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Retraction: Exploration of inhibitory mechanisms of curcumin in lung cancer metastasis using a miRNA- transcription factor-target gene network

Xia-li Tang Jun Chen Jian Wang You Li Qing-yong Chen PLOS ONE Editors After publication of this article, the corresponding author, Qing-yong Chen, notified the editorial office that the curcumin used

A Fragmentation Study on Four Unusual Secoiridoid Trimers, Swerilactones H–K, by Electrospray Tandem Mass Spectrometry

Swerilactones H–K (1–4) as four unprecedented secoiridoid trimers represent a new type of natural product, which has attracted much interest of natural chemists due to their novel skeletons and promising bioactivity. In order to well understand their MS fragmentation behaviors, they were investigated by electrospray ionization ion-trap time-of-flight multistage product ion mass...

Screening novel stress granule regulators from a natural compound library

.-J. Chen was supported by the Excellent Postdoctoral fellowship from the Tsinghua-Peking Joint Center for Life Sciences. Li-Dan Hu, Xiang-Jun Chen, Xiao-Yan Liao and Yong-Bin Yan declare no conflict ... experiments. LDH, XJC, and YBY analyzed the data. LDH and YBY wrote the paper. Li-Dan Hu, Xiang-Jun Chen, Xiao-Yan Liao, Yong-Bin Yan& OPEN ACCESS This article is distributed under the terms of the Creative

High-throughput electrophysiological assays for voltage gated ion channels using SyncroPatch 768PE

Chen 0 1 0 Department of Biochemical and Cellular Pharmacology, Genentech Inc. , South San Francisco , California, United States of America, 2 Department of Cancer Immunology, Genentech Inc. , South San

Effects of Cu addition on microstructure and mechanical properties of as-cast Mg-6Zn magnesium alloy

The application of Mg-Zn binary alloys is restricted due to their developed dendritic microstructure and poor mechanical properties. In this study, an alloying method was used to improve the mechanical properties of Mg-Zn alloy. The Mg-6Zn magnesium alloys microalloyed with varying Cu content (0, 0.8, 1.5, 2.0 and 2.5wt.%) were fabricated by permanent mould casting, and the...

Photocatalytic Properties of Co3O4-Coated TiO2 Powders Prepared by Plasma-Enhanced Atomic Layer Deposition

Co3O4-coated commercial TiO2 powders (P25) p-n junction photocatalysts were prepared by plasma-enhanced atomic layer deposition (PEALD) technique. The structure, morphology, bandgap, and photocatalytic properties under ultraviolet light were investigated systematically. Although the deposition of Co3O4 does not change the anatase structure and crystallite size of P25 powders, the...

Optimization of InGaAs/InAlAs Avalanche Photodiodes

In this paper, we report a two-dimensional (2D) simulation for InGaAs/InAlAs separate absorption, grading, charge, and multiplication avalanche photodiodes (SAGCM APDs) and study the effect of the charge layer and multiplication layer on the operating voltage ranges of APD. We find that with the increase of the thicknesses as well as the doping concentrations of the charge layer...

Research of self-power Generation Scheduling Model Base on Multi-objective in Iron and Steel Enterprises

With the targets of the minimum cost of power generation and the lowest rate of gas emission in iron and steel enterprises, a multi-objective self-power generation optimal scheduling model was built based on multi-objective particle swarm optimization the research of coupling relationship of gas and power. And by using the hierarchical decomposition method, the model was broken...

Long-term safety of human retinal progenitor cell transplantation in retinitis pigmentosa patients

Background Retinitis pigmentosa is a common genetic disease that causes retinal degeneration and blindness for which there is currently no curable treatment available. Vision preservation was observed in retinitis pigmentosa animal models after retinal stem cell transplantation. However, long-term safety studies and visual assessment have not been thoroughly tested in retinitis...

Characterization of the gut microbiota in the golden takin (Budorcas taxicolor bedfordi)

The gut microbiota of mammals is a complex ecosystem, which is essential for maintaining gut homeostasis and the host’s health. The high throughput sequencing allowed us to gain a deeper insight into the bacterial structure and diversity. In order to improve the health status of the endangered golden takins, we first characterized the fecal microbiota of healthy golden takins...

CUL4A promotes cell invasion in gastric cancer by activating the NF-κB signaling pathway

CUL4A promotes cell invasion in gastric cancer by activating the NF-KB signaling pathway Yu Gong,* Xiao-Jun Xiang,* Miao Feng, Jun Chen, Zi-Ling Fang, Jian-Ping Xiong, Department of Oncology, The

Fabrication of (Co,Mn)3O4/rGO Composite for Lithium Ion Battery Anode by a One-Step Hydrothermal Process with H2O2 as Additive

Binary transition metal oxides have been regarded as one of the most promising candidates for high-performance electrodes in energy storage devices, since they can offer high electrochemical activity and high capacity. Rational designing nanosized metal oxide/carbon composite architectures has been proven to be an effective way to improve the electrochemical performance. In this...

Radiological characteristics of pulmonary cryptococcosis in HIV-infected patients

Background Current understanding of human immunodeficiency virus (HIV)-associated pulmonary cryptococcosis (PC) is largely based on studies performed about 2 decades ago which reported that the most common findings on chest radiograph were diffuse interstitial infiltrates. Few studies are available regarding the computed tomography (CT) findings. The aim of this study was to...

Application of 3D–printed and patient-specific cast for the treatment of distal radius fractures: initial experience

Background Distal radius fracture is common in the general population. Fracture management includes a plaster cast, splint and synthetic material cast to immobilise the injured arm. Casting complications are common in those conventional casting technologies. 3D printing technology is a rapidly increasing application in rehabilitation. However, there is no clinical study...

The Profile and Bioaccessibility of Phenolic Compounds in Cereals Influenced by Improved Extrusion Cooking Treatment

The aim of this study was to investigate the effect of Improved Extrusion Cooking Treatment (IECT) on the phenolics and its bioaccessibility in cereals, represented by brown rice, wheat, and oat. Data showed that total phenolic content and total antioxidant activity in free form were significantly decreased, while the bound form was increased after IECT. After IECT, the total...

An adaptive association test for microbiome data

There is increasing interest in investigating how the compositions of microbial communities are associated with human health and disease. Although existing methods have identified many associations, a proper choice of a phylogenetic distance is critical for the power of these methods. To assess an overall association between the composition of a microbial community and an outcome...

PET/CT-guided percutaneous biopsy of FDG-avid metastatic bone lesions in patients with advanced lung cancer: a safe and effective technique

Purpose 18F-FDG PET/CT should be performed before a diagnostic biopsy site is chosen in patients with a high clinical suspicion of aggressive, advanced tumour. The aim of this study was to evaluate the safety and efficacy of 18F-FDG PET/CT in guiding biopsy of bone metastases in patients with advanced lung cancer. Methods PET/CT-guided percutaneous core biopsies were performed in...

Enhanced adsorption of carbonyl molecules on graphene via π-Li-π interaction: a first-principle study

in Nankai University under the supervision of Professor Jun Chen in 2017. His research focuses on computational design of the new secondary organic materials of Li-ion batteries. Jun Chen is a Cheung

Biomarkers for diagnosis of sepsis in patients with systemic inflammatory response syndrome: a systematic review and meta-analysis

Chen 0 Shu‑Nan Wang Jian‑min Wang 0 0 Research Institute of Surgery, Daping Hospital, Third Military Medical University , Chongqing 400042 , People's Republic of China Background: Sepsis is one of the

Current status and future prospects of mesenchymal stem cell therapy for liver fibrosis

. Compliance with ethics guidelines Yang GUO, Bo CHEN, Li-jun CHEN, Chun-feng ZHANG, and Charlie XIANG declare that they have no conflict of interest. This article does not contain any studies with human or