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121 papers found.
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Switch therapy in hospitalized patients with community-acquired pneumonia: Tigecycline vs. Levofloxacin

Background Switch therapy is a management approach combining early discontinuation of intravenous (IV) antibiotics, switch to oral antibiotics, and early hospital discharge. This analysis compares switch therapy using tigecycline versus levofloxacin in hospitalized patients with community-acquired pneumonia (CAP). Methods A prospective, randomized, double-blind, Phase 3 clinical ...

Osteoporosis in the European Union: a compendium of country-specific reports

, Stockholm, Sweden 4 E. V. McCloskey Academic Unit of Bone Metabolism, Northern General Hospital , Sheffield, UK 5 J. Stenmark International Osteoporosis Foundation , Nyon, Switzerland 6 C. Cooper NIHR ... Musculoskeletal Biomedical Research Unit, Institute of Musculoskeletal Sciences, University of Oxford , Oxford, UK 7 C. Cooper MRC Lifecourse Epidemiology Unit, University of Southampton , Southampton, UK 8 C

Xenotransplantation—will tolerance be essential?

that might induce tolerance. David K. C. Cooper Advance Access publication 5 August 2006 Sir, We appreciate Coopers opinion, which is based on a large experience in the field. Undoubtedly, major progress

Capture the Fracture: a Best Practice Framework and global campaign to break the fragility fracture cycle

Southampton , Southampton, UK 4 C. Cooper NIHR Musculoskeletal Biomedical Research Unit, University of Oxford , Oxford, UK 5 A. R. McLellan Gardiner Institute, Western Infirmary , Glasgow, UK 6 P. J. Mitchell

Claudin 1 expression in basal-like breast cancer is related to patient age

Background Defects in tight junctions, gate-keepers of the integrity of the epidermal barrier function, are known to contribute to cancer development. As such, enhancing our understanding of how the expression of proteins involved in these junctions is regulated in cancer, remains a priority. Although the expression of one of these proteins, claudin 1, is down regulated in most ...

Galaxy assembly bias on the red sequence

M. C. Cooper et al. 0 Department of Physics and Astronomy, University of Pittsburgh , 401-C Allen Hall, 3941 O'Hara Street, Pittsburgh, PA 15260, USA 1 Max-Planck-Institut fur Astronomie , Konigstuhl

Erratum to: Management of osteoporosis of the oldest old

, London , UK 8 A. Diez-Perez Servicio de Medicina Interna y Enfermedades Infecciosas, Hospital del Mar-IMIM and RETICEF , Barcelona , Spain 9 C. Cooper NIHR Musculoskeletal Biomedical Research Unit

Fracture rate in patients with myasthenia gravis: the general practice research database

Summary The aim of this study was to evaluate fracture risk after onset of myasthenia gravis using the UK General Practice Research Database. Overall fracture risk is not statistically increased compared with age- and gender-matched controls irrespective of glucocorticoid use, but was increased in those using antidepressants, anxiolytics or anticonvulsants. Introduction Myasthenia ...

The Arizona CDFS Environment Survey (ACES): A Magellan/IMACS Spectroscopic Survey of the Chandra Deep Field-South⋆

We present the Arizona CDFS Environment Survey (ACES), a recently completed spectroscopic redshift survey of the Chandra Deep Field-South (CDFS) conducted using the Inamori-Magellan Areal Camera and Spectrograph on the Magellan-Baade telescope. In total, the survey targeted 7277 unique sources down to a limiting magnitude of RAB = 24.1, yielding 5080 secure redshifts across the ∼30 ...

Automated morphological classification of Sloan Digital Sky Survey red sequence galaxies

In the last decade, the advent of enormous galaxy surveys has motivated the development of automated morphological classification schemes to deal with large data volumes. Existing automated schemes can successfully distinguish between early- and late-type galaxies and identify merger candidates, but are inadequate for studying detailed morphologies of red sequence galaxies. To fill ...

A systematic review of hip fracture incidence and probability of fracture worldwide

HP, Hiligsmann M, Kanis JA, Lau E, Lewiecki EM, Lips P, Lorenc R, McCloskey E, Ortolani S, Papaioannou A, Silverman S, Yoshimura N, and Szulc P 2 C. Cooper MRC Lifecourse Epidemiology Unit, University ... Cummings (China), B Abrahamsen (Denmark), CH Orces (Ecuador), R Sund and H Kroger (Finland), Kristin Siggeirsdottir and Vilmundur Gudnason (Iceland), D Dhanwal and C Cooper (India), Errol Hutagalung and

How does galaxy environment matter? The relationship between galaxy environments, colour and stellar mass at 0.4 < z < 1 in the Palomar/DEEP2 survey

We present a study characterizing the environments of galaxies in the redshift range of 0.4 < z < 1 based on data from the POWIR near-infrared imaging and DEEP2 spectroscopic redshift surveys, down to a stellar mass of log M*= 10.25 M⊙. Galaxy environments are measured in terms of nearest-neighbour densities as well as fixed aperture densities and kinematical and dynamical ...

Dependence of galaxy quenching on halo mass and distance from its centre

We study the dependence of star formation quenching on galaxy mass and environment, in the Sloan Digital Sky Survey (SDSS; z ∼ 0.1) and the All-Wavelength Extended Groth Strip International Survey (AEGIS; z ∼ 1). It is crucial that we define quenching by low star formation rate rather than by red colour, given that one-third of the red galaxies are star forming. We address stellar ...

Observational constraints on the physics behind the evolution of active galactic nuclei since z∼ 1

We explore the evolution with redshift of the rest-frame colours and space densities of active galactic nuclei (AGN) hosts (relative to normal galaxies) to shed light on the dominant mechanism that triggers accretion on to supermassive black holes as a function of cosmic time. Data from serendipitous wide-area XMM surveys of the Sloan Digital Sky Survey (SDSS) footprint (XMM/SDSS; ...

Available alternative incentives modulate anticipatory nucleus accumbens activation

A reward or punishment can seem better or worse depending on what else might have happened. Little is known, however, about how neural representations of an anticipated incentive might be influenced by the available alternatives. We used event-related FMRI to investigate the activation in the nucleus accumbens (NAcc), while we varied the available alternative incentives in a ...

Subtrochanteric fractures after long-term treatment with bisphosphonates: a European Society on Clinical and Economic Aspects of Osteoporosis and Osteoarthritis, and International Osteoporosis Foundation Working Group Report

of Geneva , 1211 Geneva 14, Switzerland 3 C. Cooper NIHR Musculoskeletal Biomedical Research Unit, University of Oxford , Oxford, UK 4 C. Cooper MRC Epidemiology Resource Centre, University of

A Post-Burst Afterdepolarization Is Mediated by Group I Metabotropic Glutamate Receptor-Dependent Upregulation of Cav2.3 R-Type Calcium Channels in CA1 Pyramidal Neurons

The excitability of hippocampal pyramidal neurons is regulated by activation of metabotropic glutamate receptors, an effect that is mediated by modulation of R-type calcium channels.

Osteoporosis and venous thromboembolism: a retrospective cohort study in the UK General Practice Research Database

, University of Oxford , Oxford, UK 1 C. Cooper MRC Epidemiology Resource Centre, University of Southampton , Southampton, UK 2 ) INSERM U 953, Hpital Tenon, 4 rue de la Chine, 75020 Paris, France 3 J. Y

A reappraisal of generic bisphosphonates in osteoporosis

Sheffield Medical School , Beech Hill Road, Sheffield S10 2RX, UK 2 C. Cooper NIHR Musculoskeletal Biomedical Research Unit, University of Oxford , Oxford, UK 3 C. Cooper MRC Lifecourse Epidemiology Unit ... receives consulting fees, paid advisory boards and/or lecture fees from most companies concerned with bone disease. C Cooper receives consulting fees and paid advisory boards for Alliance for Better Bone

Output-Mode Transitions Are Controlled by Prolonged Inactivation of Sodium Channels in Pyramidal Neurons of Subiculum

Transitions between different behavioral states, such as sleep or wakefulness, quiescence or attentiveness, occur in part through transitions from action potential bursting to single spiking. Cortical activity, for example, is determined in large part by the spike output mode from the thalamus, which is controlled by the gating of low-voltage–activated calcium channels. In the ...