the 11th March 2011, a megathrust event, called the Tohoku-oki earthquake, occurred at the North American-Pacific plate interface off northeast Japan. Transient crustal movements following this earthquake were clearly observed by a dense GPS network (GEONET) on land and a sparse GPS/Acoustic positioning network on seafloor. The observed crustal movements are in accordance with ...

The Invisibility of Diffeomorphisms

I examine the relationship between \((d+1)\)-dimensional Poincaré metrics and d-dimensional conformal manifolds, from both mathematical and physical perspectives. The results have a bearing on several conceptual issues relating to asymptotic symmetries in general relativity and in gauge–gravity duality, as follows: (1: Ambient Construction) I draw from the remarkable work by ...

Isolation, purification, structural analysis and coagulatory activity of water-soluble polysaccharides from Ligustrum lucidum Ait flowers

In this study, Ligustrum lucidum flowers as raw material, the extraction, isolation and coagulatory activity of polysaccharides were carried out for the first time. The crude polysaccharide was obtained by hot water extraction and ethanol precipitation, and preliminarily purified by Sevage method and D101 macroporous resin. Then the polysaccharide was further purified by DEAE-52 ...

Design, Perception and Behavior in the Innovation Era: Revisiting the Concept of Interdependence

The innovation era has seen firms adopting a variety of organization designs with autonomous teams as their basic building blocks. Such organization designs have confronted firms with the challenge of managing complex task interdependence configurations. The predominant assumption within the organization design field for decades has been that task interdependence given by design ...

Large-Area WS2 Film with Big Single Domains Grown by Chemical Vapor Deposition

High-quality WS2 film with the single domain size up to 400 μm was grown on Si/SiO2 wafer by atmospheric pressure chemical vapor deposition. The effects of some important fabrication parameters on the controlled growth of WS2 film have been investigated in detail, including the choice of precursors, tube pressure, growing temperature, holding time, the amount of sulfur powder, and ...

Contrasting resting-state fMRI abnormalities from sickle and non-sickle anemia

Sickle cell disease (SCD) is a chronic blood disorder that is often associated with acute and chronic cerebrovascular complications, including strokes and impaired cognition. Using functional resting state magnetic resonance images, we performed whole-brain analysis of the amplitude of low frequency fluctuations (ALFF), to detect areas of spontaneous blood oxygenation level ...

A role of the Atlantic Ocean in predicting summer surface air temperature over North East Asia?

We assess the ability of the DePreSys3 prediction system to predict the summer (JJAS) surface-air temperature over North East Asia. DePreSys3 is based on a high resolution ocean–atmosphere coupled climate prediction system (~ 60 km in the atmosphere and ~ 25 km in the ocean), which is full-field initialized from 1960 to 2014 (26 start-dates). We find skill in predicting surface-air ...

Is God the Necessary Being?

This paper briefly presents and engages with four competing hypotheses as to the most plausible explanation for the beginning of the universe. After clarifying some terminology, I will first establish both scientific and philosophical reasons for accepting the notion of an absolute beginning over a past eternal universe. Next, I will interact with Lawrence Krauss’ two versions of ...

Density-dependent signaling: An alternative hypothesis on the function of chemical signaling in a non-territorial solitary carnivore

Brown bears are known to use rubbing behavior as a means of chemical communication, but the function of this signaling is unclear. One hypothesis that has gained support is that male bears rub to communicate dominance to other males. We tested the communication of dominance hypothesis in a low-density brown bear population in southeast British Columbia. We contrasted rubbing rates ...