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Exploring the Intrinsic Piezofluorochromic Mechanism of TPE-An by STS Technique

9,10-bis(4-(1,2,2-triphenylvinyl)styryl)anthracene (TPE-An) materials have attracted considerable attention in recent years because they have high luminescence efficiency and excellent piezofluorochromic properties, which have potential applications in organic light-emitting display (OLED) area. Scanning tunneling spectroscopy (STS) technique was used to study the ...

Distinguishing Patients with Parkinson's Disease Subtypes from Normal Controls Based on Functional Network Regional Efficiencies

Many studies have demonstrated that the pathophysiology and clinical symptoms of Parkinson's disease (PD) are inhomogeneous. However, the symptom-specific intrinsic neural activities underlying the PD subtypes are still not well understood. Here, 15 tremor-dominant PD patients, 10 non-tremor-dominant PD patients, and 20 matched normal controls (NCs) were recruited and underwent ...

Distributed indeterminacy evaluation of cable-strut structures: formulations and applications

The indeterminacy evaluation is an effective method for system identification; it can predict the mechanical behaviors of flexible structures in the primary design. However, the conventional indeterminacy evaluation based solely on geometry and topology has neglected the influence of material properties on mechanical behavior and the contribution of each component to the total ...

Serial cfDNA assessment of response and resistance to EGFR-TKI for patients with EGFR-L858R mutant lung cancer from a prospective clinical trial

Background Detecting epidermal growth factor receptor (EGFR) activating mutations in plasma could guide EGFR-tyrosine kinase inhibitor (EGFR-TKI) treatment for advanced non-small cell lung cancer (NSCLC). However, dynamic quantitative changes of plasma EGFR mutations during the whole course of EGFR-TKI treatment and its correlation with clinical outcomes were not determined. The ...

B7H1 Expression and Epithelial-To-Mesenchymal Transition Phenotypes on Colorectal Cancer Stem-Like Cells

Cancer stem cells (CSCs) can invade and metastasize by epithelial-to-mesenchymal transition (EMT). However, how they escape immune surveillance is unclear. B7H1 is crucial negative co-stimulatory molecule but little information about whether it works in CSCs. Therefore, we determined the expression of B7H1 and EMT-associated markers in colorectal cancer stem-like cells to ...

Inorganic & organic materials for rechargeable Li batteries with multi-electron reaction

Advanced Energy Materials Chemistry (Ministry of Education) to study for his PhD degree. He is expecting to get his PhD in 2015 under the supervision of Professor Jun Chen. His research focuses on Liion ... batteries, Li-S batteries, and Na-ion batteries. Jun Chen was born in 1967. He is a Cheung Kong Scholar Professor at the College of Chemistry, Nankai University, and Vice Chairman of the Chinese Society of

Sarcoidosis misdiagnosed as malignant tumors: a case report

Song Xu 1 Jun Chen 1 0 Equal contributors 1 Department of Lung Cancer Surgery, Lung Cancer Institute, Tianjin Medical University General Hospital , No. 154 Anshan Road, Heping District, Tianjin 300052 ... manuscript. Education Ministry (to Song Xu), Tianjin Science and Technology Support Program (12ZCDZSY16100 to Jun Chen), and Tianjin Educational Committee Foundation (20120117 to Song Xu). 1. Colby TV

Causes, clinical features and outcomes of drug-induced liver injury in hospitalized patients in a Chinese tertiary care hospital

Drug-induced liver injury (DILI) is an important liver disease in China, owing to the country’s huge population and the availability of a multitude of drugs. Consequently, DILI is becoming an increasingly serious health problem. However, there is not enough relevant epidemiological data, and the clinical features of these patients are not clear. We conducted this study to report ...

Computational methods for the zero-stress state and the pre-stress state of tensile cable-net structures

This paper proposes an extended design concept and mechanical description for cable-net structures, including 10 states and 15 procedures which are defined according to their physical nature and analytical capabilities. In the pre-stress release analysis, an iterative computational method is developed for the inverse evaluation from the equilibrium state to the zero-stress state, ...

The association between S100A13 and HMGA1 in the modulation of thyroid cancer proliferation and invasion

Background S100A13 and high mobility group A (HMGA1) are known to play essential roles in the carcinogenesis and progression of cancer. However, the correlation between S100A13 and HMGA1 during cancer progression is not yet well understood. In this study, we determined the effects of S100A13 on HMGA1 expression in thyroid cancer cells and examined the role of HMGA1 in thyroid ...

A Neural Network Model for K(λ) Retrieval and Application to Global Kpar Monitoring

Accurate estimation of diffuse attenuation coefficients in the visible wavelengths Kd(λ) from remotely sensed data is particularly challenging in global oceanic and coastal waters. The objectives of the present study are to evaluate the applicability of a semi-analytical Kd(λ) retrieval model (SAKM) and Jamet’s neural network model (JNNM), and then develop a new neural network ...

Enterovirus-related diarrhoea in Guangdong, China: clinical features and implications in hand, foot and mouth disease and herpangina

Background A series of complications caused by enteroviruses, including meningitis, encephalitis, acute flaccid paralysis, acute cardiopulmonary failure, respiratory infection, and myocardial injury have been reported in hand, foot and mouth disease/herpangina (HFMD/HA). However, the complication of diarrhoea caused by enteroviruses has been neglected, and a summary of its clinical ...

Vitamin D Receptor Gene FOKI Polymorphism Contributes to Increasing the Risk of HIV-Negative Tuberculosis: Evidence from a Meta-Analysis

Background Vitamin D receptor (VDR) gene FokI polymorphism have been studied in relation to tuberculosis (TB) in many populations and provided inconsistent results. In this study, we carried out a meta-analysis to derive a more reliable assessment on FokI polymorphism and the risk of HIV-negative TB. Methods The Embase, PubMed, and Cochrane Library databases were used to undertake ...

Salidroside prevents cognitive impairment induced by chronic cerebral hypoperfusion in rats

Objective To investigate the effects of salidroside on cognitive dysfunction induced by chronic cerebral hypoperfusion in rats.

Expression of HIF-1α and HIF-2α correlates to biological and clinical significance in papillary thyroid carcinoma

Background The aim of this study was to detect the expression of hypoxia-inducible factor (HIF)-1α and HIF-2α in papillary thyroid carcinoma (PTC) compared with normal thyroid tissues. Methods The mRNA levels and protein levels of HIF-1α and HIF-2α were detected by real-time PCR and Western blot separately in 30 pairs of PTCs and normal thyroid cases. The protein levels were also ...

RNA sequencing-based analysis of the spleen transcriptome following infectious bronchitis virus infection of chickens selected for different mannose-binding lectin serum concentrations

Background Avian infectious bronchitis is a highly contagious disease of the upper-respiratory tract caused by infectious bronchitis virus (IBV). Understanding the molecular mechanisms involved in the interaction between innate and adaptive immune responses to IBV infection is a crucial element for further improvements in strategies to control IB. To this end, two chicken lines, ...

YAP Enhances Autophagic Flux to Promote Breast Cancer Cell Survival in Response to Nutrient Deprivation

The Yes-associated protein (YAP), a transcriptional coactivator inactivated by the Hippo tumor suppressor pathway, functions as an oncoprotein in a variety of cancers. However, its contribution to breast cancer remains controversial. This study investigated the role of YAP in breast cancer cells under nutrient deprivation (ND). Here, we show that YAP knockdown sensitized MCF7 ...

Health-Related Quality of Life in Patients with Primary Cutaneous Amyloidosis

Background Primary cutaneous amyloidosis (PCA) is a relatively rare and itchy skin disorder characterized by amyloid deposits in the superficial dermis. The cosmetic disfigurement and severe pruritus dramatically affects the patient’s quality of life. In spite of the prevalence of the disease in China, the quality of life (QoL) impact of the PCA has not been well defined and is the ...

MiR-506 Is Down-Regulated in Clear Cell Renal Cell Carcinoma and Inhibits Cell Growth and Metastasis via Targeting FLOT1

Background Some microRNAs (miRNAs) are abnormally expressed in cancer and contribute to tumorigenesis. In the present study, we investigated the role of miR-506 in clear cell renal cell carcinoma (ccRCC). Methods miR-506 expression was detected in renal cancer cell lines 786-O, ACHN, Caki-1, and Caki-2 and ccRCC specimens by quantitative real-time-PCR. We assessed the association ...