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71 papers found.
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A multidimensional integration analysis reveals potential bridging targets in the process of colorectal cancer liver metastasis

Supporting Information files. Funding: Harbin Medical University Postgraduate Innovative Research Projects, YJSCX2015-19HYD, Dr Bo Gao. The funders had no role in study design, data collection and analysis

The Defect in Autophagy Induction by Clinical Isolates of Mycobacterium Tuberculosis Is Correlated with Poor Tuberculosis Outcomes

Background Tuberculosis (TB) represents a major global health problem. The prognosis of clinically active tuberculosis depends on the complex interactions between Mycobacterium tuberculosis (Mtb) and its host. In recent years, autophagy receives particular attention for its role in host defense against intracellular pathogens, including Mtb. In present study, we aim to...

The prognostic value of AGR2 expression in solid tumours: a systematic review and meta-analysis

Cui Xiao-ming Shuai Jin-bo Gao Kai-lin Cai Ji-liang Wang Guo-bin Wang Lin Wang Zheng Wang OPEN Published: xx xx xxxx The prognostic value of anterior gradient-2 (AGR2) in tumours remains inconclusive

Lithium-ion-based solid electrolyte tuning of the carrier density in graphene

Changning Road, Shanghai 200050, ChinaJialin Zhao, Meng Wang, Xuefu Zhang, Lixing You, Shan Qiao, Bo Gao, Xiaoming Xie & Mianheng JiangCAS Center for Excellence in Superconducting Electronics (CENSE ... ), Shanghai 200050, ChinaJialin Zhao, Meng Wang, Xuefu Zhang, Lixing You, Shan Qiao, Bo Gao, Xiaoming Xie & Mianheng JiangShenzhen Key laboratory of Laser Engineering, College of Optoelectronic Engineering

Ionic Liquid-Assisted Synthesis of a NiO/CNTs Composite and Its Electrochemical Capacitance

A novel solid-state method has been developed for synthesizing nickel oxide (NiO)/carbon nanotubes (CNTs) composite using an ionic liquid (IL, 1-butyl-3-methylimidazolium chloride) as the reaction medium. Ultraviolet-visible (UV-vis) absorbance spectroscopy, infrared spectroscopy (IR), and scanning electron microscopy (SEM) were employed to investigate the structure, morphology...

Severe burn injury in late pregnancy: a case report and literature review

The management of serious burn injuries during pregnancy is an unsolved clinical problem because of the low incidence of this disease. Although it has been documented that the effect of burns on fetal and maternal survival is detrimental, there have been conflicting reports among the different burn centers regarding the mortality of burned pregnant women and the management of...

Genome-wide association study of paclitaxel and carboplatin disposition in women with epithelial ovarian cancer

Identifying single nucleotide polymorphisms (SNPs) that influence chemotherapy disposition may help to personalize cancer treatment and limit toxicity. Genome-wide approaches are unbiased, compared with candidate gene studies, but usually require large cohorts. As most chemotherapy is given cyclically multiple blood sampling is required to adequately define drug disposition...

HMGB1 Promotes Systemic Lupus Erythematosus by Enhancing Macrophage Inflammatory Response

Background/Purpose. HMGB1, which may act as a proinflammatory mediator, has been proposed to contribute to the pathogenesis of multiple chronic inflammatory and autoimmune diseases including systemic lupus erythematosus (SLE); however, the precise mechanism of HMGB1 in the pathogenic process of SLE remains obscure. Method. The expression of HMGB1 was measured by ELISA and western...

Exogenous Heparan Sulfate Enhances the TGF-β3-Induced Chondrogenesis in Human Mesenchymal Stem Cells by Activating TGF-β/Smad Signaling

 Taifeng Zhou,4 Bo Gao,5 Zizhao Wu,5 and Caixia Xu1 1Research Center for Translational Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China 2School of Life Sciences

microRNA Expression in Rat Apical Periodontitis Bone Lesion

AuthorsSearch for Bo Gao in:Nature Research journals • PubMed • Google ScholarSearch for Liwei Zheng in:Nature Research journals • PubMed • Google Scholar Corresponding author Correspondence to Liwei Zheng

Immunization of Epidemics in Multiplex Networks

Up to now, immunization of disease propagation has attracted great attention in both theoretical and experimental researches. However, vast majority of existing achievements are limited to the simple assumption of single layer networked population, which seems obviously inconsistent with recent development of complex network theory: each node could possess multiple roles in...

Association between Diabetes and Risk of Aortic Dissection: A Case-Control Study in a Chinese Population

Background It is well-recognized that diabetes represents a powerful independent risk factor for cardiovascular diseases. However, very few studies have investigated the relationship between diabetes and risk of aortic dissection (AD). Aim The aim of this case-control study was to evaluate the association between diabetes and risk of AD in Chinese population. Methods A hospital...

Antibacterial activity and biological performance of a novel antibacterial coating containing a halogenated furanone compound loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium

Yicheng Cheng,1,2,* Xianghui Zhao,3,* Xianghui Liu,2,* Weige Sun,2 Huifang Ren,1 Bo Gao,1 Jiang Wu1 1State Key Laboratory of Military Stomatology, Department of Prosthodontics, School of Stomatology, Fourth

Analysis on setting airshaft at mid-tunnel to reduce transient pressure variation

Setting airshaft is one of the methods efficient to control the aerodynamic effects on a train traveling through a tunnel. By using numeral simulation, analysis is carried out on the effect of airshaft on transient pressures generated in cabin. After setting airshaft, the magnitude of pressure fluctuation in cabin is reduced nearly 40%. By analyzing the role of airshaft in...

Identification of citrullinated peptides in the synovial fluid of patients with rheumatoid arthritis using LC-MALDI-TOF/TOF

The objective of the study is to investigate potential citrullinated autoantigens as targets of anti-citrullinated protein antibodies (ACPAs) response in synovial fluids (SFs) of patients with rheumatoid arthritis (RA). SFs from six RA patients and six osteoarthritis (OA) patients as controls were collected. The citrullinated proteins in SFs were extracted by immunoprecipitation...

Characteristics of Heavy Metals and Pb Isotopic Composition in Sediments Collected from the Tributaries in Three Gorges Reservoir, China

2013; Accepted 19 October 2013; Published 28 January 2014 Academic Editors: J. Lutzenkirchen and G. Sen Copyright © 2014 Bo Gao et al. This is an open access article distributed under the Creative

Inhibition of phosphodiesterase10A attenuates morphine-induced conditioned place preference

Background Phosphodiesterase (PDE) 10A is selectively expressed in medium spiny neurons of the striatum. Nucleus accumbens (NAc) is a key region that mediates drug reward and addiction-related behaviors. To investigate the potential role of PDE10A in the reinforcement properties of morphine, we tested the effect of MP-10, a selective inhibitor of PDE10A, on acquisition...

Pharmacokinetic-Pharmacodynamic Analysis on Inflammation Rat Model after Oral Administration of Huang Lian Jie Du Decoction

Huang-Lian-Jie-Du Decoction (HLJDD) is a classical Traditional Chinese Medicine (TCM) formula with heat-dissipating and detoxifying effects. It is used to treat inflammation-associated diseases. However, no systematic pharmacokinetic (PK) and pharmacodynamic (PD) data concerning the activity of HLJDD under inflammatory conditions is available to date. In the present study, the...

Thermochemical sulfate reduction in fossil Ordovician deposits of the Majiang area: Evidence from a molecular-marker investigation

The main reservoirs of Majiang fossil deposits consist of the Silurian Wengxiang group, dominantly sandstones, and the Ordovician Honghuayuan formation, dominantly carbonate rocks, and the Lower Cambrian Niutitang Formation mudstones serve as the major source rocks. Thermochemical sulfate reduction (TSR) might have taken place in the Paleozoic marine carbonate oil pools, as...