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Association of Plasma IL-32 Levels and Gene Polymorphisms with Systemic Lupus Erythematosus in Chinese Han Population

Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease. IL-32, a secreted protein, has been reported to be associated with several autoimmune diseases. Our preliminary experiment showed different plasma IL-32 levels than that mentioned in a published report on the same population. In order to elucidate the correlation between IL-32 and SLE, we determined the...

FUS-linked essential tremor associated with motor dysfunction in Drosophila

Essential tremor (ET) is one of the most common adult-onset neurological disorders which produce motor and non-motor symptoms. To date, there are no gold standard pathological hallmarks of ET, and despite a strong genetic contribution toward ET development, only a few pathogenic mutations have been identified. Recently, a pathogenic FUS-Q290X mutation has been reported in a large...

Si- and Ge-Based Electronic Devices

Institute of Standards & Technology, Washington, DC 20899, USA Received 26 March 2015; Accepted 26 March 2015 Copyright © 2015 Yi Zhao et al. This is an open access article distributed under the Creative ... , but also important solutions for the existing issues in the theory and fabrication of Si- and Ge-based electronic transistors. Yi Zhao Rui Zhang Jiwu Lu Wenfeng Zhang

NPInter v3.0: an upgraded database of noncoding RNA-associated interactions

Despite the fact that a large quantity of noncoding RNAs (ncRNAs) have been identified, their functions remain unclear. To enable researchers to have a better understanding of ncRNAs’ functions, we updated the NPInter database to version 3.0, which contains experimentally verified interactions between ncRNAs (excluding tRNAs and rRNAs), especially long noncoding RNAs (lncRNAs...

Outer Synchronization of Complex Networks with Nondelayed and Time-Varying Delayed Couplings via Pinning Control or Impulsive Control

The outer synchronization problem between two complex networks with nondelayed and time-varying delayed couplings via two different control schemes, namely, pinning control and impulsive control, is considered. Firstly, by applying pinning control to a fraction of the network nodes and using a suitable Lyapunov function, we obtain some new and useful synchronization criteria...

Targeting Th17 Cells with Small Molecules and Small Interference RNA

T helper 17 (Th17) cells play a central role in inflammatory and autoimmune diseases via the production of proinflammatory cytokines interleukin- (IL-) 17, IL-17F, and IL-22. Anti-IL-17 monoclonal antibodies show potent efficacy in psoriasis but poor effect in rheumatoid arthritis (RA) and Crohn’s disease. Alternative agents targeting Th17 cells may be a better way to inhibit the...

Impact of miRNA Sequence on miRNA Expression and Correlation between miRNA Expression and Cell Cycle Regulation in Breast Cancer Cells

The miRNAs regulate cell functions by inhibiting expression of proteins. Research on miRNAs had usually focused on identifying targets by base pairing between miRNAs and their targets. Instead of identifying targets, this paper proposed an innovative approach, namely impact significance analysis, to study the correlation between mature sequence, expression across patient samples...

Modeling miRNA-mRNA interactions: fitting chemical kinetics equations to microarray data

Background The miRNAs are small non-coding RNAs of roughly 22 nucleotides in length, which can bind with and inhibit protein coding mRNAs through complementary base pairing. By degrading mRNAs and repressing proteins, miRNAs regulate the cell signaling and cell functions. This paper focuses on innovative mathematical techniques to model gene interactions by algorithmic analysis...

Comprehensive Transcriptome Analyses of the Fructose-Fed Syrian Golden Hamster Liver Provides Novel Insights into Lipid Metabolism

Dyslipidemia has been widely proven to contribute to cardiovascular diseases and other metabolic disorders, especially in insulin resistance and type 2 diabetes. The overproduction of VLDL is a significant characteristic of dyslipidemia, indicating the dysfunction of hepatic lipid metabolism, from triglyceride synthesis to transport. The fructose-fed Syrian golden hamster is an...

Cluster Synchronization of Impulsive Complex Networks with Stochastic Perturbations and Time-Varying Delays

: Yannick De Decker Copyright © 2013 Yi Zhao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction

10-Year experience regarding the reliability and morbidity of radio guided lymph node biopsy in penile cancer patients and the associated radiation exposure of medical staff in this procedure

Background The guidelines of the European Association of Urologists (EAU), of the German Society of Nuclear Medicine (DGN), and the European Society for Medical Oncology (ESMO) recommend sentinel lymph node biopsy (SLNB) for lymph node staging in penile cancer with non-palpable inguinal lymph nodes as one diagnostic method. Despite this, the method is neither widely nor regularly...

Local administration of siRNA through Microneedle: Optimization, Bio-distribution, Tumor Suppression and Toxicity

work. AffiliationsDepartment of Obstetrics & Gynaecology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, ChinaTao Tang, Yan Deng, Jiao Chen, Yi Zhao, Kwong ... in:Nature Research journals • PubMed • Google ScholarSearch for Jiao Chen in:Nature Research journals • PubMed • Google ScholarSearch for Yi Zhao in:Nature Research journals • PubMed • Google ScholarSearch

Quantum Instanton Evaluations of the Thermal Rate Constants for Complex Systems

, Shaanxi Province, China Received 28 June 2011; Revised 26 August 2011; Accepted 10 September 2011 Academic Editor: Laimutis Bytautas Copyright © 2012 Yi Zhao and Wenji Wang. This is an open access

Global histone modification profiling reveals the epigenomic dynamics during malignant transformation in a four-stage breast cancer model

Background Epigenetic regulation has emerged to be the critical steps for tumorigenesis and metastasis. Multiple histone methyltransferase and demethylase have been implicated as tumor suppressors or oncogenes recently. But the key epigenomic events in cancer cell transformation still remain poorly understood. Methods A breast cancer transformation model was established via...

A stewardship intervention program for safe medication management and use of antidiabetic drugs

A stewardship intervention program for safe medication management and use of antidiabetic drugs Rui-yi Zhao,1 Xiao-wen He,1 Yan-min Shan,1 Ling-ling Zhu,2 Quan Zhou3 1Clinical Nurse Specialist

Synchronizability of Small-World Networks Generated from a Two-Dimensional Kleinberg Model

© 2013 Yi Zhao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the

Identification of miRNAs during mouse postnatal ovarian development and superovulation

Background MicroRNAs are small noncoding RNAs that play critical roles in regulation of gene expression in wide array of tissues including the ovary through sequence complementarity at post-transcriptional level. Tight regulation of multitude of genes involved in ovarian development and folliculogenesis could be regulated at transcription level by these miRNAs. Therefore, tissue...

Evolutionary annotation of conserved long non-coding RNAs in major mammalian species

Mammalian genomes contain tens of thousands of long non-coding RNAs (lncRNAs) that have been implicated in diverse biological processes. However, the lncRNA transcriptomes of most mammalian species have not been established, limiting the evolutionary annotation of these novel transcripts. Based on RNA sequencing data from six tissues of nine species, we built comprehensive lncRNA...

An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors

Transcription factors (TFs) play key roles in both development and stress responses. By integrating into and rewiring original systems, novel TFs contribute significantly to the evolution of transcriptional regulatory networks. Here, we report a high-confidence transcriptional regulatory map covering 388 TFs from 47 families in Arabidopsis. Systematic analysis of this map...

Hemoporfin Photodynamic Therapy for Port-Wine Stain: A Randomized Controlled Trial

Background and Objectives Photodynamic therapy (PDT) has shown potentially beneficial results in treating port-wine stain, but its benefit–risk profile remains undefined. This study aimed to evaluate the efficacy and safety of PDT conducted with hemoporfin and a 532 nm continuous wave laser to treat port-wine stain clinically. Patients and Methods This randomized clinical trial...