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Generalized logical model based on network topology to capture the dynamical trends of cellular signaling pathways

Background Cellular responses to extracellular perturbations require signaling pathways to capture and transmit the signals. However, the underlying molecular mechanisms of signal transduction are not yet fully understood, thus detailed and comprehensive models may not be available for all the signaling pathways. In particular, insufficient knowledge of parameters, which is a...

Association of In-Hospital Mortality and Dysglycemia in Septic Patients

Background The associations between dysglycemia and mortality in septic patients with and without diabetes are yet to be confirmed. Our aim was to analyze the association of diabetes and sepsis mortality, and to examine how dysglycemia (hyperglycemia, hypoglycemia and glucose variability) affects in-hospital mortality of patients with suspected sepsis in emergency department (ED...

More Dialectical Thinking, Less Creativity? The Relationship between Dialectical Thinking Style and Creative Personality: The Case of China

People use dialectical thinking to be holistic, reconcile contradictions, and emphasize changes when processing information and managing problems. Using a questionnaire survey, this study examined the relationship between dialectical thinking and creative personality in the Chinese culture, which encourages a holistic and collective thinking style. Undergraduates majoring in...

Charge Variants of an Avastin Biosimilar Isolation, Characterization, In Vitro Properties and Pharmacokinetics in Rat

Zhao and Wan-Hui Liu are employed by Luye Pharma Group Ltd. Luye Pharma Group Ltd provided support in the form of salaries for authors, but did not have any additional role in the study design, data ... of post-translational Competing Interests: The authors have the following interests: Authors Yan-Yan Zhao, Wan-Hui Liu, Wen-Jie Tao, Li-Li Liu and Zhen-Duo Shen are employed by Luye Pharma Group Ltd

Tanshinone IIA combined with adriamycin inhibited malignant biological behaviors of NSCLC A549 cell line in a synergistic way

Background The study was designed to develop a platform to verify whether the extract of herbs combined with chemotherapy drugs play a synergistic role in anti-tumor effects, and to provide experimental evidence and theoretical reference for finding new effective sensitizers. Methods Inhibition of tanshinone IIA and adriamycin on the proliferation of A549, PC9 and HLF cells were...

Histone modifications involved in cassette exon inclusions: a quantitative and interpretable analysis

Background Chromatin structure and epigenetic modifications have been shown to involve in the co-transcriptional splicing of RNA precursors. In particular, some studies have suggested that some types of histone modifications (HMs) may participate in the alternative splicing and function as exon marks. However, most existing studies pay attention to the qualitative relationship...

Symmetric Closed Characteristics on Symmetric Compact Convex Hypersurfaces in \(\mathbf{R}^8\)

Step 2. The proof of Theorem 1.1 is complete. Acknowledgments Hui Liu Partially supported by NSFC (No. 11401555), China Postdoctoral Science Foundation No. 2014T70589, CUSF (No. WK0010000037). Yiming

Short-Term Fidelity, Habitat Use and Vertical Movement Behavior of the Black Rockfish Sebastes schlegelii as Determined by Acoustic Telemetry

The recent miniaturization of acoustic tracking devices has allowed fishery managers and scientists to collect spatial and temporal data for sustainable fishery management. The spatial and temporal dimensions of fish behavior (movement and/or vertical migrations) are particularly relevant for rockfishes (Sebastes spp.) because most rockfish species are long-lived and have high...

Integrated analysis of miRNA, gene, and pathway regulatory networks in hepatic cancer stem cells

Background Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. HCC has a poor prognosis associated with tumor recurrence and drug resistance, which has been attributed to the existence of hepatic cancer stem cells (HCSCs). However, the characteristics and regulatory mechanisms of HCSCs remain unclear. We therefore established a novel system to enrich...

Autophagy induction contributes to the resistance to methotrexate treatment in rheumatoid arthritis fibroblast-like synovial cells through high mobility group box chromosomal protein 1

Background Rheumatoid arthritis fibroblast-like synovial cells (RA-FLS) show resistance to methotrexate (MTX) treatment. To better understand the mechanisms of this resistance, RA-FLS and osteoarthritis fibroblast-like synovial cells (OA-FLS) were isolated and exposed to MTX. We analyzed the autophagy induced by MTX in vitro and its relationship to apoptosis. Methods Cell...

Quality Assessment of Panax notoginseng from Different Regions through the Analysis of Marker Chemicals, Biological Potency and Ecological Factors

Panax notoginseng (Burk.) F.H. Chen, called Sanqi in China, is a perennial herb that has been used as a medicinal herb in traditional Chinese medicine for more than 400 years. Because notoginseng is included in many proprietary Chinese medicines, the quality of notoginseng directly affects its efficacy and safety. However, considering the complex and special growth environment...

Hollow MO x -RuO2 (M = Co, Cu, Fe, Ni, CuNi) nanostructures as highly efficient electrodes for supercapacitors

Engineering the internal structure and chemical composition of nanomaterials in a cost-effective way has been challenging, especially for enhancing their performance for a given application. Herein, we report a general strategy to fabricate hollow nanostructures of ruthenium-based binary or ternary oxides via a galvanic replacement process together with a subsequent thermal...

Letter regarding Wang GQ et al. entitled “Associations between Fas/FasL polymorphisms and susceptibility to cervical cancer: a meta-analysis”

Ying Zeng Jia Liu Jinjin Yan Hui Liu Shuhua Xiong 0 ) Department of Oncology, Jiangxi Maternal and Child Health Hospital , Nanchang 330006, Jiangxi Province, People's Republic of China - To the

Analysis of piston-pin lubrication considering the effects of structure deformation and cavitation

Running conditions for piston pin boss bearing have become very severe due to the high combustion pressure and piston temperature increase over the past ten years. The aim of this paper was to analyze the friction and lubrication characteristic of piston pin boss bearings and a connecting rod small end bearing. This paper provided a comprehensive analysis of piston pin based on a...

Vitamin A Intake and Risk of Melanoma: A Meta-Analysis

Background Mounting evidence from experimental and animal studies suggests that vitamin A may have a protective effect on melanoma, but the findings on the association of vitamin A intake with risk of melanoma have been inconsistently reported in epidemiologic studies. We attempted to elucidate the association by performing a meta-analysis. Methods Eligible studies were...

Low Serum Testosterone Levels Are Associated with Elevated Urinary Mandelic Acid, and Strontium Levels in Adult Men According to the US 2011–2012 National Health and Nutrition Examination Survey

Background Little is known regarding the effects of environmental exposure of chemicals on androgenic system in the general population. We studied 5,107 subjects included in the National Health and Nutrition Examination Survey (2011–2012). Methods Urinary, serum, and blood levels of 15 subclasses comprising 110 individual chemicals were analyzed for their association with serum...

Novel monoclonal antibodies against Plasmodium falciparum histidine-rich protein 2: development and application in rapid diagnostic tests of malaria in hyperendemic regions of China and Myanmar

genomic DNA was extracted from clinical blood samples provided by Prof. Hui Liu (Yunnan Provincial Institute of Parasitic Diseases, Simao, Yunnan, China), using QIAamp DNA Mini Kit (QIAGEN, Germany). Pair

ROR1, an embryonic protein with an emerging role in cancer biology

. COMPLIANCE WITH ETHICS GUIDELINES Nicholas Borcherding, David Kusner, Guang-Hui Liu and Weizhou Zhang declare that they have no conflict of interest. This article does not contain any studies with human or

Pt-Containing Ag2S-Noble Metal Nanocomposites as Highly Active Electrocatalysts for the Oxidation of Formic Acid

Nanocomposites with synergistic effect are of great interest for their enhanced properties in a given application. Herein, we reported the high catalytic activity of Pt-containing Ag2S-noble metal nanocomposites in formic acid oxidation, which is a key reaction in direct formic acid fuel cell. The electrochemical measurements including voltammograms and chronoamperograms are used...