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A Large Multicenter Study of Methicillin–Susceptible and Methicillin–Resistant Staphylococcus aureus Prosthetic Joint Infections Managed With Implant Retention

, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona , Barcelona 15 Department of Internal Medicine and Infectious Diseases, Hospital del Mar 16 Department of Infectious Diseases, Hospital ... Mar, Barcelona, Spain); Mara Franco, Marcos Jordn and Pere Coll (Hospital de la Santa Creu i Sant Pau, Barcelona, Spain); Juan Amador-Mellado, Carlos Fuster-Foz, Luis Garca-Pano (Hospital El Bierzo

Upstream transcription factor 1 influences plasma lipid and metabolic traits in mice

Upstream transcription factor 1 (USF1) has been associated with familial combined hyperlipidemia, the metabolic syndrome, and related conditions, but the mechanisms involved are unknown. In this study, we report validation of Usf1 as a causal gene of cholesterol homeostasis, insulin sensitivity and body composition in mouse models using several complementary approaches and...

Serum paraoxonase and arylesterase activities in patients with lung cancer in a Turkish population

Background Lung cancer (LC) is the leading cause of cancer-related deaths. Oxidative DNA damage may contribute to the cancer risk. The antioxidant paraoxonase (PON1) is an endogenous free radical scavenger in the human body. The aim of this study was to determine serum PON1 and arylesterase (ARE) activities in patients with newly diagnosed LC. Methods This case control study...

In rats, oral oleoyl-DHEA is rapidly hydrolysed and converted to DHEA-sulphate

Background Dehydroepiandrosterone (DHEA) released by adrenal glands may be converted to androgens and estrogens mainly in the gonadal, adipose, mammary, hepatic and nervous tissue. DHEA is also a key neurosteroid and has antiglucocorticoid activity. DHEA has been used for the treatment of a number of diseases, including obesity; its pharmacological effects depend on large oral...

Claudin-19 Mutations and Clinical Phenotype in Spanish Patients with Familial Hypomagnesemia with Hypercalciuria and Nephrocalcinosis

Familial hypomagnesemia with hypercalciuria and nephrocalcinosis is an autosomal recessive tubular disorder characterized by excessive renal magnesium and calcium excretion and chronic kidney failure. This rare disease is caused by mutations in the CLDN16 and CLDN19 genes. These genes encode the tight junction proteins claudin-16 and claudin-19, respectively, which regulate the...

Role of IAPs in prostate cancer progression: immunohistochemical study in normal and pathological (benign hyperplastic, prostatic intraepithelial neoplasia and cancer) human prostate

Background In this study was investigate IAPs in normal human prostate (NP), benign prostatic hyperplasia (BPH), prostatic intraepithelial neoplasia (PIN) and prostatic carcinoma (PC), and their involvement in apoptosis/proliferation via NF-kB (TNF-α, IL-1) stimulation. Methods Immunohistochemical and Western blot analyses were performed in 10 samples of normal prostates, 35...

The importance of visual cues for nocturnal species: eagle owls signal by badge brightness

Nocturnal species may communicate by visual signals more frequently than previously thought. In fact, such species are habitually active around sunset and sunrise, when light conditions are still suitable for visual communication. We investigated the communication function of a visual cue in the eagle owl Bubo bubo, a nocturnal predator. In this species, territorial and courtship...

Clinical characteristics and evaluation of LDL-cholesterol treatment of the Spanish Familial Hypercholesterolemia Longitudinal Cohort Study (SAFEHEART)

Rodrigo Alonso 0 Lina Badimn Teresa Padr Francisco Fuentes Ovidio Muiz Francisco Perez-Jimnez Jos Lpez-Miranda Jose L Daz Jose I Vidal A Barba Mar Piedecausa Juan F Sanchez Luis Irigoyen Eliseo Guallar Jos

Las Nuevas Adhesiones A La Union Europea De Los Paises De Europa Central y Oriental: La Estrategia De Adhesion Y Sus Implicaciones En El Ambito De La Politica Comunitaria Ambiental

. ......................................... PorDra Mar Campins Eritja*y Dr.Andreu Olesti Rayo* * • Profesora Titular de Derecho Internacional Piblico (Derecho Comunitario Europeo), Universitat de Barcelona. * Profesor Titular de Derecho Interacional ... countries COM(99)500 final a 4 (visitado Mar. 25, 2000) [de aquf en adelante ProgressReport]. 65. La Comisi6n considera que el pas ha llevado a tdmino un

The interval between Ins2 and Ascl2 is dispensable for imprinting centre function in the murine Beckwith–Wiedemann region

Imprinted genes are commonly clustered in domains across the mammalian genome, suggesting a degree of coregulation via long-range coordination of their monoallelic transcription. The distal end of mouse chromosome 7 (Chr 7) contains two clusters of imprinted genes within a ∼1 Mb domain. This region is conserved on human 11p15.5 where it is implicated in the Beckwith–Wiedemann...

European Domestic Horses Originated in Two Holocene Refugia

The role of European wild horses in horse domestication is poorly understood. While the fossil record for wild horses in Europe prior to horse domestication is scarce, there have been suggestions that wild populations from various European regions might have contributed to the gene pool of domestic horses. To distinguish between regions where domestic populations are mainly...

Preventing the onset of major depression based on the level and profile of risk of primary care attendees: protocol of a cluster randomised trial (the predictD-CCRT study)

Montn-Franco Inmaculada Ibanez-Casas Emiliano Rodrguez-Snchez Antonina Rodrguez-Bayn Antoni Serrano-Blanco Mara Cruz Gmez Pilar LaFuente Mara del Mar Muoz-Garca Pilar Mnguez-Gonzalo Luz Araujo Diego Palao

The Involvement of Thaumatin-Like Proteins in Plant Food Cross-Reactivity: A Multicenter Study Using a Specific Protein Microarray

Cross-reactivity of plant foods is an important phenomenon in allergy, with geographical variations with respect to the number and prevalence of the allergens involved in this process, whose complexity requires detailed studies. We have addressed the role of thaumatin-like proteins (TLPs) in cross-reactivity between fruit and pollen allergies. A representative panel of 16...

Expression of the UL16 glycoprotein of Human Cytomegalovirus protects the virus-infected cell from attack by natural killer cells

Mar Vals-Gmez 0 Helena Browne 0 Hugh T Reyburn 0 0 Address: Department of Pathology, Cambridge University , Tennis Court Road, Cambridge CB2 1QP , UK Background: Human Cytomegalovirus (HCMV) has

Risk factors for virological failure and subtherapeutic antiretroviral drug concentrations in HIV-positive adults treated in rural northwestern Uganda

Background Little is known about immunovirological treatment outcomes and adherence in HIV/AIDS patients on antiretroviral therapy (ART) treated using a simplified management approach in rural areas of developing countries, or about the main factors influencing those outcomes in clinical practice. Methods Cross-sectional immunovirological, pharmacological, and adherence outcomes...