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Corticolimbic Expression of TRPC4 and TRPC5 Channels in the Rodent Brain

The canonical transient receptor potential (TRPC) channels are a family of non-selective cation channels that are activated by increases in intracellular Ca2+ and Gq/phospholipase C-coupled receptors. We used quantitative real-time PCR, in situ hybridization, immunoblots and patch-clamp recording from several brain regions to examine the expression of the predominant TRPC channels ...

Use of β-Blockers and the Risk of Hip/Femur Fracture in the United Kingdom and The Netherlands

Data from in vivo studies have indicated a role for β-blockers in the prevention of bone loss. Some epidemiological studies have found protective effects of β-blockers on fracture risk. However, there is limited information on the association with cumulative dose and type of β-blockers used. We conducted two case-control studies using data from the UK General Practice Research ...

Groups of galaxies in AEGIS: the 200-ks Chandra extended X-ray source catalogue

We present the discovery of seven X-ray emitting groups of galaxies selected as extended X-ray sources in the 200-ks Chandra coverage of the All-wavelength Extended Groth Strip International Survey (AEGIS). In addition, we report on active galactic nucleus (AGN) activity associated with these systems. For the six extended sources which lie within the Deep Extragalactic Evolutionary ...

The DEEP2 Galaxy Redshift Survey: environments of post-starburst galaxies at z∼ 0.1 and ∼0.8

Post-starburst (also known as K+A) galaxies exhibit spectroscopic signatures indicating that their star formation was recently quenched; they are candidates for galaxies in transition from a star-forming phase to a passively evolving phase. We have spectroscopically identified large samples of post-starburst galaxies both in the Sloan Digital Sky Survey (SDSS) at z∼ 0.1 and in the ...

Host galaxy morphologies of X-ray selected AGN: assessing the significance of different black hole fuelling mechanisms to the accretion density of the Universe at z∼ 1.

We use morphological information of X-ray selected active galactic nuclei (AGN) hosts to set limits on the fraction of the accretion density of the Universe at z≈ 1 that is not likely to be associated with major mergers. Deep X-ray observations are combined with high-resolution optical data from the Hubble Space Telescope in the All-wavelength Extended Groth strip International ...

On the evolution of the velocity–mass–size relations of disc-dominated galaxies over the past 10 billion years

We study the evolution of the scaling relations between the maximum circular velocity, stellar mass and optical half-light radius of star-forming disc-dominated galaxies in the context of Λ cold dark matter-based galaxy formation models. Using data from the literature combined with new data from the Deep Extragalactic Evolutionary Probe 2 (DEEP2) and All-wavelength Extended Groth ...

Regulation of Hippocampal and Behavioral Excitability by Cyclin-Dependent Kinase 5

Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase that has been implicated in learning, synaptic plasticity, neurotransmission, and numerous neurological disorders. We previously showed that conditional loss of Cdk5 in adult mice enhanced hippocampal learning and plasticity via modulation of calpain-mediated N-methyl-D-aspartic acid receptor (NMDAR) ...

The DEEP2 Galaxy Redshift Survey: the red sequence AGN fraction and its environment and redshift dependence

We measure the dependence of the active galactic nuclei (AGN) fraction on local environment at z∼ 1, using spectroscopic data taken from the DEEP2 Galaxy Redshift Survey, and Chandra X-ray data from the All-Wavelength Extended Groth Strip International Survey (AEGIS). To provide a clean sample of AGN, we restrict our analysis to the red sequence population; this also reduces ...

Adverse Outcome Analyses of Observational Data: Assessing Cardiovascular Risk in HIV Disease

Clinical decisions are ideally based on randomized trials but must often rely on observational data analyses, which are less straightforward and more influenced by methodology. The authors, from a series of expert roundtables convened by the Forum for Collaborative HIV Research on the use of observational studies to assess cardiovascular disease risk in human immunodeficiency virus ...

Oxford SWIFT integral field spectrograph and multiwavelength observations of the Eagle galaxy at z= 0.77

Michael C. Cooper 8 Jeffrey A. Newman 13 Kevin Bundy 12 C. J. Conselice 7 A. M. Koekemoer 2 Lihwai Lin 3 Leonidas A. Moustakas 4 Tao Wang 1 0 Present address: Astrophysics Science Division, Goddard Space

Validation of the IOF quality of life questionnaire for patients with wrist fracture

, University of Milan , Italy S. Boonen, University of Leuven , Belgium P.M. Christensen, University of Odense , Denmark C. Cooper, University of Southampton , UK J.P. Devogelaer, St. Luc University Hospital ... subjects. The data sets (baseline data, three questionnaires) were sent to C. Cooper (Southampton) for data analysis. The wrist fracture questionnaire was scored as follows: Every question had five answer


authorized administrator of Washington & Lee University School of Law Scholarly Commons. For more information , please contact , USA 1 DARYL L. RICE and C. COOPER YOUELL, IV, TOWARD A MORE EFFECTIVE USE OF

Use of anti-depressants and the risk of fracture of the hip or femur

Netherlands 2 A. C. G. Egberts Department of Clinical Pharmacy, University Medical Centre Utrecht , Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands 3 C. Cooper Institute of Musculoskeletal Sciences

Use of anti-depressants and the risk of fracture of the hip or femur

Netherlands 2 A. C. G. Egberts Department of Clinical Pharmacy, University Medical Centre Utrecht , Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands 3 C. Cooper Institute of Musculoskeletal Sciences

Metabolic aspects of pig-to-monkey (Macaca fascicularis) islet transplantation: implications for translation into clinical practice

A. Casu R. Bottino A. N. Balamurugan H. Hara D. J. van der Windt N. Campanile C. Smetanka D. K. C. Cooper M. Trucco Aims/hypothesis Attempts to use an alternative source of islets to restore glucose

Extragalactic background light inferred from AEGIS galaxy-SED-type fractions

. Davis 14 P. Guhathakurta 13 P. Barmby 9 C. J. Conselice 4 M. Lozano 8 J. A. Newman 5 M. C. Cooper 3 0 Visiting Student at the Santa Cruz Institute for Particle Physics (SCIPP), University of California

Individual differences in trait rumination and the neural systems supporting cognitive reappraisal

Cognitive reappraisal can alter emotional responses by changing one’s interpretation of a situation’s meaning. Functional neuroimaging has revealed that using cognitive reappraisal to increase or decrease affective responses involves left prefrontal activation and goal-appropriate increases or decreases in amygdala activation (Ochsner, Bunge, Gross, Ochsner, Ray, et al., 2004). ...

Failure to perceive increased risk of fracture in women 55 years and older: the Global Longitudinal Study of Osteoporosis in Women (GLOW)

Department of Medicine, Hospital del Mar-IMIM-Autonomous, University of Barcelona , Barcelona, Spain 8 C. Cooper Institute of Musculoskeletal Sciences, University of Oxford , Oxford, UK 9 C. Cooper MRC

Hip fracture in Hong Kong over the last decade - a comparison with the UK

living in Hong Kong.2 Moreover, the age- and sex-specific rates in Hong Kong Chinese slightly exceeded those in the UK2 in 1985. We report here a further investigation into the trends of C. Cooper,2

Absence of evidence is not evidence of absence: the colour–density relation at fixed stellar mass persists to z∼ 1*

M. C. Cooper et al. E-mail: 0 0 Some of the data presented herein were obtained at the W. M. Keck Ob- servatory, which is operated as a scientific partnership among the California Institute of