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A biosystems approach to identify the molecular signaling mechanisms of TMEM30A during tumor migration

Understanding the molecular mechanisms underlying cell migration, which plays an important role in tumor growth and progression, is critical for the development of novel tumor therapeutics. Overexpression of transmembrane protein 30A (TMEM30A) has been shown to initiate tumor cell migration, however, the molecular mechanisms through which this takes place have not yet been...

Modeling the future of irrigation: A parametric description of pressure compensating drip irrigation emitter performance

Drip irrigation is a means of distributing the exact amount of water a plant needs by dripping water directly onto the root zone. It can produce up to 90% more crops than rain-fed irrigation, and reduce water consumption by 70% compared to conventional flood irrigation. Drip irrigation may enable millions of poor farmers to rise out of poverty by growing more and higher value...

Open charm contributions to the E1 transitions of \(\psi (3686)\) and \(\psi (3770)\rightarrow \gamma \chi _{cJ}\)

The E1 transitions of \(\psi (3686)\) and \(\psi (3770)\rightarrow \gamma \chi _{cJ}\) are investigated in a non-relativistic effective field theory (NREFT) where the open charm effects are included systematically as the leading corrections. It also allows a self-consistent inclusion of the S–D mixing in the same framework. We are able to show that the open charm contributions...

Incorporating GIS data into an agent-based model to support planning policy making for the development of creative industries

This paper presents an extension to the agent-based model “Creative Industries Development–Urban Spatial Structure Transformation” by incorporating GIS data. Three agent classes, creative firms, creative workers and urban government, are considered in the model, and the spatial environment represents a set of GIS data layers (i.e. road network, key housing areas, land use). With...

A method for labeling proteins with tags at the native genomic loci in budding yeast

Fluorescent proteins and epitope tags are often used as protein fusion tags to study target proteins. One prevailing technique in the budding yeast Saccharomyces cerevisiae is to fuse these tags to a target gene at the precise chromosomal location via homologous recombination. However, several limitations hamper the application of this technique, such as the selectable markers...

A Comprehensive Analysis of Plasmodium Circumsporozoite Protein Binding to Hepatocytes

Circumsporozoite protein (CSP) is the dominant protein on the surface of Plasmodium sporozoites and plays a critical role in the invasion by sporozoites of hepatocytes. Contacts between CSP and heparin sulfate proteoglycans (HSPGs) lead to the attachment of sporozoites to hepatocytes and trigger signaling events in the parasite that promote invasion of hepatocytes. The precise...

A Multiplex RT-PCR Assay for Detection and Differentiation of Avian-Origin Canine H3N2, Equine-Origin H3N8, Human-Origin H3N2, and H1N1/2009 Canine Influenza Viruses

Virological and serological surveys have documented that H1N1/2009, avian-origin canine H3N2 (cH3N2), seasonal human-origin H3N2 (hH3N2), and equine-origin H3N8 influenza viruses are consistently circulating in dogs. In the present study, a multiplex reverse-transcriptase polymerase chain reaction (mRT-PCR) assay was developed for simultaneous detection and differentiation of...

Invited Commentary on Genetically Modified Mosquitoes for Population Control of Pathogen-Transmitting Wild-Type Mosquitoes

mosquito population by releasing sterile male mosquitoes into the target area. Once these male mosquitoes are in Leroy Versteeg and Qian Wang contributed equally to this work. * the field, they will mate

Developing Inquiry for Learning: Reflecting Collaborative Ways to Learn How to Learn in Higher Education

Qian Wang (University of Oklahoma) Ovens, P., Wells, F., Wallis, P., & Hawkins, C. (2011). Developing inquiry for learning: Reflecting collaborative ways to learn how to learn in higher education. New

Field Sandbur (Cenchrus pauciflorus) Seeds in the Same Bur Respond Differently to Temperature and Water Potential in Relation to Germination in a Semi-Arid Environment, China

The success of a biological invasion relies on the environment and is closely linked to factors such as water and temperature. Invasive plant species display different seed characteristics, including shape. Field sandbur (Cenchrus pauciflorus) is a globally widespread invasive species capable of adapting to broad environmental conditions. However, its germination response to...

Disrupting ROS-protection mechanism allows hydrogen peroxide to accumulate and oxidize Sb(III) to Sb(V) in Pseudomonas stutzeri TS44

Background Microbial antimonite [Sb(III)] oxidation converts toxic Sb(III) into less toxic antimonate [Sb(V)] and plays an important role in the biogeochemical Sb cycle. Currently, little is known about the mechanisms underlying bacterial Sb(III) resistance and oxidation. Results In this study, Tn5 transposon mutagenesis was conducted in the Sb(III)-oxidizing strain Pseudomonas...

A Novel and Effective Method for Congestive Heart Failure Detection and Quantification Using Dynamic Heart Rate Variability Measurement

Risk assessment of congestive heart failure (CHF) is essential for detection, especially helping patients make informed decisions about medications, devices, transplantation, and end-of-life care. The majority of studies have focused on disease detection between CHF patients and normal subjects using short-/long-term heart rate variability (HRV) measures but not much on...

1,25(OH)2D3 and VDR Signaling Pathways Regulate the Inhibition of Dectin-1 Caused by Cyclosporine A in Response to Aspergillus Fumigatus in Human Corneal Epithelial Cells

Background The objective of this study is to observe whether cyclosporine A (CsA) inhibits the expression of dectin-1 in human corneal epithelial cells infected with Aspergillus fumigatus (A. fumigatus) and to investigate the molecular mechanisms of the inhibition. Methods Immortalized human corneal epithelial cells (HCECs) were pretreated with 1,25(OH)2D3 and VDR inhibitor for 1...

Is hyperlipidemia a potential protective factor against intraoperative awareness in cardiac surgery?

Medical University , Inner Mongolia , China 2 First co-authors are Qingshui Zheng and Qian Wang 3 Department of Anesthesiology, Fuwai Hospital, Peking Union Medical College, Chinese Academy of Medical

A multicenter randomized controlled open-label trial to assess the efficacy of compound kushen injection in combination with single-agent chemotherapy in treatment of elderly patients with advanced non-small cell lung cancer: study protocol for a randomized controlled trial

Background With the aging of the global population, an increasing number of elderly are diagnosed with advanced non-small cell lung cancer. Although systematic chemotherapy has been one of the primary treatments for advanced non-small cell lung cancer worldwide, the elderly cannot always tolerate standard platinum-based doublet chemotherapy, thus resulting in treatment failure...

Friction behavior and wear protection ability of selected base lubricants

. Preparation and properties of lubricant basestocks from epoxidized soybean oil and 2-ethylhexanol . J Amer Oil Chem Soc 80 ( 8 ): 811 - 815 ( 2003 ) Qian WANG . She received her Ph.D degree from Northwestern

A preliminary study of skin ultrasound in diffuse cutaneous systemic sclerosis: Does skin echogenicity matter?

Objective To evaluate the usefulness of skin ultrasound and acoustic radiation force impulse (ARFI) quantification in diffuse cutaneous systemic sclerosis (dcSSc). Patients and methods 28 patients with dcSSc, and 15 age gender matched normal controls were recruited. Skin echogenicity, thickness, and ARFI quantification were measured by ultrasound at 17 sites corresponding to the...

Mapping and Congenic Dissection of Genetic Loci Contributing to Hyperglycemia and Dyslipidemia in Mice

Background Patients with dyslipidemia have an increased risk of developing type 2 diabetes, and diabetic patients often have dyslipidemia. Potential genetic connections of fasting plasma glucose with plasma lipid profile were evaluated using hyperlipidemic mice. Methods 225 male F2 mice were generated from BALB/cJ (BALB) and SM/J(SM) Apoe-deficient (Apoe−/−) mice and fed a...

Biodegradation of lignin and nicotine with white rot fungi for the delignification and detoxification of tobacco stalk

Background Tobacco stalk is one kind of abundant crop residues in China. The high lignification of tobacco stalk increases its reusing cost and the existing of nicotine will cause serious pollution. The biodegradation of lignocellulosic biomass has been demonstrated to be an environmental and economical approach for the utilization of plant stalk. Meanwhile, many nicotine...

Identification of endoplasmic reticulum-shaping proteins in Plasmodium parasites

University. Sha Sun, Li Lv, Zhi Yao, Purnima Bhanot, Junjie Hu and Qian Wang declare that they have no conflict of interest. This article does not contain any studies with human or animal subjects performed by