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Myocyte membrane and microdomain modifications in diabetes: determinants of ischemic tolerance and cardioprotection

Cardiovascular disease, predominantly ischemic heart disease (IHD), is the leading cause of death in diabetes mellitus (DM). In addition to eliciting cardiomyopathy, DM induces a ‘wicked triumvirate’: (i) increasing the risk and incidence of IHD and myocardial ischemia; (ii) decreasing myocardial tolerance to ischemia–reperfusion (I–R) injury; and (iii) inhibiting or eliminating ...

New clues to the nature of immunoglobulin G4-related disease: a retrospective Japanese multicenter study of baseline clinical features of 334 cases

The aim was to further characterize immunoglobulin G4-related disease (IgG4-RD) by a large-scale multicenter study of its clinical and laboratory features conducted by multidisciplinary physicians of IgG4-RD in Japan. Various specialists retrospectively evaluated IgG4-RD patients diagnosed between 1996 and 2015 in five hospitals by analyzing their baseline clinical features, ...

Diagnostic value of 99mTc-ethambutol scintigraphy in tuberculosis: compared to microbiological and histopathological tests

Objective Tuberculosis (TB) still remains the world’s endemic infection. TB affects the lungs and any part of the body other than the lung. The diagnosis of TB has not changed much over the decades. Ethambutol is one of the first line treatments for TB. It can be labeled using 99mTc. 99mTc-ethambutol will be accumulated in the site of TB lesion and can be imaged using gamma camera. ...

Copy number variation arising from gene conversion on the human Y chromosome

We describe the variation in copy number of a ~ 10 kb region overlapping the long intergenic noncoding RNA (lincRNA) gene, TTTY22, within the IR3 inverted repeat on the short arm of the human Y chromosome, leading to individuals with 0–3 copies of this region in the general population. Variation of this CNV is common, with 266 individuals having 0 copies, 943 (including the ...

Effect of EMG-triggered neuromuscular electrical stimulation with bilateral arm training on hemiplegic shoulder pain and arm function after stroke: a randomized controlled trial

Hemiplegic shoulder pain is a frequent complication after stroke, leading to limited use of the affected arm. Neuromuscular electrical stimulation (NMES) and transcutaneous electrical nerve stimulation (TENS) are two widely used interventions to reduce pain, but the comparative efficacy of these two modalities remains uncertain. The purpose of this research was to compare the ...

Benefits of One-On-One Prescriptive Reading Tutoring to an Elementary Student

Many struggling readers at the elementary level benefit from additional tutoring to meet grade level standards. The purpose of this research is to evaluate the effectiveness of a one-on-one, prescriptive tutoring program designed to increase the reading abilities of an elementary student. This study seeks to identify the benefits of individualized tutoring to an elementary student ...

Effect of medium pH on chemical selectivity of oxalic acid biosynthesis by Aspergillus niger W78C in submerged batch cultures with sucrose as a carbon source

The pH of the medium is the key environmental parameter of chemical selectivity of oxalic acid biosynthesis by Aspergillus niger. The activity of the enzyme oxaloacetate hydrolase, which is responsible for decomposition of oxaloacetate to oxalate and acetate inside the cell of the fungus, is highest at pH 6. In the present study, the influence of pH in the range of 3–7 on oxalic ...

Minimally invasive esophagectomy: a propensity score-matched analysis of semiprone versus prone position

Background The preferred surgical approach for esophageal cancer is a minimally invasive transthoracic esophagectomy with a two-field lymph node dissection. The thoracoscopic phase may be performed either in prone- or in left lateral decubitus (LLD) position. Prone positioning has been associated with better pulmonary outcomes compared to LLD positioning; however, conversion to a ...

Manual physical balance assistance of therapists during gait training of stroke survivors: characteristics and predicting the timing

During gait training, physical therapists continuously supervise stroke survivors and provide physical support to their pelvis when they judge that the patient is unable to keep his balance. This paper is the first in providing quantitative data about the corrective forces that therapists use during gait training. It is assumed that changes in the acceleration of a patient’s COM ...

Genetic parameters and expected responses to selection for components of feed efficiency in a Duroc pig line

Improving feed efficiency ( $${\text{FE}}$$ FE ) is a key factor for any pig breeding company. Although this can be achieved by selection on an index of multi-trait best linear unbiased prediction of breeding values with optimal economic weights, considering deviations of feed intake from actual needs ( $${\text{RFI}}$$ RFI ) should be of value for further research on biological ...

The prognostic value of asymmetric dimethylarginine in patients with cardiac syndrome X

Background The pathophysiology of cardiac syndrome X is multifactorial and endothelial dysfunction has been implicated as important contributing factor. Asymmetric dimethylarginine (ADMA), characterized as a circulating endogenous inhibitor of nitric oxide synthase, may have been implicated as an important contributing factor for the development of endothelial dysfunction. In this ...

Doping für das Gehirn

Ebenso wie die Steigerung der körperlichen Leistungsfähigkeit stellt auch die mögliche Verbesserung neurokognitiver Fähigkeiten wie Konzentration, Aufmerksamkeit oder Gedächtnis eine interessante Option dar. Als pharmakologisches „neuroenhancement“ bezeichnet man den Ge- oder Missbrauch psychoaktiver, nicht verbotener oder verschreibungspflichtiger Substanzen durch Gesunde mit Ziel ...

Increased PKMζ activity impedes lateral movement of GluA2-containing AMPA receptors

Protein kinase M zeta (PKMζ), a constitutively active, atypical protein kinase C isoform, maintains a high level of expression in the brain after the induction of learning and long-term potentiation (LTP). Further, its overexpression enhances long-term memory and LTP. Thus, multiple lines of evidence suggest a significant role for persistently elevated PKMζ levels in long-term ...

Correction to: A Two-Layer Computational Model for Discrimination of Enhancer and Their Types Using Hybrid Features Space of Pseudo K-Tuple Nucleotide Composition

The original version of this article unfortunately contained a mistake. One character was missing in the title, which was therefore incorrectly given as “A Two-Layer Computational Model for Discrimination of Enhancer and Their Types Using Hybrid Features Pace of Pseudo K-Tuple Nucleotide Composition”.

A robust structured preconditioner for time-harmonic parabolic optimal control problems

We consider the iterative solution of optimal control problems constrained by the time-harmonic parabolic equations. Due to the time-harmonic property of the control equations, a suitable discretization of the corresponding optimality systems leads to a large complex linear system with special two-by-two block matrix of saddle point form. For this algebraic system, an efficient ...

Setting priorities for knowledge translation of Cochrane reviews for health equity: Evidence for Equity

A focus on equity in health can be seen in many global development goals and reports, research and international declarations. With the development of a relevant framework and methods, the Campbell and Cochrane Equity Methods Group has encouraged the application of an ‘equity lens’ to systematic reviews, and many organizations publish reviews intended to address health equity. The ...