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An unusual function of RON receptor tyrosine kinase as a transcriptional regulator in cooperation with EGFR in human cancer cells

Homodimerization of RON (MST1R), a receptor tyrosine kinase, usually occurs in cells stimulated by a ligand and leads to the downstream activation of signaling pathways. Here we report that bladder cancer cells, in response to physiological stress, use an alternative mechanism for signaling activation. Time-course studies indicated that RON migrated directly from the membrane to ...

Extracellular zinc and ATP-gated P2X receptor calcium entry channels: New zinc receptors as physiological sensors and therapeutic targets

In this review, we focus on two attributes of P2X receptor channel function, one essential and one novel. First, we propose that P2X receptors are extracellular sensors as well as receptors and ion channels. In particular, the large extracellular domain (that comprises 70% of the molecular mass of the receptor channel protein) lends itself to be a cellular sensor. Moreover, its ...

Significance of platelet activation in vascular access survival of haemodialysis patients

Background. Vascular access failure is the most common cause of morbidity and hospitalization in haemodialysis (HD) patients. Although there are reports that anti‐platelet agents can prevent vascular access thrombosis, the relationship between platelet activation and vascular access failure is not clear. The aim of this study was to investigate the role of platelet activation in ...

Loss of apical monocilia on collecting duct principal cells impairs ATP secretion across the apical cell surface and ATP-dependent and flow-induced calcium signals

Michael B. Hovater Dragos Olteanu Elizabeth L. Hanson Nai-Lin Cheng Brian Siroky Attila Fintha Peter Komlosi Wen Liu Lisa M. Satlin P. Darwin Bell Bradley K. Yoder Erik M. Schwiebert 0 ) Departments

Intrathecal bupivacaine with morphine or neostigmine for postoperative analgesia after total knee replacement surgery

Ping-Heng Tan Yuan-Yi Chia Yuan Lo Kang Liu Lin-Cheng Yang Tsung-Hsing Lee [L'administration intrathcale de bupivacane avec morphine ou nostigmine comme analgsie postopratoire suivant la mise en

CKD-MBD - A

Introduction and Aims:In patients with chronic renal failure, secondary hyperparathyroidism (sHPT) sometimes requires parathyroidectomy. Prospectively, we compared total parathyroidectomy without autotransplantation and without thymectomy (tPTX) with subtotal parathyreoidectomy with thymectomy (sPTX) for renal hyperparathyroidism. Methods:From 11/2004 to 11/2008, 43 consecutive ...

Intramuscular electroporation with the pro-opiomelanocortin gene in rat adjuvant arthritis

alpha and opioids in the disease . J Neuroimmunol 1994 , 51 : 169 - 176 . Correspondence Lin-Cheng Yang MD , Associate Professor , Gene Therapy Laboratory, Tajen Institute of Technology, Pingtung, 907

The Effect of Tenidap on Cytokines, Acute-Phase Proteins, and Virus Load in Human Immunodeficiency Virus (HIV)-Infected Patients: Correlation between Plasma HIV-1 RNA and Proinflammatory Cytokine Levels

Proinflammatory cytokines may be important in the pathogenesis of human immunodeficiency virus type 1 (HIV-1) disease. Tenidap decreases interleukin (IL)-6, IL-1, and tumor necrosis factor (TNF) production by peripheral blood mononuclear cells and decreases IL-6 plasma levels in rheumatoid arthritis patients. In this randomized double-blind study, 43 HIV-1-infected patients ...

Role of Benzathine Penicillin G in Prophylaxis for Recurrent Streptococcal Cellulitis of the Lower Legs

Cellulitis of the lower leg is an infection caused by streptococci or, less commonly, Staphylococcus aureus and other gram-negative rods. Recurrence of cellulitis is a common problem. In the present study, we evaluated the use of monthly intramuscular injections of benzathine penicillin G to prevent recurrences of cellulitis. A total of 115 patients with definite or presumptive ...

Skin and Soft-Tissue Manifestations of Shewanella putrefaciens Infection

Shewanella putrefaciens, a saprophytic gram-negative rod, is infrequently recovered from clinical specimens. Although a number of clinical syndromes have been attributed to S. putrefaciens, the pathogenic role of this agent remains largely undefined. We report 16 cases of S. putrefaciens infection that occurred at the Veterans General Hospital—Kaohsiung in Taiwan between 1990 and ...

Mycotic Aneurysm Due to Non-typhi Salmonella: Report of 16 Cases

From 1990 through 1994, we collected information on all cases of mycotic aneurysms due to non-typhi Salmonella that occurred at the Veterans General Hospital in Kaohsiung, Taiwan. All cases of salmonella bacteremia were reviewed to find any additional cases. A total of 16 cases of salmonella mycotic aneurysms occurred. The mortality rate was 100% among the three patients treated ...

STEM CELLS

Hospital, Baylor College of Medicine , Houston, TX , USA 5 SC-001. ROLES OF GLIOBLASTOMA STEM CELL-DERIVED VASCULAR PERICYTES Lin Cheng, Zhi Huang, Wenchao Zhou, Qiulian Wu, Jeremy Rich, and Shideng Bao

LAB-STEM CELLS

INTRODUCTION: Recent evidence suggests that glioblastoma is driven by a subset of tumor initiating (TI) cells characterized by their capacity to form tumors in xenograft models and self-renew in vitro. These TI cells share many properties of neural stem/progenitor cells, including the expression of certain cell surface markers. With serial passage, many cells lose their capacity to ...