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Social defeat stress causes depression-like behavior with metabolite changes in the prefrontal cortex of rats

Major depressive disorder is a serious mental disorder with high morbidity and mortality. The role of social stress in the development of depression remains unclear. Here, we used the social defeat stress paradigm to induce depression-like behavior in rats, then evaluated the behavior of the rats and measured metabolic changes in the prefrontal cortex using gas chromatography...

Dendritic-Tumor Fusion Cells Derived Heat Shock Protein70-Peptide Complex Has Enhanced Immunogenicity

Tumor-derived heat shock protein70-peptide complexes (HSP70.PC-Tu) have shown great promise in tumor immunotherapy due to numerous advantages. However, large-scale phase III clinical trials showed that the limited immunogenicity remained to be enhanced. In previous research, we demonstrated that heat shock protein 70-peptide complexes (HSP70.PC-Fc) derived from dendritic cell (DC...

Prediction of microstructural evolution during hot forging

Microstructural evolution, which is governed by temperature, strain and strain rate during hot forging, is a key factor influencing mechanical properties. Understanding the microstructural evolution of metals and alloys in hot forging has a great importance for the designers of metal forming processes. The principal objective of this paper is to provide an overview of the models...

Differential gene expression in patients with subsyndromal symptomatic depression and major depressive disorder

Background Subsyndromal symptomatic depression (SSD) is a subtype of subthreshold depressive and can lead to significant psychosocial functional impairment. Although the pathogenesis of major depressive disorder (MDD) and SSD still remains poorly understood, a set of studies have found that many same genetic factors play important roles in the etiology of these two disorders...

Distinguishing Patients with Parkinson's Disease Subtypes from Normal Controls Based on Functional Network Regional Efficiencies

Many studies have demonstrated that the pathophysiology and clinical symptoms of Parkinson's disease (PD) are inhomogeneous. However, the symptom-specific intrinsic neural activities underlying the PD subtypes are still not well understood. Here, 15 tremor-dominant PD patients, 10 non-tremor-dominant PD patients, and 20 matched normal controls (NCs) were recruited and underwent...

Circulating Tumor DNA Mutation Profiling by Targeted Next Generation Sequencing Provides Guidance for Personalized Treatments in Multiple Cancer Types

• PubMed • Google Scholar Search for Liangjun Zhu in:Nature Research journals • PubMed • Google Scholar Search for Chunrong Zhu in:Nature Research journals • PubMed • Google Scholar Search for Jun Chen

Investigation on Dynamic Recrystallization Behavior of Martensitic Stainless Steel

The hot deformation behavior of X20Cr13 martensitic stainless steel was studied using the hot compression flow curves corresponding to the temperature range of 900–1150°C under strain rates from 0.01 to 10 s−1. A new mathematical model to estimate the flow stress under hot deformation conditions up to the peak of the flow curves was developed. The critical strains for initiation...

Inorganic & organic materials for rechargeable Li batteries with multi-electron reaction

Advanced Energy Materials Chemistry (Ministry of Education) to study for his PhD degree. He is expecting to get his PhD in 2015 under the supervision of Professor Jun Chen. His research focuses on Liion ... batteries, Li-S batteries, and Na-ion batteries. Jun Chen was born in 1967. He is a Cheung Kong Scholar Professor at the College of Chemistry, Nankai University, and Vice Chairman of the Chinese Society of

An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis

Background The adaptive immune response in rheumatoid arthritis (RA) is influenced by an interaction between host genetics and environment, particularly the host microbiome. Association of the gut microbiota with various diseases has been reported, though the specific components of the microbiota that affect the host response leading to disease remain unknown. However, there is...

Critical appraisal of pemetrexed in the treatment of NSCLC and metastatic pulmonary nodules

Critical appraisal of pemetrexed in the treatment of NSCLC and metastatic pulmonary nodules Xin Li, Sen Wei, Jun ChenTianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, Heping District, Tianjin, People's Republic of ChinaAbstract: Pemetrexed, a...

Recent advances in nanorobotic manipulation inside scanning electron microscopes

grant. Author information AffiliationsDepartment of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, Canada M5S 3G8Chaoyang Shi, Devin K Luu, Jun Liu, Jun Chen, Ji Ge & Yu ... Research journals • PubMed • Google ScholarSearch for Qinmin Yang in:Nature Research journals • PubMed • Google ScholarSearch for Jun Liu in:Nature Research journals • PubMed • Google ScholarSearch for Jun

Quasi-Bézier Curves with Shape Parameters

2013 Academic Editor: Juan Manuel Peña Copyright © 2013 Jun Chen. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use

Radial Basis Point Interpolation Method with Reordering Gauss Domains for 2D Plane Problems

We present novel Gauss integration schemes with radial basis point interpolation method (RPIM). These techniques define new Gauss integration scheme, researching Gauss points (RGD), and reconstructing Gauss domain (RGD), respectively. The developments lead to a curtailment of the elapsed CPU time without loss of the accuracy. Numerical results show that the schemes reduce the...

A Neural Network Model for K(λ) Retrieval and Application to Global Kpar Monitoring

Accurate estimation of diffuse attenuation coefficients in the visible wavelengths Kd(λ) from remotely sensed data is particularly challenging in global oceanic and coastal waters. The objectives of the present study are to evaluate the applicability of a semi-analytical Kd(λ) retrieval model (SAKM) and Jamet’s neural network model (JNNM), and then develop a new neural network Kd...

Phase and composition controllable synthesis of cobalt manganese spinel nanoparticles towards efficient oxygen electrocatalysis

ChenCollaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, ChinaFangyi Cheng & Jun Chen AuthorsSearch for Chun Li in:Nature Research journals • PubMed ... Research journals • PubMed • Google ScholarSearch for Chengcheng Chen in:Nature Research journals • PubMed • Google ScholarSearch for Jun Chen in:Nature Research journals • PubMed • Google Scholar

Distributed indeterminacy evaluation of cable-strut structures: formulations and applications

The indeterminacy evaluation is an effective method for system identification; it can predict the mechanical behaviors of flexible structures in the primary design. However, the conventional indeterminacy evaluation based solely on geometry and topology has neglected the influence of material properties on mechanical behavior and the contribution of each component to the total...

Potential contribution of the uterine microbiome in the development of endometrial cancer

Background Endometrial cancer studies have led to a number of well-defined but mechanistically unconnected genetic and environmental risk factors. One of the emerging modulators between environmental triggers and genetic expression is the microbiome. We set out to inquire about the composition of the uterine microbiome and its putative role in endometrial cancer. Methods We...

Health-Related Quality of Life in Patients with Primary Cutaneous Amyloidosis

Background Primary cutaneous amyloidosis (PCA) is a relatively rare and itchy skin disorder characterized by amyloid deposits in the superficial dermis. The cosmetic disfigurement and severe pruritus dramatically affects the patient’s quality of life. In spite of the prevalence of the disease in China, the quality of life (QoL) impact of the PCA has not been well defined and is...