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110 papers found.
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Pre-diagnostic concordance with the WCRF/AICR guidelines and survival in European colorectal cancer patients: a cohort study

Genevieve Buckland Mara Jos Snchez Miren Dorronsoro Carmen Navarro Aurelio Barricarte Timothy J Key Antonia Trichopoulou Christos Tsironis Pagona Lagiou Giovanna Masala Valeria Pala Rosario Tumino Paolo ... Vineis 1 Salvatore Panico H Bas Bueno-de-Mesquita 1 Peter D Siersema Bodil Ohlsson Karin Jirstrm Maria Wennberg Lena M Nilsson Elisabete Weiderpass Tilman Khn Verena Katzke Kay-Tee Khaw Nick J Wareham Anne

Plasma Elaidic Acid Level as Biomarker of Industrial Trans Fatty Acids and Risk of Weight Change: Report from the EPIC Study

Background Few epidemiological studies have examined the association between dietary trans fatty acids and weight gain, and the evidence remains inconsistent. The main objective of the study was to investigate the prospective association between biomarker of industrial trans fatty acids and change in weight within the large study European Prospective Investigation into Cancer and...

Circulating Biomarkers of One-Carbon Metabolism in Relation to Renal Cell Carcinoma Incidence and Survival

Background The etiology of renal cell carcinoma (RCC) is only partially understood, but a metabolic component appears likely. We investigated biomarkers of one-carbon metabolism and RCC onset and survival.

Fish consumption and mortality in the European Prospective Investigation into Cancer and Nutrition cohort

Fish is a source of important nutrients and may play a role in preventing heart diseases and other health outcomes. However, studies of overall mortality and cause-specific mortality related to fish consumption are inconclusive. We examined the rate of overall mortality, as well as mortality from ischaemic heart disease and cancer in relation to the intake of total fish, lean...

Circulating 25-Hydroxyvitamin D3 in Relation to Renal Cell Carcinoma Incidence and Survival in the EPIC Cohort

Severi, Paolo Vineis); Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany (Tilman Kühn, Verena Katzke); Public Health Directorate, Asturias, Spain (Ramón Alonso de la Torre ... of Public Health, Imperial College London, London, United Kingdom (Paolo Vineis, H. Bas Bueno-de-Mesquita, Petra H. Peeters, Neil Murphy, Elio Riboli); Dopartimento di Medicina Clinica e Sperimentale

STrengthening the Reporting of OBservational studies in Epidemiology – Molecular Epidemiology (STROBE-ME): An extension of the STROBE statement

Advances in laboratory techniques have led to a rapidly increasing use of biomarkers in epidemiological studies. Biomarkers of internal dose, early biological change, susceptibility and clinical outcomes are used as proxies for investigating interactions between external and / or endogenous agents and body components or processes. The need for improved reporting of scientific...

STrengthening the Reporting of OBservational studies in Epidemiology – Molecular Epidemiology (STROBE-ME): An Extension of the STROBE Statement

Paolo Vineis 0 0 1 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London , London , United Kingdom , 2 Social and Environmental Health Research, London School of

Expectations and challenges stemming from genome-wide association studies

There are considerable expectations about the ability of genome-wide association (GWA) studies to make exciting discoveries about the role of genes in common diseases. GWA studies may allow researchers to identify causal pathways that have not been unveiled before, thus opening new avenues to disease understanding, prevention and therapy. However, there are still many open...

Thyroid-Stimulating Hormone, Thyroglobulin, and Thyroid Hormones and Risk of Differentiated Thyroid Carcinoma: The EPIC Study

Heiner Boeing Antonia Trichopoulou Pagona Lagiou Dimitrios Trichopoulos Domenico Palli Claudia Agnoli Rosario Tumino Paolo Vineis Salvatore Panico H. Bas Bueno-de-Mesquita Petra H Peeters Elisabete

Occult HCV Infection: An Unexpected Finding in a Population Unselected for Hepatic Disease

Background Occult Hepatitis C virus (HCV) infection is a new pathological entity characterized by presence of liver disease and absence or very low levels of detectable HCV-RNA in serum. Abnormal values of liver enzymes and presence of replicative HCV-RNA in peripheral blood mononuclear cells are also observed. Aim of the study was to evaluate occult HCV occurrence in a...

XRCC3 and XPD/ERCC2 Single Nucleotide Polymorphisms and the Risk of Cancer: A HuGE Review

associations are weak and presently do not justify screening. This research was made possible by a grant from the Compagnia di San Paolo (Progetto Oncologia) to Dr. Paolo Vineis and a grant from the

A Field Synopsis on Low-Penetrance Variants in DNA Repair Genes and Cancer Susceptibility

, University of Ioannina School of Medicine , Ioannina 45110, Greece ( 1 Paolo Vineis, Maurizio Manuguerra, Fotini K. Kavvoura, Simonetta Guarrera, Alessandra Allione, Fabio Rosa, Alessandra Di Gregorio, Silvia

Methylome Analysis and Epigenetic Changes Associated with Menarcheal Age

Elio Riboli James M. Flanagan Paolo Vineis Wei Yan, University of Nevada School of Medicine, United States of America Reproductive factors have been linked to both breast cancer and DNA methylation

Proteome characterization of a human urothelial cell line resistant to the bladder carcinogen 4-aminobiphenyl

Background The aromatic amine 4-aminobiphenyl (4-ABP) is an environmental and occupational contaminant known to be a major etiological agent of human bladder cancer. 4-ABP metabolites are able to form DNA adducts that may induce mutations and initiate bladder carcinogenesis. Cells exposed to 4-ABP may develop resistance to the carcinogen. The aim of the present study was to...

Consumption of Dairy Products and Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Background Prospective studies have consistently reported lower colorectal cancer risks associated with higher intakes of total dairy products, total milk and dietary calcium. However, less is known about whether the inverse associations vary for individual dairy products with differing fat contents. Materials and Methods In the European Prospective Investigation into Cancer and...

Development and Validation of a Risk Score Predicting Substantial Weight Gain over 5 Years in Middle-Aged European Men and Women

Vittorio Krogh Paolo Vineis Antonia Trichopoulou Philippos Orfanos Dimitrios Trichopoulos Bo Hedblad Peter Wallstro m Kim Overvad Jytte Halkjaer Anne Tjnneland Guy Fagherazzi Laureen Dartois Francesca Crowe

Hemochromatosis (HFE) gene mutations and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Hereditary hemochromatosis (HH) is a strong risk factor for hepatocellular cancer, and mutations in the HFE gene associated with HH and iron overload may be related to other tumors, but no studies have been reported for gastric cancer (GC). A nested case–control study was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC), including 365...

Association Between Genetic Variants on Chromosome 15q25 Locus and Objective Measures of Tobacco Exposure

George R. Uhl Paolo Vineis Sandosh Padmanabhan Barbara J. Jefferis Antoinette Amuzu Elio Riboli Mark N. Upton Paul Aveyard Shah Ebrahim Aroon D. Hingorani Graham Watt Tom M. Palmer Nicholas J. Timpson EPIC

Evidence of gene–gene interactions in lung carcinogenesis in a large pooled analysis

To test the hypothesis of interaction among genetic variants in increasing the individual risk of cancer, we have studied the cumulative effect on lung cancer risk of variants in three metabolic genes, CYP1A1, GSTM1 and GSTT1, which are involved in the metabolism of the tobacco smoke constituents and environmental contaminants, polycyclic aromatic hydrocarbons and of other lung...