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Optimal Evidence in Difficult Settings: Improving Health Interventions and Decision Making in Disasters

Martin Gerdin and colleagues argue that disaster health interventions and decision-making can benefit from an evidence-based approach Please see later in the article for the Editors' Summary

Establishing a Minimum Dataset for Prospective Registration of Systematic Reviews: An International Consultation

Background In response to growing recognition of the value of prospective registration of systematic review protocols, we planned to develop a web-based open access international register. In order for the register to fulfil its aims of reducing unplanned duplication, reducing publication bias, and providing greater transparency, it was important to ensure the appropriate data were ...

Developing core outcome sets for clinical trials: issues to consider

Paula R Williamson 0 Douglas G Altman Jane M Blazeby Mike Clarke Declan Devane Elizabeth Gargon 0 Peter Tugwell 0 Department of Biostatistics, University of Liverpool , Shelley's Cottage, Brownlow

Comparison of midwife-led and consultant-led care of healthy women at low risk of childbirth complications in the Republic of Ireland: a randomised trial

Background No midwifery-led units existed in Ireland before 2004. The aim of this study was to compare midwife-led (MLU) versus consultant-led (CLU) care for healthy, pregnant women without risk factors for labour and delivery. Methods An unblinded, pragmatic randomised trial was designed, funded by the Health Service Executive (Dublin North-East). Following ethical approval, all ...

How the Cochrane Collaboration Is Responding to the Asian Tsunami

colloquia. Mike Clarke is employed as Director of the UK Cochrane Centre and to work on systematic reviews.This employment depends on the value placed on the work of the Cochrane Collaboration and systematic ... Christian Medical College in Vellore,Tamil Nadu, India, and Coordinator of the South Asian Cochrane Network. Mike Clarke is Director of the UK Cochrane Centre in Oxford, United Kingdom. Sally Green is

Is Evidence-Based Medicine Relevant to the Developing World?

Siegfried is a South African Nuffield Medical Fellow at the University of Oxford (Oxford, United Kingdom). Mike Clarke is Director of the United Kingdom Cochrane Centre (Oxford, United Kingdom).The authors ... are involved in the work of the Cochrane Collaboration, but the views expressed in this article are their own and are not necessarily those of the Cochrane Collaboration 1 , Nandi Siegfried , Mike

Can We Systematically Review Studies That Evaluate Complex Interventions?

In three Viewpoints, Sasha Shepperd and colleagues, Geoff Wong, and Aziz Sheikh explore various approaches to help systematic reviewers who wish to review complex health interventions.

CONSORT for Reporting Randomized Controlled Trials in Journal and Conference Abstracts: Explanation and Elaboration

Background Clear, transparent, and sufficiently detailed abstracts of conferences and journal articles related to randomized controlled trials (RCTs) are important, because readers often base their assessment of a trial solely on information in the abstract. Here, we extend the CONSORT (Consolidated Standards of Reporting Trials) Statement to develop a minimum list of essential ...

The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration

Alessandro Liberati and colleagues present an Explanation and Elaboration of the PRISMA Statement, updated guidelines for the reporting of systematic reviews and meta-analyses.

Chlorpromazine for schizophrenia: a Cochrane systematic review of 50 years of randomised controlled trials

Background Chlorpromazine (CPZ) remains one of the most common drugs used for people with schizophrenia worldwide, and a benchmark against which other treatments can be evaluated. Quantitative reviews are rare; this one evaluates the effects of chlorpromazine in the treatment of schizophrenia in comparison with placebo. Methods We sought all relevant randomised controlled trials ...