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Association Between Genetic Variants on Chromosome 15q25 Locus and Objective Measures of Tobacco Exposure

George R. Uhl Paolo Vineis Sandosh Padmanabhan Barbara J. Jefferis Antoinette Amuzu Elio Riboli Mark N. Upton Paul Aveyard Shah Ebrahim Aroon D. Hingorani Graham Watt Tom M. Palmer Nicholas J. Timpson EPIC

Evidence of gene–gene interactions in lung carcinogenesis in a large pooled analysis

To test the hypothesis of interaction among genetic variants in increasing the individual risk of cancer, we have studied the cumulative effect on lung cancer risk of variants in three metabolic genes, CYP1A1, GSTM1 and GSTT1, which are involved in the metabolism of the tobacco smoke constituents and environmental contaminants, polycyclic aromatic hydrocarbons and of other lung...

Lactase Persistence and Bitter Taste Response: Instrumental Variables and Mendelian Randomization in Epidemiologic Studies of Dietary Factors and Cancer Risk

Consumption of dairy products seems to increase the risk of cancer at several sites, while intake of cruciferous vegetables could have protective effects. However, these dietary intakes are subject to measurement error, and associations with cancer could be due to confounders. Mendelian randomization has been suggested as a way to overcome confounding by exploiting the random...

Intake of fruits and vegetables and polymorphisms in DNA repair genes in bladder cancer

The objective is to investigate the relationships between fruit and vegetable intake, DNA repair gene polymorphisms and the risk of bladder cancer. We have analyzed a hospital-based case–control study of 266 individuals with incident, histologically confirmed bladder cancer diagnosed between 1994 and 2003. Controls (n = 193) were patients treated for benign diseases recruited...

Plasma Alkylresorcinols, Biomarkers of Whole-Grain Wheat and Rye Intake, and Incidence of Colorectal Cancer

Background Few studies have investigated the association between whole-grain intake and colorectal cancer. Because whole-grain intake estimation might be prone to measurement errors, more objective measures (eg, biomarkers) could assist in investigating such associations.

Combined Impact of Lifestyle Factors on Prospective Change in Body Weight and Waist Circumference in Participants of the EPIC-PANACEA Study

Trichopoulou Domenico Palli Claudia Agnoli Rosario Tumino Paolo Vineis Salvatore Panico H. Bas Bueno-de-Mesquita Monique Verschuren Isabel Drake Emily Sonestedt Tonje Braaten Sabina Rinaldi Isabelle Romieu Nadia

Single-nucleotide polymorphisms (5p15.33, 15q25.1, 6p22.1, 6q27 and 7p15.3) and lung cancer survival in the European Prospective Investigation into Cancer and Nutrition (EPIC)

The single-nucleotide polymorphisms (SNPs) rs402710 (5p15.33), rs16969968 and rs8034191 (15q25.1) have been consistently identified by genome-wide association studies (GWAS) as significant predictors of lung cancer risk, while rs4324798 (6p22.1) was previously found to influence survival time in small-cell lung cancer (SCLC) patients. Using the same population of one of the...

An Absolute Risk Model to Identify Individuals at Elevated Risk for Pancreatic Cancer in the General Population

Den Eeden Paolo Vineis Jarmo Virtamo Jean Wactawski-Wende Brian M. Wolpin Herbert Yu Kai Yu Anne Zeleniuch-Jacquotte Stephen J. Chanock Robert N. Hoover Patricia Hartge Peter Kraft - Purpose: We

Randomized controlled trial: effects of diet on DNA damage in heavy smokers

Armelle Munnia 0 Monica Bianchini 6 Giovanni Allegro 5 Giuseppe Matullo 4 Carlotta Sacerdote 6 Paolo Vineis 3 4 0 Cancer Risk Factor Branch, Molecular Biology Laboratory, CSPO-Scientific Institute of

DNA adducts and cancer risk in prospective studies: a pooled analysis and a meta-analysis

Bulky DNA adducts are biomarkers of exposure to aromatic compounds and of the ability of the individual to metabolically activate carcinogens and to repair DNA damage. Their ability to predict cancer onset is uncertain. We have performed a pooled analysis of three prospective studies on cancer risk in which bulky DNA adducts have been measured in blood samples collected from...

Social Inequalities and Mortality in Europe – Results from a Large Multi-National Cohort

P. Peeters Sophia Zackrisson Martin Almquist Sture Eriksson Go ran Hallmans Guri Skeie Tonje Braaten Eiliv Lund Anne-Kathrin Illner Traci Mouw Elio Riboli Paolo Vineis Background: Socio-economic

Sources of Pre-Analytical Variations in Yield of DNA Extracted from Blood Samples: Analysis of 50,000 DNA Samples in EPIC

EPIC Elodie Caboux Christophe Lallemand Gilles Ferro Bertrand He mon Maimuna Mendy Carine Biessy Matt Sims Nick Wareham Abigail Britten Anne Boland Amy Hutchinson Afshan Siddiq Paolo Vineis Elio Riboli

Prediagnostic concentrations of plasma genistein and prostate cancer risk in 1,605 men with prostate cancer and 1,697 matched control participants in EPIC

Purpose Data from prospective epidemiological studies in Asian populations and from experimental studies in animals and cell lines suggest a possible protective association between dietary isoflavones and the development of prostate cancer. We examined the association between circulating concentrations of genistein and prostate cancer risk in a case–control study nested in the...

Total and high-molecular weight adiponectin and risk of colorectal cancer: the European Prospective Investigation into Cancer and Nutrition Study

Mattiello Calogero Saieva Paolo Vineis Rosario Tumino Petra H.Peeters Marcial Argu elles Catalina Bonet Mara-Jose Sa nchez Miren Dorronsoro Jose-Mara Huerta Aurelio Barricarte Richard Palmqvist Go ran

Genome-wide interaction study of smoking and bladder cancer risk

Bladder cancer is a complex disease with known environmental and genetic risk factors. We performed a genome-wide interaction study (GWAS) of smoking and bladder cancer risk based on primary scan data from 3002 cases and 4411 controls from the National Cancer Institute Bladder Cancer GWAS. Alternative methods were used to evaluate both additive and multiplicative interactions...

Adiposity, hormone replacement therapy use and breast cancer risk by age and hormone receptor status: a large prospective cohort study

Birgit Teucher 0 Heiner Boeing Krasimira Aleksandrova Antonia Trichopoulou Pagona Lagiou Dimitrios Trichopoulos Domenico Palli Sabina Sieri Salvatore Panico Rosario Tumino Paolo Vineis Jos Ramn Quirs

Biomarkers of Oxidative Stress and Risk of Developing Colorectal Cancer: A Cohort-nested Case-Control Study in the European Prospective Investigation Into Cancer and Nutrition

London, London, United Kingdom (Paolo Vineis); HuGeF Foundation, Turin, Italy (Paolo Vineis); Department of Clinical and Experimental Medicine, Faculty of Medicine, Federico II University, Naples, Italy

Genetic variation in alcohol dehydrogenase (ADH1A, ADH1B, ADH1C, ADH7) and aldehyde dehydrogenase (ALDH2), alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Studies that have examined the association between alcohol consumption and gastric cancer (GC) risk have been inconsistent. We conducted an investigation of 29 genetic variants in alcohol metabolism loci (alcohol dehydrogenase, ADH1 gene cluster: ADH1A, ADH1B and ADH1C; ADH7 and aldehyde dehydrogenase, ALDH2), alcohol intake and GC risk. We analyzed data from a nested case...

Birth Order and Risk of Non-Hodgkin Lymphoma—True Association or Bias?

There is inconsistent evidence that increasing birth order may be associated with risk of non-Hodgkin lymphoma (NHL). The authors examined the association between birth order and related variables and NHL risk in a pooled analysis (1983–2005) of 13,535 cases and 16,427 controls from 18 case-control studies within the International Lymphoma Epidemiology Consortium (InterLymph...

White blood cell DNA adducts and fruit and vegetable consumption in bladder cancer

The `Mediterranean diet', a diet rich in cereals, fruit and vegetables, has been associated with lowering the risk of a variety of cancers of the digestive tract and the bladder. In a previous study, we showed that the high phenolic content these dietary components produce in the urine could be associated with higher antimutagenic properties of the urine and lower arylamine–DNA...