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99 papers found.
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Dasatinib inhibits c-src phosphorylation and prevents the proliferation of Triple-Negative Breast Cancer (TNBC) cells which overexpress Syndecan-Binding Protein (SDCBP)

Triple negative breast cancer (TNBC) progresses rapidly but lacks effective targeted therapies. Our previous study showed that downregulating syndecan-binding protein (SDCBP) in TNBC inhibits the proliferation of TNBC cells. Dasatinib is a new small-molecule inhibitor of c-src phosphorylation. The aim of this study was to investigate if SDCBP is a potential marker to indicate...

Aurora-A promotes the establishment of spindle assembly checkpoint by priming the Haspin-Aurora-B feedback loop in late G2 phase

, Jing Guo & Zhenye YangCenter for Advanced Preclinical Research, the Center for Cancer Research, National Cancer Institute, Frederick, MD, USALucy Lu & Terry Van DykeAnhui Key laboratory for Cellular ... journals • PubMed • Google ScholarSearch for Fangwei Wang in:Nature Research journals • PubMed • Google ScholarSearch for Xuebiao Yao in:Nature Research journals • PubMed • Google ScholarSearch for Jing Guo

Epithelia-derived wingless regulates dendrite directional growth of drosophila ddaE neuron through the Fz-Fmi-Dsh-Rac1 pathway

Background Proper dendrite patterning is critical for the receiving and processing of information in the nervous system. Cell-autonomous molecules have been extensively studied in dendrite morphogenesis; however, the regulatory mechanisms of environmental factors in dendrite growth remain to be elucidated. Results By evaluating the angle between two primary dendrites (PD-Angle...

Rapid Photodegradation of Methyl Orange (MO) Assisted with Cu(II) and Tartaric Acid

Cu(II) and organic carboxylic acids, existing extensively in soil and aquatic environments, can form complexes that may play an important role in the photodegradation of organic contaminants. In this paper, the catalytic role of Cu(II) in the removal of methyl orange (MO) in the presence of tartaric acid with light was investigated through batch experiments. The results...

Public Attitudes and Gender Policy Regimes: Coherence and Stability in Hard Times

Drawing upon data from the European Social Survey on public attitudes and social welfare, this paper analyzes the extent to which attitudes toward gender equality in work and family life vary among 13 countries which represent different welfare regimes. The analysis also examines how these attitudes have changed with the onset of the economic recession in 2007. The findings...

Depression among Migrant and Left-Behind Children in China in Relation to the Quality of Parent-Child and Teacher-Child Relationships

The objective of this study was to examine rates of depression among migrant children (MC) and left-behind children (LBC) as compared to non-left-behind children (NLBC) and also to examine the relationship between depression among these children and the quality of their parent-child and teacher-child relationships. This study collected data from a large sample of 3,759 children...

ARG-walker: inference of individual specific strengths of meiotic recombination hotspots by population genomics analysis

Background Meiotic recombination hotspots play important roles in various aspects of genomics, but the underlying mechanisms for regulating the locations and strengths of recombination hotspots are not yet fully revealed. Most existing algorithms for estimating recombination rates from sequence polymorphism data can only output average recombination rates of a population...

Three new species of Primulina (Gesneriaceae) from limestone karsts of China based on morphological and molecular evidence

Background With more than 160 described species, Primulina is one of the most characteristic plant groups of the Sino-Vietnamese limestone flora. In our continous botanical inventory of the limestone flora of South China, we collected three new Primulina species not identifiable to known species. Results Molecular phylogenetic analyses based on nuclear ITS and chloroplast trnL-F...

Molecular study on the carAB operon reveals that carB gene is required for swimming and biofilm formation in Xanthomonas citri subsp. citri

Background The carA and carB genes code the small and large subunits of carbamoyl-phosphate synthase (CPS) that responsible for arginine and pyrimidine production. The purpose of this work was to study the gene organization and expression pattern of carAB operon, and the biological functions of carA and carB genes in Xanthomonas citri subsp. citri. Methods RT-PCR method was...

Systematic Characteristic Exploration of the Chimeras Generated in Multiple Displacement Amplification through Next Generation Sequencing Data Reanalysis

Background The chimeric sequences produced by phi29 DNA polymerase, which are named as chimeras, influence the performance of the multiple displacement amplification (MDA) and also increase the difficulty of sequence data process. Despite several articles have reported the existence of chimeric sequence, there was only one research focusing on the structure and generation...

Zinc Chloride Transiently Maintains Mouse Embryonic Stem Cell Pluripotency by Activating Stat3 Signaling

An improved understanding of the pluripotency maintenance of embryonic stem (ES) cells is important for investigations of early embryo development and for cell replacement therapy, but the mechanism behind pluripotency is still incompletely understood. Recent findings show that zinc, an essential trace element in humans, is critically involved in regulating various signaling...

Null mutation of chloride channel 7 (Clcn7) impairs dental root formation but does not affect enamel mineralization

ClC-7, located in late endosomes and lysosomes, is critical for the function of osteoclasts. Secretion of Cl− by the ruffled border of osteoclasts enables H+ secretion by v-H+-ATPases to dissolve bone mineral. Mice lacking ClC-7 show altered lysosomal function that leads to severe lysosomal storage. Maturation ameloblasts are epithelial cells with a ruffled border that secrete Cl...

Solution-Processed Cu2ZnSn(S,Se)4 Thin-Film Solar Cells Using Elemental Cu, Zn, Sn, S, and Se Powders as Source

Solution-processed approach for the deposition of Cu2ZnSn (S,Se)4 (CZTSSe) absorbing layer offers a route for fabricating thin film solar cell that is appealing because of simplified and low-cost manufacturing, large-area coverage, and better compatibility with flexible substrates. In this work, we present a simple solution-based approach for simultaneously dissolving the low...

Overexpression of TMEM158 contributes to ovarian carcinogenesis

Background Transmembrane protein 158 (TMEM158) is a recently identified upregulated gene during Ras-induced senescence. Its association with various cancers has been recently reported. However, the expression and biological function of TMEM158 in ovarian cancer is still unclear. This study was aimed to elucidate the roles of TMEM158 in cell proliferation, adhesion and cell...

Comparative Study on Serum Levels of 10 Trace Elements in Schizophrenia

The etiology and pathophysiology of schizophrenia remain obscure. This study explored the associations between schizophrenia risk and serum levels of 10 trace elements. A 1:1 matched case-control study was conducted and matched by age and sex. Blood samples were collected to determine the concentrations of nickel, molybdenum, arsenic, aluminum, chromium, manganese, selenium...

Does introducing an immunization package of services for migrant children improve the coverage, service quality and understanding? An evidence from an intervention study among 1548 migrant children in eastern China

Background An EPI (Expanded Program on Immunization) intervention package was implemented from October 2011 to May 2014 among migrant children in Yiwu, east China. This study aimed to evaluate its impacts on vaccination coverage, maternal understanding of EPI and the local immunization service performance. Methods A pre- and post-test design was used. The EPI intervention package...

IL4I1 Is a Novel Regulator of M2 Macrophage Polarization That Can Inhibit T Cell Activation via L-Tryptophan and Arginine Depletion and IL-10 Production

Interleukin 4-induced gene-1 (IL4I1) was initially described as an early IL-4-inducible gene in B cells. IL4I1 protein can inhibit T cell proliferation by releasing its enzymatic catabolite, H2O2, and this effect is associated with transient down-regulation of T cell CD3 receptor-zeta (TCRζ) expression. Herein, we show that IL4I1 contributes to the regulation of macrophage...

The association of CD40 polymorphisms with CD40 serum levels and risk of systemic lupus erythematosus

Background Current evidence shows that the CD40–CD40 ligand (CD40–CD40L) system plays a crucial role in the development, progression and outcome of systemic lupus erythematosus (SLE). The aim of this study was to investigate whether a CD40 gene single nucleotide polymorphism (SNP) is associated with SLE and CD40 expression in the Chinese population. We included controls (n = 220...

Single-cell transcriptional analysis to uncover regulatory circuits driving cell fate decisions in early mouse development

Motivation: Transcriptional regulatory networks controlling cell fate decisions in mammalian embryonic development remain elusive despite a long time of research. The recent emergence of single-cell RNA profiling technology raises hope for new discovery. Although experimental works have obtained intriguing insights into the mouse early development, a holistic and systematic view...