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HAEMODIALYSIS TECHNIQUES AND ADEQUACY 1

-Parodi1, German Perez Suarez1, Gloria Anton Perez1, Fatima Batista Garcia1, Mar Lago Alonso2 and Cesar Garcia Canton2 1Avericum, Telde, Spain, 2Hospital Insular Gran Canaria, Las Palmas, Spain

Choline deficiency selects for resistance to p53-independent apoptosis and causes tumorigenic transformation of rat hepatocytes.

The mechanisms which drive initiated cells to progress to form carcinomas are poorly understood. CWSV-1 rat hepatocytes, in which p53 protein is inactivated by SV40 large T antigen, respond by inducing p53-independent apoptosis when acutely switched to medium containing low choline (16% apoptotic at 48 h in 5 microM choline) as compared with controls (1% apoptotic at 48 h in 70 ...

DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

SPA KKa RVM AG DSL OMS SMaz FDa BPo KC MPi KT FB GR WB KWa TR TCa HN KA MAR TAMvO LvdK JLdL HEJMH AHvdH CJvA EBBG NH JMC CHMvD RBvdL PD EO CL AT MMe AJ CC JGr JLu KD KJB OTJ CM MMo ST MRT SHe CO LG NLi

Endocarditis Caused by Stenotrophomonas maltophilia: Case Report and Review

Stenotrophomonas (Xanthomonas) maltophilia is a rare cause of endocarditis. The extensive resistance of this organism to several antibiotics leaves few options for antimicrobial therapy. In vitro synergism of the combination of trimethoprim-sulfamethoxazole (TMP-SMZ) and ticarcillin/clavulanic acid (TIC/CA) has been demonstrated. To our knowledge, we report the first case of ...

Protective Immunization against Inhalational Anthrax: A Comparison of Minimally Invasive Delivery Platforms

A new anthrax vaccine under clinical investigation is based on recombinant Bacillus anthracis protective antigen (rPA). Here, we investigated microneedle-based cutaneous and nasal mucosal delivery of rPA in mice and rabbits. In mice, intradermal (id) delivery achieved up to 90% seroconversion after a single dose, compared with 20% after intramuscular (im) injection. Intranasal ...

Encoding processes and the recall of text

Two experiments investigated the proposition that the amount of cognitive effort expended to encode information will be directly related to recall of that information. While previous research has shown that amount of processing may affect recall, these studies have generally drawn on the notion of an elaborated memory representation to explain their results. In this study, the ...

LAB-ANGIOGENESIS AND INVASION

OBJECTIVE: Glioblastoma multiforme is the most frequent primary brain tumor in adults. The major obstacle for successful treatment is the invasive growth pattern. Metabolically, glioblastomas are highly glycolytic, leading to increased levels of lactic acid production. The carbonic anhydrase IX (CAIX) moderates the extrusion of hydrogen ions into the extracellular space, which may ...

The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data

& Dara S. Manoach & Jean-Luc Martinot & Mar Matarin & Karen A. Mather & Manuel Mattheisen & Morten Mattingsdal & Andreas Meyer-Lindenberg & Colm McDonald & Andrew M. McIntosh & Francis J. McMahon & Katie L

DIALYSIS. PATHOPHYSIOLOGY AND CLINICAL STUDIES

HEMODIALYSIS PATIENTS Elvira Bosch Benitez-Parodi1, Eduardo Baamonde Laborda2, Fatima Batista Garcia2, German Perez Suarez2, Gloria Anton Perez2, Cesar Garcia Canton3, Agustin Toledo Gonzalez3, M. Mar Lago

Protein-energy wasting

Guerra2, Ana Ramirez Puga2, Agustin Toledo2, M. Mar Lago Alonso2 and M. Dolores Checa Andres2 1Centro de Hemodilisis Avericum, Las Palmas de Gran Canaria, Spain, 2Hospital Universitario Insular de Gran

Extracorporeal dialysis: techniques and adequacy - A

Puga2, Rita Guerra2, Cesar Garcia Canton2, M. Mar Lago Alonso2, Agustin Toledo2 and M. Dolores Checa Andres2 1Centro de Hemodilisis Avericum Las Palmas de Gran Canaria Spain, 2Servicio de Nefrologa

Mineral and bone disease - CKD 5D

Introduction and Aims: In Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) patients, most treatment decisions concerning vitamin D use, administration of calcimimetics and parathyroidectomy are guided by parathyroid hormone (PTH) levels. The quality of the PTH test has been judged of paramount importance. Various fully automated assays are currently available, measuring ...

Alzheimer's Disease Associated with Mutations in Presenilin 2 is Rare and Variably Penetrant

Missense mutations in the presenilin 2 (PS-2) gene on chromosome 1 were sought by direct nucleotide sequence analysis of the open reading frame of 60 pedigrees with familial Alzheimer's disease (FAD). In the majority of these pedigrees, PS-1 and β-amyloid precursor protein (βAPP) gene mutations had been excluded. While no additional PS-2 pathogenic mutations were detected, four ...

Cardiovascular complications in CKD 5D

Introduction and Aims: Proton pump inhibitors (PPIs) are extensively used for the chronic treatment of common gastrointestinal disorders. Chronic PPI use is associated with increased risk of fractures. The primary endpoint was the extent of aortic and iliac calcifications, in relation to PPI use. Methods: Multicenter, cross-sectional study in hemodialysis patients, 18 hospital ...

CELL BIOLOGY AND SIGNALING

Glioblastoma multiforme (GBM) is the most aggressive of the astrocytic malignancies and the most common intracranial tumor in adults. Although the epidermal growth factor receptor (EGFR) is overexpressed and/or mutated in at least 50% of GBM cases and is required for tumor maintenance in animal models, EGFR inhibitors have thus far failed to deliver significant responses in GBM ...

Cell Biology and Signaling

CIRCUIT IN GLIOBLASTOMA Frank Furnari 1, Maria-del-Mar Inda 1, Rudy Bonavia 1, Akitake Mukasa 2, Yoshitake Narita 3, Dinak Sah 4, Scott Vandenberg 5, Cameron Brennan 6, Terrance Johns 7, Robert Bachoo 8