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Comparison of ISS, NISS, and RTS score as predictor of mortality in pediatric fall

Background Studies to identify an ideal trauma score tool representing prediction of outcomes of the pediatric fall patient remains elusive. Our study was undertaken to identify better predictor of mortality in the pediatric fall patients. Methods Data was retrieved from prospectively maintained trauma registry project at level 1 trauma center developed as part of Multicentric ...

Statistical inference in mechanistic models: time warping for improved gradient matching

Inference in mechanistic models of non-linear differential equations is a challenging problem in current computational statistics. Due to the high computational costs of numerically solving the differential equations in every step of an iterative parameter adaptation scheme, approximate methods based on gradient matching have become popular. However, these methods critically depend ...

Identification of the primary peptide contaminant that inhibits fibrillation and toxicity in synthetic amyloid-β42

Understanding the pathophysiology of Alzheimer disease has relied upon the use of amyloid peptides from a variety of sources, but most predominantly synthetic peptides produced using t-butyloxycarbonyl (Boc) or 9-fluorenylmethoxycarbonyl (Fmoc) chemistry. These synthetic methods can lead to minor impurities which can have profound effects on the biological activity of amyloid ...

An enhanced reliability-oriented workforce planning model for process industry using combined fuzzy goal programming and differential evolution approach

This paper draws on the “human reliability” concept as a structure for gaining insight into the maintenance workforce assessment in a process industry. Human reliability hinges on developing the reliability of humans to a threshold that guides the maintenance workforce to execute accurate decisions within the limits of resources and time allocations. This concept offers a ...

The Patterns of Non-vitamin K Antagonist Oral Anticoagulants (NOACs) Use in Patients with Atrial Fibrillation in Seven Balkan Countries: a Report from the BALKAN-AF Survey

Introduction Data on management of atrial fibrillation (AF) in the Balkan Region are scarce. To capture the patterns in AF management in contemporary clinical practice in the Balkan countries a prospective survey was conducted between December 2014 and February 2015, and we report results pertinent to the use of non-vitamin K antagonist oral anticoagulants (NOACs). Methods A ...

Estimation of sickness absenteeism among Italian healthcare workers during seasonal influenza epidemics

Objectives To analyze absenteeism among healthcare workers (HCWs) at a large Italian hospital and to estimate the increase in absenteeism that occurred during seasonal flu periods. Design Retrospective observational study. Methods The absenteeism data were divided into three “epidemic periods,” starting at week 42 of one year and terminating at week 17 of the following year ...

Exodus! Large-scale displacement and social adjustments of resident Atlantic spotted dolphins (Stenella frontalis) in the Bahamas

Over the last 20 years, significant habitat shifts have been documented in some populations of cetaceans. On Little Bahama Bank (LBB) there are sympatric communities of resident Atlantic spotted dolphins (Stenella frontalis) and bottlenose dolphins (Tursiops truncatus), monitored since 1985. The size and social structure (three clusters: Northern, Central, Southern) have been ...

Behaviour of model footing resting on sand reinforced with number of layers of coir geotextile

Several methods of ground improvement techniques were developed and tried for stabilizing weak soils. The technique of reinforcing the soil becomes one of the important methods. The performance of granular soils which are strong in compression and shear, but weak in tension can be substantially improved by introducing reinforcing element in the direction of tensile strain. Compared ...

Vergleich der Testung von Sonnenschutzmitteln durch Stiftung Warentest und Öko-Test

The results of Stiftung Warentest, ÖKO-TEST and the official control laboratories are poorly comparable because of their different objects, even if there are some overlaps. Given the example of cosmetic sunscreen products, which had been tested by all 3 institutions over several years, the differences in testing and evaluation are presented. We show that also the testings of the ...

Aberrant cGMP signaling persists during recovery in mice with oxygen-induced pulmonary hypertension

Bronchopulmonary dysplasia (BPD), a common complication of preterm birth, is associated with pulmonary hypertension (PH) in 25% of infants with moderate to severe BPD. Neonatal mice exposed to hyperoxia for 14d develop lung disease similar to BPD, with evidence of associated PH. The cyclic guanosine monophosphate (cGMP) signaling pathway has not been well studied in BPD-associated ...

Isolation and identification of bacteria from rotary drum compost of water hyacinth

Purpose The present work aims to isolate and identify bacterial community from the rotary drum compost of green waste such as the water hyacinth. Compost quality was also investigated with the physicochemical parameters and the heavy metal analysis. Methods For rotary drum composting, a waste mixture of 150 kg with water hyacinth, cow dung and sawdust were prepared in the ...

Testing and comparing two self-care-related instruments among older Chinese adults

Objectives The study aimed to test and compare the reliability and validity, including sensitivity and specificity of the two self-care-related instruments, the Self-care Ability Scale for the Elderly (SASE), and the Appraisal of Self-care Agency Scale-Revised (ASAS-R), among older adults in the Chinese context. Methods A cross-sectional design was used to conduct this study. The ...

The impact of the implementation of physician assistants in inpatient care: A multicenter matched-controlled study

Background Medical care for admitted patients in hospitals is increasingly reallocated to physician assistants (PAs). There is limited evidence about the consequences for the quality and safety of care. This study aimed to determine the effects of substitution of inpatient care from medical doctors (MDs) to PAs on patients’ length of stay (LOS), quality and safety of care, and ...

SFRP2 enhances the osteogenic differentiation of apical papilla stem cells by antagonizing the canonical WNT pathway

Background Exploring the molecular mechanisms underlying directed differentiation is helpful in the development of clinical applications of mesenchymal stem cells (MSCs). Our previous study on dental tissue-derived MSCs demonstrated that secreted frizzled-related protein 2 (SFRP2), a Wnt inhibitor, could enhance osteogenic differentiation in stem cells from the apical papilla ...

The effect on turnout of campaign mobilization messages addressing ballot secrecy concerns: A replication experiment

Given the persistence of public doubts about the integrity of ballot secrecy, which depress turnout, two prior experiments have shown precise evidence that both official governmental and unofficial mobilization campaigns providing assurances about ballot secrecy increase turnout among recently registered nonvoters. To assess whether these findings replicate in other political ...

A systematic review of adverse drug events associated with administration of common asthma medications in children

Objective To systematically review the literature and determine frequencies of adverse drug events (ADE) associated with pediatric asthma medications. Methods Following PRISMA guidelines, we systematically searched six bibliographic databases between January 1991 and January 2017. Study eligibility, data extraction and quality assessment were independently completed and verified by ...

Extracting discourse elements and annotating scientific documents using the SciAnnotDoc model: a use case in gender documents

When scientists are searching for information, they generally have a precise objective in mind. Instead of looking for documents “about a topic T”, they try to answer specific questions such as finding the definition of a concept, finding results for a particular problem, checking whether an idea has already been tested, or comparing the scientific conclusions of two articles. ...

The ever-evolving role of pathologists in the management of breast cancer with neoadjuvant treatment: recommendations based on the Spanish clinical experience

Purpose To compare the current international standards for neoadjuvant systemic therapy (NAST) protocols, and establish consensus recommendations by Spanish breast pathologists; and to look into the Spanish reality of defining pathological complete response in daily practice. Materials and methods A modified Delphi technique was used to gain consensus among a panel of 46 experts ...

The Invention of Consciousness

In English we use the word “invention” in two ways. First, to mean a new device or process developed by experimentation, and designed to fulfill a practical goal. Second, to mean a mental fabrication, especially a falsehood, designed to please or persuade. In this paper I argue that human consciousness is an invention in both respects. First, it is a cognitive faculty, evolved by ...

Decoupling in the age of market-embedded morality: responsible gambling in a hybrid organization

This paper contributes to the understanding of hybrid organizations by refining the concept of decoupling as a strategic response to conflicting objectives and institutional expectations (Meyer and Rowan in Am J Soc 83:340–363, 1977). In today’s popular responsibility discourse one notes a hopeful “win–win” ideal that invites attempts, by companies in particular, to realize and ...