Advanced search    

Search: authors:"Kun Liu"

72 papers found.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

Regulation of HSP27 on NF-κB pathway activation may be involved in metastatic hepatocellular carcinoma cells apoptosis

Background During the process of metastasis, cells are subjected to various apoptotic stimuli. Aberrant expression of apoptotic regulators often contribute to cell metastasis. Heat shock protein 27(HSP27) is confirmed as an apoptosis regulator, but its antiapoptotic mechanism in metastatic hepatocellular carcinoma (HCC) cells remains unclear. Methods Levels of HSP27 protein and...

Silver-coated TiO2 nanostructured anode materials for lithium ion batteries

Anatase TiO2 nanoribbons/nanotubes (TiO2-NRTs) have been synthesised successfully via a reflux method followed by drying in a vacuum oven, and then, silver-coated TiO2 NRTs (Ag/TiO2-NRTs) were prepared by coating silver particles onto the TiO2-NRTs surface by the traditional silver mirror reaction. The physical properties of the synthesised products were examined in detail using...

PROPERTY RIGHTS, DEPENDENCE ON TRANSACTION PARTNERS, AND FIRM VALUATION: WHO APPROPRIATES VALUE? (INTERACTIVE PAPER)

A key issue gaining attention in the field of entrepreneurship is answering the question of who will appropriate the rents associated with entrepreneurial activity. While entrepreneurs may expend substantial resources to pursue an opportunity, others may be able to appropriate value if the entrepreneurs have not established protections. For example, a key supplier who provides a...

INFORMATION DISCLOSURE AND IPO VALUATION: WHAT KINDS OF INFORMATION MATTER AND IS MORE INFORMATION ALWAYS BETTER?

University, USA Fariss Mousa, Washington State University, USA Kun Liu, Washington State University , USA Daeil Nam Recommended Citation Nam, Daeil; Arthurs, Jonathan D.; Nielsen, Marsha; Mousa, Fariss; and

Case-Fatality Ratio and Effectiveness of Ribavirin Therapy Among Hospitalized Patients in China Who Had Severe Fever With Thrombocytopenia Syndrome

Background. The wide distribution and high case-fatality ratio of severe fever with thrombocytopenia syndrome (SFTS) have made it a significant public health problem. This study was designed to identify the predictors of fatal outcomes and to evaluate the effectiveness of antiviral therapy in treating SFTS virus (SFTSV)–infected patients. Methods. A cross-sectional study was...

The Antibody Targeting the E314 Peptide of Human Kv1.3 Pore Region Serves as a Novel, Potent and Specific Channel Blocker

Selective blockade of Kv1.3 channels in effector memory T (TEM) cells was validated to ameliorate autoimmune or autoimmune-associated diseases. We generated the antibody directed against one peptide of human Kv1.3 (hKv1.3) extracellular loop as a novel and possible Kv1.3 blocker. One peptide of hKv1.3 extracellular loop E3 containing 14 amino acids (E314) was chosen as an...

GenoWatch: a disease gene mining browser for association study

A human gene association study often involves several genomic markers such as single nucleotide polymorphisms (SNPs) or short tandem repeat polymorphisms, and many statistically significant markers may be identified during the study. GenoWatch can efficiently extract up-to-date information about multiple markers and their associated genes in batch mode from many relevant...

Suppression of growth, migration and invasion of highly-metastatic human breast cancer cells by berbamine and its molecular mechanisms of action

Background Breast cancer is the second leading cause of cancer related deaths among females worldwide. Berbamine (BER), a kind of bis-benzylisoquinoline alkaloid, has been used to treat clinical patients with inflammation and cancer for many years in China. The purpose of this study is to investigate the activity of BER against highly-metastatic human breast cancer and its...

Functional analysis of novel SNPs and mutations in human and mouse genomes

Background With the flood of information generated by the new generation of sequencing technologies, more efficient bioinformatics tools are needed for in-depth impact analysis of novel genomic variations. FANS (Functional Analysis of Novel SNPs) was developed to streamline comprehensive but tedious functional analysis steps into a few clicks and to offer a carefully designed...

FASTSNP: an always up-to-date and extendable service for SNP function analysis and prioritization

Single nucleotide polymorphism (SNP) prioritization based on the phenotypic risk is essential for association studies. Assessment of the risk requires access to a variety of heterogeneous biological databases and analytical tools. FASTSNP (function analysis and selection tool for single nucleotide polymorphisms) is a web server that allows users to efficiently identify and...

LAB-PEDIATRICS LABORATORY RESEARCH

Chromosomal rearrangements resulting in novel fusion genes are among the most prevalent form of genetic alterations known in cancer, and numerous examples exist in both adult and childhood malignancies. To date, however, none have been reported in pediatric high-grade glioma (pHGG), so we have undertaken to search for novel structural rearrangements using three distinct...