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The role of aberrant expression of T cell miRNAs affected by TNF-α in the immunopathogenesis of rheumatoid arthritis

Tumor necrosis factor-alpha (TNF-α) can cause diverse T cell dysfunctions in patients with rheumatoid arthritis (RA). It is involved in the regulation of microRNAs (miRNAs) expression in different cell types. We hypothesized that the expression of T cell miRNAs would be affected by TNF-α, and these miRNAs could participate in the immunopathogenesis of RA. Expression profiles of 270 ...

Treatment of splenic trauma in Norway: a retrospective cohort study

Non-operative management of splenic injuries has become the treatment of choice in hemodynamically stable patients over the last decades. The aim of the study is to describe the incidence, initial treatment and early outcome of patients with splenic injuries on a national level. All hospitals in Norway admitting trauma patients were invited to participate in the study. The study ...

ApoA-I/A-II-HDL positively associates with apoB-lipoproteins as a potential atherogenic indicator

We recently reported distinct nature of high-density lipoproteins (HDL) subgroup particles with apolipoprotein (apo) A-I but not apoA-II (LpAI) and HDL having both (LpAI:AII) based on the data from 314 Japanese. While plasma HDL level almost exclusively depends on concentration of LpAI having 3 to 4 apoA-I molecules, LpAI:AII appeared with almost constant concentration regardless ...

Ovarian mucinous borderline tumor accompanied by LGESS with myxoid change: a case report and literature review

To report an extremely rare case of ovarian borderline mucinous cystic tumor accompanied by low-grade endometrial stromal sarcoma (LGESS) with myxoid change. A 42-year-old woman complained of lower left abdominal fullness. Her serum carcinoembryonic antigen, cancer antigen (CA) 125, and CA19-9 levels were normal. Magnetic resonance imaging showed a 10-cm cystic mass with a 5-cm ...

Image-based quantitative analysis of tear film lipid layer thickness for meibomian gland evaluation

Dry eye syndrome is one of the most common ocular diseases, and meibomian gland dysfunction (MGD) is the leading cause of evaporative dry eye syndrome. When the tear film lipid layer becomes thin due to obstructive or hyposecretory meibomian gland dysfunction, the excessive evaporation of the aqueous layer can occur, and this causes evaporative dry eye syndrome. Thus, measuring the ...

Unusual presentations of functional parathyroid cysts: a case series and review of the literature

Cysts of parathyroid origin are sometimes encountered and can easily be mistaken as thyroidal cysts. Functional parathyroid cysts, with symptoms and signs of hyperparathyroidism, are rare and may be a diagnostic challenge to clinicians. We report here on three cases of functional parathyroid cysts that illustrate diagnosis difficulties related to unusual clinical presentations in ...

An evaluation of four modes of low-dose anticoagulation during intermittent haemodialysis

Introduction Intensive care participants that need dialysis frequently suffer from increased risk of bleeding. Standard intermittent haemodialysis (SHD) includes anticoagulation to avoid clotting of the dialysis system. The aim of this study was to clarify which of four different low-dose anticoagulant modes was preferable in reducing the exposure to i.v. unfractionated heparin ...

Correction to: Fused features mining for depth-based hand gesture recognition to classify blind human communication

In the original publication, the first author name and his affiliation were incorrectly published. The correct author name and his affiliation are as follows:

Systematic review of randomized controlled trials in the treatment of dry eye disease in Sjogren syndrome

Primary Sjögren’s syndrome is an autoimmune disease characterized by dry eye and dry mouth. We systematically reviewed all the randomized controlled clinical trials published in the last 15 years that included ocular outcomes. We found 22 trials involving 9 topical, 10 oral, 2 intravenous and 1 subcutaneous modalities of treatment. Fluoromethalone eye drops over 8 weeks were more ...

Genetic parameters and expected responses to selection for components of feed efficiency in a Duroc pig line

Improving feed efficiency ( $${\text{FE}}$$ FE ) is a key factor for any pig breeding company. Although this can be achieved by selection on an index of multi-trait best linear unbiased prediction of breeding values with optimal economic weights, considering deviations of feed intake from actual needs ( $${\text{RFI}}$$ RFI ) should be of value for further research on biological ...

Citizen Science and Wildlife Conservation: Lessons from 34 Years of the Maine Loon Count

Since the early 1980s—long before the term citizen science was widely adopted— Maine Audubon has engaged thousands of dedicated volunteers in myriad wildlife surveys and studies, from bat colony monitoring to spring amphibian surveys to loon counts. In this article, the authors describe some of those citizen science projects and use the longest-running program, the Maine Loon ...

Comparison of the characteristics of suicide attempters with major depressive disorder and those with no psychiatric diagnosis in emergency departments of general hospitals in China

Major depressive disorder (MDD) is a known major risk factor for suicide due to the high suicide mortality. However, studies comparing the characteristics of suicide attempters with major depressive disorder and those with no psychiatric diagnosis in China are very limited. This study examined and compared the sociodemographic and psychological characteristics of suicide attempters ...

The effect of liquid hot water pretreatment on the chemical–structural alteration and the reduced recalcitrance in poplar

Hydrothermal pretreatment using liquid hot water (LHW) is capable of substantially reducing the cell wall recalcitrance of lignocellulosic biomass. It enhances the saccharification of polysaccharides, particularly cellulose, into glucose with relatively low capital required. Due to the close association with biomass recalcitrance, the structural change of the components of ...

Safety and efficacy of an oxycodone vaccine: Addressing some of the unique considerations posed by opioid abuse

Among vaccines aimed at treating substance use disorders, those targeting opioids present several unique medication development challenges. 1) Opioid overdose is a common complication of abuse, so it is desirable for an opioid vaccine to block the toxic as well as the addictive effects of opioids. 2) It is important that an opioid vaccine not interfere with the action of opioid ...

Active versus passive adverse event reporting after pediatric chiropractic manual therapy: study protocol for a cluster randomized controlled trial

Patient safety performance can be assessed with several systems, including passive and active surveillance. Passive surveillance systems provide opportunity for health care personnel to confidentially and voluntarily report incidents, including adverse events, occurring in their work environment. Active surveillance systems systematically monitor patient encounters to seek detailed ...

Zigzag Structure of Thin Chamber Complexes

Zigzags in thin chamber complexes are investigated, in particular, all zigzags in the Coxeter complexes are described. Using this description, we show that the lengths of all zigzags in the simplex \(\alpha _{n}\), the cross-polytope \(\beta _{n}\), the 24-cell, the icosahedron and the 600-cell are equal to the Coxeter numbers of \(\mathsf{A}_{n}\), ...

Fine-scale population genetic structure of arctic foxes (Vulpes lagopus) in the High Arctic

Objective The arctic fox (Vulpes lagopus) is a circumpolar species inhabiting all accessible Arctic tundra habitats. The species forms a panmictic population over areas connected by sea ice, but recently, kin clustering and population differentiation were detected even in regions where sea ice was present. The purpose of this study was to examine the genetic structure of a ...

Kinetics and dissolution of intratracheally administered nickel oxide nanomaterials in rats

The toxicokinetics of nanomaterials are an important factor in toxicity, which may be affected by slow clearance and/or distribution in the body. Four types of nickel oxide (NiO) nanoparticles were single-administered intratracheally to male F344 rats at three doses of 0.67–6.0 mg/kg body weight. The rats were sacrificed under anesthesia and the lung, thoracic lymph nodes, ...

Neutrino mixing and leptonic CP violation from S 4 flavour and generalised CP symmetries

We consider a class of models of neutrino mixing with S 4 lepton flavour symmetry combined with a generalised CP symmetry, which are broken to residual Z 2 and Z 2 × H CP ν symmetries in the charged lepton and neutrino sectors, respectively, H CP ν being a remnant CP symmetry of the neutrino Majorana mass term. In this set-up the neutrino mixing angles and CP violation (CPV) phases ...