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Heat kernel asymptotics of the subordinator and subordinate Brownian motion

For a class of Laplace exponents, we consider the transition density of the subordinator and the heat kernel of the corresponding subordinate Brownian motion. We derive explicit approximate expressions for these objects in the form of asymptotic expansions: via the saddle point method for the subordinator’s transition density and via the Mellin transform for the subordinate heat...

The relationship between depression and cognitive function in adults with cardiovascular risk: Evidence from a randomised attention-controlled trial

Background and aim This study assessed the association between depressive symptom severity and cognition in middle-to-older aged adults with mild-to-moderate depression and cardiovascular risk factors using an online test battery (CogState) and whether changes in depressive symptoms over 3 months were associated with changes in cognition. Methods Participants (mean age = 57.8...

Effectiveness of educational outreach visits compared with usual guideline dissemination to improve family physician prescribing—an 18-month open cluster-randomized trial

Educational outreach visits are meant to improve the practice of health professionals by promoting face-to-face visits to deliver educational contents. They have been shown to change prescription behavior, but long-term effects are still uncertain. This trial aimed to determine if they improve family physician prescribing compared with passive guideline dissemination. Parallel...

The biological basis and clinical symptoms of CAR-T therapy-associated toxicites

Currently, immunotherapy is attracting a lot of attention and may potentially become a leading approach in the treatment of cancer. One emerging therapeutic, the chimeric-antigen receptor T-cell adoptive immunotherapy (CAR-T) is showing remarkable efficacy in the treatment of several B-cell malignancies. The popularity of CAR-T has been founded on two CAR T-cell products recently...

Five steps to improve air-quality forecasts

A worldwide monitoring and modelling network would reduce the dramatic toll of air pollution on health and food production, urge Rajesh Kumar and colleagues.

Why New Zealand is an attractive destination for scientists

The nation’s fertile research landscape, combined with a sustained funding drive, makes it a rewarding place to work.

Hierarchical Control of Drosophila Sleep, Courtship, and Feeding Behaviors by Male-Specific P1 Neurons

Animals choose among sleep, courtship, and feeding behaviors based on the integration of both external sensory cues and internal states; such choices are essential for survival and reproduction. These competing behaviors are closely related and controlled by distinct neural circuits, but whether they are also regulated by shared neural nodes is unclear. Here, we investigated how...

Room-temperature polarized spin-photon interface based on a semiconductor nanodisk-in-nanopillar structure driven by few defects

Owing to their superior optical properties, semiconductor nanopillars/nanowires in one-dimensional (1D) geometry are building blocks for nano-photonics. They also hold potential for efficient polarized spin-light conversion in future spin nano-photonics. Unfortunately, spin generation in 1D systems so far remains inefficient at room temperature. Here we propose an approach that...

Pupil dilation but not microsaccade rate robustly reveals decision formation

Pupil dilation, an indicator of arousal that is generally regarded as unspecific, amongst others reflects decision formation and reveals choice. Employing letter selection in a Go/NoGo task, we show that choice can robustly be predicted by the pupillary signal, even under the presence of strong interfering factors such as changes in brightness or motor execution. In addition, a...

Quantitative progression of retinitis pigmentosa by optical coherence tomography angiography

Optical coherence tomography angiography (OCT-A) is a non-invasive alternative to fluorescein angiography that allows for the study of the retinal and choroidal vasculatures. In this retrospective cohort study of 28 patients with retinitis pigmentosa (RP), we used OCT-A to quantify changes in perfusion density, foveal avascular zone (FAZ) area, and choriocapillaris blood flow...

Different associations of sufficient and vigorous physical activity with BMI in Northwest China

Physical activity (PA) plays an important role in maintaining a healthy weight. To develop targeted strategies that encourage physical activity, knowledge of associations between intensity of physical activity (PA) levels and body mass index (BMI) is essential. We aimed to examine the relationship between sufficient and vigorous PA and BMI distribution among adults in northwest...

An iPhone Application for Blood Pressure Monitoring via the Oscillometric Finger Pressing Method

We developed an iPhone X application to measure blood pressure (BP) via the “oscillometric finger pressing method”. The user presses her fingertip on both the front camera and screen to increase the external pressure of the underlying artery, while the application measures the resulting variable-amplitude blood volume oscillations via the camera and applied pressure via the...

Resting Frontal Asymmetry and Reward Sensitivity Theory Motivational Traits

The revised reinforcement sensitivity theory (rRST) of personality has conceptualized three main systems: the behavioural approach system (BAS), behavioural inhibition system (BIS), and fight-flight-freeze system (FFFS). Research links greater relative left-frontal activity with BAS-related tendencies and impulsivity and greater relative right-frontal activity with “withdrawal...

Negative fluorescence anisotropy of phosphole oxide-based dyes in nematic liquid crystals

It is important to understand how solute molecules align in anisotropic media such as liquid crystals and biological membranes. Alignment of fluorescent probes used in polarised fluorescence microscopy is of interest because anisotropy of the medium is indirectly estimated through the fluorescence intensity originating from the transition dipole moments fixed on the molecule...

EGF-induced nuclear localization of SHCBP1 activates β-catenin signaling and promotes cancer progression

Aberrant activation of EGFR represents a common event in non-small cell lung carcinoma (NSCLC) and activates various downstream signaling pathways. While EGFR activation of β-catenin signaling was previously reported, the mediating mechanism remains unclear. Our current study found that EGFR activation in NSCLC cells releases SHC-binging protein 1 (SHCBP1) from SHC adaptor...

Steroid Receptor Coactivator-2 Controls the Pentose Phosphate Pathway through RPIA in Human Endometrial Cancer Cells

Steroid receptor coactivator-2 (SRC-2) is a transcriptional coregulator that modulates the activity of many transcription factors. Levels of SRC-2 are elevated in endometrial biopsies from polycystic ovary syndrome patients, a population predisposed to endometrial cancer (EC). Increased expression of SRC-2 is also detected in neoplastic endometrium suggesting a causal link...

Mechanistic modelling of viral spreading on empirical social network and popularity prediction

Online social networks are becoming major platforms for people to exchange opinions and information. While spreading models have been used to study the dynamics of spreading on social networks, the actual spreading mechanism on social networks may be different from these previous models due to users’ limited attention and heterogeneous interests. The tractability of the spreading...

Ultra-low noise optical injection locking amplifier with AOM-based coherent detection scheme

A novel optical injection locking amplifier with acousto-optic modulator based phase modulation and a coherent detection scheme for optical frequency transfer applications is experimentally demonstrated in this study. A commercial distributed feedback diode laser is injection-locked to the resonant frequency of the optical signal with an optical fiber path length of hundreds of...