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Curcumin Inhibits Imiquimod-Induced Psoriasis-Like Inflammation by Inhibiting IL-1beta and IL-6 Production in Mice

Curcumin, a selective phosphorylase kinase inhibitor, is a naturally occurring phytochemical present in turmeric. Curcumin has been confirmed to have anti-inflammatory properties in addition to the ability to decrease the expression of pro-inflammatory cytokines in keratinocytes. The interleukin-23 (IL-23)/IL-17A cytokine axis plays a critical role in the pathogenesis of...

Single Impulsive Controller for Exponential Synchronization of Stochastic Lur'e Networks with Impulsive Disturbance

Sciences, Shenzhen University, Shenzhen 518060, China Received 8 January 2013; Accepted 22 April 2013 Academic Editor: Jinde Cao Copyright © 2013 Yi Zhao et al. This is an open access article

M2-polarized macrophages in keratocystic odontogenic tumor: relation to tumor angiogenesis

of Stomatology, Wuhan University, Wuhan, ChinaWen-Qun Zhong, Gang Chen, Wei Zhang, Xue-Peng Xiong, Yi Zhao, Bing Liu & Yi-Fang ZhaoDepartment of Oral and Maxillofacial Surgery, School and Hospital of ... • PubMed • Google ScholarSearch for Xue-Peng Xiong in:Nature Research journals • PubMed • Google ScholarSearch for Yi Zhao in:Nature Research journals • PubMed • Google ScholarSearch for Bing Liu in:Nature

Transcriptome analysis of Brassica napus pod using RNA-Seq and identification of lipid-related candidate genes

Xiang-Yang Lou 0 Jian-Yi Zhao 1 0 Department of Biostatistics and Bioinformatics, Tulane University , 1440 Canal St., Suite 2001, New Orleans, LA 70112-2632 , USA 1 State Key Laboratory Breeding Base

Identification and analysis of unitary loss of long-established protein-coding genes in Poaceae shows evidences for biased gene loss and putatively functional transcription of relics

Background Long-established protein-coding genes may lose their coding potential during evolution (“unitary gene loss”). Members of the Poaceae family are a major food source and represent an ideal model clade for plant evolution research. However, the global pattern of unitary gene loss in Poaceae genomes as well as the evolutionary fate of lost genes are still less-investigated...

Evolution of Gene Regulation during Transcription and Translation

Understanding how gene regulation evolves is a key area in the current evolutionary field. Gene regulation occurs at various levels. Previous work on the evolution of gene regulation has largely focused on gene transcription. In this study, we used a recently developed ribosomal footprint profiling method to investigate how gene regulation evolves at both the transcription (mRNA...

High-performance flexible Ag nanowire electrode with low-temperature atomic-layer-deposition fabrication of conductive-bridging ZnO film

As material for flexible transparent electrodes for organic photoelectric devices, the silver nanowires (AgNWs) have been widely studied. In this work, we propose a hybrid flexible anode with photopolymer substrate, which is composed of spin-coating-processed AgNW meshes and of zinc oxide (ZnO) prepared by low-temperature (60°C) atomic layer deposition. ZnO effectively fills in...

PEComa of the uterus with coexistence of situs inversus totalis, a case report and literature review

PEComas are a group of very rare mesenchymal neoplasms, which express myogenic and melanocytic markers, such as HMB-45 and actin. Situs inversus totalis represents a complete left to right side transposition of the asymmetrical thoracic and abdominal organs and incorporates dextrocardia. The presence of uterus PEComa in the setting of situs inversus totalis is extremely rare...

The GSTM1 Null Genotype Increased Risk of Gastric Cancer: A Meta-Analysis Based on 46 Studies

BackgroundGlutathione S-transferases M1 (GSTM1) is an important phase II metabolizing enzyme. The null genotype of GSTM1 causes total loss of GSTM1 enzyme activity and numerous studies have investigated the association between GSTM1 null genotype and gastric cancer risk. MethodsThis meta-analysis was designed to investigate the relationship between GSTM1 null genotype and...

NONCODE 2016: an informative and valuable data source of long non-coding RNAs

NONCODE (http://www.bioinfo.org/noncode/) is an interactive database that aims to present the most complete collection and annotation of non-coding RNAs, especially long non-coding RNAs (lncRNAs). The recently reduced cost of RNA sequencing has produced an explosion of newly identified data. Revolutionary third-generation sequencing methods have also contributed to more accurate...

Preliminary expression profile of cytokines in brain tissue of BALB/c mice with Angiostrongylus cantonensis infection

Background Angiostrongylus cantonensis (A. cantonensis) infection can result in increased risk of eosinophilic meningitis. Accumulation of eosinophils and inflammation can result in the A. cantonensis infection playing an important role in brain tissue injury during this pathological process. However, underlying mechanisms regarding the transcriptomic responses during brain...

Cluster Synchronization for Linearly Coupled Complex Networks with Identical and Nonidentical Nodes

University, Guangdong Shenzhen 518060, China Received 11 April 2012; Accepted 7 July 2012 Academic Editor: Hai L. Liu Copyright © 2012 Yi Zhao et al. This is an open access article distributed under the

In vivo evidence of pathogenicity of VPS35 mutations in the Drosophila

Mutations of VPS35, a component of the retromer complex have been associated with late onset familial Parkinson�s disease. The D620N mutation in VPS35 appears to be most prevalent, however, P316S was found in two cases within the same family and a control, whereas L774M was identified in 6 cases and 1 control. In vivo evidence of their pathogenicity is lacking. Here we...

Effect of Doxorubicin/Pluronic SP1049C on Tumorigenicity, Aggressiveness, DNA Methylation and Stem Cell Markers in Murine Leukemia

National Institutes of Health 2RO1 CA89225, UO1 CA151806, Center of Biomedical Research Excellence (COBRE) Nebraska Center for Nanomedicine 1P20RR021937, and a China Scholarship Council PhD Scholarship (Yi ... Zhao). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: AVK is a co-founder of Supratek Pharma, Inc. He

Association between non-alcoholic fatty liver disease and arterial stiffness in the non-obese, non-hypertensive, and non-diabetic young and middle-aged Chinese population

Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. Compliance with ethics guidelines Xin-yan YU, Yi ZHAO, Xiao-xiao SONG, and Zhen-ya SONG declare that they have no conflict of

Impulsive Pinning Markovian Switching Stochastic Complex Networks with Time-Varying Delay

The synchronization problem of stochastic complex networks with Markovian switching and time-varying delays is investigated by using impulsive pinning control scheme. The complex network possesses noise perturbations, Markovian switching, and internal and outer time-varying delays. Sufficient conditions for synchronization are obtained by employing the Lyapunov-Krasovskii...

The Effects of a Community-Based Sodium Reduction Program in Rural China – A Cluster-Randomized Trial

Background Average sodium intake and stroke mortality in northern China are both among the highest in the world. An effective, low-cost strategy to reduce sodium intake in this population is urgently needed. Objective We sought to determine the effects of a community-based sodium reduction program on salt consumption in rural northern China. Design This study was a cluster...

Accelerated green process of tetramethylpyrazine production from glucose and diammonium phosphate

Background 2,3,5,6-Tetramethylpyrazine (TMP) is a popular food flavour additive. This biologically active ingredient has additional potential dietotherapy functions, such as in cardiovascular and cerebrovascular health. Previous production methods from renewable materials suffer from low yields and efficiency which seriously hampers the scaling up of the laboratory processes...

The Quaternary Lidocaine Derivative QX-314 Produces Long-Lasting Intravenous Regional Anesthesia in Rats

Background The lidocaine derivative, QX-314, produces long-lasting regional anesthesia in various animal models. We designed this study to examine whether QX-314 could produce long-lasting intravenous regional anesthesia (IVRA) in a rat model. Methods IVRA was performed on tail of rats. EC50 (median effective concentration) of QX-314 in IVRA was determined by up-and-down method...

Evaluation of the Role of Dynamic Contrast-Enhanced MR Imaging for Patients with BI-RADS 3–4 Microcalcifications

Objective The purpose of study was to prospectively evaluate the diagnostic performance of dynamic contrast-enhanced MR imaging in the differentiation of malignant lesions from benign ones in patients with BI-RADS 3–4 microcalcifications detected by mammography. Materials and Methods 93 women with 100 microcalcifications had undergone breast MRI from June 2010 to July 2013...