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Involvement of aberrantly activated HOTAIR/EZH2/miR-193a feedback loop in progression of prostate cancer

Though androgen deprivation therapy is the standard treatment for prostate cancer (PCa), most patients would inevitably progress to castration-resistant prostate cancer (CRPC) which is the main cause of PCa death. Therefore, the identification of novel molecular mechanism regulating cancer progression and achievement of new insight into target therapy would be necessary for...

Prevalence of hand osteoarthritis and knee osteoarthritis in Kashin-Beck disease endemic areas and non Kashin-Beck disease endemic areas: A status survey

thank the patients and controls for participating in this study. 13 / 15 Author Contributions Conceptualization: Wei Lian, Hui Liu, Jun Yu. Data curation: Wei Lian, Hui Liu, Yun Qi Liu, Shao Ping Wang ... , Jun Yu. Formal analysis: Wei Lian, QuanQuan Song. Investigation: Wei Lian, Hui Liu, QuanQuan Song, Yun Qi Liu, Li Yan Sun, Qing Deng, Shao Ping Wang, Yan Hong Cao, Xue Ying Zhang, Yuan Yuan Jiang

The relationship of malaria between Chinese side and Myanmar’s five special regions along China–Myanmar border: a linear regression analysis

Background Understanding malaria along the international border of two countries is important for malaria control and elimination; however, it is difficult to investigate a quantitative relationship between two countries’ border areas due to a shortage of malaria surveillance data. Methods A linear regression analysis was conducted to investigate the logarithmic annual parasite...

Melanosis coli: Harmless pigmentation? A case-control retrospective study of 657 cases

analysis: Fion Siu Yin Chan. Investigation: Zhong Hui Liu. Methodology: Zhong Hui Liu, Dominic Chi Chung Foo, Wai Lun Law. Project administration: Jun Sheng Peng. Resources: Fion Siu Yin Chan. Software ... : Dominic Chi Chung Foo. Supervision: Wai Lun Law, Joe King Man Fan, Jun Sheng Peng. Writing ± original draft: Zhong Hui Liu. Writing ± review & editing: Joe King Man Fan. 11 / 13 12 / 13 1. Steer HW

Basic characteristics of Australian iron ore concentrate and its effects on sinter properties during the high-limonite sintering process

The basic characteristics of Australian iron ore concentrate (Ore-A) and its effects on sinter properties during a high-limonite sintering process were studied using micro-sinter and sinter pot methods. The results show that the Ore-A exhibits good granulation properties, strong liquid flow capability, high bonding phase strength and crystal strength, but poor assimilability...

Late Neolithic phytolith and charcoal records of human activities and vegetation change in Shijiahe culture, Tanjialing site, China

There is significant archaeological evidence marking the collapse of the Shijiahe culture in the middle reaches of the Yangtze River in China during the late Neolithic Period. However, the causes for this cultural collapse remain unclear. Our sedimentary records from a 3.3 m long profile and 76 phytolith and charcoal samples from the Tanjialing archaeological sites provide...

Molecular exploration of hidden diversity in the Indo-West Pacific sciaenid clade

The family Sciaenidae, known as croakers or drums, is one of the largest perciform fish families. A recent multi-gene based study investigating the phylogeny and biogeography of global sciaenids revealed that the origin and early diversification of this family occurred in tropical America during the Late Oligocene—Early Miocene before undergoing range expansions to other seas...

Frequent gene flow blurred taxonomic boundaries of sections in Lilium L. (Liliaceae)

: Chao-Li Huang. 15 / 19 Supervision: Tzen-Yuh Chiang. Validation: Kuo-Hsiang Hung, Huyen Trang Tran, Chao-Li Huang, Shih-Hui Liu. Visualization: Yu-Wei Ting, Lenka Malikova, Chao-Li Huang, Shih-Hui Liu ... . Writing ± original draft: Xun Gong, Kuo-Hsiang Hung, Lenka Malikova, Chao-Li Huang, Shih-Hui Liu, Tzen-Yuh Chiang. Writing ± review & editing: Lenka Malikova, Huyen Trang Tran, Chao-Li Huang, Shih-Hui

Vulnerability of China’s nearshore ecosystems under intensive mariculture development

Rapid economic development and increasing population in China have exerted tremendous pressures on the coastal ecosystems. In addition to land-based pollutants and reclamation, fast expansion of large-scale intensive mariculture activities has also brought about additional effects. So far, the ecological impact of rapid mariculture development and its large-scale operations has...

Comparative genomic study of ALDH gene superfamily in Gossypium: A focus on Gossypium hirsutum under salt stress

Aldehyde dehydrogenases (ALDHs) are a superfamily of enzymes which play important role in the scavenging of active aldehydes molecules. In present work, a comprehensive whole-genomic study of ALDH gene superfamily was carried out for an allotetraploid cultivated cotton species, G. hirsutum, as well as in parallel relative to their diploid progenitors, G. arboreum and G. raimondii...

Comparative analyses of structural features and scaffold diversity for purchasable compound libraries

Large purchasable screening libraries of small molecules afforded by commercial vendors are indispensable sources for virtual screening (VS). Selecting an optimal screening library for a specific VS campaign is quite important to improve the success rates and avoid wasting resources in later experimental phases. Analysis of the structural features and molecular diversity for...

The 100 most-cited articles on aortic dissection

Lai et al. BMC Cardiovascular Disorders Ping Lai Yuan-hui Liu 0 Jin-hua Xue Peng-cheng He 0 Yue-qun Qiu 1 0 Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key

Enzymatic process optimization for the in vitro production of isoprene from mevalonate

Background As an important bulk chemical for synthetic rubber, isoprene can be biosynthesized by robust microbes. But rational engineering and optimization are often demanded to make the in vivo process feasible due to the complexities of cellular metabolism. Alternative synthetic biochemistry strategies are in fast development to produce isoprene or isoprenoids in vitro. Results...

N-terminal pro-brain natriuretic peptide improves the C-ACS risk score prediction of clinical outcomes in patients with ST-elevation myocardial infarction

Background It remained unclear whether the combination of the Canada Acute Coronary Syndrome Risk Score (CACS-RS) and N-terminal pro-brain natriuretic peptide (NT-pro-BNP) could have a better performance in predicting clinical outcomes in acute ST-elevation myocardial infarction (STEMI) patients with primary percutaneous coronary intervention. Methods A total of 589 consecutive...

SynLethDB: synthetic lethality database toward discovery of selective and sensitive anticancer drug targets

Synthetic lethality (SL) is a type of genetic interaction between two genes such that simultaneous perturbations of the two genes result in cell death or a dramatic decrease of cell viability, while a perturbation of either gene alone is not lethal. SL reflects the biologically endogenous difference between cancer cells and normal cells, and thus the inhibition of SL partners of...

MicROS-drt: supporting real-time and scalable data distribution in distributed robotic systems

A primary requirement in distributed robotic software systems is the dissemination of data to all interested collaborative entities in a timely and scalable manner. However, providing such a service in a highly dynamic and resource-limited robotic environment is a challenging task, and existing robot software infrastructure has limitations in this aspect. This paper presents a...

Risk analysis of use of different classes of antidepressants on subsequent dementia: A nationwide cohort study in Taiwan

Depression and dementia are common mental health problems and are associated in several ways. Early-life depression is associated with increased risk of later life dementia, and depression can present as a preclinical symptom or consequence of dementia. Despite the plausible relationship between these two clinical entities, the potential association between antidepressant...