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Evaluation of the Immunochromatographic Binax NOW Assay for Detection of Streptococcus pneumoniae Urinary Antigen in a Prospective Study of Community-Acquired Pneumonia in Spain

We evaluated the Binax NOW rapid immunochromatographic membrane test (ICT) for detection of Streptococcus pneumoniae urinary antigen in a population-based prospective study of adults with community-acquired pneumonia (CAP). ICT was performed with urine samples obtained from 452 (91.7%) of 493 patients enrolled. Pneumococcal antigen was detected in 19 (70.4%) of 27 patients with ...

Sperm motility index: a quick screening parameter from sperm quality analyser-IIB to rule out oligo- and asthenozoospermia in male fertility study

The aim of this study was to evaluate the sperm quality analyser (SQA)-IIB, a new automated sperm analyser, and to compare its results with those obtained with a method based on the World Health Organization recommendations. Eighty-nine unprocessed semen samples and 53 selected sperm suspensions were analysed. Concentration, motility and morphology were evaluated using the routine ...

Superinfection Following Smallpox Vaccination (Vaccinia), United States: Surveillance January 2003 through January 2004

Background. Superinfection is an adverse event following smallpox vaccination. The clinical presentation is similar to that of a large normal vaccine reaction or “robust take,” and the frequency is unknown. Methods. We retrospectively reviewed all reported severe local reactions consistent with superinfection among United States civilian smallpox vaccinees from January 2003 through ...

Genome-wide SNP assay reveals structural genomic variation, extended homozygosity and cell-line induced alterations in normal individuals

The recent hapmap effort has placed focus on the application of genome-wide SNP analysis to assess the contribution of genetic variability, particularly SNPs, to traits such as disease. Here, we describe the utility of genome-wide SNP analysis in the direct detection of extended homozygosity and structural genomic variation. We use this approach to assess the frequency of genomic ...

Clinical Outcome of HIV-Infected Patients with Sustained Virologic Response to Antiretroviral Therapy: Long-Term Follow-Up of a Multicenter Cohort

Universitario de Canarias, Santa Cruz de Tenerife: Ma Remedios Aleman Valls, Ma del Mar Alonso Socas, Carlos Hernandez Calzadilla; Hospital Universitari de Tarragona Joan XXIII, Universitat Rovira y Virgili

Broad-band and Hα surface photometry of the central regions of nearby active galaxies — I. Observations

Broad-band V, R and I and narrow-band Hα CCD surface photometry of a sample of 24 active and three normal nearby galaxies is presented, in order to study their morphological and structural properties. This first paper presents the observations, data reduction and processing techniques used; the main characteristics of the central regions of the sample galaxies are derived from ...

Diethanolamine Induces Hepatic Choline Deficiency in Mice

The purpose of the present experiments was to test the hypothesis that diethanolamine (DEA), an alkanolamine shown to be hepatocarcinogenic in mice, induces hepatic choline deficiency and to determine whether altered choline homeostasis was causally related to the carcinogenic outcome. To examine this hypothesis, the biochemical and histopathological changes in male B6C3F1 mice ...

V, R, I and Hα photometry of circumnuclear star-forming regions in four galaxies with different levels of nuclear activity

We present photometry, in the V, R and I continuum bands and in the Hα+[N ii] emission lines, for a sample of circumnuclear star-forming regions (CNSFR), located in four galaxies with different kinds of activity in their nuclei: NGC 7469 (Seyfert 1), NGC 1068 (Seyfert 2), NGC 7177 (LINER) and NGC 3310 (starburst). Hα luminosities for the CNSFR range from 0.02 to 7×1040 erg s−1 ...

RAGE Control of Diabetic Nephropathy in a Mouse Model: Effects of RAGE Gene Disruption and Administration of Low–Molecular Weight Heparin

Khin-Mar Myint Yasuhiko Yamamoto Toshio Doi Ichiro Kato Ai Harashima Hideto Yonekura Takuo Watanabe Harumichi Shinohara Masayoshi Takeuchi Koichi Tsuneyama Noriyoshi Hashimoto Masahide Asano Shin

Phase 1 Safety and Immunogenicity Evaluation of ADMVA, a Multigenic, Modified Vaccinia Ankara-HIV-1 B'/C Candidate Vaccine

Background We conducted a Phase I dose-escalation trial of ADMVA, a Clade-B'/C-based HIV-1 candidate vaccine expressing env, gag, pol, nef, and tat in a modified vaccinia Ankara viral vector. Sequences were derived from a prevalent circulating HIV-1 recombinant form in Yunnan, China, an area of high HIV incidence. The objective was to evaluate the safety and immunogenicity of ADMVA ...

Contribution of Genetic Background, Traditional Risk Factors, and HIV-Related Factors to Coronary Artery Disease Events in HIV-Positive Persons

Background Persons infected with human immunodeficiency virus (HIV) have increased rates of coronary artery disease (CAD). The relative contribution of genetic background, HIV-related factors, antiretroviral medications, and traditional risk factors to CAD has not been fully evaluated in the setting of HIV infection. Methods In the general population, 23 common single-nucleotide ...

The Parahippocampal Gyrus in the Baboon: Anatomical, Cytoarchitectonic and Magnetic Resonance Imaging (MRI) Studies

electrophysiological studies in nonhuman primates (see for a review, see Squire and Zola, 1996). Indeed, several studies based on the lesion of the Xavier Blaizot1, Alino Martinez-Marcos1, Maria del Mar ArroyoJimenez1

Clinical application of multiplex quantitative fluorescent polymerase chain reaction (QF-PCR) for the rapid prenatal detection of common chromosome aneuploidies

The clinical application of quantitative fluorescent polymerase chain reaction (QF-PCR) for rapid prenatal detection of chromosome aneuploidies has been limited in most studies to the detection of autosomal trisomies. Recently it has been shown that a newly identified highly polymorphic marker, termed X22, which maps to the Xq/Yq pseudoautosomal region of the sex chromosomes, used ...

Detecting single DNA copy number variations in complex genomes using one nanogram of starting DNA and BAC-array CGH

Comparative genomic hybridization to bacterial artificial chromosome (BAC)-arrays (array-CGH) is a highly efficient technique, allowing the simultaneous measurement of genomic DNA copy number at hundreds or thousands of loci, and the reliable detection of local one-copy-level variations. We report a genome-wide amplification method allowing the same measurement sensitivity, using 1 ...

Predicting the onset and persistence of episodes of depression in primary health care. The predictD-Spain study: Methodology

Background The effects of putative risk factors on the onset and/or persistence of depression remain unclear. We aim to develop comprehensive models to predict the onset and persistence of episodes of depression in primary care. Here we explain the general methodology of the predictD-Spain study and evaluate the reliability of the questionnaires used. Methods This is a prospective ...

Effect of high CO2 level on the titres of γ-aminobutyric acid, total polyamines and some pathogenesis-related proteins in cherimoya fruit stored at low temperature

In this study the effect of treatment with 20% CO2 plus 20% O2 for 3 d on γ-aminobutyric acid (GABA) was analysed and total polyamine titres and the production of some pathogenesis-related proteins (PR-proteins) in cherimoya (Annona cherimola Mill.) fruit stored at low temperature. In immunoassays with anti-PR-Q and PR-2 protein sera, high CO2 levels were found to provoke the ...

VIDA: a virus database system for the organization of animal virus genome open reading frames

VIDA is a new virus database that organizes open reading frames (ORFs) from partial and complete genomic sequences from animal viruses. Currently VIDA includes all sequences from GenBank for Herpesviridae, Coronaviridae and Arteriviridae. The ORFs are organized into homologous protein families, which are identified on the basis of sequence similarity relationships. Conserved ...

Loss- and gain-of-function mutations show a polycomb group function for Ring1A in mice

Bonn , Rmerstrasse 164, Bonn 53117, Germany 5 M. del Mar Lorente and others SUMMARY The products of the Polycomb group (PcG) of genes act as transcriptional repressors involved in the maintenance of

Regulation of glycogen synthesis by the laforin–malin complex is modulated by the AMP-activated protein kinase pathway

Lafora progressive myoclonus epilepsy (LD) is a fatal autosomal recessive neurodegenerative disorder characterized by the presence of glycogen-like intracellular inclusions called Lafora bodies. LD is caused by mutations in two genes, EPM2A and EPM2B, encoding respectively laforin, a dual-specificity protein phosphatase, and malin, an E3 ubiquitin ligase. Previously, we and others ...

Role of Kras Status in Patients with Metastatic Colorectal Cancer Receiving First-Line Chemotherapy plus Bevacizumab: A TTD Group Cooperative Study

, Hospital General de Valencia , Valencia , Spain , 8 Department of Medical Oncology, Hospital del Mar , Barcelona , Spain , 9 Department of Medical Oncology, Hospital Virgen de las Nieves , Granada , Spain ... Coruna); A. Abad (ICO. H. Germans Trias i Pujol ); F. Rivera (H. Marques de Valdecilla); Ma J. Safont (H. General Universitario de Valencia); M. Gallen (H. del Mar); E. Gonzalez (H. Virgen de las Nieves