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102 papers found.
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T cell immunohistochemistry refines lung transplant acute rejection diagnosis and grading

Objective Lung transplant volume has been increasing. However, inaccurate and uncertain diagnosis for lung transplant rejection hurdles long-term outcome due to, in part, interobserver variability in rejection grading. Therefore, a more reliable method to facilitate diagnosing and grading rejection is warranted. Method Rat lung grafts were harvested on day 3, 7, 14 and 28 post...

RNA-binding protein RNPC1: acting as a tumor suppressor in breast cancer

Jin-Qiu Xue 0 Tian-Song Xia 0 Xiu-Qing Liang Wenbin Zhou Lin Cheng Liang Shi Ying Wang Qiang Ding 0 Equal contributors Jiangsu Breast Disease Center, the First Affiliated Hospital with Nanjing

Job autonomy, its predispositions and its relation to work outcomes in community health centers in Taiwan

It has been debated that employees in a government or public ownership agency may perceive less need for growth opportunities or high-powered incentives than is the case for employees in private organizations. This study examined employees’ job autonomy in government-run community health centers, its predispositions and its relation to their work outcomes. A cross-sectional study...

Podocalyxin-like 1 promotes invadopodia formation and metastasis through activation of Rac1/Cdc42/cortactin signaling in breast cancer cells

Metastatic disease is the leading cause of cancer mortality. Identifying biomarkers and regulatory mechanisms is important toward developing diagnostic and therapeutic tools against metastatic cancer. In this study, we demonstrated that podocalyxin-like 1 (PODXL) is overexpressed in breast tumor cells and increased in lymph node metastatic cancer. Mechanistically, we found that...

Up-regulation of S100A16 expression promotes epithelial-mesenchymal transition via Notch1 pathway in breast cancer

Background Our previous studies demonstrated that S100A16 promotes adipogenesis and is involved in weight gain attenuation induced by dietary calcium. Till now, the function of S100A16 in the breast cancer remains to be elucidated. Results In this study, we observed that S100A16 was expressed in higher levels in human breast cancer tissues compared with paired adjacent non...

Systematic Review and Meta-Analysis of 16 Randomized Clinical Trials of Radix Astragali and Its Prescriptions for Diabetic Retinopathy

Editor: Benny Tan Kwong Huat Copyright © 2013 Lin Cheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution

Entransy dissipation minimization for optimization of heat exchanger design

In this paper, by taking the water-water balanced counterflow heat exchanger as an example, the entransy dissipation theory is applied to optimizing the design of heat exchangers. Under certain conditions, the optimal duct aspect ratio is determined analytically. When the heat transfer area or the duct volume is fixed, analytical expressions of the optimal mass velocity and the...

Visualized Gene Network Reveals the Novel Target Transcripts Sox2 and Pax6 of Neuronal Development in Trans-Placental Exposure to Bisphenol A

Background Bisphenol A (BPA) is a ubiquitous endocrine disrupting chemical in our daily life, and its health effect in response to prenatal exposure is still controversial. Early-life BPA exposure may impact brain development and contribute to childhood neurological disorders. The aim of the present study was to investigate molecular target genes of neuronal development in trans...

RHBDL2 Is a Critical Membrane Protease for Anoikis Resistance in Human Malignant Epithelial Cells

10 February 2014; Revised 14 April 2014; Accepted 11 May 2014; Published 28 May 2014 Academic Editor: Luca Scorrano Copyright © 2014 Tsung-Lin Cheng et al. This is an open access article ... -2320-B-006-037- for Tsung-Lin Cheng) and by the National Cheng Kung University, “Aim for the Top University Plan” grant from the Ministry of Education, Taiwan. References L. A. Liotta, “Tumor

Visual Agreement Analyses of Traditional Chinese Medicine: A Multiple-Dimensional Scaling Approach

The study of TCM agreement in terms of a powerful statistical tool becomes critical in providing objective evaluations. Several previous studies have conducted on the issue of consistency of TCM, and the results have indicated that agreements are low. Traditional agreement measures only provide a single value which is not sufficient to justify if the agreement among several...

Clinical Significance of ErbB Receptor Family in Urothelial Carcinoma of the Bladder: A Systematic Review and Meta-Analysis

The prognostic importance of examining ErbB receptor family expression in human bladder cancer remains uncertain. Using published evidence, we examined the clinical value and the updated results of clinical trials targeting ErbB receptor family members. Twenty-seven articles from 65 references related to ErbB receptor expression assessment in bladder cancer were reviewed. The...

The Study on the Agreement between Automatic Tongue Diagnosis System and Traditional Chinese Medicine Practitioners

Tongue diagnosis is an important practice in traditional Chinese medicine (TCM) for diagnosing diseases before determining proper means of treatments. Traditionally, it depends solely on personal knowledge and experience of the practitioner, thereby being criticized as lacking of objectivity. Currently, no research regarding intra- and inter-agreements of automatic tongue...

The Apoptotic Effect of D Rhamnose β-Hederin, a Novel Oleanane-Type Triterpenoid Saponin on Breast Cancer Cells

There is growing interest in development of natural products as anti-cancer and chemopreventive agents. Many triterpenoids have been proved as potential agents for chemoprevention and therapy of breast cancer. Ginsenosides from ginseng, which mostly belong to dammarane-type triterpenoids, have gained great attention for their anti-breast cancer activity with diverse mechanisms...

Family history and risk of ductal carcinoma in situ and triple negative breast cancer in a Han Chinese population: a case–control study

Background The association between family history and risk of triple negative breast cancer and ductal carcinoma in situ (DCIS) has not been well investigated, especially in Asian populations. We investigated the association between family history and risk of DCIS or triple negative breast cancer in a Han Chinese population. Methods A case–control study, comprising 926 breast...

Fatty Acid Binding Proteins FABP9 and FABP10 Participate in Antibacterial Responses in Chinese Mitten Crab, Eriocheir sinensis

Invertebrates rely solely on the innate immune system for defense against pathogens and other stimuli. Fatty acid binding proteins (FABP), members of the lipid binding proteins superfamily, play a crucial role in fatty acid transport and lipid metabolism and are also involved in gene expression induced by fatty acids. In the vertebrate immune system, FABP is involved in...

Cellular immunotherapy using irradiated lung cancer cell vaccine co-expressing GM-CSF and IL-18 can induce significant antitumor effects

Hongwei Tian 0 Gang Shi 0 Guoyou Yang Junfeng Zhang Yiming Li Tao Du Jianzhou Wang Fen Xu Lin Cheng Xiaomei Zhang Lei Dai Xiaolei Chen Shuang Zhang Yang Yang Dechao Yu Yuquan Wei Hongxin Deng 0

Chemokine CXCL14 is associated with prognosis in patients with colorectal carcinoma after curative resection

Background The chemokine CXCL14 has been reported to play an important role in the progression of many malignancies such as breast cancer and papillary thyroid carcinoma, but the role of CXCL14 in colorectal carcinoma (CRC) remains to be established. The purpose of this study was to investigate the expression pattern and significance of CXCL14 in CRC progression. Method 265...

HIV-1 Tat Promotes Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) vIL-6-Induced Angiogenesis and Tumorigenesis by Regulating PI3K/PTEN/AKT/GSK-3β Signaling Pathway

Kaposi’s sarcoma (KS)-associated herpesvirus (KSHV) is etiologically associated with KS, the most common AIDS-related malignancy. KS is characterized by vast angiogenesis and hyperproliferative spindle cells. We have previously reported that HIV-1 Tat can trigger KSHV reactivation and accelerate Kaposin A-induced tumorigenesis. Here, we explored Tat promotion of KSHV vIL-6...

Connectivity Features for Identifying Cognitive Impairment in Presymptomatic Carotid Stenosis

Severe asymptomatic stenosis of the internal carotid artery (ICA) leads to increased incidence of mild cognitive impairment (MCI) likely through silent embolic infarcts and/or chronic hypoperfusion, but the brain dysfunction is poorly understood and difficult to diagnose. Thirty cognitively intact subjects with asymptomatic, severe (≧70%), unilateral stenosis of the ICA were...