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Decreased expression of microRNA let-7i and its association with chemotherapeutic response in human gastric cancer

Background MicroRNA let-7i has been proven to be down-regulated in many human malignancies and correlated with tumor progression and anticancer drug resistance. Our study aims to characterize the contribution of miRNA let-7i to the initiation and malignant progression of locally advanced gastric cancer (LAGC), and evaluate its possible value in neoadjuvant chemotherapeutic...

A Novel Role of IGFBP7 in Mouse Uterus: Regulating Uterine Receptivity through Th1/Th2 Lymphocyte Balance and Decidualization

Previously we have screened out Insulin-like Growth Factor Binding Protein 7 (IGFBP7) as a differentially expressed gene in post-implantation uterus versus pre-implantation uterus by suppressive subtractive hybridation. However its function in uterus was not clearly identified. In this research, the expression and function of IGFBP7 during post-implantation were studied. We found...

Aberrant Serum Immunoglobulin G Glycosylation in Chronic Hepatitis B Is Associated With Histological Liver Damage and Reversible by Antiviral Therapy

analyses, and manuscript writing; Cheng-Kun Liu and Chih-Sheng Su analyzed clinical data from patients with liver cirrhosis; Pin-Nan Cheng provided samples from healthy controls; Hung-Wen Tsai was

Recombinant Mammaglobin A Adenovirus-Infected Dendritic Cells Induce Mammaglobin A-Specific CD8+ Cytotoxic T Lymphocytes against Breast Cancer Cells In Vitro

Mammaglobin A (MGBA) is a novel breast cancer-associated antigen almost exclusively over-expressed in primary and metastatic human breast cancers, making it a potential therapeutic target for breast cancer. The development of dendritic cell (DC)-induced tumor antigen specific CD8+ cytotoxic T lymphocytes (CTLs) may hold promise in cancer immunotherapy. In this study we...

A Rapid, Highly Efficient and Economical Method of Agrobacterium-Mediated In planta Transient Transformation in Living Onion Epidermis

Transient transformation is simpler, more efficient and economical in analyzing protein subcellular localization than stable transformation. Fluorescent fusion proteins were often used in transient transformation to follow the in vivo behavior of proteins. Onion epidermis, which has large, living and transparent cells in a monolayer, is suitable to visualize fluorescent fusion...

Evaluation of the Highly Variable Agomelatine Pharmacokinetics in Chinese Healthy Subjects to Support Bioequivalence Study

Objectives We aim to obtain the intra-subject coefficient of variability of a highly variable antidepressant agomelatine in humans, and propose an adjusted bioequivalence assessment strategy. Methods A single-dose, randomized crossover design was conducted in four periods (reference administered thrice, placebo administered once) separated by seven days. A validated LC-MS/MS...

MicroRNA Expression Profile of Mouse Lung Infected with 2009 Pandemic H1N1 Influenza Virus

MicroRNAs have been implicated in the regulation of gene expression of various biological processes in a post-transcriptional manner under physiological and pathological conditions including host responses to viral infections. The 2009 pandemic H1N1 influenza virus is an emerging reassortant strain of swine, human and bird influenza virus that can cause mild to severe illness and...

Regeneration of Solanum nigrum by Somatic Embryogenesis, Involving Frog Egg-Like Body, a Novel Structure

A new protocol was established for the regeneration of Solanum nigrum by frog egg-like bodies (FELBs), which are novel somatic embryogenesis (SE) structures induced from the root, stem, and leaf explants. The root, stem, and leaf explants (93.33%, 85.10%, and 100.00%, respectively) were induced to form special embryonic calli on Murashige and Skoog (MS) medium containing 1.0 mg/L...

Novel Antibody against a Glutamic Acid-Rich Human Fibrinogen-Like Protein 2-Derived Peptide near Ser91 Inhibits hfgl2 Prothrombinase Activity

Fibrinogen-like protein 2 (fgl2) is highly expressed in microvascular endothelial cells in diseases associated with microcirculatory disturbances and plays a crucial role in microthrombosis. Previous studies have demonstrated that the Ser89 residue is a critical site for mouse fgl2 prothrombinase activity. The aim of this study was to investigate the prothrombinase inhibitory...

Suppression of growth of highly-metastatic human breast cancer cells by norcantharidin and its mechanisms of action

Erratum to: Cytotechnology DOI 10.1007/s10616-009-9210-3In the original version of this article, in the “Materials and methods” section, under the subsection “Animal experimentation and preparation of sera from NCTD-treated rabbits”, the third sentence currently reads:‘NCTD was given via the intravenous injection to the rabbits once daily at a dose of 10 mg mL−1 100 g−1 body...

Dynamic Expression Patterns of Differential Proteins during Early Invasion of Hepatocellular Carcinoma

Background Tumor cell invasion into the surrounding matrix has been well documented as an early event of metastasis occurrence. However, the dynamic expression patterns of proteins during early invasion of hepatocellular carcinoma (HCC) are largely unknown. Using a three-dimensional HCC invasion culture model established previously, we investigated the dynamic expression patterns...

Photonic sensors review recent progress of fiber sensing technologies in Tianjin University

The up to date progress of fiber sensing technologies in Tianjin University are proposed in this paper. Fiber-optic temperature sensor based on the interference of selective higher-order modes in circular optical fiber is developed. Parallel demodulation for extrinsic Fabry-Perot interferometer (EFPI) and fiber Bragg grating (FBG) sensors is realized based on white light...

FOUNDERS, GOVERNANCE, AND FIRM VALUATION: DOES THE MARKET PERCEIVE PSYCHOLOGICAL OWNERSHIP?

We examine the impact of the governance in entrepreneurial firms at the time of the IPO focusing on market valuation based on whether the founder is still with the company. Using agency theory to explain the governance devices (and their purpose), we probe their impact on firm valuation. We develop hypotheses using concepts from psychological ownership to explain why the devices...

FOUNDERS, GOVERNANCE, AND FIRM VALUATION: DOES THE MARKET PERCEIVE PSYCHOLOGICAL OWNERSHIP?

We examine the impact of the governance in entrepreneurial firms at the time of the IPO focusing on market valuation based on whether the founder is still with the company. Using agency theory to explain the governance devices (and their purpose), we probe their impact on firm valuation. We develop hypotheses using concepts from psychological ownership to explain why the devices...

Expression of podoplanin in human astrocytic brain tumors is controlled by the PI3K-AKT-AP-1 signaling pathway and promoter methylation

Recently, we found strong overexpression of the mucin-type glycoprotein podoplanin (PDPN) in human astrocytic brain tumors, specifically in primary glioblastoma multiforme (GB). In the current study, we show an inverse correlation between PDPN expression and PTEN levels in primary human GB and glioma cell lines, and we report elevated PDPN protein levels in the subventricular...

A novel panel of biomarkers in distinction of small well-differentiated HCC from dysplastic nodules and outcome values

Background Differential diagnosis of high-grade dysplastic nodules (HGDN) and well-differentiated hepatocellular carcinoma (WDHCC) represents a challenge to experienced hepatic clinicians, radiologists and hepatopathologists. Methods The expression profiles of aminoacylase-1 (ACY1), sequestosome-1 (SQSTM1) and glypican-3 (GPC3) in low-grade dysplastic nodules (LGDN), HGDN and...

Epidemiologic Features and Environmental Risk Factors of Severe Fever with Thrombocytopenia Syndrome, Xinyang, China

Background Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease discovered in rural areas of Central China in 2009, caused by a novel bunyavirus, SFTS virus (SFTSV). The disease usually presents as fever, thrombocytopenia, and leukocytopenia, with case-fatality rates ranging from 2.5% to 30%. Haemaphysalis longicornis was suspected to be the most...

Interactions between galectin-3 and integrinβ3 in regulating endometrial cell proliferation and adhesion

BACKGROUND Galectin-3 (gal-3) is a β-galactoside-binding protein which can be detected in endometrium. The study was designed to investigate synergism of gal-3 and integrinβ3 in endometrial cell proliferation and adhesion in an in vitro model of endometrial receptivity. METHODS The RL95-2 cell line was employed as an in vitro model for receptive endometrium. Cells transfected...

Mimotopes selected with neutralizing antibodies against multiple subtypes of influenza A

Background The mimotopes of viruses are considered as the good targets for vaccine design. We prepared mimotopes against multiple subtypes of influenza A and evaluate their immune responses in flu virus challenged Balb/c mice. Methods The mimotopes of influenza A including pandemic H1N1, H3N2, H2N2 and H1N1 swine-origin influenza virus were screened by peptide phage display...