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Changing roles and new perspectives: towards market orientation in public transport

The general international trend of increasingly subjecting the public transport industry to market principles has been concretized via various developments in many countries. In line with this trend, there is an increased interest in public procurement processes as a model for public service delivery. Sweden is one of the leading countries where public procurement is the prevailing ...

Advances in Valveless Piezoelectric Pump with Cone-shaped Tubes

This paper reviews the development of valveless piezoelectric pump with cone-shaped tube chronologically, which have widely potential application in biomedicine and micro-electro-mechanical systems because of its novel principles and deduces the research direction in the future. Firstly, the history of valveless piezoelectric pumps with cone-shaped tubes is reviewed and these pumps ...

Inter-evaluator heterogeneity of clinical diagnosis for locally advanced esophageal squamous cell carcinoma

Background Identifying clinical resectability of locally advanced esophageal squamous cell carcinoma (ESCC) is important, although inter-evaluator heterogeneity (IEH) could exist, especially in borderline resectable (BLR) cases. To investigate the extent of heterogeneity, we conducted clinical diagnostic imaging questionnaires. Materials and methods Five cases with clinical T3 or ...

Insights into the prevalence and underlying causes of clonal variation through transcriptomic analysis in Pichia pastoris

Clonal variation, wherein a range of specific productivities of secreted proteins are observed from supposedly identical transformants, is an accepted aspect of working with Pichia pastoris. It means that a significant number of transformants need to be tested to obtain a representative sample, and in commercial protein production, companies regularly screen thousands of ...

Efficient importance sampling in low dimensions using affine arithmetic

Despite the development of sophisticated techniques such as sequential Monte Carlo (Del Moral et al. in J R Stat Soc Ser B 68(3):411–436, 2006), importance sampling (IS) remains an important Monte Carlo method for low dimensional target distributions (Chopin and Ridgway in Leave Pima Indians alone: binary regression as a benchmark for Bayesian computation, 32:64–87, 2017). This ...

An evolutionary approach to a combined mixed integer programming model of seaside operations as arise in container ports

This paper puts forward an integrated optimisation model that combines three distinct problems, namely berth allocation, quay crane assignment, and quay crane scheduling that arise in container ports. Each one of these problems is difficult to solve in its own right. However, solving them individually leads almost surely to sub-optimal solutions. Hence, it is desirable to solve ...

Acoustic Emissions of Semi-Permeable Trailing Edge Serrations

The trailing edge of a NACA 0018 airfoil is modified through the attachment of serrations with different degrees of permeability. Acoustic beamforming is used to inspect the turbulent boundary layer-trailing edge noise emissions from the unmodified and serrated trailing edges. Different freestream velocities and angles of attack are investigated. The serration permeability is ...

Experimental study on seepage flow patterns in heterogeneous low-permeability reservoirs

Heterogeneous artificial core plate models with low permeability are designed, made and evaluated based on similarity theory of heterogeneous reservoir with low-permeability physical simulation by artificial core plate model; then, simulative experiments for seepage flow patterns can be carried out. Pressure data are obtained by pressure transducers symmetrically arranged in ...

Experimental and Numerical Assessment of the Service Behaviour of an Innovative Long-Span Precast Roof Element

The control of the deformative behaviour of pre-stressed concrete roof elements for a satisfactory service performance is a main issue of their structural design. Slender light-weight wing-shaped roof elements, typical of the European heritage, are particularly sensitive to this problem. The paper presents the results of deformation measurements during storage and of both ...

Experimental Cyclic Behavior of Precast Hybrid Beam-Column Connections with Welded Components

Post-earthquake observations revealed that seismic performance of beam-column connections in precast concrete structures affect the overall response extensively. Seismic design of precast reinforced concrete structures requires improved beam-column connections to transfer reversed load effects between structural elements. In Turkey, hybrid beam-column connections with welded ...

Measuring outcomes in adult spinal deformity surgery: a systematic review to identify current strengths, weaknesses and gaps in patient-reported outcome measures

Purpose Adult spinal deformity (ASD) causes severe disability, reduces overall quality of life, and results in a substantial societal burden of disease. As healthcare is becoming more value based, and to facilitate global benchmarking, it is critical to identify and standardize patient-reported outcome measures (PROMs). This study aims to identify the current strengths, weaknesses, ...

Solidification Reaction Sequence of Co-Rich Nb-Al-Co Alloys

The freezing reaction sequence of Co-rich Nb-Al-Co ternary alloys with emphasis on the formation of Laves and Heusler phases has been examined. For Co-rich alloys, the solidification reaction sequence is observed as primary freezing of α-Co and CoAl phases, subsequent [Co + C36] and [CoAl + C36] eutectics, and the final ternary eutectic reaction [L → α-Co + C36 + CoAl]. The ...

Autoantibodies to Osteoprotegerin are Associated with Low Hip Bone Mineral Density and History of Fractures in Axial Spondyloarthritis: A Cross-Sectional Observational Study

Osteoporosis is a recognised complication of axial spondyloarthritis (axSpA) and is thought to be due to functional impairment and the osteoclast-activating effects of proinflammatory cytokines. The development of autoantibodies to OPG (OPG-Ab) has been associated with severe osteoporosis and increased bone resorption in rheumatoid arthritis. In this study, we screened for the ...

Validation of the Social support and Pain Questionnaire (SPQ) in patients with painful temporomandibular disorders

Background The present study aimed to validate of Social support and Pain Questionnaire (SPQ) for use in Chinese patients with painful temporomandibular disorders (TMD). Methods The Chinese version of SPQ was produced by translation and cross-culturally adaptation of the original English version according to international guidelines. The Chinese version of SPQ was then distributed ...