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Improvement of sexual function in POEMS syndrome after combination therapy of Lenalidomide and dexamethasone

Background POEMS syndrome is a rare paraneoplastic syndrome due to an underlying plasma cell neoplasm. Hypogonadism is the most common endocrine abnormality in POEMS syndrome. There is no data about improvement of hypogonadism and sexual dysfunction after appropriate treatment of POEMS syndrome so far. In this single-center prospective study, the efficacy of low-dose lenalidomide...

Risk alleles for IgA nephropathy-associated SNPs conferred completely opposite effects to idiopathic membranous nephropathy in Chinese Han

were found to be significantly associated with the susceptibility of IMN, with rs9275596 as the top one (p = 1.97E-43, Xiaosong Qin and Chen Wang contributed equally to the work. - Department of

Identification of downstream target genes regulated by the nitric oxide–soluble guanylate cyclase–cyclic guanosine monophosphate signal pathway in pulmonary hypertension

Objective To investigate the downstream target genes regulated by the nitric oxide–soluble guanylate cyclase–cyclic guanosine monophosphate (NO-sGC-cGMP) signal pathway and their possible roles in the pathogenesis of pulmonary hypertension (PH).

Oolong tea made from tea plants from different locations in Yunnan and Fujian, China showed similar aroma but different taste characteristics

Consistent aroma characteristics are important for tea products. However, understanding the formation of tea aroma flavor and correspondingly proposing applicable protocols to control tea quality and consistency remain major challenges. Oolong tea is one of the most popular teas with a distinct flavor. Generally, oolong tea is processed with the leaves of tea trees belonging to...

Elevated Serum Uric Acid Is Associated with Greater Bone Mineral Density and Skeletal Muscle Mass in Middle-Aged and Older Adults

Background and objective Previous studies have suggested a positive link between serum uric acid (UA) and bone mineral density (BMD). In this study, we re-examined the association between UA and BMD and further explored whether this was mediated by skeletal muscle mass in a general Chinese population. Method This community-based cross-sectional study was conducted among 3079 (963...

Phylogenetic Analyses of Armillaria Reveal at Least 15 Phylogenetic Lineages in China, Seven of Which Are Associated with Cultivated Gastrodia elata

Fungal species of Armillaria, which can act as plant pathogens and/or symbionts of the Chinese traditional medicinal herb Gastrodia elata (“Tianma”), are ecologically and economically important and have consequently attracted the attention of mycologists. However, their taxonomy has been highly dependent on morphological characterization and mating tests. In this study, we...

Enhanced performance of solar cells via anchoring CuGaS2 quantum dots

Ternary I–III–VI quantum dots (QDs) of chalcopyrite semiconductors exhibit excellent optical properties in solar cells. In this study, ternary chalcopyrite CuGaS2 nanocrystals (2–5 nm) were one-pot anchored on TiO2 nanoparticles (TiO2@CGS) without any long ligand. The solar cell with TiO2@CuGaS2/N719 has a power conversion efficiency of 7.4%, which is 23% higher than that of...

Tumor Necrosis Factor-Like Weak Inducer of Apoptosis Promotes Hepatic Stellate Cells Migration via Canonical NF-κB/MMP9 Pathway

In the liver, the signal and function of tumor necrosis factor-like weak inducer of apoptosis (TWEAK) have mainly been assessed in association with liver regeneration. However, the effects of TWEAK on liver fibrosis have not been fully elucidated. To investigate the effects of TWEAK on human hepatic stellate cells (HSCs) and to explore the relevant potential mechanisms, human...

The optimum timing to wean invasive ventilation for patients with AECOPD or COPD with pulmonary infection

The optimum timing to wean invasive ventilation for patients with AECOPD or COPD with pulmonary infection Yuanlin Song,1 Rongchang Chen,2 Qingyuan Zhan,3 Shujing Chen,1 Zujin Luo,4 Jiaxian Ou,1 Chen Wang3 1Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, 2Guangzhou Institute of Respiratory Disease, Guangzhou, 3Department of Respiratory and...

Comparative analysis of volatiles difference of Yunnan sun-dried Pu-erh green tea from different tea mountains: Jingmai and Wuliang mountain by chemical fingerprint similarity combined with principal component analysis and cluster analysis

Background Modern instrumental analysis technology can provide various chemical data and information on tea samples. Unfortunately, it remains difficult to extract the useful information. We describe the use of chemical fingerprint similarities, combined with principal component and cluster analyses, to distinguish and recognize Pu-erh green teas, which from two tea mountains...

Cloning and molecular identification of triosephosphate isomerase gene from Apis cerana cerana and its role in response to various stresses

Apis cerana cerana triosephosphate isomerase (AccTPI), a key regulatory enzyme in glycolysis and gluconeogenesis pathway, catalyzes the interconversion of glyceraldehyde 3-phosphate to dihydroxyacetone phosphate. However, its role in A. cerana cerana has not been completely clarified. In this study, a TPI gene was cloned from A. cerana cerana and named AccTPI. The open reading...

NanoString-based breast cancer risk prediction for women with sclerosing adenosis

Purpose Sclerosing adenosis (SA), found in ¼ of benign breast disease (BBD) biopsies, is a histological feature characterized by lobulocentric proliferation of acini and stromal fibrosis and confers a two-fold increase in breast cancer risk compared to women in the general population. We evaluated a NanoString-based gene expression assay to model breast cancer risk using RNA...

Asthma, corticosteroid use and schizophrenia: A nationwide population-based study in Taiwan

Objective Asthma and corticosteroid use have been implicated as possible risk factors for schizophrenia. The retrospective cohort study herein aimed to investigate the association between asthma, corticosteroid use, and schizophrenia. Method Longitudinal data (2000 to 2007) from adults with asthma (n = 50,046) and without asthma (n = 50,046) were compared on measures of...

Alteration in Expression and Methylation of IGF2/H19 in Placenta and Umbilical Cord Blood Are Associated with Macrosomia Exposed to Intrauterine Hyperglycemia

Objective Macrosomia is one of the most common complications in gestational diabetes mellitus. Insulin-like growth factor 2 and H19 are two of the imprinted candidate genes that are involved in fetal growth and development. Change in methylation at differentially methylated region of the insulin-like growth factor 2 and H19 has been proved to be an early event related to the...

The impacts of network competence, knowledge sharing on service innovation performance: Moderating role of relationship quality

Zhaoquan Jian 0 Chen Wang 0 0 School of Business Administration, South China University of Technology (China) Purpose: To examine how network competence, knowledge sharing and relationship quality affect

Differentiating Ideals versus Practices in the Discussion of Confucian Influences on Chinese Parent–Child Relationships

The primary purpose of this essay is to call for a renewed understanding of Confucianism in the discussion of Chinese parent-child relationships. Citing historical evidence, we present the evolution of Confucianism as a school of thought in China. In addition, we present research on Chinese parent–child relationships, which to a varying degree are said to be associated with...

Extra-Nuclear Signaling Pathway Involved in Progesterone-Induced Up-Regulations of p21cip1 and p27kip1 in Male Rat Aortic Smooth Muscle Cells

Previously, we demonstrated that progesterone (P4) at physiologic levels (5-500 nM) inhibited proliferation in cultured rat aortic smooth muscle cells (RASMCs) through a P4 receptor (PR)-dependent pathway. We also showed that P4-induced cell cycle arrest in RASMCs occurs when the cyclin-CDK2 system is inhibited just as p21cip1 and p27kip1 protein levels are augmented. In the...