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De novo identification of viral pathogens from cell culture hologenomes

Background Fast, specific identification and surveillance of pathogens is the cornerstone of any outbreak response system, especially in the case of emerging infectious diseases and viral epidemics. This process is generally tedious and time-consuming thus making it ineffective in traditional settings. The added complexity in these situations is the non-availability of pure...

Protein structure analysis of mutations causing inheritable diseases. An e-Science approach with life scientist friendly interfaces

Background Many newly detected point mutations are located in protein-coding regions of the human genome. Knowledge of their effects on the protein's 3D structure provides insight into the protein's mechanism, can aid the design of further experiments, and eventually can lead to the development of new medicines and diagnostic tools. Results In this article we describe HOPE, a...

Spontaneous regression of curve in immature idiopathic scoliosis - does spinal column play a role to balance? An observation with literature review

Background Child with mild scoliosis is always a subject of interest for most orthopaedic surgeons regarding progression. Literature described Hueter-Volkmann theory regarding disc and vertebral wedging, and muscular imbalance for the progression of adolescent idiopathic scoliosis. However, many authors reported spontaneous resolution of curves also without any reason for that...

WildSilkbase: An EST database of wild silkmoths

Background Functional genomics has particular promise in silkworm biology for identifying genes involved in a variety of biological functions that include: synthesis and secretion of silk, sex determination pathways, insect-pathogen interactions, chorionogenesis, molecular clocks. Wild silkmoths have hardly been the subject of detailed scientific investigations, owing largely to...

Differential replication of avian influenza H9N2 viruses in human alveolar epithelial A549 cells

Avian influenza virus H9N2 isolates cause a mild influenza-like illness in humans. However, the pathogenesis of the H9N2 subtypes in human remains to be investigated. Using a human alveolar epithelial cell line A549 as host, we found that A/Quail/Hong Kong/G1/97 (H9N2/G1), which shares 6 viral "internal genes" with the lethal A/Hong Kong/156/97 (H5N1/97) virus, replicates...

Brief report. Respiratory distress syndrome among neonates admitted at Muhimbili Medical Centre, Dar es Salaam, Tanzania

A prospective unmatched case-control study of 256 neonates with Respiratory Distress Syndrome (RDS) and 256 controls was conducted to study risk factors and outcome during March to November 1995. RDS contributed to 6 per cent of all neonatal admissions and was significantly associated with lower birthweights, gestational age, birth asphyxia and male sex. Maternal hypertension...

Effects of pretreatment on morphology, chemical composition and enzymatic digestibility of eucalyptus bark: a potentially valuable source of fermentable sugars for biofuel production – part 1

Background In recent years, the growing demand for biofuels has encouraged the search for different sources of underutilized lignocellulosic feedstocks that are available in sufficient abundance to be used for sustainable biofuel production. Much attention has been focused on biomass from grass. However, large amounts of timber residues such as eucalyptus bark are available and...

An unusual presentation of a Gastrointestinal stromal tumour (GIST)

Background Gastrointestinal stromal tumours (GIST) are rare tumours, now more frequently identified with the new imaging modalities like computerised tomography (CT) and magnetic resonance imaging (MRI). We report a rare presentation of a GIST with an unusual diagnostic workup in a multidisciplinary setting leading to a definitive diagnosis and treatment. Case presentation A 55...

The approximate entropy of the electromyographic signals of tremor correlates with the osmotic fragility of human erythrocytes

Background The main problem of tremor is the damage caused to the quality of the life of patients, especially those at more advanced ages. There is not a consensus yet about the origins of this disorder, but it can be examined in the correlations between the biological signs of aging and the tremor characteristics. Methods This work sought correlations between the osmotic...

Case report. Intracranial haemorrhage due to vitamin K deficiency following gastroenteritis in an infant

Breastfed infants who are not given supplemental vitamin K after birth may develop vitamin K deficiency following gastroenteritis. Severe intracranial haemorrhage may occur.

Chronic, low-dose rotenone reproduces Lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells

transgenic mitochondrial cybrids generate Lewy inclusion bodies . J Neurochem 2004 , 88 : 800 - 812 . 21. Borland MK , Mohanakumar KP , Rubinstein JD , Keeney PM , Xie J , Capaldi R , Dunham LD , Trimmer PA

Altered Neocortical Cell Density and Layer Thickness in Serotonin Transporter Knockout Mice: A Quantitation Study

, Wichems CH , Feltner D , Heils A , Moessner R , Westphal H , Lesch KP . 1998 . Altered brain serotonin homeostasis and locomotor insensitivity to 3,4-methylenedioxymethamphetamine (''Ecstasy'') in serotonin ... . Program No. 481.15 , 2005 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience [online]. Canli T , Omura K , Haas BW , Fallgatter A , Constable RT , Lesch KP . 2005 . Beyond affect: a

The C5a anaphylatoxin receptor CD88 is expressed in presynaptic terminals of hippocampal mossy fibres

Background In the periphery, C5a acts through the G-protein coupled receptor CD88 to enhance/maintain inflammatory responses. In the brain, CD88 can be expressed on astrocytes, microglia and neurons. Previous studies have shown that the hippocampal CA3 region displays CD88-immunolabelling, and CD88 mRNA is present within dentate gyrus granule cells. As granule cells send dense...

Impact of immune escape mutations on HIV-1 fitness in the context of the cognate transmitted/founder genome

Background A modest change in HIV-1 fitness can have a significant impact on viral quasispecies evolution and viral pathogenesis, transmission and disease progression. To determine the impact of immune escape mutations selected by cytotoxic T lymphocytes (CTL) on viral fitness in the context of the cognate transmitted/founder (T/F) genome, we developed a new competitive fitness...