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322 papers found.
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Enhanced adsorption of carbonyl molecules on graphene via π-Li-π interaction: a first-principle study

receivedhisBScdegreeinmaterialschemistryfromNankaiUniversityin2012. HeisgettinghisPhDdegree in Nankai University under the supervision of Professor Jun Chen in 2017. His research focuses on computational design of the new secondary organic materials of Li-ion ... batteries. Jun Chen is a Cheung Kong Scholar Professor and the Director of the Key Laboratory of KLAEMC at Nankai University, a Principle Investigator at the Collaborative Innovation Center of Chemical

The Profile and Bioaccessibility of Phenolic Compounds in Cereals Influenced by Improved Extrusion Cooking Treatment

The aim of this study was to investigate the effect of Improved Extrusion Cooking Treatment (IECT) on the phenolics and its bioaccessibility in cereals, represented by brown rice, wheat, and oat. Data showed that total phenolic content and total antioxidant activity in free form were significantly decreased, while the bound form was increased after IECT. After IECT, the total free ...

PET/CT-guided percutaneous biopsy of FDG-avid metastatic bone lesions in patients with advanced lung cancer: a safe and effective technique

Purpose 18F-FDG PET/CT should be performed before a diagnostic biopsy site is chosen in patients with a high clinical suspicion of aggressive, advanced tumour. The aim of this study was to evaluate the safety and efficacy of 18F-FDG PET/CT in guiding biopsy of bone metastases in patients with advanced lung cancer. Methods PET/CT-guided percutaneous core biopsies were performed in ...

Biomarkers for diagnosis of sepsis in patients with systemic inflammatory response syndrome: a systematic review and meta-analysis

Chen 0 Shu‑Nan Wang Jian‑min Wang 0 0 Research Institute of Surgery, Daping Hospital, Third Military Medical University , Chongqing 400042 , People's Republic of China Background: Sepsis is one of the

An adaptive association test for microbiome data

There is increasing interest in investigating how the compositions of microbial communities are associated with human health and disease. Although existing methods have identified many associations, a proper choice of a phylogenetic distance is critical for the power of these methods. To assess an overall association between the composition of a microbial community and an outcome ...

Synthesis and Cytotoxicity Evaluation of Tropinone Derivatives

-Jun Chen 0 1 2 0 C.-A. Geng T.-H. Yang T.-Z. Li X.-M. Zhang J.-J. Chen Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201

Metabolic engineering of oleaginous yeast Yarrowia lipolytica for limonene overproduction

Background Limonene, a monocyclic monoterpene, is known for its using as an important precursor of many flavoring, pharmaceutical, and biodiesel products. Currently, d-limonene has been produced via fractionation from essential oils or as a byproduct of orange juice production, however, considering the increasing need for limonene and a certain amount of pesticides may exist in the ...

Exploration of inhibitory mechanisms of curcumin in lung cancer metastasis using a miRNA- transcription factor-target gene network

The present study was aimed to unravel the inhibitory mechanisms of curcumin for lung cancer metastasis via constructing a miRNA-transcription factor (TF)-target gene network. Differentially expressed miRNAs between human high-metastatic non-small cell lung cancer 95D cells treated with and without curcumin were identified using a TaqMan human miRNA array followed by real-time PCR, ...

Asymmetric exponential amplification reaction on a toehold/biotin featured template: an ultrasensitive and specific strategy for isothermal microRNAs analysis

The sensitive and specific analysis of microRNAs (miRNAs) without using a thermal cycler instrument is significant and would greatly facilitate biological research and disease diagnostics. Although exponential amplification reaction (EXPAR) is the most attractive strategy for the isothermal analysis of miRNAs, its intrinsic limitations of detection efficiency and inevitable ...

Social defeat stress causes depression-like behavior with metabolite changes in the prefrontal cortex of rats

Major depressive disorder is a serious mental disorder with high morbidity and mortality. The role of social stress in the development of depression remains unclear. Here, we used the social defeat stress paradigm to induce depression-like behavior in rats, then evaluated the behavior of the rats and measured metabolic changes in the prefrontal cortex using gas chromatography-mass ...

Temperature-Related Reaction Norms of Gene Expression: Regulatory Architecture and Functional Implications

The environment has profound effects on the expression of many traits and reaction norms describe the expression dynamics of a trait across a broad range of environmental conditions. Here, we analyze gene expression in Drosophila melanogaster across four different developmental temperatures (13–29 °C). Gene expression is highly plastic with 83.3% of the genes being differentially ...

PET/CT-guided percutaneous biopsy of FDG-avid metastatic bone lesions in patients with advanced lung cancer: a safe and effective technique

Purpose 18F-FDG PET/CT should be performed before a diagnostic biopsy site is chosen in patients with a high clinical suspicion of aggressive, advanced tumour. The aim of this study was to evaluate the safety and efficacy of 18F-FDG PET/CT in guiding biopsy of bone metastases in patients with advanced lung cancer. Methods PET/CT-guided percutaneous core biopsies were performed in ...

TRPA1 as a drug target—promise and challenges

Jun Chen 0 David H. Hackos 0 0 D. H. Hackos Department of Neuroscience, Genentech , South San Francisco, CA 94080 , USA 1 ) Department of Biochemical and Cellular Pharmacology, Genentech , South

Differential gene expression in patients with subsyndromal symptomatic depression and major depressive disorder

Background Subsyndromal symptomatic depression (SSD) is a subtype of subthreshold depressive and can lead to significant psychosocial functional impairment. Although the pathogenesis of major depressive disorder (MDD) and SSD still remains poorly understood, a set of studies have found that many same genetic factors play important roles in the etiology of these two disorders. ...

Cooperation of Genomic and Rapid Nongenomic Actions of Estrogens in Synaptic Plasticity

Neuroplasticity refers to the changes in the molecular and cellular processes of neural circuits that occur in response to environmental experiences. Clinical and experimental studies have increasingly shown that estrogens participate in the neuroplasticity involved in cognition, behavior, and memory. It is generally accepted that estrogens exert their effects through genomic ...

Local and distant trauma after hypervelocity ballistic impact to the pig hind limb

The development of high-energy weapons could increase the velocity of projectiles to well over 1000 m/s. The nature of the injuries caused by the ballistic impact of projectiles at velocities much faster than 1000 m/s is unclear. This study characterizes the mechanical and biochemical alterations caused by high-speed ballistic impact generated by spherical steel ball to the hind ...

Dental caries is negatively correlated with body mass index among 7-9 years old children in Guangzhou, China

Background Evidence linking caries in primary dentition and children’s anthropometric measures is contradictory. We aimed to evaluate the prevalence of primary dental caries and its relationship with body mass index (BMI) among 7-9 years old school children in urban Guangzhou, China. Methods This cross-sectional study enrolled 32,461 pupils (14,778 girls and 17,683 boys) aged 7-9 ...