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The Role of the Posterior Temporal and Medial Prefrontal Cortices in Mediating Learning from Romantic Interest and Rejection

Romantic interest or rejection can be powerful incentives not merely for their emotional impact, but for their potential to transform, in a single interaction, what we think we know about another person—or ourselves. Little is known, though, about how the brain computes expectations for, and learns from, real-world romantic signals. In a novel “speed-dating” paradigm, we had ...

Non-invasive Assessment of Lower Limb Geometry and Strength Using Hip Structural Analysis and Peripheral Quantitative Computed Tomography: A Population-Based Comparison

. J. Denison, K. A. Jameson, M. H. Edwards, A. A. Sayer, P. Taylor, C. Cooper, E. M. Dennison) declare no conflict of interest Human and Animal Rights and Informed Consent Ethical permission for the

Ischaemic cardiac events and use of strontium ranelate in postmenopausal osteoporosis: a nested case–control study in the CPRD

Summary We explored the cardiac safety of the osteoporosis treatment strontium ranelate in the UK Clinical Practice Research Datalink. While known cardiovascular risk factors like obesity and smoking were associated with increased cardiac risk, use of strontium ranelate was not associated with any increase in myocardial infarction or cardiovascular death. Introduction It has been ...

Impact of hip fracture on hospital care costs: a population-based study

fractures in postmenopausal women . NICE technology appraisal guidance TA161 . 31. Åkesson K , Marsh D , Mitchell PJ , McLellan AR , Stenmark J , Pierroz DD , Kyer C ... , Cooper C ( 2013 ) Capture the fracture: a best practice framework and global campaign to break the fragility fracture cycle . Osteoporos Int 24 : 2135 - 2152 32. Abrahamsen B , van Staa T , Ariely R

The unfolded protein response is required for dendrite morphogenesis

Taylor, Roshni C Cooper, Kang Shen Xing Wei, Audrey S Howell, Xintong Dong, Caitlin A Taylor, Roshni C Cooper, Kang Shen The funders had no role in study design, data collection and interpretation, or the ... . the python code for image processing and data analysis. DOI: 10.7554/eLife.06963.025 5R01NS082208-02 Xing Wei, Audrey S Howell, Xintong Dong , Caitlin A Taylor, Roshni C Cooper, Kang Shen Arakawa

Effect of Roux-en-Y Gastric Bypass Surgery on Bile Acid Metabolism in Normal and Obese Diabetic Rats

In addition to classic functions of facilitating hepatobiliary secretion and intestinal absorption of lipophilic nutrients, bile acids (BA) are also endocrine factors and regulate glucose and lipid metabolism. Recent data indicate that antiobesity bariatric procedures e.g. Roux-en-Y gastric bypass surgery (RYGB), which also remit diabetes, increase plasma BAs in humans, leading to ...

Where now with NICE?

E. M. Dennison C. Cooper 0 ) MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital , Southampton SO16 6YD, UK - The National Institute of Clinical Excellence

Behavioral economics: implications for regulatory behavior

James C. Cooper 0 William E. Kovacic 0 0 J. C. Cooper Law & Economics Center, George Mason University School of Law , Arlington, VA, USA Behavioral economics (BE) examines the implications for

A comprehensive fracture prevention strategy in older adults: the European Union Geriatric Medicine Society (EUGMS) statement

Prevention of fragility fractures in older people has become a public health priority, although the most appropriate and cost-effective strategy remains unclear. In the present statement, the Interest Group on Falls and Fracture Prevention of the European Union Geriatric Medicine Society, in collaboration with the International Association of Gerontology and Geriatrics for the ...

Osteoporosis epidemiology in UK Biobank: a unique opportunity for international researchers

GlaxoSmithKline Research and Development , London, UK 1 C. Cooper MRC Lifecourse Epidemiology Unit, University of Southampton , Southampton, UK 2 UK Biobank Musculoskeletal Advisory Group: Chair : Cyrus Cooper (MRC

Impact of clinical osteoarthritis of the hip, knee and hand on self-rated health in six European countries: the European Project on OSteoArthritis

. Dennison (Principal Investigator), C. Cooper, M.H. Edwards. Compliance with ethical standards Ethical approval All procedures performed in studies involving human participants were in accordance with the

Lack of Modulation of Nicotinic Acetylcholine Alpha-7 Receptor Currents by Kynurenic Acid in Adult Hippocampal Interneurons

Kynurenic acid (KYNA), a classical ionotropic glutamate receptor antagonist is also purported to block the α7-subtype nicotinic acetylcholine receptor (α7* nAChR). Although many published studies cite this potential effect, few have studied it directly. In this study, the α7*-selective agonist, choline, was pressure-applied to interneurons in hippocampal subregions, CA1 stratum ...

Post-traumatic Stress Disorder, Race/Ethnicity, and Coronary Artery Disease Among Older Patients with Depression

, VA Palo Alto Health Care System , Palo Alto, CA , USA 1 D. C. Cooper 2 HSR&D, VA Puget Sound Health Care System , 1100 Olive Way, Suite 1400, Seattle, WA 98101 , USA 3 D. C. Cooper ( 4 K. M. Nelson 5 R

Ion Channel Expression in the Developing Enteric Nervous System

The enteric nervous system arises from neural crest-derived cells (ENCCs) that migrate caudally along the embryonic gut. The expression of ion channels by ENCCs in embryonic mice was investigated using a PCR-based array, RT-PCR and immunohistochemistry. Many ion channels, including chloride, calcium, potassium and sodium channels were already expressed by ENCCs at E11.5. There was ...

Osteoporosis in the European Union: medical management, epidemiology and economic burden

, Sweden 4 E. V. McCloskey Academic Unit of Bone Metabolism, Northern General Hospital, University of Sheffield , Sheffield, UK 5 J. Stenmark International Osteoporosis Foundation , Nyon, Switzerland 6 C

The US FRAX® filter: avoiding confusion or hindering progress?

Briefing , July 2003 2 ) Academic Unit of Bone Metabolism, University of Sheffield , Sheffield S5 7AU, UK 3 C. Cooper MRC Epidemiology Resource Centre, University of Southampton , Southampton, UK - The

Switch therapy in hospitalized patients with community-acquired pneumonia: Tigecycline vs. Levofloxacin

Background Switch therapy is a management approach combining early discontinuation of intravenous (IV) antibiotics, switch to oral antibiotics, and early hospital discharge. This analysis compares switch therapy using tigecycline versus levofloxacin in hospitalized patients with community-acquired pneumonia (CAP). Methods A prospective, randomized, double-blind, Phase 3 clinical ...