Advanced search    

Search: authors:"mar"

692 papers found.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

A Nanoconjugate Apaf-1 Inhibitor Protects Mesothelial Cells from Cytokine-Induced Injury

Background Inflammation may lead to tissue injury. We have studied the modulation of inflammatory milieu-induced tissue injury, as exemplified by the mesothelium. Peritoneal dialysis is complicated by peritonitis episodes that cause loss of mesothelium. Proinflammatory cytokines are increased in the peritoneal cavity during peritonitis episodes. However there is scarce information ...

In Vivo Electroporation Enhances the Immunogenicity of an HIV-1 DNA Vaccine Candidate in Healthy Volunteers

Background DNA-based vaccines have been safe but weakly immunogenic in humans to date. Methods and Findings We sought to determine the safety, tolerability, and immunogenicity of ADVAX, a multigenic HIV-1 DNA vaccine candidate, injected intramuscularly by in vivo electroporation (EP) in a Phase-1, double-blind, randomized placebo-controlled trial in healthy volunteers. Eight ...

Comparative efficacy of two primary care interventions to assist withdrawal from long term benzodiazepine use: A protocol for a clustered, randomized clinical trial

Josep Llus Piol Magdalena Esteva Miguel Roca Arturo Arenas Mara del Mar Sureda Francisco Campoamor Francisca Fiol 0 0 Son Serra- La Vileta Health Care Centre, Balearic Mental Health Research Group

Interleukin-2 and its receptor complex (α, β and γ chains) in in situ and infiltrative human breast cancer: an immunohistochemical comparative study

Introduction The presence and distribution of interleukin-2 (IL-2) and its receptor complex (Rα, Rβ, Rγ) were studied in 52 women who were clinically and histopathologically diagnosed with breast tumours (17 in situ and 35 infiltrating), and in 13 women with benign fibrocystic lesions in the breast. Methods Immunohistochemistry with antibodies against IL-2, IL-2Rα, IL-2Rβ and ...

Measures of Autozygosity in Decline: Globalization, Urbanization, and Its Implications for Medical Genetics

- 676 . 14. Purcell S , Neale B , Todd-Brown K , Thomas L , Ferreira MAR , et al. ( 2007 ) PLINK: a toolset for whole-genome association and population-based linkage analysis . American Journal of Human

Assessment of a primary and tertiary care integrated management model for chronic obstructive pulmonary disease

Background The diagnosis and treatment of patients with chronic obstructive pulmonary disease (COPD) in Spain continues to present challenges, and problems are exacerbated when there is a lack of coordinated follow-up between levels of care. This paper sets out the protocol for assessing the impact of an integrated management model for the care of patients with COPD. The new model ...

Identification of patterns in biological sequences at the ALGGEN server: PROMO and MALGEN

In this paper we present several web-based tools to identify conserved patterns in sequences. In particular we present details on the functionality of PROMO version 2.0, a program for the prediction of transcription factor binding site in a single sequence or in a group of related sequences and, of MALGEN, a tool to visualize sequence correspondences among long DNA sequences. The ...

Therapeutic Implications of GIPC1 Silencing in Cancer

Niall Prendergast Vladimir Glinskii Yi Cai Aedin Culhane Stefan Bentink Mathew Schwede Jessica C. Mar Eleanor A. Howe Martin Aryee Razvan Sultana Anthony A. Lanahan Jennifer M. Taylor Chris Holmes William

Detection of mitomycin C-induced genetic damage in fish cells by use of RAPD

Concern about genetic alterations in fish populations arising from anthropogenic activities has led to the adaptation and/or development of new tests and techniques that shed light on these alterations. The high number and the reduced size of chromosomes and the long cell cycle associated with most fish species preclude the use of most accepted genotoxicity assays. The purpose of ...

Incidence and risk factors of exacerbations among COPD patients in primary health care: APMPOC study

, Spain 1 Primary Healtcare Centre Canet de Mar, Catalan Health Institute, Costa de l'Hospital s/n, 08640 Canet de Mar , Spain 2 Primary Healthcare Centre Sant Roc, Catalan Health Institute , Velez Rubio s ... , Spain): Anna Rubiales, Carolina Berengu, Anna Altaba, Gustavo Losada, Miriam Matamoros, From Primary Healthcare Centre Llefi (Badalona, Spain): Mar Baranda, From Primary Healthcare Centre La Salut

The role of pneumolysin in mediating lung damage in a lethal pneumococcal pneumonia murine model

Background Intranasal inoculation of Streptococcus pneumoniae D39 serotype 2 causes fatal pneumonia in mice. The cytotoxic and inflammatory properties of pneumolysin (PLY) have been implicated in the pathogenesis of pneumococcal pneumonia. Methods To examine the role of PLY in this experimental model we performed ELISA assays for PLY quantification. The distribution patterns of PLY ...

Use of Epidemiology in Clinical Medical Publications, 1983–1999: A Citation Analysis

, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention , Atlanta, GA 2 Reprint requests to Dr. La Mar Hasbrouck, CDC-NCIPC , 4770 Buford Highway, NE, Mailstop K-60

The genes encoding Arabidopsis ORC subunits are E2F targets and the two ORC1 genes are differently expressed in proliferating and endoreplicating cells

Initiation of eukaryotic DNA replication depends on the function of pre-replication complexes (pre-RC), one of its key component being the six subunits origin recognition complex (ORC). In spite of a significant degree of conservation among ORC proteins from different eukaryotic sources, the regulation of their availability varies considerably in different model systems and cell ...

Large Outbreak of Measles in a Community with High Vaccination Coverage: Implications for the Vaccination Schedule

Background. Attempts to eliminate measles from a country or region may be disrupted by an imported case that affects indigenous persons. The objective of this study was to analyze epidemiological and clinical characteristics of a measles outbreak in Catalonia, Spain, in 2006. Methods. Data on cases of measles reported to the Department of Health, Generalitat of Catalonia, during ...

Immunogenetics of CD4 Lymphocyte Count Recovery during Antiretroviral Therapy: An AIDS Clinical Trials Group Study

During antiretroviral therapy, CD4 lymphocyte count increases are modest in some patients despite virologic control. We explored whether polymorphisms in genes important for T cell expansion, survival, and apoptosis are associated with the magnitude of CD4 lymphocyte count recovery during antiretroviral therapy. We studied treatment-naive individuals who achieved sustained control ...

Leaders, leadership and future primary care clinical research

John Furler 3 Jennifer Cleland 1 Chris Del Mar 0 Barbara Hanratty 7 Umesh Kadam 6 Daniel Lasserson 5 Colin McCowan 4 Parker Magin 9 Caroline Mitchell 8 Nadeem Qureshi 2 Greta Rait 12 Nick

Vascular involvement and cell damage in experimental AA and clinical β2‐microglobulin amyloidosis

Background. Amyloidosis is a highly prevalent disease characterized by the deposition of amyloid fibrils. Although several types of amyloidosis can be identified according to their protein constituents and suggest putative aetiological factors, the causes of amyloidosis remain unknown. Furthermore, the cellular participation and the ultrastructural particularities of amyloidosis ...