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Determinants of 4-aminobiphenyl-DNA adducts in bladder cancer biopsies

Exposure to 4-aminobiphenyl (4-ABP) is an important determinant of urinary bladder cancer in humans. We have analyzed by gas chromatography–mass spectrometry the DNA adducts of 4-ABP in 75 bladder cancer biopsies. The purpose was to understand whether smoking, N-acetyltransferase 2 (NAT2) polymorphism, diet or tumor grade were determinants of 4-ABP-DNA levels. 4-ABP-DNA adducts...

Genome-wide association study identifies multiple loci associated with bladder cancer risk

Candidate gene and genome-wide association studies (GWAS) have identified 11 independent susceptibility loci associated with bladder cancer risk. To discover additional risk variants, we conducted a new GWAS of 2422 bladder cancer cases and 5751 controls, followed by a meta-analysis with two independently published bladder cancer GWAS, resulting in a combined analysis of 6911...

Ras gene mutations in patients with acute myeloid leukaemia and exposure to chemical agents

Mutations of the N- and K-ras genes occur in ∼15–30% of acute myeloid leukaemia patients. The role of the oncogenic ras in leukaemogenesis remains unclear. Few studies have revealed that mutations in the ras oncogene family are more probably found in acute myeloid leukaemia patients with previous exposure to toxic agents. A case–case study was conducted in the areas of Florence...

The effects of diet on DNA bulky adduct levels are strongly modified by GSTM1 genotype: a study on 634 subjects

Frequent consumption of fresh fruit and vegetables, and polymorphisms in the detoxifying enzyme glutathione S-transferase M1 (GSTM1) and other metabolic genes have been shown to modulate cancer risk at some sites. We have shown recently that DNA adducts, a reliable indicator of genotoxic damage and, possibly, of cancer risk, are modulated by plasma levels of selected...

The association of education with body mass index and waist circumference in the EPIC-PANACEA study

Background To examine the association of education with body mass index (BMI) and waist circumference (WC) in the European Prospective Investigation into Cancer and Nutrition (EPIC). Method This study included 141,230 male and 336,637 female EPIC-participants, who were recruited between 1992 and 2000. Education, which was assessed by questionnaire, was classified into four...

Dietary Fibre Intake and Risks of Cancers of the Colon and Rectum in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Manuela M. Bergmann Antonia Trichopoulou Dimitrios Trichopoulos Pagona Lagiou Domenico Palli Valeria Pala Salvatore Panico Rosario Tumino Paolo Vineis Peter Siersema Franzel van Duijnhoven Petra H. M

Biomarkers of dietary intake of micronutrients modulate DNA adduct levels in healthy adults

DNA adducts, a reliable indicator of internal dose exposure to genotoxic agents and, possibly, of cancer risk, have been shown to be modulated by diet, particularly by the consumption of fresh fruit and vegetables, and by the intake of antioxidants (Palli et al., 2000, Int. J. Cancer, 87, 444–451). We have therefore investigated the association between DNA adducts in peripheral...

The Contribution of Risk Factors to the Higher Incidence of Invasive and In Situ Breast Cancers in Women With Higher Levels of Education in the European Prospective Investigation Into Cancer and Nutrition

. Reeves , Ve ronique Chajes, Sabina Rinaldi, Nadia Slimani, Valentina Gallo, Paolo Vineis, Elio Riboli, and H. Bas Bueno-de-Mesquita American Journal of Epidemiology The Author 2010. Published by Oxford ... Epidemiology and Public Health, Imperial College, London, United Kingdom (Petra H. Peeters, Valentina Gallo, Paolo Vineis, Elio Riboli); Department of Cardiology, Aarhus University Hospital, Aalborg, Denmark

Genome-Wide Association Studies, Field Synopses, and the Development of the Knowledge Base on Genetic Variation and Human Diseases

Seminara, Deborah M. Winn); Division of Epidemiology, Imperial College London, London, United Kingdom (Paolo Vineis); Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina

Dietary phenolics as anti-mutagens and inhibitors of tobacco-related DNA adduction in the urothelium of smokers

Human urine is known to contain substances that strongly inhibit bacterial mutagenicity of aromatic and heterocyclic amines in vitro. The biological relevance of these anti-mutagens was examined by comparing levels of tobacco-related DNA ad ducts in exfoliated urothelial cells from smokers with the anti-mutagenic activity in corresponding 24-h urine samples. An inverse...

Circulating C-Reactive Protein Concentrations and Risks of Colon and Rectal Cancer: A Nested Case-Control Study Within the European Prospective Investigation into Cancer and Nutrition

-Christine Boutron-Ruault, Francxoise Clavel-Chapelon, Sophie Morois, Domenico Palli, Vittorio Krogh, Rosario Tumino, Paolo Vineis, Salvatore Panico, Rudolf Kaaks, Sabine Rohrmann, Antonia Trichopoulou, Pagona ... Health and Primary Care, Imperial College London, London, United Kingdom (Elio Riboli, Paolo Vineis, Dora Romaguera, Teresa Norat); Department of Epidemiology, Institute of Public Health, Aarhus University

Genome-wide association study identifies new prostate cancer susceptibility loci

Edward L. Giovannucci Mattias Johansson Loic Le Marchand Jing Ma Sabina Sieri Pa r Stattin Meir J. Stampfer Anne Tjonneland Paolo Vineis Jarmo Virtamo Ulla Vogel Stephanie J. Weinstein Meredith Yeager

XRCC1, XRCC3, XPD gene polymorphisms, smoking and 32P-DNA adducts in a sample of healthy subjects

Paolo Vineis 7 0 Unita` di Epidemiologia , CSPO, 50135, Firenze 1 ISI Foundation, Institute for Scientific Interchange , Villa Gualino, 10133, Torino 2 Dipartimento di Genetica , Biologia e Biochimica ... : Paolo Vineis (P.I), Laura Davico, Laura Fiorini, Maria Luisa Abbadini and Fabrizio Veglia (ISI Foundation). (iii) EPIC-Florence: Unita` di Epidemiologia, CSPO, Firenze. Key personnel: Domenico Palli (P.I

Inverse correlation between alcohol consumption and lymphocyte levels of 8-hydroxydeoxyguanosine in humans

In a cross-sectional study of 115 premenopausal non-smoking women, we examined the relationship between lymphocyte levels of 8-hydroxy-2′-deoxyguanosine (8-oxodGuo) and habitual alcohol consumption. The study was conducted in four different regions of Europe, including Potsdam (Germany), Turin (Italy), Malmö (Sweden) and Granada (Spain). Mean 8-oxodGuo levels differed...

Blood Pressure and Risk of Renal Cell Carcinoma in the European Prospective Investigation into Cancer and Nutrition

Elevated blood pressure has been implicated as a risk factor for renal cell carcinoma (RCC), but prospective studies were confined to men and did not consider the effect of antihypertensive medication. The authors examined the relation among blood pressure, antihypertensive medication, and RCC in the European Prospective Investigation into Cancer and Nutrition (EPIC). Blood...

Serum Vitamin D and Risk of Prostate Cancer in a Case-Control Analysis Nested Within the European Prospective Investigation into Cancer and Nutrition (EPIC)

, Imperial College, London, United Kingdom (Paolo Vineis, Elio Riboli); Division of Epidemiology and Life Sciences, Institute for Scientific Interchange Foundation, Torino, Italy (Paolo Vineis); Molecular and

The Role of Smoking and Diet in Explaining Educational Inequalities in Lung Cancer Incidence

Menvielle, Hendriek Boshuizen, Anton E. Kunst , Susanne O. Dalton, Paolo Vineis, Manuela M. Bergmann, Silke Hermann, Pietro Ferrari, Ole Raaschou-Nielsen, Anne Tjønneland, Rudolf Kaaks, Jakob Linseisen, Maria

A Network of Investigator Networks in Human Genome Epidemiology

Julia A. Newton Bishop 8 Thomas R. O'Brien Gloria Petersen 9 Elio Riboli () 6 Daniela Seminara 7 Emanuela Taioli 4 Andre G. Uitterlinden () 5 Paolo Vineis 2 Deborah M. Winn Georgia Salanti 1 Julian P. T

Lung cancers attributable to environmental tobacco smoke and air pollution in non-smokers in different European countries: a prospective study

Paolo Vineis Gerard Hoek Michal Krzyzanowski Federica Vigna- Taglianti Fabrizio Veglia Luisa Airoldi airoldi

A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23

. Grubb III Heiner Boeing Paolo Vineis Franc¸ oise Clavel-Chapelon Domenico Palli Rosario Tumino Vittorio Krogh Salvatore Panico Eric J. Duell Jose´ Ramo´ n Quiro´ s Maria-Jose´ Sanchez Carmen Navarro Eva