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180 papers found.
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Blockade of Hedgehog Signaling Synergistically Increases Sensitivity to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non-Small-Cell Lung Cancer Cell Lines

Aberrant activation of the hedgehog (Hh) signaling pathway has been implicated in the epithelial-to-mesenchymal transition (EMT) and cancer stem-like cell (CSC) maintenance; both processes can result in tumor progression and treatment resistance in several types of human cancer. Hh cooperates with the epidermal growth factor receptor (EGFR) signaling pathway in embryogenesis. We...

Quantum secure direct communication against the collective noise with polarization-entangled Bell states

We propose a quantum secure direct communication protocol via a collective noise channel, exploiting polarization-entangled Bell states and the nondemolition parity analysis based on weak cross-Kerr nonlinearities. The participant Bob, who will receive the secret information, sends one of two photons in a polarization-entangled Bell state exploiting the transmission circuit...

Quantum secure direct communication against the collective noise with polarization-entangled Bell states

We propose a quantum secure direct communication protocol via a collective noise channel, exploiting polarization-entangled Bell states and the nondemolition parity analysis based on weak cross-Kerr nonlinearities. The participant Bob, who will receive the secret information, sends one of two photons in a polarization-entangled Bell state exploiting the transmission circuit...

Significant Association of Glutathione S-Transferase T1 Null Genotype with Prostate Cancer Risk: A Meta-Analysis of 26,393 Subjects

Subjects Qing Yang 0 Jun Du 0 Xin Yao 0 Georgina L. Hold, University of Aberdeen, United Kingdom 0 Department of Genitourinary Oncology, Tianjin Medical University Cancer Hospital, Key Laboratory of Cancer

A Sperm–Plasma β-N-Acetyl-D-Hexosaminidase Interacting with a Chitinolytic β-N-Acetyl-D-Hexosaminidase in Insect Molting Fluid

Insects require molting fluids to shed the old cuticle during molting. β-N-acetyl-D-hexosaminidase, known as Hex1, together with various chitinases, is responsible for degrading the chitin component of the old cuticle. This study showed that another β-N-acetyl-D-hexosaminidase, termed OfHex3, interacted with Hex1 and functioned in the molting fluid, although the homolog of OfHex3...

Reduced cortical thickness in right Heschl’s gyrus associated with auditory verbal hallucinations severity in first-episode schizophrenia

Weidan Pu Yinnan Song Tumbwene E. Mwansisya 0 Qing Yang Haihong Liu Zhening Liu 0 Baoci Shan Zhimin Xue 0 0 Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental

Promoter hypomethylation, especially around the E26 transformation-specific motif, and increased expression of poly (ADP-ribose) polymerase 1 in BRCA-mutated serous ovarian cancer

Background Poly (ADP-ribose) polymerase 1 (PARP1) overexpression plays a critical role in ovarian cancer progression and the clinical development of PARP1 inhibitors to treat BRCA-mutated ovarian cancer has advanced rapidly. However, the mechanism regulating PARP1 expression remains unknown. Alterations in gene expression mediated by promoter methylation are being increasingly...

Complete Mitochondrial Genome of Eruca sativa Mill. (Garden Rocket)

Eruca sativa (Cruciferae family) is an ancient crop of great economic and agronomic importance. Here, the complete mitochondrial genome of Eruca sativa was sequenced and annotated. The circular molecule is 247 696 bp long, with a G+C content of 45.07%, containing 33 protein-coding genes, three rRNA genes, and 18 tRNA genes. The Eruca sativa mitochondrial genome may be divided...

Biofortification of rice with the essential amino acid lysine: molecular characterization, nutritional evaluation, and field performance

Rice (Oryza sativa L.), a major staple crop worldwide, has limited levels of the essential amino acid lysine. We previously produced engineered rice with increased lysine content by expressing bacterial aspartate kinase and dihydrodipicolinate synthase and inhibiting rice lysine ketoglutarate reductase/saccharopine dehydrogenase activity. However, the grain quality, field...

Mathematical Model and Analysis of Negative Skin Friction of Pile Group in Consolidating Soil

In order to calculate negative skin friction (NSF) of pile group embedded in a consolidating soil, the dragload calculating formulas of single pile were established by considering Davis one-dimensional nonlinear consolidation soils settlement and hyperbolic load-transfer of pile-soil interface. Based on effective influence area theory, a simple semiempirical mathematical model of...

Serum Dickkopf-1 expression level positively correlates with a poor prognosis in breast cancer

Background The different expression level of Dickkopf-1 (DKK-1) in different cancers shows that the function of DKK-1 depends on the histological type of the cancer cells and the tissue microenvironment. To our knowledge, the serum expression level of DKK-1 in breast cancer is little known. Methods Blood samples from 125 consecutive patients diagnosed with breast cancer and 53...

Biological Values of Acupuncture and Chinese Herbal Medicine: Impact on the Life Science

Grove, QLD 4059, Australia Received 19 November 2013; Accepted 19 November 2013; Published 12 January 2014 Copyright © 2014 Yong-Qing Yang et al. This is an open access article distributed under the ... and Dr. Yu-Dong Xu for their excellent secretary assistance for the special issue. Yong-Qing Yang Chen Yan Chris J. Branford-White Xiang-Yu Hou References F. Cheung, “TCM: made in China,” Nature

Depth-image-based rendering with spatial and temporal texture synthesis for 3DTV

A depth-image-based rendering (DIBR) method with spatial and temporal texture synthesis is presented in this article. Theoretically, the DIBR algorithm can be used to generate arbitrary virtual views of the same scene in a three-dimensional television system. But the disoccluded area, which is occluded in the original views and becomes visible in the virtual views, makes it very...

Regulation of angiotensin II type 1 receptor expression in ovarian cancer: a potential role for BRCA1

Background Both BRCA1 and angiotensin II type 1 receptor (AGTR1) play a critical role in ovarian cancer progression. However, the crosstalk between BRCA1 and AGTR1 signaling pathways remains largely unknown. Methods BRCA1 promoter methylation was analyzed by bisulfite sequence using primers focused on the core promoter region. Expression levels of BRCA1 and AGTR1 were assessed by...

Vergence and Standing Balance in Subjects with Idiopathic Bilateral Loss of Vestibular Function

There is a natural symbiosis between vergence and vestibular responses. Deficits in vergence can lead to vertigo, disequilibrium, and postural instability. This study examines both vergence eye movements in patients with idiopathic bilateral vestibular loss, and their standing balance in relation to vergence. Eleven patients participated in the study and 16 controls. Bilateral...

Screening of feature genes of the ovarian cancer epithelia with DNA microarray

Objective We aimed to screen differentially expressed genes (DEGs) of ovarian surface epithelia in order to provide beneficial help for early diagnosis and treatment of ovarian cancer with DNA microarrays. Methods We extracted the microarray expression profile GSE14407 from Gene Expression Omnibus database which conducted gene expression profiling analysis of 12 ovarian surface...

Two Distinct Calmodulin Binding Sites in the Third Intracellular Loop and Carboxyl Tail of Angiotensin II (AT1A) Receptor

supported by the National Institutes of Health (DK63252 to Qing Yang, www2.niddk.nih.gov) and the Tang Aoqing professor award of Jilin University to Qing Yang. The funders had no role in study design, data

Association of Serum Uric Acid and Coronary Artery Disease in Premenopausal Women

Objective To date, no study in the published literature has investigated the role of various serum uric acid (SUA) concentrations in the development of angiographically-proven coronary artery disease (CAD) in premenopausal women. Therefore, the aim of this study was to investigate the role SUA levels may play in the prevalence, severity, and prognosis of CAD in premenopausal...

Distinct Control of Initiation and Metrics of Memory-Guided Saccades and Vergence by the FEF: A TMS Study

Background The initiation of memory guided saccades is known to be controlled by the frontal eye field (FEF). Recent physiological studies showed the existence of an area close to FEF that controls also vergence initiation and execution. This study is to explore the effect of transcranial magnetic simulation (TMS) over FEF on the control of memory-guided saccade-vergence eye...