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Optimal Road Toll Design from the Perspective of Sustainable Development

; Accepted 23 August 2014; Published 1 September 2014 Academic Editor: Yongjun Shen Copyright © 2014 Lin Cheng and Fei Han. This is an open access article distributed under the Creative Commons Attribution

Editor's Highlight: Periodic Exposure to Smartphone-Mimic Low-Luminance Blue Light Induces Retina Damage Through Bcl-2/BAX-Dependent Apoptosis

Blue light-induced phototoxicity plays an important role in retinal degeneration and might cause damage as a consequence of smartphone dependency. Here, we investigated the effects of periodic exposure to blue light-emitting diode in a cell model and a rat retinal damage model. Retinal pigment epithelium (RPE) cells were subjected to blue light in vitro and the effects of blue...

Cellular and Physiological Effects of Dietary Supplementation with β-Hydroxy-β-Methylbutyrate (HMB) and β-Alanine in Late Middle-Aged Mice

There is growing evidence that severe decline of skeletal muscle mass and function with age may be mitigated by exercise and dietary supplementation with protein and amino acid ingredient technologies. The purposes of this study were to examine the effects of the leucine catabolite, beta-hydroxy-beta-methylbutyrate (HMB), in C2C12 myoblasts and myotubes, and to investigate the...

Operational reliability evaluation of restructured power systems with wind power penetration utilizing reliability network equivalent and time-sequential simulation approaches

assessment. Lin CHENG was born in 1973. He received the B.S. degree in electrical engineering from Tianjin University, Tianjin, China, in 1996, and the Ph.D. degree in electrical engineering from Tsinghua

A New Cellular Automaton Model for Urban Two-Way Road Networks

A new cellular automaton (CA) model is proposed to simulate traffic dynamics in urban two-way road network systems. The NaSch rule is adopted to represent vehicle movements on road sections. Two novel rules are proposed to move the vehicles in intersection areas, and an additional rule is developed to avoid the “gridlock” phenomenon. Simulation results show that the network...

The Health Monitoring Method of Concrete Dams Based on Ambient Vibration Testing and Kernel Principle Analysis

: Mickaël Lallart Copyright © 2015 Lin Cheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction

Intradermal microbubbles and contrast-enhanced ultrasound (CEUS) is a feasible approach for sentinel lymph node identification in early-stage breast cancer

Background Microbubbles and contrast-enhanced ultrasound (CEUS) is a new technique for locating sentinel lymph node (SLN). The aim of this study is to explore the feasibility of SLNs tracing by CEUS using microbubbles in breast cancer patients and the value of enhancing patterns in diagnosing lymph nodes metastases. Methods A clinical trial was registered (trial registration...

Polymorphisms in FADS1 and FADS2 alter plasma fatty acids and desaturase levels in type 2 diabetic patients with coronary artery disease

Background To explore whether plasma fatty acids and SNPs in the fatty acid desaturase (FADS) gene associated with type 2 diabetes (T2D) and coronary artery disease (CAD). Methods In this cross-sectional study, we utilized gas chromatography–mass spectrometric analysis and the high-resolution melting method to detect plasma fatty acids and SNPs respectively (rs174537G>T...

The Effects and Mechanism of Atorvastatin on Pulmonary Hypertension Due to Left Heart Disease

Background Pulmonary hypertension due to left heart disease (PH-LHD) is one of the most common forms of PH, termed group 2 PH. Atorvastatin exerts beneficial effects on the structural remodeling of the lung in ischemic heart failure. However, few studies have investigated the effects of atorvastatin on PH due to left heart failure induced by overload. Methods Group 2 PH was...

A Bayesian Network Model for Origin-Destination Matrices Estimation Using Prior and Some Observed Link Flows

University, Nanjing 210096, China Received 1 November 2013; Accepted 11 March 2014; Published 13 April 2014 Academic Editor: Wuhong Wang Copyright © 2014 Lin Cheng et al. This is an open access article

Tetraspanin CD9 stabilizes gp130 by preventing its ubiquitin-dependent lysosomal degradation to promote STAT3 activation in glioma stem cells

Glioblastoma (GBM) is the most malignant and lethal brain tumor harboring glioma stem cells (GSCs) that promote tumor propagation and therapeutic resistance. GSCs preferentially express several critical cell surface molecules that regulate the pro-survival signaling for maintaining the stem cell-like phenotype. Tetraspanin CD9 has recently been reported as a GSC biomarker that is...

Pharmacokinetics and Bioequivalence Study of Hydroxychloroquine Sulfate Tablets in Chinese Healthy Volunteers by LC–MS/MS

Introduction Hydroxychloroquine (HCQ), 4-aminoquinoline, is an antimalarial drug and has become a basic therapy for rheumatic disease treatment. It can stabilize the condition of SLE patients and reduce the chances of patient relapse through its immunosuppressive function and antiinflammatory effects. This drug was absorbed completely and rapidly by oral administration, but has a...

Association between Estrogen Receptor α Gene (ESR1) PvuII (C/T) and XbaI (A/G) Polymorphisms and Hip Fracture Risk: Evidence from a Meta-Analysis

Background and Objective Genetic factors are important in the pathogenesis of fractures. Notably, estrogen receptor α (ESR1) has been suggested as a possible candidate gene for hip fractures; however, published studies of ESR1 gene polymorphisms have been hampered by small sample sizes and inconclusive or ambiguous results. The aim of this meta-analysis is to investigate the...

Predictors of Infant Age at Enrollment in Early Infant Diagnosis Services in Kenya

Despite the importance of early detection to signal lifesaving treatment initiation for HIV+ infants, early infant diagnosis (EID) services have received considerably less attention than other aspects of prevention of mother to child transmission care. This study draws on baseline data from an on-going cluster randomized study of an intervention to improve EID services at six...

Treadmill exercise enhances therapeutic potency of transplanted bone mesenchymal stem cells in cerebral ischemic rats via anti-apoptotic effects

Background The transplantation of bone marrow stromal cells (MSCs) has proved to ameliorate ischemic brain injury in animals, but most transplanted MSCs undergo apoptosis in the ischemic penumbra, greatly compromising the therapeutic value of this treatment. Meanwhile, cell apoptosis can be inhibited by post-ischemia exercise which has been demonstrated to improve the expression...

A Spectral Graph Regression Model for Learning Brain Connectivity of Alzheimer’s Disease

Understanding network features of brain pathology is essential to reveal underpinnings of neurodegenerative diseases. In this paper, we introduce a novel graph regression model (GRM) for learning structural brain connectivity of Alzheimer's disease (AD) measured by amyloid-β deposits. The proposed GRM regards 11C-labeled Pittsburgh Compound-B (PiB) positron emission tomography...

Closed-Loop and Robust Control of Quantum Systems

For most practical quantum control systems, it is important and difficult to attain robustness and reliability due to unavoidable uncertainties in the system dynamics or models. Three kinds of typical approaches (e.g., closed-loop learning control, feedback control, and robust control) have been proved to be effective to solve these problems. This work presents a self-contained...

Design and experimental study of thermal control system for AMS cryocoolers

The Alpha Magnetic Spectrometer (AMS) is an instrument for the international scientific experiment, composed of six detectors and 650 micro-electronics. The objective of AMS experiment is to search for dark matter and anti-matter in space. In this paper, the thermal control system for AMS cryocoolers is designed, analyzed and experimentally studied. Using loop heat pipes (LHPs...

Evaluate the Impact of Cold Wave on Face Slab Cracking Using Fuzzy Finite Element Method

We use fuzzy finite element method (FEM) to analyze the impact of cold wave on face slab cracking of a concrete-faced rockfill dam (CFRD). The static response of dam and the temperature field of face slab are calculated using deterministic FEM since some observed and test data can be obtained. Some parameters of Goodman contact element between face slabs and cushion material are...