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Circulating histones for predicting prognosis after cardiac surgery: a prospective study

OBJECTIVES The objective of this study was to assess the perioperative changes in circulating histones and their relationships with other biomarkers and clinical outcomes after cardiac surgery with cardiopulmonary bypass (CPB) in patients.

Macrophage-derived MCPIP1 mediates silica-induced pulmonary fibrosis via autophagy

Background Silicosis is characterized by accumulation of fibroblasts and excessive deposition of extracellular matrix. Monocyte chemotactic protein-1-induced protein 1 (MCPIP1) plays a critical role in fibrosis induced by SiO 2 . However, the details of the downstream events of MCPIP1 activity in pulmonary fibrosis remain unclear. To elucidate the role of MCPIP1-induced autophagy ...

Human perception of electrical stimulation on the surface of somatosensory cortex

Recent advancement in electrocorticography (ECoG)-based brain-computer interface technology has sparked a new interest in providing somatosensory feedback using ECoG electrodes, i.e., cortical surface electrodes. We conducted a 28-day study of cortical surface stimulation in an individual with arm paralysis due to brachial plexus injury to examine the sensation produced by ...

Sphingolipids Are Required for Efficient Triacylglycerol Loss in Conjugated Linoleic Acid Treated Adipocytes

Conjugated linoleic acid (CLA) reduces adiposity in human and mouse adipocytes. This outcome is achieved through a variety of biological responses including increased energy expenditure and fatty acid oxidation, increased inflammation, repression of fatty acid biosynthesis, attenuated glucose transport, and apoptosis. In the current study, profiling of 261 metabolites was conducted ...

Clinicopathologic analysis of lymph node status in superficial esophageal squamous carcinoma

Wei Wang 0 0 Department of Cardiothoracic Surgery, First Affiliated Hospital of Nanjing Medical University , No. 300 Guangzhou Road, Nanjing 210029 , China 1 Department of Pathology, First Affiliated

Regulatory mechanisms of microRNAs in lung cancer stem cells

Increasing evidence suggests that cancer stem cells (CSCs) are a key occurrence in the process of many human cancers. Lung cancer is the most common aggressive malignancy and cause of cancer death worldwide. The research on lung cancer stem cells has been highlighted for many years. Lung CSCs seem to play a major role in lung cancer metastasis, drug resistance and ...

The study of statistical methods for evaluating the comparability of routine chemistry analytes among 3 routine laboratory measurement systems in China

Background Clinical laboratory tests are important for clinicians to make diagnostic decisions, but discrepancies may directly lead to incorrect diagnosis. We would like to introduce some statistical methods to evaluate the comparability of chemistry analytes while comparing the performances of different measurement systems. Methods We used a panel of 10 fresh-frozen single ...

Masked repetition priming hinders subsequent recollection but not familiarity: A behavioral and event-related potential study

The present study used the masked repetition priming paradigm in the study phase and the R/K paradigm in the test phase to investigate whether repetition priming can hinder recognition memory and which recognition process (familiarity or recollection) is hindered. Event-related potentials (ERPs) in the study and test phase were recorded to explore the temporal course of how ...

Radiative leptonic \(B_c\rightarrow \gamma \ell {\bar{\nu }}\) decay in effective field theory beyond leading order

We study the radiative leptonic \(B_c\rightarrow \gamma \ell {\bar{\nu }}\) decays in nonrelativistic QCD effective field theory, and we explore the contribution from a fast-moving photon. As a result, interactions between the photon and the heavy quarks can be integrated out, resulting in the factorization formula for the decay amplitude. We calculate not only the relevant ...

Stem cell therapy: a novel treatment option for cerebral malaria?

Cerebral malaria, a severe form of the disease, is one of the most severe complications of infection with Plasmodium parasites and a leading cause of malaria mortality. Currently available antimalarial therapy has proven insufficient to prevent neurological complications and death in all cases of cerebral malaria. Souza and colleagues observed that transplantation of bone ...

Integration of suboptimal health status and endothelial dysfunction as a new aspect for risk evaluation of cardiovascular disease

Background Suboptimal health status (SHS) is recognized as a subclinical, reversible stage of chronic disease. Association has been confirmed between SHS and cardiovascular risk factors, indicating that SHS may contribute to the development of cardiovascular disease. This study explored integrated risk assessment of cardiovascular disease by combining SHS questionnaire-25 (SHSQ-25) ...

Seasonality, Rather than Nutrient Addition or Vegetation Types, Influenced Short-Term Temperature Sensitivity of Soil Organic Carbon Decomposition

The response of microbial respiration from soil organic carbon (SOC) decomposition to environmental changes plays a key role in predicting future trends of atmospheric CO2 concentration. However, it remains uncertain whether there is a universal trend in the response of microbial respiration to increased temperature and nutrient addition among different vegetation types. In this ...

The association between CDH1 promoter methylation and patients with ovarian cancer: a systematic meta-analysis

Wang 0 0 Radiology Department, The First Hospital of Jilin University , Changchun 130041 , China 1 Obstetrics and Gynecology Department , The Second People's 2 Plastic Surgery Department, China-Japan

Prognostic value of angiopoietin-2 in non-small cell lung cancer patients: a meta-analysis

Background Non-small cell lung cancer (NSCLC) is the most frequent cause of cancer deaths worldwide. The targeted therapy had made important progress in recent years, but few potential predictive biomarkers for prognosis of NSCLC patients were identified. Angiopoietin-2 (Ang-2), a cytokine upregulated in tumor endothelial cells and some tumor cells including NSCLC, is a partial ...

Post-Marketing Safety Surveillance of the Salvia Miltiorrhiza Depside Salt for Infusion: A Real World Study

Background Salvia Miltiorrhiza Depside Salt for Infusion (SMDS) is made of a group of highly purified listed drugs. However, its safety data is still reported limitedly. Compared with the clinical trials, its safety in the real world setting is barely assessed. Objective To investigate the safety issues, including adverse events (AEs), adverse events related to SMDS (ADEs), and ...

Predicting personality disorder functioning styles by the Chinese Adjective Descriptors of Personality: a preliminary trial in healthy people and personality disorder patients

Background Cultural and personality factors might contribute to the clinical differences of psychiatric patients all over the world including China. One cultural oriented Chinese Adjective Descriptors of Personality (CADP) designed to measure normal personality traits, might be specifically associated with different personality disorder functioning styles. Methods We therefore have ...

The morphological features of different Schatzker types of tibial plateau fractures: a three-dimensional computed tomography study

Background Tibial plateau fractures are of great challenge to treat with open reduction and internal fixation, because fractures vary from simple to complex, with little or extensive articular involvement. Hence, recognition and comprehension of the fracture features will help orthopedic surgeons understand the injury mechanism better and manage these fractures by planning optimal ...

Let-7 inhibits self-renewal of hepatocellular cancer stem-like cells through regulating the epithelial-mesenchymal transition and the Wnt signaling pathway

Background Tumor suppressive let-7 miRNAs are universally down-regulated in human hepatocellular carcinoma (HCC) versus normal tissues; however, the roles and related molecular mechanisms of let-7 in HCC stem cells are poorly understood. Methods We examined the inhibitory effect of let-7 miRNAs on the proliferation of MHCC97-H and HCCLM3 hepatic cancer cells by using MTT ...