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Comprehensive Pharmacokinetic, Pharmacodynamic and Pharmacogenetic Evaluation of Once-Daily Efavirenz 400 and 600 mg in Treatment-Naïve HIV-Infected Patients at 96 Weeks: Results of the ENCORE1 Study

and Pfizer; David A. Cooper has received honoraria and research grant support from Gilead Sciences, Merck Research Laboratories and Bristol–Myers Squibb; and Sean Emery has received research grant

Rehabilitation of People with Lower-Limb Amputations

Affairs , 6425 Penn Avenue, Suite 400, Pittsburgh, PA 15206, USA 1 R. Cooper UPMC Health System Center for Assistive Technology , Pittsburgh, PA 15260, USA 2 G. Fiedler J. Akins R. Cooper S. Munoz R. A ... . Cooper Department of Rehabilitation Science & Technology, University of Pittsburgh , Pittsburgh, PA 15260, USA Rehabilitation of persons with lower-limb amputation is a complex endeavor that requires the

Impaired Mitochondrial Energy Production Causes Light-Induced Photoreceptor Degeneration Independent of Oxidative Stress

Two insults often underlie a variety of eye diseases including glaucoma, optic atrophy, and retinal degeneration—defects in mitochondrial function and aberrant Rhodopsin trafficking. Although mitochondrial defects are often associated with oxidative stress, they have not been linked to Rhodopsin trafficking. In an unbiased forward genetic screen designed to isolate mutations that ...

How Accurate Is MOLLI T1 Mapping In Vivo? Validation by Spin Echo Methods

T1 mapping is a promising quantitative tool for assessing diffuse cardiomyopathies. The purpose of this study is to quantify in vivo accuracy of the Modified Look-Locker Inversion Recovery (MOLLI) cardiac T1 mapping sequence against the spin echo gold standard, which has not been done previously. T1 accuracy of MOLLI was determined by comparing with the gold standard inversion ...

Clinical Utility of a Coronary Heart Disease Risk Prediction Gene Score in UK Healthy Middle Aged Men and in the Pakistani Population

Background Numerous risk prediction algorithms based on conventional risk factors for Coronary Heart Disease (CHD) are available but provide only modest discrimination. The inclusion of genetic information may improve clinical utility. Methods We tested the use of two gene scores (GS) in the prospective second Northwick Park Heart Study (NPHSII) of 2775 healthy UK men (284 cases), ...

You Turn Me Cold: Evidence for Temperature Contagion

Introduction During social interactions, our own physiological responses influence those of others. Synchronization of physiological (and behavioural) responses can facilitate emotional understanding and group coherence through inter-subjectivity. Here we investigate if observing cues indicating a change in another's body temperature results in a corresponding temperature change in ...

Effect of the PPARG2 Pro12Ala Polymorphism on Associations of Physical Activity and Sedentary Time with Markers of Insulin Sensitivity in Those with an Elevated Risk of Type 2 Diabetes

Background Peroxisome proliferator-activated receptor gamma (PPARγ) is an important regulator of metabolic health and a common polymorphism in the PPAR-γ2 gene (PPARG2) may modify associations between lifestyle behaviour and health. Objective To investigate whether the PPARG2 Pro12Ala genotype modifies the associations of sedentary behaviour and moderate-to-vigorous intensity ...

Correction: Raltegravir Non-Inferior to Nucleoside Based Regimens in SECOND-LINE Therapy with Lopinavir/Ritonavir over 96 Weeks: A Randomised Open Label Study for the Treatment Of HIV-1 Infection

. Sohn Hedy Teppler Boris Renjifo Jean-Michel Molina Sean Emery David A. Cooper SECOND-LINE - The group author, SECOND-LINE, was omitted from the author byline and should be listed as the fifteenth

Poverty, Wealth, and Health Care Utilization: A Geographic Assessment

Geographic variation has been of interest to both health planners and social epidemiologists. However, while the major focus of interest of planners has been on variation in health care spending, social epidemiologists have focused on health; and while social epidemiologists have observed strong associations between poor health and poverty, planners have concluded that income is ...

The RNA-binding protein Rbfox1 regulates splicing required for skeletal muscle structure and function

The Rbfox family of RNA-binding proteins is highly conserved with established roles in alternative splicing (AS) regulation. High-throughput studies aimed at understanding transcriptome remodeling have revealed skeletal muscle as displaying one of the largest number of AS events. This finding is consistent with requirements for tissue-specific protein isoforms needed to sustain ...

Post-diagnostic prescriptions for low-dose aspirin and breast cancer-specific survival: a nested case-control study in a breast cancer cohort from the UK Clinical Practice Research Datalink

Practice Research Datalink Liam J Murray 0 1 Janine A Cooper Carmel M Hughes Des G Powe Chris R Cardwell 1 0 Centre of Excellence for Public Health (NI), Queen's University Belfast, Institute of Clinical

Ribonuclease L and metal-ion–independent endoribonuclease cleavage sites in host and viral RNAs

Ribonuclease L (RNase L) is a metal-ion–independent endoribonuclease associated with antiviral and antibacterial defense, cancer and lifespan. Despite the biological significance of RNase L, the RNAs cleaved by this enzyme are poorly defined. In this study, we used deep sequencing methods to reveal the frequency and location of RNase L cleavage sites within host and viral RNAs. To ...

Maximizing the Benefits of “We” in Race-Discordant Patient–Physician Relationships: Novel Insights Raise Intriguing Questions

Over the last decade, research on racial differences in the quality of the patient–physician relationship has yielded mounting evidence of lower levels of trust,1 satisfaction2 and perceived partnership2 in race-discordant patient–physician relationships. Evidence linking race discordance to technical aspects of care and health outcomes is limited and results are mixed.3 However, ...

HLA Alleles Association with Changes in Bone Mineral Density in HIV-1-Infected Adults Changing Treatment to Tenofovir-Emtricitabine or Abacavir-Lamivudine

Background There are limited data regarding the influence of human leukocyte antigen (HLA) polymorphisms on reduced bone mineral density (BMD). We investigated the relationship between HLA supertypes and BMD in HIV-infected adults changing their existing treatment to tenofovir-emtricitabine (TDF-FTC) or abacavir-lamivudine (ABC-3TC) in the STEAL study. Methods Lumbar spine and ...

Osmoregulatory bicarbonate secretion exploits H+-sensitive haemoglobins to autoregulate intestinal O2 delivery in euryhaline teleosts

Marine teleost fish secrete bicarbonate (HCO3 −) into the intestine to aid osmoregulation and limit Ca2+ uptake by carbonate precipitation. Intestinal HCO3 − secretion is associated with an equimolar transport of protons (H+) into the blood, both being proportional to environmental salinity. We hypothesized that the H+-sensitive haemoglobin (Hb) system of seawater teleosts could be ...

Impact of heavy-flavour production cross sections measured by the LHCb experiment on parton distribution functions at low x

:10.1007/ JHEP01(2010)109 11. A. Cooper-Sarkar , P. Mertsch , S. Sarkar , JHEP 1108 , ( 2011 ) 042 arXiv:1106.3723. doi:10.1007/ JHEP08(2011)042 12. L. Pasquali , M.H. Reno , I. Sarcevic , Phys. Rev. D 59

Erratum to: Are Quadrilateral Surface Buttress Plates Comparable to Traditional Forms of Transverse Acetabular Fracture Fixation?

, Foundation for Orthopaedic Research & Education , Tampa, FL , USA 1 I. R. Smithson, S. A. Cooper, B. G. Santoni Department of Orthopaedic Surgery & Sports Medicine, University of South Florida , Tampa, FL

The influence of moisture content variation on fungal pigment formation in spalted wood

Daniela Tudor 0 Sara C Robinson 0 Paul A Cooper 0 0 Faculty of Forestry, University of Toronto , 33 Willcocks Street, Toronto M5S 3B3, Canada Eight fungal species known to produce wood pigmentation

Moving Away from Ritonavir, Abacavir, Tenofovir, and Efavirenz (RATE) - Agents That Concern Prescribers and Patients: A Feasibility Study and Call for a Trial

Objectives Regimens sparing RATE (ritonavir, abacavir, tenofovir, efavirienz) agents might have better long-term safety. We conducted a feasibility exercise to assess the potential for a randomised trial evaluating RATE-sparing regimens. Design Observational. Methods We first calculated RATE-sparing options available to an average patient receiving RATE agents. We reviewed ...