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Inhibitory effect of magnetic Fe3O4 nanoparticles coloaded with homoharringtonine on human leukemia cells in vivo and in vitro

Wang,1–3 Lijun Wen,1–3 Qian Wang,1–3 Ning Gu,4,5 Suning Chen1–3 1Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, 2Key Laboratory of Thrombosis and Hemostasis

Association of Genotyping of Bacillus cereus with Clinical Features of Post-Traumatic Endophthalmitis

Bacillus cereus is the second most frequent cause of post-traumatic bacterial endophthalmitis. Although genotyping of B. cereus associated with gastrointestinal infections has been reported, little is known about the B. cereus clinical isolates associated with post-traumatic endophthalmitis. This is largely due to the limited number of clinical strains available isolated from...

A positive feedback loop involving the Wnt/β-catenin/MYC/Sox2 axis defines a highly tumorigenic cell subpopulation in ALK-positive anaplastic large cell lymphoma

Background We have previously described the existence of two phenotypically distinct cell subsets in ALK-positive anaplastic large cell lymphoma (ALK + ALCL) based on their differential responsiveness to a Sox2 reporter (SRR2), with reporter-responsive (RR) cells being more tumorigenic and chemoresistant than reporter-unresponsive (RU) cells. However, the regulator(s) of RU/RR...

Dietary Restriction Affects Neuronal Response Property and GABA Synthesis in the Primary Visual Cortex

Previous studies have reported inconsistent effects of dietary restriction (DR) on cortical inhibition. To clarify this issue, we examined the response properties of neurons in the primary visual cortex (V1) of DR and control groups of cats using in vivo extracellular single-unit recording techniques, and assessed the synthesis of inhibitory neurotransmitter GABA in the V1 of...

eHUGS: Enhanced Hierarchical Unbiased Graph Shrinkage for Efficient Groupwise Registration

Effective and efficient spatial normalization of a large population of brain images is critical for many clinical and research studies, but it is technically very challenging. A commonly used approach is to choose a certain image as the template and then align all other images in the population to this template by applying pairwise registration. To avoid the potential bias...

A retrospective analysis of eleven cases of invasive rhino-orbito-cerebral mucormycosis presented with orbital apex syndrome initially

Background Rhino-orbito-cerebral mucormycosis(ROCM) is an invasive fungal infection that usually occurs in immunocompromised patients and sometimes presents as orbital apex syndrome(OAS) initially. It is rapidly fatal without an early diagnosis and treatment. We report the cases of invasive ROCM presenting with OAS initially in order to raise the attention of clinicians. Methods...

Review on Application of Control Algorithms to Power Regulations of Reactor Cores

This research is to solve the stability analysis issue of nonlinear pressurized water reactor cores. On the basis of modeling a nonlinear pressurized water reactor core using the lumped parameter method, its linearized model is achieved via the small perturbation linearization way. Linearized models of the nonlinear core at six power levels are selected as local models of this...

Cadmium Induces Apoptosis in Freshwater Crab Sinopotamon henanense through Activating Calcium Signal Transduction Pathway

Calcium ion (Ca2+) is one of the key intracellular signals, which is implicated in the regulation of cell functions such as impregnation, cell proliferation, differentiation and death. Cadmium (Cd) is a toxic environmental pollutant that can disturb cell functions and even lead to cell death. Recently, we have found that Cd induced apoptosis in gill cells of the freshwater crab...

The epidemic characteristics of short stature in school students

Yang participated in data analysis and performed the data acquisition. Qian Wang conceived of the study, and participated in its design and coordination and helped to draft the manuscript. All authors

Dermatomyositis and Polymyositis in the Intensive Care Unit: A Single-Center Retrospective Cohort Study of 102 Patients

Introduction Patients with idiopathic inflammatory myopathies (IIMs) are sometimes complicated with life-threatening conditions requiring intensive care unit (ICU) admission. In the past, owing to the low incidence of IIM, little was known about such patients. Our aim was to investigate the clinical features and outcomes of these patients and identify their risk factors for...

Janus colloidal copolymers

We propose a new type of nanocomposite that we call Janus colloidal copolymers (JCCPs). JCCPs have two different polymers conjugated on opposite sides of a nanosized colloid. Janus clusters of copolymer PS-b-PAA (where PS is polystyrene and PAA is poly(acrylic acid)) are self-organized within confined mesoporous silica channels onto the surface of iron oxide (Fe3O4) core...

Human amniotic epithelial cells inhibit granulosa cell apoptosis induced by chemotherapy and restore the fertility

Introduction Premature ovarian failure and insufficiency are significant long-term side-effects of chemotherapy for female cancer patients. Recently, stem cell transplantation has been identified as a promising treatment for premature ovarian failure and insufficiency. We have previously demonstrated that human amniotic epithelial cells (hAECs) migrate into injured tissue and...

Use of Pulmonary Artery Catheter in Coronary Artery Bypass Graft. Costs and Long-Term Outcomes

Background Pulmonary artery catheters (PAC) are used widely to monitor hemodynamics in patients undergoing coronary bypass graft (CABG) surgery. However, recent studies have raised concerns regarding both the effectiveness and safety of PAC. Therefore, our aim was to determine the effects of the use of PAC on the short- and long-term health and economic outcomes of patients...

Amine/acid composite Janus nanosheets

Janus materials have witnessed fast development due to their diversified promising performances and practical applications. Compared with their spherical counterparts, Janus nanosheets have gained more concerns for their highly anisotropic shape besides chemistry. Herein, 3.5 nm ultrathin and flexible Janus nanosheets with carboxyl group terminated onto one side are fabricated by...

Genetic linkage of hyperglycemia and dyslipidemia in an intercross between BALB/cJ and SM/J Apoe-deficient mouse strains

Background Individuals with dyslipidemia often develop type 2 diabetes, and diabetic patients often have dyslipidemia. It remains to be determined whether there are genetic connections between the 2 disorders. Methods A female F 2 cohort, generated from BALB/cJ (BALB) and SM/J (SM) Apoe-deficient (Apoe −/− ) strains, was started on a Western diet at 6 weeks of age and maintained...

Morphology Control for Al2O3 Inclusion Without Ca Treatment in High-Aluminum Steel

Nozzle blockage is a major problem during continuous casting of Al-containing steel. Herein, we analyzed the thermodynamic equilibrium behavior between aluminum and oxygen in steel at 1873 K (1600 °C) and demonstrated that, the dissolved [O] initially decreases with increasing the dissolved [Al] until approximately 0.1 wt pct [Al], and after that, the dissolved [O] increases with...

A transcriptome profile in hepatocellular carcinomas based on integrated analysis of microarray studies

Background Despite new treatment options for hepatocellular carcinomas (HCC) recently, 5-year survival remains poor, ranging from 50 to 70%, which may attribute to the lack of early diagnostic biomarkers. Thus, developing new biomarkers for early diagnosis of HCC, is extremely urgent, aiming to decrease HCC-related deaths. Methods In the study, we conducted a comprehensive...

Re-Identification Risk versus Data Utility for Aggregated Mobility Research Using Mobile Phone Location Data

Mobile phone location data is a newly emerging data source of great potential to support human mobility research. However, recent studies have indicated that many users can be easily re-identified based on their unique activity patterns. Privacy protection procedures will usually change the original data and cause a loss of data utility for analysis purposes. Therefore, the need...

Role of Dectin-1 in the innate immune response of rat corneal epithelial cells to Aspergillus fumigatus

Background To observe Dectin-1 expression in fungal keratitis on rat models and to determine the role of Dectin-1 in innate immune response to Aspergillus fumigatus. Methods Wistar rats were randomly divided into control, fungal keratitis and pretreatment (pretreated with Laminarin) groups. Samples were used for conducting immunohistochemical staining and real-time PCR to observe...

Spatiotemporal hierarchy in antibody recognition against transmitted HIV-1 envelope glycoprotein during natural infection

Background Majority of HIV-1 infection is established by one transmitted/founder virus and understanding how the neutralizing antibodies develop against this virus is critical for our rational design an HIV-1 vaccine. Results We report here antibody profiling of sequential plasma samples against transmitted/founder HIV-1 envelope glycoprotein in an epidemiologically linked...