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Examining the psychometric properties of a sport-related concussion survey: a Rasch measurement approach

Background Awareness of sport-related concussion (SRC) is an essential step in increasing the number of athletes or parents who report on SRC. This awareness is important, as there is no established data on medical care at youth-level sports and may be limited to individuals with only first aid training. In this circumstance, aside from the coach, it is the players and their ...

Simple synthesis of 32P-labelled inositol hexakisphosphates for study of phosphate transformations

Background and aims In many soils inositol hexakisphosphate in its various forms is as abundant as inorganic phosphate. The organismal and geochemical processes that exchange phosphate between inositol hexakisphosphate and other pools of soil phosphate are poorly defined, as are the organisms and enzymes involved. We rationalized that simple enzymic synthesis of inositol ...

Public Sector Accounting: Transparency Issues

Public accounting systems differ among countries so the reform towards harmonization is needed especially for EU Member Countries. The transition from cash-based to accrual-based accounting is necessary in order to provide the wide scope of relevant information to the internal and external users. The objectives of the paper are: to examine the level of conversance with IPSAS ...

Ramucirumab for Treating Advanced Gastric Cancer or Gastro-Oesophageal Junction Adenocarcinoma Previously Treated with Chemotherapy: An Evidence Review Group Perspective of a NICE Single Technology Appraisal

The National Institute for Health and Care Excellence (NICE) invited the company that manufactures ramucirumab (Cyramza®, Eli Lilly and Company) to submit evidence of the clinical and cost effectiveness of the drug administered alone (monotherapy) or with paclitaxel (combination therapy) for treating adults with advanced gastric cancer or gastro-oesophageal junction (GC/GOJ) ...

Association between untreated carious lesions and asthma in adults at Rabat University Hospital, Morocco: a cross sectional study

Background Depending on risk factors, cumulative risk of developing more dental caries by age has been reported. However, the association between dental caries and asthma is less studied among adults. The aims of this study were to evaluate the severity of untreated carious lesions in a population of asthmatic adults and to evaluate the mediation of socio-economic and oral health ...

Dissecting Kawasaki disease: a state-of-the-art review

Kawasaki disease (KD) is a pediatric vasculitis with coronary artery aneurysms (CAA) as its main complication. The diagnosis is based on the presence of persistent fever and clinical features including exanthema, lymphadenopathy, conjunctival injection, and changes to the mucosae and extremities. Although the etiology remains unknown, the current consensus is that it is likely ...

Cerebrospinal fluid monoamine metabolite profiles in bipolar disorder, ADHD, and controls

Alterations in monoaminergic signaling are suggested as key aspects of the pathophysiology in bipolar disorder and ADHD, but it is not known if the monoamine metabolic profile differs between these disorders. One method to study monoaminergic systems in humans is to measure monoamine end-point metabolite concentrations in cerebrospinal fluid (CSF). Here, we analyzed CSF monoamine ...

Methods of Model Reduction for Large-Scale Biological Systems: A Survey of Current Methods and Trends

Complex models of biochemical reaction systems have become increasingly common in the systems biology literature. The complexity of such models can present a number of obstacles for their practical use, often making problems difficult to intuit or computationally intractable. Methods of model reduction can be employed to alleviate the issue of complexity by seeking to eliminate ...

Ensemble prospectism

Incomplete preferences displaying ‘mildly sweetened’ structure are common, yet theoretically problematic. This paper examines the properties of the rankings induced by the set of all coherent completions of the mildly sweetened partial preference structure. Building on these properties, I propose an ensemble-based refinement of Hare’s (Analysis 70:237–247, 2010) prospectism ...

Effects of Business Education on Consumer Awareness and Conscious Consumption

Consumer awareness and conscious consumption are well known concepts that gained higher value in time. Increased communication networks and tools let people to reach information sources about products and companies easier and faster. Consumer mind is affected by many other factors indeed. Education itself has pretty much effect on these concepts since it begins at very young ages ...

Establishing energy requirements for body weight maintenance: validation of an intake-balance method

Background Experimentally establishing a group’s body weight maintenance energy requirement is an important component of metabolism research. At present, the reference approach for measuring the metabolizable energy intake (MEI) from foods required for body weight maintenance in non-confined subjects is the doubly-labeled water (DLW)–total energy expenditure (TEE) method. In the ...

Is the Personal Identity Debate a “Threat” to Neurosurgical Patients? A Reply to Müller et al.

In their article in this journal, Sabine Müller, Merlin Bittlinger, and Henrik Walter launch a sweeping attack against what they call the “personal identity debate” as it relates to patients treated with deep brain stimulation (DBS). In this critique offered by Müller et al., the personal identity debate is said to: (a) be metaphysical in a problematic way, (b) constitute a threat ...

Identifying Subpopulations with Distinct Response to Treatment Using Plasma Biomarkers in Acute Heart Failure: Results from the PROTECT Trial

Background Over the last 50 years, clinical trials of novel interventions for acute heart failure (AHF) have, with few exceptions, been neutral or shown harm. We hypothesize that this might be related to a differential response to pharmacological therapy. Methods We studied the magnitude of treatment effect of rolofylline across clinical characteristics and plasma biomarkers in ...