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114 papers found.
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European guidance for the diagnosis and management of osteoporosis in postmenopausal women

of Medicine of Geneva , Geneva, Switzerland 1 C. Cooper MRC Lifecourse Epidemiology Unit, University of Southampton and NIHR Musculoskeletal Biomedical Research Unit, University of Oxford , Oxford, UK

Endothelial Function: The Impact of Objective and Subjective Socioeconomic Status on Flow-Mediated Dilation

Background Although objective and subjective indicators of socioeconomic status (SES) are linked to cardiovascular disease (CVD), little is known about their relationship to endothelial dysfunction, which often precedes CVD. Purpose This study examined how objective and subjective SES relate to brachial artery flow-mediated dilation (FMD). Methods FMD was assessed in 72 healthy ...

Strong size evolution of the most massive galaxies since z ∼ 2

Using the combined capabilities of the large near-infrared Palomar/DEEP-2 survey, and the superb resolution of the Advanced Camera for Surveys HST camera, we explore the size evolution of 831 very massive galaxies (M⋆≥ 1011h−270 M⊙) since z∼ 2. We split our sample according to their light concentration using the Sérsic index n. At a given stellar mass, both low (n 2.5) concentrated ...

Erythropoietin resistance: the role of inflammation and pro‐inflammatory cytokines

Up to 10% of patients with renal disease receiving recombinant human erythropoietin (rHuEPO) therapy show poor responsiveness to the drug. Even in patients who do respond to rHuEPO, there is a marked variability in drug sensitivity. Several factors have been recognized as causing resistance to rHuEPO, notably iron deficiency, infection/inflammation, and underdialysis. However, when ...

Antipsychotic use and the risk of hip/femur fracture: a population-based case–control study

, Utrecht, The Netherlands 1 ) Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University , Utrecht, The Netherlands 2 C. Cooper Institute of

Ion Channel Clustering at the Axon Initial Segment and Node of Ranvier Evolved Sequentially in Early Chordates

Yasushi Okamura 0 Edward C. Cooper 0 Wayne N. Frankel, The Jackson Laboratory, United States of America 0 1 Penn Epilepsy Center, Department of Neurology, University of Pennsylvania, Philadelphia

X-ray selected AGN in groups at redshifts z≈ 1

We explore the role of the group environment in the evolution of active galactic nuclei (AGN) at the redshift interval 0.7 < z < 1.4, by combining deep Chandra observations with extensive optical spectroscopy from the All-wavelength Extended Groth strip International Survey (AEGIS). The sample consists of 3902 optical sources and 71 X-ray AGN. Compared to the overall optically ...

Corticolimbic Expression of TRPC4 and TRPC5 Channels in the Rodent Brain

The canonical transient receptor potential (TRPC) channels are a family of non-selective cation channels that are activated by increases in intracellular Ca2+ and Gq/phospholipase C-coupled receptors. We used quantitative real-time PCR, in situ hybridization, immunoblots and patch-clamp recording from several brain regions to examine the expression of the predominant TRPC channels ...

Groups of galaxies in AEGIS: the 200-ks Chandra extended X-ray source catalogue

We present the discovery of seven X-ray emitting groups of galaxies selected as extended X-ray sources in the 200-ks Chandra coverage of the All-wavelength Extended Groth Strip International Survey (AEGIS). In addition, we report on active galactic nucleus (AGN) activity associated with these systems. For the six extended sources which lie within the Deep Extragalactic Evolutionary ...

Use of β-Blockers and the Risk of Hip/Femur Fracture in the United Kingdom and The Netherlands

Data from in vivo studies have indicated a role for β-blockers in the prevention of bone loss. Some epidemiological studies have found protective effects of β-blockers on fracture risk. However, there is limited information on the association with cumulative dose and type of β-blockers used. We conducted two case-control studies using data from the UK General Practice Research ...

On the evolution of the velocity–mass–size relations of disc-dominated galaxies over the past 10 billion years

We study the evolution of the scaling relations between the maximum circular velocity, stellar mass and optical half-light radius of star-forming disc-dominated galaxies in the context of Λ cold dark matter-based galaxy formation models. Using data from the literature combined with new data from the Deep Extragalactic Evolutionary Probe 2 (DEEP2) and All-wavelength Extended Groth ...

The DEEP2 Galaxy Redshift Survey: environments of post-starburst galaxies at z∼ 0.1 and ∼0.8

Post-starburst (also known as K+A) galaxies exhibit spectroscopic signatures indicating that their star formation was recently quenched; they are candidates for galaxies in transition from a star-forming phase to a passively evolving phase. We have spectroscopically identified large samples of post-starburst galaxies both in the Sloan Digital Sky Survey (SDSS) at z∼ 0.1 and in the ...

Host galaxy morphologies of X-ray selected AGN: assessing the significance of different black hole fuelling mechanisms to the accretion density of the Universe at z∼ 1.

We use morphological information of X-ray selected active galactic nuclei (AGN) hosts to set limits on the fraction of the accretion density of the Universe at z≈ 1 that is not likely to be associated with major mergers. Deep X-ray observations are combined with high-resolution optical data from the Hubble Space Telescope in the All-wavelength Extended Groth strip International ...

Regulation of Hippocampal and Behavioral Excitability by Cyclin-Dependent Kinase 5

Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase that has been implicated in learning, synaptic plasticity, neurotransmission, and numerous neurological disorders. We previously showed that conditional loss of Cdk5 in adult mice enhanced hippocampal learning and plasticity via modulation of calpain-mediated N-methyl-D-aspartic acid receptor (NMDAR) ...

Adverse Outcome Analyses of Observational Data: Assessing Cardiovascular Risk in HIV Disease

Clinical decisions are ideally based on randomized trials but must often rely on observational data analyses, which are less straightforward and more influenced by methodology. The authors, from a series of expert roundtables convened by the Forum for Collaborative HIV Research on the use of observational studies to assess cardiovascular disease risk in human immunodeficiency virus ...

The DEEP2 Galaxy Redshift Survey: the red sequence AGN fraction and its environment and redshift dependence

We measure the dependence of the active galactic nuclei (AGN) fraction on local environment at z∼ 1, using spectroscopic data taken from the DEEP2 Galaxy Redshift Survey, and Chandra X-ray data from the All-Wavelength Extended Groth Strip International Survey (AEGIS). To provide a clean sample of AGN, we restrict our analysis to the red sequence population; this also reduces ...

Oxford SWIFT integral field spectrograph and multiwavelength observations of the Eagle galaxy at z= 0.77

Michael C. Cooper 8 Jeffrey A. Newman 13 Kevin Bundy 12 C. J. Conselice 7 A. M. Koekemoer 2 Lihwai Lin 3 Leonidas A. Moustakas 4 Tao Wang 1 0 Present address: Astrophysics Science Division, Goddard Space

Validation of the IOF quality of life questionnaire for patients with wrist fracture

, University of Milan , Italy S. Boonen, University of Leuven , Belgium P.M. Christensen, University of Odense , Denmark C. Cooper, University of Southampton , UK J.P. Devogelaer, St. Luc University Hospital ... subjects. The data sets (baseline data, three questionnaires) were sent to C. Cooper (Southampton) for data analysis. The wrist fracture questionnaire was scored as follows: Every question had five answer

Use of anti-depressants and the risk of fracture of the hip or femur

Netherlands 2 A. C. G. Egberts Department of Clinical Pharmacy, University Medical Centre Utrecht , Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands 3 C. Cooper Institute of Musculoskeletal Sciences

Use of anti-depressants and the risk of fracture of the hip or femur

Netherlands 2 A. C. G. Egberts Department of Clinical Pharmacy, University Medical Centre Utrecht , Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands 3 C. Cooper Institute of Musculoskeletal Sciences