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A transcription network of interlocking positive feedback loops maintains intracellular iron balance in archaea

Iron is required for key metabolic processes but is toxic in excess. This circumstance forces organisms across the tree of life to tightly regulate iron homeostasis. In hypersaline lakes dominated by archaeal species, iron levels are extremely low and subject to environmental change; however, mechanisms regulating iron homeostasis in archaea remain unclear. In previous work, we...

Entrevista a Edgardo Rodríguez Juliá

Entrevista al escritor puertorriqueño Edgardo Rodríguez Juliá, autor de La renuncia del héroe Baltasar (1974) y otras novelas y galardonado con premios como el “Premio Bolívar Pagán” del Instituto de Literatura de Puerto Rico y la beca “Guggenheim de Literatura”.En la entrevista cuenta el efecto que tiene la tecnología en la literatura y sus experiencias como escritor y profesor...

An optimization design proposal of automated guided vehicles for mixed type transportation in hospital environments

Aim The aim of this paper is to present an optimization proposal in the automated guided vehicles design used in hospital logistics, as well as to analyze the impact of its implementation in a real environment. Method This proposal is based on the design of those elements that would allow the vehicles to deliver an extra cart by the towing method. So, the proposal intention is to...

Weight Management in Patients with Type 1 Diabetes and Obesity

surgeries are valid methods for weight management in patients with T1D. Compliance with Ethical Standards Conflict of Interest Adham Mottalib, Megan Kasetty, Jessica Y. Mar, Taha Elseaidy, and Sahar

BMP type II receptor as a therapeutic target in pulmonary arterial hypertension

cell; Signal transduction; Inflammation; Vascular remodeling and autophagy - Mar Orriols and Maria Catalina Gomez-Puerto the authors have contributed equally to this work. RV SMC TGF-β TNFα Pulmonary

A user-friendly tool to evaluate the effectiveness of no-take marine reserves

Conceptualization: Juan Carlos Villaseñor-Derbez, Caio Faro, Melaina Wright, Jael MartÂõnez, Sean Fitzgerald, Stuart Fulton, Maria del Mar Mancha-Cisneros, Gavin McDonald, Fiorenza Micheli, Alvin SuaÂrez, Jorge Torre ... : Juan Carlos Villaseñor-Derbez, Caio Faro, Melaina Wright, Jael MartÂõnez, Christopher Costello. Methodology: Juan Carlos Villaseñor-Derbez, Caio Faro, Melaina Wright, Jael MartÂõnez, Maria del Mar

Die Migrantin retten!?

. Gender trouble: Feminism and the Subversion of Identity . London: Routledge. Butler , Judith. 2004 . Precarious Life: The Powers of Mourning and Violence . London: Verso. Castro Varela , María do Mar, und ... Nikita Dhawan . 2015 . Postkoloniale Theorie . Eine kritische Einführung , 2. Aufl ., Bielefeld: transcript. Castro Varela , María do Mar . 2005 . Integrationsregime und Gouvernementalität

Treatment of Soft Tissue Filler Complications: Expert Consensus Recommendations

Background Dermal fillers have been increasingly used in minimally invasive facial esthetic procedures. This widespread use has led to a rise in reports of associated complications. The aim of this expert consensus report is to describe potential adverse events associated with dermal fillers and to provide guidance on their treatment and avoidance. Methods A multidisciplinary...

SlowMo, a digital therapy targeting reasoning in paranoia, versus treatment as usual in the treatment of people who fear harm from others: study protocol for a randomised controlled trial

Paranoia is one of the most common symptoms of schizophrenia-spectrum disorders, and is associated with significant distress and disruption to the person’s life. Developing more effective and accessible psychological interventions for paranoia is a clinical priority. Our research team has approached this challenge in two main ways: firstly, by adopting an interventionist causal...

Leveraging workflow control patterns in the domain of clinical practice guidelines

Background Clinical practice guidelines (CPGs) include recommendations describing appropriate care for the management of patients with a specific clinical condition. A number of representation languages have been developed to support executable CPGs, with associated authoring/editing tools. Even with tool assistance, authoring of CPG models is a labor-intensive task. We aim at...

Correction to: Influence of community-based natural resource management strategies in the resilience of social-ecological systems

The published online version contains mistake. Author name was incorrectly captured. Instead of Maria del Mar Delgado-Serrano was incorrectly captured as Ma del Mar Delgado-Serrano. Correct author

Guidelines for Biomarker of Food Intake Reviews (BFIRev): how to conduct an extensive literature search for biomarker of food intake discovery

Identification of new biomarkers of food and nutrient intake has developed fast over the past two decades and could potentially provide important new tools for compliance monitoring and dietary intake assessment in nutrition and health science. In recent years, metabolomics has played an important role in identifying a large number of putative biomarkers of food intake (BFIs...

Trace element contents in toenails are related to regular physical activity in older adults

Conceptualization: Marcela Gonzalez-Gross, Josep A. Tur. Formal analysis: Maria del Mar Bibiloni. Funding acquisition: Antoni Pons. Investigation: Antoni Sureda, Maria del Mar Bibiloni, Alicia Julibert, Raquel ... Aparicio-Ugar riza, Gonzalo Palacios-Le BleÂ. Supervision: Josep A. Tur. Writing ± original draft: Antoni Sureda, Maria del Mar Bibiloni, Josep A. Tur. Writing ± review & editing: Antoni Sureda, Maria del

The structure of transcription termination factor Nrd1 reveals an original mode for GUAA recognition

Transcription termination of non-coding RNAs is regulated in yeast by a complex of three RNA binding proteins: Nrd1, Nab3 and Sen1. Nrd1 is central in this process by interacting with Rbp1 of RNA polymerase II, Trf4 of TRAMP and GUAA/G terminator sequences. We lack structural data for the last of these binding events. We determined the structures of Nrd1 RNA binding domain and...

A scheme for a flexible classification of dietary and health biomarkers

Manach 5 Lorraine Brennan 4 Lydia A. Afman 9 David S. Wishart 8 Cristina Andres-Lacueva 3 11 Mar Garcia-Aloy 3 11 Hans Verhagen 10 12 Edith J. M. Feskens 9 Lars O. Dragsted 0 0 Department of Nutrition

Screening for precancerous anal lesions with P16/Ki67 immunostaining in HIV-infected MSM

-Molina. Data curation: Sergio Serrano-Villar, Beatriz HernaÂndez-Novoa, Jorge del Romero, Antonio Ocampo, Jose RamoÂn Blanco, Mar MasiaÂ, Elena Sendagorta, Gonzalo Sanz, Jose A. PeÂrezMolina. Formal

PREditOR: a synthetic biology approach to removing heterochromatin from cells

It is widely accepted that heterochromatin is necessary to maintain genomic stability. However, direct experimental evidence supporting this is slim. Previous studies using either enzyme inhibitors, gene knockout or knockdown studies all are subject to the caveat that drugs may have off-target effects and enzymes that modify chromatin proteins to support heterochromatin formation...

PREditOR: a synthetic biology approach to removing heterochromatin from cells

It is widely accepted that heterochromatin is necessary to maintain genomic stability. However, direct experimental evidence supporting this is slim. Previous studies using either enzyme inhibitors, gene knockout or knockdown studies all are subject to the caveat that drugs may have off-target effects and enzymes that modify chromatin proteins to support heterochromatin formation...

New Genes and Functional Innovation in Mammals

Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF) , Barcelona , Spain 1 Evolutionary Genomics Group, Research Programme in Biomedical Informatics, Hospital del Mar Research