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Individual Participant Data (IPD) Meta-analyses of Randomised Controlled Trials: Guidance on Their Use

Jayne Tierney and colleagues offer guidance on how to spot a well-designed and well-conducted individual participant data meta-analysis.

Do Cochrane summaries help student midwives understand the findings of Cochrane systematic reviews: the BRIEF randomised trial

0 2 Toby Lasserson 1 Elaine Beller Margaret Carroll Vanora Hundley Judith Sunderland Declan Devane Jane Noyes Susan Key Sarah Norris Janine Wyn-Davies Mike Clarke 0 School of Nursing and Midwifery ... practice; OSCEs: objective structured clinical examinations; OR: odds ratio; RD: risk difference; 95 % CI: 95 % confidence interval. Competing interests Fiona Alderdice, Mike Clarke, Toby Lasserson, Declan

Patience, Persistence and Pragmatism: Experiences and Lessons Learnt from the Implementation of Clinically Integrated Teaching and Learning of Evidence-Based Health Care – A Qualitative Study

Background Clinically integrated teaching and learning are regarded as the best options for improving evidence-based healthcare (EBHC) knowledge, skills and attitudes. To inform implementation of such strategies, we assessed experiences and opinions on lessons learnt of those involved in such programmes. Methods and Findings We conducted semi-structured interviews with 24 EBHC ...

Improving the organisation of maternal health service delivery and optimising childbirth by increasing vaginal birth after caesarean section through enhanced women-centred care (OptiBIRTH trial): study protocol for a randomised controlled trial (ISRCTN10612254)

Background The proportion of pregnant women who have a caesarean section shows a wide variation across Europe, and concern exists that these proportions are increasing. Much of the increase in caesarean sections in recent years is due to a cascade effect in which a woman who has had one caesarean section is much more likely to have one again if she has another baby. In some places, ...

Evidence for disaster risk reduction, planning and response: design of the Evidence Aid survey

Systematic reviews are now regarded as a key component of the decision making process in health care, and, increasingly, in other areas. This should also be true in disaster risk reduction, planning and response. Since the Indian Ocean tsunami in 2004, The Cochrane Collaboration and others have been working together to strengthen the use and usefulness of systematic reviews in this ...

What Are the Effects of Teaching Evidence-Based Health Care (EBHC)? Overview of Systematic Reviews

Background An evidence-based approach to health care is recognized internationally as a key competency for healthcare practitioners. This overview systematically evaluated and organized evidence from systematic reviews on teaching evidence-based health care (EBHC). Methods/Findings We searched for systematic reviews evaluating interventions for teaching EBHC to health professionals ...

Can you believe what you read in the papers?

The number of reports of clinical trials grows by hundreds every week. However, this does not mean that people making decisions about healthcare are finding it easier to obtain reliable knowledge for these decisions. Some of the information is unreliable. Systematic reviews are helping to resolve this by bringing together the research on a topic, appraising and summarising it. But ...

Effects on patients of their healthcare practitioner's or institution's participation in clinical trials: a systematic review

Background Systematic reviews have shown uncertainty about the size or direction of any 'trial effect' for patients in trials compared to those treated outside trials. We are not aware of any systematic review of whether there is a 'trial effect' related to being treated by healthcare practitioners or institutions that take part in research. Methods We searched the Cochrane ...

Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement

for Healthcare Research and Quality (Rockville, USA); Mike Clarke, Queen’s University of Belfast (Belfast, Ireland); Tammy Clifford, Canadian Agency for Drugs and Technologies in Health (CADTH) (Ottawa

The COMET Initiative database: progress and activities from 2011 to 2013

The Core Outcome Measures in Effectiveness Trials (COMET) Initiative database is an international repository of studies relevant to the development of core outcome sets. By the end of 2013, it included a unique collection of 306 studies. The website is increasingly being used, with more than 12,000 visits in 2013 (a 55% increase over 2012), 8,369 unique visitors (a 53% increase) ...

Sharing Individual Participant Data from Clinical Trials: An Opinion Survey Regarding the Establishment of a Central Repository

Background Calls have been made for increased access to individual participant data (IPD) from clinical trials, to ensure that complete evidence is available. However, despite the obvious benefits, progress towards this is frustratingly slow. In the meantime, many systematic reviews have already collected IPD from clinical trials. We propose that a central repository for these IPD ...

A study protocol for a pilot randomised trial of a structured education programme for the self-management of Type 2 diabetes for adults with intellectual disabilities

Background The need for structured education programmes for type 2 diabetes is a high priority for many governments around the world. One such national education programme in the United Kingdom is the DESMOND Programme, which has been shown to be robust and effective for patients in general. However, these programmes are not generally targeted to people with intellectual ...

Standardising Outcomes in Paediatric Clinical Trials

Mike Clarke discusses a new systematic review examining studies that involved the selection of outcomes for use in paediatric clinical trials. ... 0 0 Mike Clarke is at the School of Nursing and Midwifery, Trinity College Dublin , Dublin , Ireland - Whealth care of children are hether decisions about the made by parents, carers, health