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Cerebrospinal fluid is drained primarily via the spinal canal and olfactory route in young and aged spontaneously hypertensive rats

Background Many aspects of CSF dynamics are poorly understood due to the difficulties involved in quantification and visualization. In particular, there is debate surrounding the route of CSF drainage. Our aim was to quantify CSF flow, volume, and drainage route dynamics in vivo in young and aged spontaneously hypertensive rats (SHR) using a novel contrast-enhanced computed...

Tongxinluo Protects against Pressure Overload–Induced Heart Failure in Mice Involving VEGF/Akt/eNOS Pathway Activation

Background It has been demonstrated that Tongxinluo (TXL), a traditional Chinese medicine compound, improves ischemic heart disease in animal models via vascular endothelial growth factor (VEGF) and endothelial nitric oxide synthase (eNOS). The present study aimed to investigate whether TXL protects against pressure overload–induced heart failure in mice and explore the possible...

F-Spondin Deficient Mice Have a High Bone Mass Phenotype

F-spondin is a pericellular matrix protein upregulated in developing growth plate cartilage and articular cartilage during osteoarthritis. To address its function in bone and cartilage in vivo, we generated mice that were deficient for the F-spondin gene, Spon1. Spon1−/− mice were viable and developed normally to adulthood with no major skeletal abnormalities. At 6 months, femurs...

Expression of COX-2, CD44v6 and CD147 and Relationship with Invasion and Lymph Node Metastasis in Hypopharyngeal Squamous Cell Carcinoma

To assess the expression of COX-2,CD44v6 and CD147 in hypopharyngeal squamous cell carcinomas and the three biomarkers correlation with tumor invasion and lymph node metastasis of Chinese people. 101 cases of surgically excised primary tumor were included in this study, and 40 tissues of epithelium adjacent to carcinoma were used as controls. We characterized the...

Identification of MiRNA from Eggplant (Solanum melongena L.) by Small RNA Deep Sequencing and Their Response to Verticillium dahliae Infection

Zhang 0 Min Chen 0 Qing Yang 0 Boris Alexander Vinatzer, Virginia Tech, United States of America 0 College of Life Sciences, Nanjing Agricultural University , Nanjing , P.R. China MiRNAs are a class of

Depth-image-based rendering with spatial and temporal texture synthesis for 3DTV

A depth-image-based rendering (DIBR) method with spatial and temporal texture synthesis is presented in this article. Theoretically, the DIBR algorithm can be used to generate arbitrary virtual views of the same scene in a three-dimensional television system. But the disoccluded area, which is occluded in the original views and becomes visible in the virtual views, makes it very...

Some properties of meromorphically multivalent functions

By using the method of differential subordinations, we derive certain properties of meromorphically multivalent functions. 2010 Mathematics Subject Classification: 30C45; 30C55.

T1 Relaxation Rate (R1) Indicates Nonlinear Mn Accumulation in Brain Tissue of Welders With Low-Level Exposure

Although the essential element manganese (Mn) is neurotoxic at high doses, the effects of lower exposure are unclear. MRI T1-weighted (TIW) imaging has been used to estimate brain Mn exposure via the pallidal index (PI), defined as the T1W intensity ratio in the globus pallidus (GP) versus frontal white matter (FWM). PI may not, however, be sensitive to Mn in GP because Mn also...

Relationships between the West Asian subtropical westerly jet and summer precipitation in northern Xinjiang

The relation between the spatial and temporal variations of the West Asian subtropical westerly jet (WASWJ) and the summer precipitation in northern Xinjiang has been explored using the NCEP/NCAR reanalysis data and the summer precipitation data at 43 stations in northern Xinjiang during 1961 to 2007. Results show that the position of the WASWJ is more important than its strength...

Are quit attempts among U.S. female nurses who smoke different from female smokers in the general population? An analysis of the 2006/2007 tobacco use supplement to the current population survey

Background Smoking is a significant women's health issue. Examining smoking behaviors among occupational groups with a high prevalence of women may reveal the culture of smoking behavior and quit efforts of female smokers. The purpose of this study was to examine how smoking and quitting characteristics (i.e., ever and recent quit attempts) among females in the occupation of...

Systematic characterization of small RNAome during zebrafish early developmental stages

Background During early vertebrate development, various small non-coding RNAs (sRNAs) such as MicroRNAs (miRNAs) and Piwi-interacting RNAs (piRNAs) are dynamically expressed for orchestrating the maternal-to-zygotic transition (MZT). Systematic analysis of expression profiles of zebrafish small RNAome will be greatly helpful for understanding the sRNA regulation during embryonic...

CPLM: a database of protein lysine modifications

We reported an integrated database of Compendium of Protein Lysine Modifications (CPLM; http://cplm.biocuckoo.org) for protein lysine modifications (PLMs), which occur at active ε-amino groups of specific lysine residues in proteins and are critical for orchestrating various biological processes. The CPLM database was updated from our previously developed database of Compendium...

Inhibition of LDHA suppresses tumor progression in prostate cancer

A key hallmark of cancer cells is their altered metabolism, known as Warburg effect. Lactate dehydrogenase A (LDHA) executes the final step of aerobic glycolysis and has been reported to be involved in the tumor progression. However, the function of LDHA in prostate cancer has not been studied. In current study, we observed overexpression of LDHA in the clinical prostate cancer...

RETRACTED ARTICLE: Gene-gene interaction network analysis of ovarian cancer using TCGA data

Bin Yuan 2 Qing Yang 0 0 Department of Gynecology and Obstetrics, Shengjing Hospital of China Medical University , No.36, Sanhao Street, Heping District, Shenyang, Liaoning Province 110004 , China 1

Differential Modulation by IL-17A of Cholangitis versus Colitis in IL-2Rα Deleted Mice

IFN-γ is a signature Th1 cell associated cytokine critical for the inflammatory response in autoimmunity with both pro-inflammatory and potentially protective functions. IL-17A is the hallmark of T helper 17 (Th17) cell subsets, produced by γδT, CD8+ T, NK and NKT cells. We have taken advantage of our colony of IL-2Rα−/− mice that spontaneously develop both autoimmune cholangitis...

Identification of a novel mutation in a Chinese family with Nance-Horan syndrome by whole exome sequencing

the present study. Compliance with ethics guidelines Nan HONG, Yan-hua CHEN, Chen XIE, Bai-sheng XU, Hui HUANG, Xin LI, Yue-qing YANG, Ying-ping HUANG, Jian-lian DENG, Ming QI, and Yang-shun GU declare

Plesiomonas shigelloides Infection in Southeast China

Background Plesiomonas shigelloides can cause gastroenteritis and extra-intestinal diseases in humans. However, the prevalence of P. shigelloides infections has not been investigated in China. Methods Consecutive fecal specimens from outpatients with acute diarrhea and non-diarrheal patients at nine sentinel hospitals in southeast China were collected from March 2010 to May 2012...

Genetic Heterogeneity of the β-Globin Gene in Various Geographic Populations of Yunnan in Southwestern China

Objectives The aim of this study was to investigate the geographic distribution of β-globin gene mutations in different ethnic groups in Yunnan province. Methods From 2004 to 2014, 1,441 subjects with hemoglobin disorders, identified by PCR-reverse dot blot and DNA sequencing, were studied according to ethnicity and geographic origin. Haplotypes were examined among 41 unrelated...

Fast access and early ligation of the renal pedicle significantly facilitates retroperitoneal laparoscopic radical nephrectomy procedures: modified laparoscopic radical nephrectomy

radical nephrectomy Qing Yang 0 Jun Du 0 Zhi-Hua Zhao Xu-Sheng Chen Lei Zhou Xin Yao 0 Equal contributors Department of Genitourinary Oncology, Tianjin Medical University Cancer Institute and Hospital