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The Global Longitudinal Study of Osteoporosis in Women (GLOW): rationale and study design

8 P. Delmas Department of Rheumatology , Hpital Edouard Herriot, 5 Place d'Arsonval, Lyon, France 69437 9 C. Cooper Institute of Musculoskeletal Sciences, University of Oxford , Oxford, UK 10 J ... . Pfeilschifter Alfried Krupp Krankenhaus, Department of Internal Medicine III , Essen, Germany 11 C. Cooper MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital , Southampton

The DEEP2 galaxy redshift survey: the evolution of the blue fraction in groups and the field

We explore the behaviour of the blue galaxy fraction over the redshift range 0.75 ≤ z ≤ 1.3 in the DEEP2 Survey, both for field galaxies and for galaxies in groups. The primary aim is to determine the role that groups play in driving the evolution of galaxy colour at high z. In pursuing this aim, it is essential to define a galaxy sample that does not suffer from redshift-dependent ...

The DEEP2 galaxy redshift survey: evolution of the colour–density relation at 0.4 < z < 1.35

Using a sample of 19 464 galaxies drawn from the DEEP2 Galaxy Redshift Survey, we study the relationship between galaxy colour and environment at 0.4 1, being larger in regions of greater galaxy density. At all epochs probed, we also find a small population of red, morphologically early-type galaxies residing in regions of low measured overdensity. The observed correlations between ...

Factors Associated with Osteoarthritis of the Hip and Knee in Hong Kong Chinese: Obesity, Joint Injury, and Occupational Activities

In 1998, a case-control study was conducted in Hong Kong on hospital patients with osteoarthritis of the hip (n = 138) and osteoarthritis of the knee (n = 658). Age- and sex-matched controls were recruited consecutively from general practice clinics in the same region. The following three risk factors were found to be associated with osteoarthritis of both the hip and the knee: ...

A deep Chandra survey of the Groth Strip – II. Optical identification of the X-ray sources

In this paper, we discuss the optical and X-ray spectral properties of the sources detected in a single 200-ks Chandra pointing in the Groth-Westphal Strip region. A wealth of optical photometric and spectroscopic data are available in this field providing optical identifications and redshift determinations for the X-ray population. The optical photometry and spectroscopy used here ...

The DEEP2 Galaxy Redshift Survey: the relationship between galaxy properties and environment at z∼ 1

We study the mean environment of galaxies in the DEEP2 Galaxy Redshift Survey as a function of rest-frame colour, luminosity, and [O-ii] 3727-Å equivalent width. The local galaxy overdensity for >14-000 galaxies at 0.75 < z < 1.35 is estimated using the projected third-nearest-neighbour surface density. Of the galaxy properties studied, mean environment is found to depend most ...

Scleroderma and Solvent Exposure among Women

Exposure to solvents has been reported to increase the risk of scleroderma. The authors investigated the relation between exposures to solvents in occupational and hobby settings and the development of scleroderma among women in a case-control study with population-based controls in Michigan (1980–1991) and Ohio (1980–1992). A total of 660 cases and 2,227 frequency-matched controls ...

Sex Hormones and Osteoporosis in Men

) Effect of testosterone and estradiol in a man with aromatase deficiency . N Engl J Med 337 : 91 - 95 30. Anderson FH , Francis RM , Hindmarsh P , Fall C , Cooper C ( 1996 ) Serum oestradiol in osteoporotic

Potential Risk Factors for Undifferentiated Connective Tissue Disease among Women: Implanted Medical Devices

A case-control study was conducted among 205 women in Michigan and Ohio who were diagnosed with undifferentiated connective tissue disease (UCTD) to investigate the significance of self-reported past exposures to implanted silicone-containing or non-silicone-containing medical devices. The 205 UCTD cases were compared with 2,095 controls who were sampled by random digit dialing. ...

Activation of Porcine Cytomegalovirus, but Not Porcine Lymphotropic Herpesvirus, in Pig-to-Baboon Xenotransplantation

Tissue-invasive disease due to porcine cytomegalovirus (PCMV) has been demonstrated after pig-to-baboon solid-organ xenotransplantation. Porcine lymphotropic herpesvirus (PLHV)-1 is associated with B cell proliferation and posttransplant lymphoproliferative disorder after allogeneic bone marrow transplantation in swine but has not been observed in pig-to-primate ...

Prion protein expression in Chinese hamster ovary cells using a glutamine synthetase selection and amplification system.

Syrian hamster prion protein (PrPC) and a truncated Syrian hamster prion protein lacking the glycosylphosphatidylinositol (GPI) anchor C-terminal signal sequence (GPI-) were expressed in Chinese hamster ovary cells using a glutamine synthetase selection and amplification system. The CHO cell clones expressing the GPI- PrP secreted the majority of the protein into the media, whereas ...

Efficacy and Safety of Oral Pleconaril for Treatment of Colds Due to Picornaviruses in Adults: Results of 2 Double-Blind, Randomized, Placebo-Controlled Trials

The novel capsid-binding antiviral pleconaril inhibits in vitro replication of most rhinoviruses and enteroviruses. Oral pleconaril treatment was studied in 2 parallel randomized, double-blind, placebo-controlled trials. Among 1363 picornavirus-infected participants (65%) in the studies combined, the median time to alleviation of illness was 1 day shorter for pleconaril recipients ...

Anthropometric Measurements and Vertebral Deformities

To investigate the association between anthropometric indices and morphometrically determined vertebral deformity, the authors carried out a cross-sectional study using data from the European Vertebral Osteoporosis Study (EVOS), a population-based study of vertebral osteoporosis in 36 European centers from 19 countries. A total of 16,047 EVOS subjects were included in this ...

Petroleum Distillate Solvents as Risk Factors for Undifferentiated Connective Tissue Disease (UCTD)

Occupational solvent exposure may increase the risk of connective tissue disease (CTD). The objective of this case-control study was to investigate the relation between undifferentiated connective tissue disease (UCTD) and solvent exposure in Michigan and Ohio. Women were considered to have UCTD if they did not meet the American College of Rheumatology classification criteria for ...

Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes

Lars Lind 9 11 Cyrus C. Cooper 11 14 Manuel Serrano- 11 Ele Ferrannini 11 56 Tom J. Forsen 11 18 58 Robert Clarke 11 47 Maria Grazia Franzosi 11 60 Francis S. Collins 11 51 Markku Laakso 5 11 Emmanouil T

A Randomized Study of the Safety and Antiretroviral Activity of Hydroxyurea Combined with Didanosine in Persons Infected with Human Immunodeficiency Virus Type 1

This randomized open-label trial of human immunodeficiency virus type 1-infected persons compared safety and efficacy for 38 patients receiving hydroxyurea/didanosine combination therapy with findings in 42 persons given didanosine monotherapy for 12 weeks, followed by 12 weeks of hydroxyurea/didanosine combination therapy for all patients. Week 12 on-treatment group comparisons ...

Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans

Peter Chines Francis S. Collins Cyrus C. Cooper Elaine M. Dennison Michael R. Erdos Ele Ferrannini Caroline S. Fox Ju rgen Graessler Ke Hao Bo Isomaa Karen A. Jameson Peter Kovacs Johanna Kuusisto Markku

Trimethoprim-Sulfamethoxazole (TMP-SMZ) Dose Escalation versus Direct Rechallenge for Pneumocystis Carinii Pneumonia Prophylaxis in Human Immunodeficiency Virus—Infected Patients with Previous Adverse Reaction to TMP-SMZ

Trimethoprim-sulfamethoxazole (TMP-SMZ) is the most effective Pneumocystis carinii pneumonia (PCP) prophylactic agent, but adverse reactions are common among human immunodeficiency virus (HIV)—infected patients and limit its use. This randomized, double-blind controlled trial compared 2 methods of TMP-SMZ reintroduction, 6-day dose escalation and direct rechallenge, for PCP ...