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The entransy dissipation minimization principle under given heat duty and heat transfer area conditions

Under given heat duty and heat transfer area conditions, the equipartition of the entransy dissipation (EoED) principle, the equipartition of the temperature difference (EoTD) principle, and the equipartition of the heat flux (EoHF) principle are applied to the optimization design of a heat exchanger with a variable heat transfer coefficient. The results show that the difference...

Theoretical analysis of a method for segmented heat exchanger design

In the process of the design of heat exchangers, it is difficult to establish the factors governing the optimal points of the design objective functions due to the contradictions and uncertainties of the design objectives. The variation of fluid properties is one of the main factors causing this type of uncertainty. Conventional design methods have not completely solved these...

A Comparison of the Microwave Photoconductivity Decay and Open-Circuit Voltage Decay Lifetime Measurement Techniques for Lifetime-Enhanced 4H-SiC Epilayers

This work compares the optical microwave photoconductivity decay (μPCD) and electrical open-circuit voltage decay (OCVD) techniques for measuring the ambipolar carrier lifetime in 4H-silicon carbide (4H-SiC) epitaxial layers. Lifetime measurements were carried out by fabricating P+/intrinsic/N+ (PiN) diodes on 100-μm-thick, 1 × 1014 cm−3 to 4.5 × 1014 cm−3 doped N-type 4 H-SiC...

Identification of Mur34 as the Novel Negative Regulator Responsible for the Biosynthesis of Muraymycin in Streptomyces sp. NRRL30471

Background Muraymycin, a potent translocase I (MraY) inhibitor, is produced by Streptomyces sp. NRRL30471. The muraymycin gene cluster (mur) was recently cloned, and bioinformatic analysis of mur34 revealed its encoding product exhibits high homology to a large family of proteins, including KanI and RacI in individual biosynthetic pathway of kanamycin and ribostamycin. However...

T cell immunohistochemistry refines lung transplant acute rejection diagnosis and grading

Objective Lung transplant volume has been increasing. However, inaccurate and uncertain diagnosis for lung transplant rejection hurdles long-term outcome due to, in part, interobserver variability in rejection grading. Therefore, a more reliable method to facilitate diagnosing and grading rejection is warranted. Method Rat lung grafts were harvested on day 3, 7, 14 and 28 post...

RNA-binding protein RNPC1: acting as a tumor suppressor in breast cancer

Jin-Qiu Xue 0 Tian-Song Xia 0 Xiu-Qing Liang Wenbin Zhou Lin Cheng Liang Shi Ying Wang Qiang Ding 0 Equal contributors Jiangsu Breast Disease Center, the First Affiliated Hospital with Nanjing

Podocalyxin-like 1 promotes invadopodia formation and metastasis through activation of Rac1/Cdc42/cortactin signaling in breast cancer cells

Metastatic disease is the leading cause of cancer mortality. Identifying biomarkers and regulatory mechanisms is important toward developing diagnostic and therapeutic tools against metastatic cancer. In this study, we demonstrated that podocalyxin-like 1 (PODXL) is overexpressed in breast tumor cells and increased in lymph node metastatic cancer. Mechanistically, we found that...

Up-regulation of S100A16 expression promotes epithelial-mesenchymal transition via Notch1 pathway in breast cancer

Background Our previous studies demonstrated that S100A16 promotes adipogenesis and is involved in weight gain attenuation induced by dietary calcium. Till now, the function of S100A16 in the breast cancer remains to be elucidated. Results In this study, we observed that S100A16 was expressed in higher levels in human breast cancer tissues compared with paired adjacent non...

Visualized Gene Network Reveals the Novel Target Transcripts Sox2 and Pax6 of Neuronal Development in Trans-Placental Exposure to Bisphenol A

Background Bisphenol A (BPA) is a ubiquitous endocrine disrupting chemical in our daily life, and its health effect in response to prenatal exposure is still controversial. Early-life BPA exposure may impact brain development and contribute to childhood neurological disorders. The aim of the present study was to investigate molecular target genes of neuronal development in trans...

Entransy dissipation minimization for optimization of heat exchanger design

In this paper, by taking the water-water balanced counterflow heat exchanger as an example, the entransy dissipation theory is applied to optimizing the design of heat exchangers. Under certain conditions, the optimal duct aspect ratio is determined analytically. When the heat transfer area or the duct volume is fixed, analytical expressions of the optimal mass velocity and the...

The Apoptotic Effect of D Rhamnose β-Hederin, a Novel Oleanane-Type Triterpenoid Saponin on Breast Cancer Cells

There is growing interest in development of natural products as anti-cancer and chemopreventive agents. Many triterpenoids have been proved as potential agents for chemoprevention and therapy of breast cancer. Ginsenosides from ginseng, which mostly belong to dammarane-type triterpenoids, have gained great attention for their anti-breast cancer activity with diverse mechanisms...

Family history and risk of ductal carcinoma in situ and triple negative breast cancer in a Han Chinese population: a case–control study

Background The association between family history and risk of triple negative breast cancer and ductal carcinoma in situ (DCIS) has not been well investigated, especially in Asian populations. We investigated the association between family history and risk of DCIS or triple negative breast cancer in a Han Chinese population. Methods A case–control study, comprising 926 breast...

Cellular immunotherapy using irradiated lung cancer cell vaccine co-expressing GM-CSF and IL-18 can induce significant antitumor effects

Hongwei Tian 0 Gang Shi 0 Guoyou Yang Junfeng Zhang Yiming Li Tao Du Jianzhou Wang Fen Xu Lin Cheng Xiaomei Zhang Lei Dai Xiaolei Chen Shuang Zhang Yang Yang Dechao Yu Yuquan Wei Hongxin Deng 0

Connectivity Features for Identifying Cognitive Impairment in Presymptomatic Carotid Stenosis

Severe asymptomatic stenosis of the internal carotid artery (ICA) leads to increased incidence of mild cognitive impairment (MCI) likely through silent embolic infarcts and/or chronic hypoperfusion, but the brain dysfunction is poorly understood and difficult to diagnose. Thirty cognitively intact subjects with asymptomatic, severe (≧70%), unilateral stenosis of the ICA were...

Fatty Acid Binding Proteins FABP9 and FABP10 Participate in Antibacterial Responses in Chinese Mitten Crab, Eriocheir sinensis

Invertebrates rely solely on the innate immune system for defense against pathogens and other stimuli. Fatty acid binding proteins (FABP), members of the lipid binding proteins superfamily, play a crucial role in fatty acid transport and lipid metabolism and are also involved in gene expression induced by fatty acids. In the vertebrate immune system, FABP is involved in...

Chemokine CXCL14 is associated with prognosis in patients with colorectal carcinoma after curative resection

Background The chemokine CXCL14 has been reported to play an important role in the progression of many malignancies such as breast cancer and papillary thyroid carcinoma, but the role of CXCL14 in colorectal carcinoma (CRC) remains to be established. The purpose of this study was to investigate the expression pattern and significance of CXCL14 in CRC progression. Method 265...

HIV-1 Tat Promotes Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) vIL-6-Induced Angiogenesis and Tumorigenesis by Regulating PI3K/PTEN/AKT/GSK-3β Signaling Pathway

Kaposi’s sarcoma (KS)-associated herpesvirus (KSHV) is etiologically associated with KS, the most common AIDS-related malignancy. KS is characterized by vast angiogenesis and hyperproliferative spindle cells. We have previously reported that HIV-1 Tat can trigger KSHV reactivation and accelerate Kaposin A-induced tumorigenesis. Here, we explored Tat promotion of KSHV vIL-6...

GPR48, a poor prognostic factor, promotes tumor metastasis and activates β-catenin/TCF signaling in colorectal cancer

G-protein-coupled receptor 48 (GPR48) is an orphan receptor belonging to the G-protein-coupled receptors family, which plays an important role in the development of various organs and cancer development and progression such as gastric cancer and colorectal cancer (CRC). However, the prognostic value of GPR48 expression in patients with CRC has not been reported. In this study, we...

Cancer stem cells in glioblastoma—molecular signaling and therapeutic targeting

Glioblastomas (GBMs) are highly lethal primary brain tumors. Despite current therapeutic advances in other solid cancers, the treatment of these malignant gliomas remains essentially palliative. GBMs are extremely resistant to conventional radiation and chemotherapies. We and others have demonstrated that a highly tumorigenic subpopulation of cancer cells called GBM stem cells...