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Social defeat stress causes depression-like behavior with metabolite changes in the prefrontal cortex of rats

Major depressive disorder is a serious mental disorder with high morbidity and mortality. The role of social stress in the development of depression remains unclear. Here, we used the social defeat stress paradigm to induce depression-like behavior in rats, then evaluated the behavior of the rats and measured metabolic changes in the prefrontal cortex using gas chromatography...

Machine Learning Classification of Cirrhotic Patients with and without Minimal Hepatic Encephalopathy Based on Regional Homogeneity of Intrinsic Brain Activity

Machine learning-based approaches play an important role in examining functional magnetic resonance imaging (fMRI) data in a multivariate manner and extracting features predictive of group membership. This study was performed to assess the potential for measuring brain intrinsic activity to identify minimal hepatic encephalopathy (MHE) in cirrhotic patients, using the support...

Dental caries is negatively correlated with body mass index among 7-9 years old children in Guangzhou, China

Background Evidence linking caries in primary dentition and children’s anthropometric measures is contradictory. We aimed to evaluate the prevalence of primary dental caries and its relationship with body mass index (BMI) among 7-9 years old school children in urban Guangzhou, China. Methods This cross-sectional study enrolled 32,461 pupils (14,778 girls and 17,683 boys) aged 7-9...

Nonlinear optomechanical detection for Majorana fermions via a hybrid nanomechanical system

The pursuit for detecting the existence of Majorana fermions is a challenging task in condensed matter physics at present. In this work, we theoretically propose a novel nonlinear optical method for probing Majorana fermions in the hybrid semiconductor/superconductor heterostructure. Our proposal is based on a hybrid system constituted by a quantum dot embedded in a...

Increased risk of benign paroxysmal positional vertigo in patients with anxiety disorders: a nationwide population-based retrospective cohort study

to the NHIRD (http://nhird.nhri.org.tw). Authors’ contributions Zi-Jun Chen, Cheng-Ho Chang, and Li-Yu Hu participated in the design of the study, analyzed the data, and wrote the manuscript. Ming

Liver-Enriched Gene 1, a Glycosylated Secretory Protein, Binds to FGFR and Mediates an Anti-stress Pathway to Protect Liver Development in Zebrafish

Unlike mammals and birds, teleost fish undergo external embryogenesis, and therefore their embryos are constantly challenged by stresses from their living environment. These stresses, when becoming too harsh, will cause arrest of cell proliferation, abnormal cell death or senescence. Such organisms have to evolve a sophisticated anti-stress mechanism to protect the process of...

Circulating Tumor DNA Mutation Profiling by Targeted Next Generation Sequencing Provides Guidance for Personalized Treatments in Multiple Cancer Types

• PubMed • Google Scholar Search for Liangjun Zhu in:Nature Research journals • PubMed • Google Scholar Search for Chunrong Zhu in:Nature Research journals • PubMed • Google Scholar Search for Jun Chen

Dendritic-Tumor Fusion Cells Derived Heat Shock Protein70-Peptide Complex Has Enhanced Immunogenicity

Tumor-derived heat shock protein70-peptide complexes (HSP70.PC-Tu) have shown great promise in tumor immunotherapy due to numerous advantages. However, large-scale phase III clinical trials showed that the limited immunogenicity remained to be enhanced. In previous research, we demonstrated that heat shock protein 70-peptide complexes (HSP70.PC-Fc) derived from dendritic cell (DC...

Prediction of microstructural evolution during hot forging

Microstructural evolution, which is governed by temperature, strain and strain rate during hot forging, is a key factor influencing mechanical properties. Understanding the microstructural evolution of metals and alloys in hot forging has a great importance for the designers of metal forming processes. The principal objective of this paper is to provide an overview of the models...

Differential gene expression in patients with subsyndromal symptomatic depression and major depressive disorder

Background Subsyndromal symptomatic depression (SSD) is a subtype of subthreshold depressive and can lead to significant psychosocial functional impairment. Although the pathogenesis of major depressive disorder (MDD) and SSD still remains poorly understood, a set of studies have found that many same genetic factors play important roles in the etiology of these two disorders...

The epidemic characteristics of short stature in school students

, participated in data analysis, drafted the manuscript and participated in its design and coordination. Yue Liu and Xian-jun Chen participated in the design of the study and performed the data acquisition. Li-qi

Altered gut microbiota in female mice with persistent low body weights following removal of post-weaning chronic dietary restriction

Background Nutritional interventions often fail to prevent growth failure in childhood and adolescent malnutrition and the mechanisms remain unclear. Recent studies revealed altered microbiota in malnourished children and anorexia nervosa. To facilitate mechanistic studies under physiologically relevant conditions, we established a mouse model of growth failure following chronic...

Comparison of tripterygium wilfordii multiglycosides and tacrolimus in the treatment of idiopathic membranous nephropathy: a prospective cohort study

Li 0 Heng Li Qian Liang Jun Chen Jianghua Chen 0 Equal contributors Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University , 79 Qingchun Road, Hangzhou 310003

Lung ultrasonography for the diagnosis of 11 patients with acute respiratory distress syndrome due to bird flu H7N9 infection

Ying Zhan Jun Chen 0 Equal contributors Intensive Care Unit of the Department of Anesthesiology, The First Hospital Affiliated to Suzhou University , Suzhou 215006, Jiangsu , China Background: A novel ... where H7N9 infection is emergent in humans. Authors’ contributions Yu-kun Zhang, Jian Li, and Jun Chen designed the study and co-wrote the manuscript. Yu-kun Zhang, Jian Li, Jian-ping Yang, and Ying Zhan

Distinguishing Patients with Parkinson's Disease Subtypes from Normal Controls Based on Functional Network Regional Efficiencies

Many studies have demonstrated that the pathophysiology and clinical symptoms of Parkinson's disease (PD) are inhomogeneous. However, the symptom-specific intrinsic neural activities underlying the PD subtypes are still not well understood. Here, 15 tremor-dominant PD patients, 10 non-tremor-dominant PD patients, and 20 matched normal controls (NCs) were recruited and underwent...

Changes in enterovirus serotype constituent ratios altered the clinical features of infected children in Guangdong Province, China, from 2010 to 2013

Background Enterovirus (EV)-related hand, foot, and mouth disease/herpangina (HFMD/HA) has been prevalent in Guangdong Province, China, since 2010. Methods Clinical data for EV-related HFMD/HA inpatients admitted to the Department of Paediatrics of Zhujiang Hospital from 2010 to 2013 were retrospectively reviewed. The corresponding EV serotypes were also determined by reverse...

Inorganic & organic materials for rechargeable Li batteries with multi-electron reaction

Advanced Energy Materials Chemistry (Ministry of Education) to study for his PhD degree. He is expecting to get his PhD in 2015 under the supervision of Professor Jun Chen. His research focuses on Liion ... batteries, Li-S batteries, and Na-ion batteries. Jun Chen was born in 1967. He is a Cheung Kong Scholar Professor at the College of Chemistry, Nankai University, and Vice Chairman of the Chinese Society of

Prediction of microstructural evolution during hot forging

Microstructural evolution, which is governed by temperature, strain and strain rate during hot forging, is a key factor influencing mechanical properties. Understanding the microstructural evolution of metals and alloys in hot forging has a great importance for the designers of metal forming processes. The principal objective of this paper is to provide an overview of the models...