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133 papers found.
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Observational constraints on the physics behind the evolution of active galactic nuclei since z∼ 1

We explore the evolution with redshift of the rest-frame colours and space densities of active galactic nuclei (AGN) hosts (relative to normal galaxies) to shed light on the dominant mechanism that triggers accretion on to supermassive black holes as a function of cosmic time. Data from serendipitous wide-area XMM surveys of the Sloan Digital Sky Survey (SDSS) footprint (XMM/SDSS; ...

Subtrochanteric fractures after long-term treatment with bisphosphonates: a European Society on Clinical and Economic Aspects of Osteoporosis and Osteoarthritis, and International Osteoporosis Foundation Working Group Report

of Geneva , 1211 Geneva 14, Switzerland 3 C. Cooper NIHR Musculoskeletal Biomedical Research Unit, University of Oxford , Oxford, UK 4 C. Cooper MRC Epidemiology Resource Centre, University of

A Post-Burst Afterdepolarization Is Mediated by Group I Metabotropic Glutamate Receptor-Dependent Upregulation of Cav2.3 R-Type Calcium Channels in CA1 Pyramidal Neurons

The excitability of hippocampal pyramidal neurons is regulated by activation of metabotropic glutamate receptors, an effect that is mediated by modulation of R-type calcium channels.

Osteoporosis and venous thromboembolism: a retrospective cohort study in the UK General Practice Research Database

, University of Oxford , Oxford, UK 1 C. Cooper MRC Epidemiology Resource Centre, University of Southampton , Southampton, UK 2 ) INSERM U 953, Hpital Tenon, 4 rue de la Chine, 75020 Paris, France 3 J. Y

Output-Mode Transitions Are Controlled by Prolonged Inactivation of Sodium Channels in Pyramidal Neurons of Subiculum

Transitions between different behavioral states, such as sleep or wakefulness, quiescence or attentiveness, occur in part through transitions from action potential bursting to single spiking. Cortical activity, for example, is determined in large part by the spike output mode from the thalamus, which is controlled by the gating of low-voltage–activated calcium channels. In the ...

A reappraisal of generic bisphosphonates in osteoporosis

Sheffield Medical School , Beech Hill Road, Sheffield S10 2RX, UK 2 C. Cooper NIHR Musculoskeletal Biomedical Research Unit, University of Oxford , Oxford, UK 3 C. Cooper MRC Lifecourse Epidemiology Unit ... receives consulting fees, paid advisory boards and/or lecture fees from most companies concerned with bone disease. C Cooper receives consulting fees and paid advisory boards for Alliance for Better Bone

The epidemiology of osteonecrosis: findings from the GPRD and THIN databases in the UK

Epidemiology Resource Centre, University of Southampton , Southampton, UK 2 C. Cooper Rheumatology, University of Southampton , Southampton, UK 3 N. B. Watts Bone Health and Osteoporosis Center, University of

The role of environment in the mass–metallicity relation

Using a sample of 57 377 star-forming galaxies drawn from the Sloan Digital Sky Survey, we study the relationship between gas-phase oxygen abundance and environment in the local Universe. We find that there is a strong relationship between metallicity and environment such that more metal-rich galaxies favour regions of higher overdensity. Furthermore, this metallicity–density ...

Use of proton pump inhibitors and risk of hip/femur fracture: a population-based case-control study

Summary Previous studies evaluated the association between proton pump inhibitor (PPI) use and subsequent fracture risk, but they showed ambiguous results. Therefore, the objective was to evaluate this association in a different study population. Our findings show that there is probably no causal relationship between PPI use and hip fracture risk. Introduction Previous studies ...

The DEEP3 Galaxy Redshift Survey: the impact of environment on the size evolution of massive early-type galaxies at intermediate redshift*,†

Using data drawn from the DEEP2 and DEEP3 Galaxy Redshift Surveys, we investigate the relationship between the environment and the structure of galaxies residing on the red sequence at intermediate redshift. Within the massive (10 < log10(M★/h−2 M⊙) < 11) early-type population at 0.4 < z < 1.2, we find a significant correlation between local galaxy overdensity (or environment) and ...

Genetically-Engineered Pig-to-Baboon Liver Xenotransplantation: Histopathology of Xenografts and Native Organs

Orthotopic liver transplantation was carried out in baboons using wild-type (WT, n = 1) or genetically-engineered pigs (α1,3-galactosyltransferase gene-knockout, GTKO), n = 1; GTKO pigs transgenic for human CD46, n = 7) and a clinically-acceptable immunosuppressive regimen. Biopsies were obtained from the WT pig liver pre-Tx and at 30 min, 1, 2, 3, 4 and 5 h post-transplantation. ...

Erythropoietin resistance: the role of inflammation and pro‐inflammatory cytokines

Up to 10% of patients with renal disease receiving recombinant human erythropoietin (rHuEPO) therapy show poor responsiveness to the drug. Even in patients who do respond to rHuEPO, there is a marked variability in drug sensitivity. Several factors have been recognized as causing resistance to rHuEPO, notably iron deficiency, infection/inflammation, and underdialysis. However, when ...

Erratum to: Impact of nutrition on muscle mass, strength, and performance in older adults

, Belgium 2 J.-P. Bonjour 3 N. Yoshimura Department of Joint Disease Research, 22nd Century Medical and Research Center, The University of Tokyo , Tokyo , Japan 4 C. Cooper NIHR Musculoskeletal Biomedical ... Research Unit, Institute of Musculoskeletal Sciences, University of Oxford , Oxford , UK 5 C. Cooper MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital , Southampton

Strong size evolution of the most massive galaxies since z ∼ 2

Using the combined capabilities of the large near-infrared Palomar/DEEP-2 survey, and the superb resolution of the Advanced Camera for Surveys HST camera, we explore the size evolution of 831 very massive galaxies (M⋆≥ 1011h−270 M⊙) since z∼ 2. We split our sample according to their light concentration using the Sérsic index n. At a given stellar mass, both low (n 2.5) concentrated ...

Endothelial Function: The Impact of Objective and Subjective Socioeconomic Status on Flow-Mediated Dilation

Background Although objective and subjective indicators of socioeconomic status (SES) are linked to cardiovascular disease (CVD), little is known about their relationship to endothelial dysfunction, which often precedes CVD. Purpose This study examined how objective and subjective SES relate to brachial artery flow-mediated dilation (FMD). Methods FMD was assessed in 72 healthy ...

Antipsychotic use and the risk of hip/femur fracture: a population-based case–control study

, Utrecht, The Netherlands 1 ) Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University , Utrecht, The Netherlands 2 C. Cooper Institute of

Ion Channel Clustering at the Axon Initial Segment and Node of Ranvier Evolved Sequentially in Early Chordates

Yasushi Okamura 0 Edward C. Cooper 0 Wayne N. Frankel, The Jackson Laboratory, United States of America 0 1 Penn Epilepsy Center, Department of Neurology, University of Pennsylvania, Philadelphia

European guidance for the diagnosis and management of osteoporosis in postmenopausal women

of Medicine of Geneva , Geneva, Switzerland 1 C. Cooper MRC Lifecourse Epidemiology Unit, University of Southampton and NIHR Musculoskeletal Biomedical Research Unit, University of Oxford , Oxford, UK

X-ray selected AGN in groups at redshifts z≈ 1

We explore the role of the group environment in the evolution of active galactic nuclei (AGN) at the redshift interval 0.7 < z < 1.4, by combining deep Chandra observations with extensive optical spectroscopy from the All-wavelength Extended Groth strip International Survey (AEGIS). The sample consists of 3902 optical sources and 71 X-ray AGN. Compared to the overall optically ...