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Safety and tolerability of high-dose ulinastatin after 2-hour intravenous infusion in adult healthy Chinese volunteers: A randomized, double-blind, placebo-controlled, ascending-dose study

Ulinastatin, is a broad-spectrum protease inhibitor purified from human urine, inhibits endogenous proteases such as trypsin, α-chymotrypsin, hyaluronidase, and plasmin. It is widely being used at increasingly higher doses for the treatment of acute or chronic pancreatitis, severe infection, and acute organ failure. We aimed to evaluate the safety and tolerability of high-dose ...

Analysis of the Negative-SET Behaviors in Cu/ZrO2/Pt Devices

Metal oxide-based electrochemical metallization memory (ECM) shows promising performance for next generation non-volatile memory. The negative-SET behavior has been observed in various oxide-based ECM devices. But the underlying mechanism of this behavior remains unaddressed and the role of the metal cation and oxygen vacancy in this behavior is unclear. In this work, we have ...

Analysis of the Negative-SET Behaviors in Cu/ZrO2/Pt Devices

Metal oxide-based electrochemical metallization memory (ECM) shows promising performance for next generation non-volatile memory. The negative-SET behavior has been observed in various oxide-based ECM devices. But the underlying mechanism of this behavior remains unaddressed and the role of the metal cation and oxygen vacancy in this behavior is unclear. In this work, we have ...

Bibliographic Analysis of Nature Based on Twitter and Facebook Altmetrics Data

This paper presents a bibliographic analysis of Nature articles based on altmetrics. We assess the concern degree of social users on the Nature articles through the coverage analysis of Twitter and Facebook by publication year and discipline. The social media impact of a Nature article is examined by evaluating the mention rates on Twitter and on Facebook. Moreover, the correlation ...

Challenges for strengthening the health workforce in the Lao People’s Democratic Republic: perspectives from key stakeholders

Background The Lao People’s Democratic Republic is facing a critical shortage and maldistribution of health workers. Strengthening of the health workforce has been adopted as one of the five priorities of the National Health Sector Strategy (2013–2025). This study aims to identify, explore, and better understand the key challenges for strengthening the Laotian health workforce. ...

Dysregulation of endothelial colony-forming cell function by a negative feedback loop of circulating miR-146a and -146b in cardiovascular disease patients

CAD ECFCs (RPM > 5 and > 3-fold change). (TIF) Acknowledgments This paper is dedicated to the memory of Dr. Hsei-Wei Wang, April 1969~Sep 2015. We thank Dr. Pei-Ching Chang (National Yang-Ming ... : Ting-Yu Chang, Shu-Meng Cheng, Hsei-Wei Wang. Data curation: Ting-Yu Chang, Tse-Shun Huang. Formal analysis: Ting-Yu Chang, Tse-Shun Huang. Funding acquisition: Wei-Chi Tsai, Chun-Hsien Wu, Cheng

Increased expression of TROP2 in airway basal cells potentially contributes to airway remodeling in chronic obstructive pulmonary disease

Background The airway epithelium of chronic obstructive pulmonary disease (COPD) patients undergoes aberrant repair and remodeling after repetitive injury following exposure to environmental factors. Abnormal airway regeneration observed in COPD is thought to originate in the stem/progenitor cells of the airway epithelium, the basal cells (BCs). However, the molecular mechanisms ...

Transcriptome Analysis of the Chrysanthemum Foliar Nematode, Aphelenchoides ritzemabosi (Aphelenchida: Aphelenchoididae)

The chrysanthemum foliar nematode (CFN), Aphelenchoides ritzemabosi, is a plant parasitic nematode that attacks many plants. In this study, a transcriptomes of mixed-stage population of CFN was sequenced on the Illumina HiSeq 2000 platform. 68.10 million Illumina high quality paired end reads were obtained which generated 26,817 transcripts with a mean length of 1,032 bp and an N50 ...

Radiative leptonic \(B_c\rightarrow \gamma \ell {\bar{\nu }}\) decay in effective field theory beyond leading order

We study the radiative leptonic \(B_c\rightarrow \gamma \ell {\bar{\nu }}\) decays in nonrelativistic QCD effective field theory, and we explore the contribution from a fast-moving photon. As a result, interactions between the photon and the heavy quarks can be integrated out, resulting in the factorization formula for the decay amplitude. We calculate not only the relevant ...

Comparison of the complications of traditional 12 cores transrectal prostate biopsy with image fusion guided transperineal prostate biopsy

Background To compare the complications of traditional transrectal (TR) prostate biopsy and image fusion guided transperineal (TP) prostate biopsy in our center. Methods Two hundred and fourty-two patients who underwent prostate biopsy from August 2014 to January 2015were reviewed. Among them, 144 patients underwent systematic 12-core transrectal ultrasonography (TRUS) guided ...

The chimeric Japanese encephalitis/Dengue 2 virus protects mice from challenge by both dengue virus and JEV virulent virus

funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Jian Yang, Huiqiang Yang, Zhushi Li, Hua Lin, Yu Zhao, Wei Wang, Shuai Tan, Xianwu

Fungal spondylodiscitis in a patient recovered from H7N9 virus infection: a case study and a literature review of the differences between Candida and Aspergillus spondylodiscitis

treatment, the present case had a good result following one-stage radical debridement and internal fixation. Compliance with ethic guideline Lie-dao YU, Zhi-yun FENG, Xuan-wei WANG, Zhi-heng LING, and Xiang

Masked repetition priming hinders subsequent recollection but not familiarity: A behavioral and event-related potential study

The present study used the masked repetition priming paradigm in the study phase and the R/K paradigm in the test phase to investigate whether repetition priming can hinder recognition memory and which recognition process (familiarity or recollection) is hindered. Event-related potentials (ERPs) in the study and test phase were recorded to explore the temporal course of how ...

DNA Double-Strand Breaks Induce the Nuclear Actin Filaments Formation in Cumulus-Enclosed Oocytes but Not in Denuded Oocytes

As a gamete, oocyte needs to maintain its genomic integrity and passes this haploid genome to the next generation. However, fully-grown mouse oocyte cannot respond to DNA double-strand breaks (DSBs) effectively and it is also unable to repair them before the meiosis resumption. To compensate for this disadvantage and control the DNA repair events, oocyte needs the cooperation with ...

Stem cell therapy: a novel treatment option for cerebral malaria?

Cerebral malaria, a severe form of the disease, is one of the most severe complications of infection with Plasmodium parasites and a leading cause of malaria mortality. Currently available antimalarial therapy has proven insufficient to prevent neurological complications and death in all cases of cerebral malaria. Souza and colleagues observed that transplantation of bone ...

Circulating histones for predicting prognosis after cardiac surgery: a prospective study

OBJECTIVES The objective of this study was to assess the perioperative changes in circulating histones and their relationships with other biomarkers and clinical outcomes after cardiac surgery with cardiopulmonary bypass (CPB) in patients.

Macrophage-derived MCPIP1 mediates silica-induced pulmonary fibrosis via autophagy

Background Silicosis is characterized by accumulation of fibroblasts and excessive deposition of extracellular matrix. Monocyte chemotactic protein-1-induced protein 1 (MCPIP1) plays a critical role in fibrosis induced by SiO 2 . However, the details of the downstream events of MCPIP1 activity in pulmonary fibrosis remain unclear. To elucidate the role of MCPIP1-induced autophagy ...

Facing the challenges in ophthalmology clerkship teaching: Is flipped classroom the answer?

Recent reform of medical education highlights the growing concerns about the capability of the current educational model to equip medical school students with essential skills for future career development. In the field of ophthalmology, although many attempts have been made to address the problem of the decreasing teaching time and the increasing load of course content, a growing ...

Clinicopathologic analysis of lymph node status in superficial esophageal squamous carcinoma

Wei Wang 0 0 Department of Cardiothoracic Surgery, First Affiliated Hospital of Nanjing Medical University , No. 300 Guangzhou Road, Nanjing 210029 , China 1 Department of Pathology, First Affiliated

Regulatory mechanisms of microRNAs in lung cancer stem cells

Increasing evidence suggests that cancer stem cells (CSCs) are a key occurrence in the process of many human cancers. Lung cancer is the most common aggressive malignancy and cause of cancer death worldwide. The research on lung cancer stem cells has been highlighted for many years. Lung CSCs seem to play a major role in lung cancer metastasis, drug resistance and ...