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PD-L1-expressing neutrophils as a novel indicator to assess disease activity and severity of systemic lupus erythematosus

Background It is well-known that increased frequency of neutrophils was found in patients with systemic lupus erythematosus (SLE). However, the immunomodulatory roles and mechanisms of neutrophils in SLE are poorly understood. Methods Patients with SLE were recruited from the First Affiliated Hospital of Nanchang University. The medical history, clinical manifestations, physical...

Mycobacterium tuberculosis-Induced Polarization of Human Macrophage Orchestrates the Formation and Development of Tuberculous Granulomas In Vitro

The tuberculous granuloma is an elaborately organized structure and one of the main histological hallmarks of tuberculosis. Macrophages, which are important immunologic effector and antigen-presenting cells, are the main cell type found in the tuberculous granuloma and have high plasticity. Macrophage polarization during bacterial infection has been elucidated in numerous recent...

Association between IL-10 Gene Polymorphisms and Susceptibility of Tuberculosis: Evidence Based on a Meta-Analysis

Background A number of observational studies have been conducted to investigate the association of IL-10 gene polymorphisms with tuberculosis (TB) susceptibility. However, the results of different studies were inconsistent. The aim of this study was to investigate the relationship between IL-10 -1082G/A, -819T/C, and -592A/C polymorphisms and TB risk by meta-analysis. Methods A...

Ultrasound-guided RNA interference targeting HIF-1 alpha improves the effects of transarterial chemoembolization in rat liver tumors

Chen-Yang Guo,2 Wei Zhang,1 Zhi-Ping Yan,1 Rong Liu,1 Jian-Hua Wang1 1Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China; 2Department of ... scientific and medical research O r i g i n a l r e s e a r c h cheng-shi chen 1,2,* chen-Yang guo 2 *These authors contributed equally to this work Introduction Transarterial chemoembolization (TACE) and

β2-Adrenoceptor Involved in Smoking-Induced Airway Mucus Hypersecretion through β-Arrestin-Dependent Signaling

Progression of chronic obstructive pulmonary disease is associated with small airway obstruction by accumulation of inflammatory mucous exudates. However, the mechanism of mucin hypersecretion after exposure to cigarette smoke (CS) is still not clear. In this study, we explored the contribution of β2-adrenoceptor (β2-AR) signaling to CS extract (CSE)-induced mucus hypersecretion...

Detection of Fusobacterium Nucleatum and fadA Adhesin Gene in Patients with Orthodontic Gingivitis and Non-Orthodontic Periodontal Inflammation

Fusobacterium nucleatum is one of the most abundant gram-negative bacilli colonizing the subgingival plaque and closely associated with periodontal disease. However it is unclear whether F. nucleatum is involved in gingival inflammation under orthodontic appliance. A novel adhesin, FadA, which is unique to oral Fusobacteria, is required for F. nucleatum binding and invasion to...

Soluble LRIG2 Ectodomain Is Released from Glioblastoma Cells and Promotes the Proliferation and Inhibits the Apoptosis of Glioblastoma Cells In Vitro and In Vivo in a Similar Manner to the Full-Length LRIG2

The human leucine-rich repeats and immunoglobulin-like domains (LRIG) gene family contains LRIG1, 2 and 3, encoding integral membrane proteins with an ectodomain, a transmembrane domain and a cytoplasmic tail. LRIG1 negatively regulates multiple receptor tyrosine kinases signaling including the epidermal growth factor receptor (EGFR) and is a proposed tumor suppressor. The...

State space reduction in modeling checking parameterized cache coherence protocol by two-dimensional abstraction

Yang Guo Wanxia Qu Long Zhang Weixia Xu model of an unbounded system is constructed out of finite states. The mathematical principles underlying TDA is presented. Theoretical reasoning

Prevalence of Porphyromonas gingivalis Four rag Locus Genotypes in Patients of Orthodontic Gingivitis and Periodontitis

Porphyromonas gingivalis is considered as a major etiological agent in periodontal diseases and implied to result in gingival inflammation under orthodontic appliance. rag locus is a pathogenicity island found in Porphyromonas gingivalis. Four rag locus variants are different in pathogenicity of Porphyromonas gingivalis. Moreover, there are different racial and geographic...

Where do flare ribbons stop?

The standard flare model, which was proposed based on observations and magnetohydrodynamic theory, can successfully explain many observational features of solar flares. However, this model is just a framework, with many details awaiting to be filled in, including how reconnection is triggered. In this paper, we address an unanswered question: where do flare ribbons stop? With the...

A simple approach of three-isocenter IMRT planning for craniospinal irradiation

Purpose To develop a new IMRT technique to simplify the process and improve efficiency in radiotherapy treatment planning for craniospinal irradiation (CSI) treatment. Methods Image data of 9 patients who received CSI treatment in 2012 were used, the prescription was 36Gy in 20 fractions. Two treatment plans were created for each patient, one was with the new technique called...

Comparative efficacy of glimepiride and metformin in monotherapy of type 2 diabetes mellitus: meta-analysis of randomized controlled trials

Background Metformin treatment has been the most recommended monotherapy of type 2 diabetes mellitus (T2DM) for decades but is challenged by new antidiabetic drugs. This study conducted a meta-analysis of randomized controlled trials (RCT) comparing the efficacy of metformin and glimepiride in monotherapy of T2DM. Methods A literature search for RCTs on glimepiride and metformin...

Electrospun vancomycin-loaded coating on titanium implants for the prevention of implant-associated infections

Electrospun vancomycin-loaded coating on titanium implants for the prevention of implant-associated infections Li Zhang,* Junwei Yan,* Zhaowei Yin, Cheng Tang, Yang Guo, Dong Li, Bo Wei, Yan Xu

Endoscopic versus microscopic transsphenoidal pituitary adenoma surgery: a meta-analysis

-investigative studies (technical reports, case series, letters, and comments). The search results were assessed independently by two authors (Siyi Xu and Yang Guo). Any disagreement was resolved unanimously by

The antitumor activity of tumor-homing peptide-modified thermosensitive liposomes containing doxorubicin on MCF-7/ADR: in vitro and in vivo

Zhang,1 Wei Ren,1 Dan Huang,1 Shuang Zhang,1 Yang Guo,1 Xin Yao,1 Yi-Qun Tang,2 Xuan Zhang,1 Qiang Zhang1,3 1Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing

High glucose induces apoptosis and suppresses proliferation of adult rat neural stem cells following in vitro ischemia

design, established the OGD model and drafted the manuscript. Yang Guo carried out western blot analysis, immunoassays, and statistical analysis. Wei Cheng participated in flow cytometry. Ruiqing Chen

Renal Denervation Suppresses Atrial Fibrillation in a Model of Renal Impairment

Background A close association exists between renal impairment (RI) and atrial fibrillation (AF) occurrence. Increased activity of the sympathetic nervous system (SNS) may contribute to the development of AF associated with RI. Renal denervation (RDN) decreases central sympathetic activity. Objective The main objective of the study was to explore the effects of RDN on AF...

Establishment of a Model of Renal Impairment with Mild Renal Insufficiency Associated with Atrial Fibrillation in Canines

Background Chronic kidney disease and occurrence of atrial fibrillation (AF) are closely related. No studies have examined whether renal impairment (RI) without severe renal dysfunction is associated with the occurrence of AF. Methods Unilateral RI with mild renal insufficiency was induced in beagles by embolization of small branches of the renal artery in the left kidney for 2...

Characterization and Evolutionary Implications of the Triad Asp-Xxx-Glu in Group II Phosphopantetheinyl Transferases

Phosphopantetheinyl transferases (PPTases), which play an essential role in both primary and secondary metabolism, are magnesium binding enzymes. In this study, we characterized the magnesium binding residues of all known group II PPTases by biochemical and evolutionary analysis. Our results suggested that group II PPTases could be classified into two subgroups, two-magnesium...

Integrating computational modeling and functional assays to decipher the structure-function relationship of influenza virus PB1 protein

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