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Periodic solutions to a generalized Liénard neutral functional differential system with p-Laplacian

By means of the generalized Mawhin’s continuation theorem, we present some sufficient conditions which guarantee the existence of at least one T-periodic solution for a generalized Liénard neutral functional differential system with p-Laplacian.MSC: 34B15, 34L30.

ESC reverses epithelial mesenchymal transition induced by transforming growth factor-β via inhibition of Smad signal pathway in HepG2 liver cancer cells

Background Epithelial mesenchymal transition (EMT) mediated by TGF-β pays an important role in malignant tumor acquired abilities of migration and invasion. Our previous study showed that the extract of Stellera chamaejasme L. (ESC) was against proliferation of a variety of tumor cells, but there were no studies in the effects of ESC on EMT in tumor cells. In this study, TGF...

Resveratrol suppresses glial activation and alleviates trigeminal neuralgia via activation of AMPK

Background Glial activation and neuroinflammation in the spinal trigeminal nucleus (STN) play a pivotal role in the genesis and maintenance of trigeminal neuralgia (TN). Resveratrol, a natural compound from grape and red wine, has a potential anti-inflammatory effect. We hypothesized that resveratrol could significantly suppress neuroinflammation in the STN mediated by glial...

A Unified Comparison of Stimulus-Driven, Endogenous Mandatory and ‘Free Choice’ Saccades

It has been claimed that saccades arising from the three saccade triggering modes–stimulus-driven, endogenous mandatory and ‘free choice’–are driven by distinct mechanisms. We tested this claim by instructing observers to saccade from a white or black fixation disc to a same polarity (white or black) disc flashed for 100 or 200 ms presented either alone (Exo), or together with an...

Petrov type I condition and Rindler fluid in vacuum Einstein-Gauss-Bonnet gravity

Recently the Petrov type I condition is introduced to reduce the degrees of freedom of the extrinsic curvature of a timelike hypersurface to the degrees of freedom in the dual Rindler fluid in Einstein gravity. In this paper we show that the Petrov type I condition holds for the solutions of vacuum Einstein-Gauss-Bonnet gravity up to the second order in the relativistic...

ATF2 predicts poor prognosis and promotes malignant phenotypes in renal cell carcinoma

Background Activating transcription factor 2 (ATF2) is a basic helix-loop-helix transcription factor, which has been shown to participate in the pathobiology of numerous cancers. However, the role of ATF2 in renal cell carcinoma (RCC) remains unclear. Methods ATF2 knockdown and overexpression studies were performed in RCC cells to evaluate changes in cell viability, cell cycle...

Land use/land cover changes and regional climate over the Loess Plateau during 2001–2009. Part II: interrelationship from observations

Afforestation efforts in China resulted in significant changes in vegetation coverage over the Loess Plateau during 2001–2009. While regional climate conditions dominate the distribution of major vegetation types, human activities, primarily afforestation/reforestation and the resultant land use/land cover (LULC) changes (LULCC) and their impacts, are the focus of this study. A...

Nitrogen (N) Deposition Impacts Seedling Growth of Pinus massoniana via N:P Ratio Effects and the Modulation of Adaptive Responses to Low P (Phosphorus)

Zhou 0 Qing Yang 0 Han Y.H. Chen, Lakehead University, Canada 0 Research Institute of Subtropical Forestry, Chinese Academy of Forestry , Fu Yang, Zhe Jiang , P. R. China Background: In forest

Dissemination of NDM-1-Producing Enterobacteriaceae Mediated by the IncX3-Type Plasmid

The emergence and spread of NDM-1-producing Enterobacteriaceae have resulted in a worldwide public health risk that has affected some provinces of China. China is an exceptionally large country, and there is a crucial need to investigate the epidemic of blaNDM-1-positive Enterobacteriaceae in our province. A total of 186 carbapenem-resistant Enterobacteriaceae isolates (CRE) were...

Evolutionary study of the isoflavonoid pathway based on multiple copies analysis in soybean

Background Previous studies suggest that the metabolic pathway structure influences the selection and evolution rates of involved genes. However, most of these studies have exclusively considered a single gene copy encoding each enzyme in the metabolic pathway. Considering multiple-copy encoding enzymes could provide direct evidence of gene evolution and duplication patterns in...

Metformin Treatment for the Prevention and/or Treatment of Breast/Mammary Tumorigenesis

article is part of the Topical Collection on Cancer Chemoprevention Metformin; Breast cancer; Chemoprevention; AMPK; Rodents; Humans - Michael E. Grossmann and Da-Qing Yang contributed equally to this ... Foundation (DAP) and Community Fund (DAP). Compliance with Ethics Guidelines Conflict of Interest Michael E. Grossmann, Da-Qing Yang, Zhijun Guo, David A. Potter, and Margot P. Cleary declare that they have

Distinct Control of Initiation and Metrics of Memory-Guided Saccades and Vergence by the FEF: A TMS Study

Background The initiation of memory guided saccades is known to be controlled by the frontal eye field (FEF). Recent physiological studies showed the existence of an area close to FEF that controls also vergence initiation and execution. This study is to explore the effect of transcranial magnetic simulation (TMS) over FEF on the control of memory-guided saccade-vergence eye...

Blockade of Hedgehog Signaling Synergistically Increases Sensitivity to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non-Small-Cell Lung Cancer Cell Lines

Aberrant activation of the hedgehog (Hh) signaling pathway has been implicated in the epithelial-to-mesenchymal transition (EMT) and cancer stem-like cell (CSC) maintenance; both processes can result in tumor progression and treatment resistance in several types of human cancer. Hh cooperates with the epidermal growth factor receptor (EGFR) signaling pathway in embryogenesis. We...

Promoter hypomethylation, especially around the E26 transformation-specific motif, and increased expression of poly (ADP-ribose) polymerase 1 in BRCA-mutated serous ovarian cancer

Background Poly (ADP-ribose) polymerase 1 (PARP1) overexpression plays a critical role in ovarian cancer progression and the clinical development of PARP1 inhibitors to treat BRCA-mutated ovarian cancer has advanced rapidly. However, the mechanism regulating PARP1 expression remains unknown. Alterations in gene expression mediated by promoter methylation are being increasingly...

Significant Association of Glutathione S-Transferase T1 Null Genotype with Prostate Cancer Risk: A Meta-Analysis of 26,393 Subjects

Subjects Qing Yang 0 Jun Du 0 Xin Yao 0 Georgina L. Hold, University of Aberdeen, United Kingdom 0 Department of Genitourinary Oncology, Tianjin Medical University Cancer Hospital, Key Laboratory of Cancer

Reduced cortical thickness in right Heschl’s gyrus associated with auditory verbal hallucinations severity in first-episode schizophrenia

Weidan Pu Yinnan Song Tumbwene E. Mwansisya 0 Qing Yang Haihong Liu Zhening Liu 0 Baoci Shan Zhimin Xue 0 0 Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental

Concomitant coronary and renal revascularization improves left ventricular hypertrophy more than coronary stenting alone in patients with ischemic heart and renal disease

HUANG, De-mou LUO, Jingguang YE, Jun-qing YANG, Guang LI, Jian-fang LUO, and Ying-ling ZHOU declare that they have no conflict of interest. All procedures followed were in accordance with the ethical

Biofortification of rice with the essential amino acid lysine: molecular characterization, nutritional evaluation, and field performance

Rice (Oryza sativa L.), a major staple crop worldwide, has limited levels of the essential amino acid lysine. We previously produced engineered rice with increased lysine content by expressing bacterial aspartate kinase and dihydrodipicolinate synthase and inhibiting rice lysine ketoglutarate reductase/saccharopine dehydrogenase activity. However, the grain quality, field...

Quantum secure direct communication against the collective noise with polarization-entangled Bell states

We propose a quantum secure direct communication protocol via a collective noise channel, exploiting polarization-entangled Bell states and the nondemolition parity analysis based on weak cross-Kerr nonlinearities. The participant Bob, who will receive the secret information, sends one of two photons in a polarization-entangled Bell state exploiting the transmission circuit...

Quantum secure direct communication against the collective noise with polarization-entangled Bell states

We propose a quantum secure direct communication protocol via a collective noise channel, exploiting polarization-entangled Bell states and the nondemolition parity analysis based on weak cross-Kerr nonlinearities. The participant Bob, who will receive the secret information, sends one of two photons in a polarization-entangled Bell state exploiting the transmission circuit...