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422 papers found.
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B7H1 Expression and Epithelial-To-Mesenchymal Transition Phenotypes on Colorectal Cancer Stem-Like Cells

Cancer stem cells (CSCs) can invade and metastasize by epithelial-to-mesenchymal transition (EMT). However, how they escape immune surveillance is unclear. B7H1 is crucial negative co-stimulatory molecule but little information about whether it works in CSCs. Therefore, we determined the expression of B7H1 and EMT-associated markers in colorectal cancer stem-like cells to...

Complete Inverse Method Using Ant Colony Optimization Algorithm for Structural Parameters and Excitation Identification from Output Only Measurements

Copyright © 2014 Jun Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium ... publication of this paper. Acknowledgment Professor Jun Chen gratefully acknowledges financial support for the research represented by this paper, which came from The Project of National Key Technology R&D

Complete Inverse Method Using Ant Colony Optimization Algorithm for Structural Parameters and Excitation Identification from Output Only Measurements

Copyright © 2014 Jun Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium ... publication of this paper. Acknowledgment Professor Jun Chen gratefully acknowledges financial support for the research represented by this paper, which came from The Project of National Key Technology R&D

Protocol of a prospective study for the combination treatment of Shu-Gan-jian-Pi decoction and steroid standard therapy in autoimmune hepatitis patients

Background Prednisone plus azathioprine is considered the mainstay of therapy in the current recommendations for autoimmune hepatitis (AIH). However, it does not provide good benefits for AIH patients because of its serious side effects. Therefore, more and more AIH patients prefer to seek for traditional Chinese medicine (TCM) to manage their symptoms and reduce the side effects...

Computational methods for the zero-stress state and the pre-stress state of tensile cable-net structures

This paper proposes an extended design concept and mechanical description for cable-net structures, including 10 states and 15 procedures which are defined according to their physical nature and analytical capabilities. In the pre-stress release analysis, an iterative computational method is developed for the inverse evaluation from the equilibrium state to the zero-stress state...

Prognostic nomogram integrated systemic inflammation score for patients with esophageal squamouscell carcinoma undergoing radical esophagectomy

Affiliated Hospital of Soochow University, 185 Juqian Street, Changzhou 213003, P.R. ChinaYingjie Shao, Zhonghua Ning, Jun Chen, Wendong Gu, Jin Huang & Honglei PeiDepartment of Oncology, The Third Affiliated ... Jiang AuthorsSearch for Yingjie Shao in:Nature Research journals • PubMed • Google ScholarSearch for Zhonghua Ning in:Nature Research journals • PubMed • Google ScholarSearch for Jun Chen in:Nature

Application of Variational Iteration Method for Dropping Damage Evaluation of the Suspension Spring Packaging System

The dropping damage evaluation for packaging system is essential for safe transportation and storage. A dynamic model of nonlinear cubic-quintic Duffing oscillator for the suspension spring packaging system was proposed. Then, a first-order approximate solution was obtained by applying He’s variable iteration method. Based on the results, a damage evaluation equation was derived...

Sarcoidosis misdiagnosed as malignant tumors: a case report

Song Xu 1 Jun Chen 1 0 Equal contributors 1 Department of Lung Cancer Surgery, Lung Cancer Institute, Tianjin Medical University General Hospital , No. 154 Anshan Road, Heping District, Tianjin 300052 ... manuscript. Education Ministry (to Song Xu), Tianjin Science and Technology Support Program (12ZCDZSY16100 to Jun Chen), and Tianjin Educational Committee Foundation (20120117 to Song Xu). 1. Colby TV

Prediction of microstructural evolution during hot forging

Microstructural evolution, which is governed by temperature, strain and strain rate during hot forging, is a key factor influencing mechanical properties. Understanding the microstructural evolution of metals and alloys in hot forging has a great importance for the designers of metal forming processes. The principal objective of this paper is to provide an overview of the models...

The Incidence, Clinical Outcomes, and Risk Factors of Thrombocytopenia in Intra-Abdominal Infection Patients: A Retrospective Cohort Study

Background Studies on the incidence and risk factors of thrombocytopenia among intra-abdominal infection patients remain absent, hindering efficacy assessments regarding thrombocytopenia prevention strategies. Methods We retrospectively studied 267 consecutively enrolled patients with intra-abdominal infections. Occurrence of thrombocytopenia was scanned for all patients. All...

A naturally occurring 4-bp deletion in the intron 4 of p53 creates a spectrum of novel p53 isoforms with anti-apoptosis function

p53 functions as a tumor suppressor by transcriptionally regulating the expression of genes involved in controlling cell proliferation or apoptosis. p53 and its isoform Δ133p53/Δ113p53 form a negative regulation loop in that p53 activates the expression of Δ133p53/Δ113p53 while Δ133p53/Δ113p53 specifically antagonizes p53 apoptotic activity. This pathway is especially important...

Vitamin D Receptor Gene FOKI Polymorphism Contributes to Increasing the Risk of HIV-Negative Tuberculosis: Evidence from a Meta-Analysis

Background Vitamin D receptor (VDR) gene FokI polymorphism have been studied in relation to tuberculosis (TB) in many populations and provided inconsistent results. In this study, we carried out a meta-analysis to derive a more reliable assessment on FokI polymorphism and the risk of HIV-negative TB. Methods The Embase, PubMed, and Cochrane Library databases were used to...

M(Salen)-derived Nitrogen-doped M/C (M = Fe, Co, Ni) Porous Nanocomposites for Electrocatalytic Oxygen Reduction

, Tianran Zhang & Jun Chen AuthorsSearch for Jing Du in:Nature Research journals • PubMed • Google ScholarSearch for Fangyi Cheng in:Nature Research journals • PubMed • Google ScholarSearch for Shiwen Wang ... in:Nature Research journals • PubMed • Google ScholarSearch for Tianran Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Jun Chen in:Nature Research journals • PubMed • Google Scholar

A Mixture Model for Robust Point Matching under Multi-Layer Motion

This paper proposes an efficient mixture model for establishing robust point correspondences between two sets of points under multi-layer motion. Our algorithm starts by creating a set of putative correspondences which can contain a number of false correspondences, or outliers, in addition to the true correspondences (inliers). Next we solve for correspondence by interpolating a...

Transcriptome Immune Analysis of the Invasive Beetle Octodonta nipae (Maulik) (Coleoptera: Chrysomelidae) Parasitized by Tetrastichus brontispae Ferrière (Hymenoptera: Eulophidae)

The beetle Octodonta nipae (Maulik) (Coleoptera: Chrysomelidae) is a serious invasive insect pest of palm plants in southern China, and the endoparasitoid Tetrastichus brontispae Ferrière (Hymenoptera: Eulophidae) is a natural enemy of this pest that exhibits great ability in the biocontrol of O. nipae. For successful parasitism, endoparasitoids often introduce or secrete various...

MiR-506 Is Down-Regulated in Clear Cell Renal Cell Carcinoma and Inhibits Cell Growth and Metastasis via Targeting FLOT1

Background Some microRNAs (miRNAs) are abnormally expressed in cancer and contribute to tumorigenesis. In the present study, we investigated the role of miR-506 in clear cell renal cell carcinoma (ccRCC). Methods miR-506 expression was detected in renal cancer cell lines 786-O, ACHN, Caki-1, and Caki-2 and ccRCC specimens by quantitative real-time-PCR. We assessed the association...

Causes, clinical features and outcomes of drug-induced liver injury in hospitalized patients in a Chinese tertiary care hospital

Drug-induced liver injury (DILI) is an important liver disease in China, owing to the country’s huge population and the availability of a multitude of drugs. Consequently, DILI is becoming an increasingly serious health problem. However, there is not enough relevant epidemiological data, and the clinical features of these patients are not clear. We conducted this study to report...

Haploinsufficiency of Def Activates p53-Dependent TGFβ Signalling and Causes Scar Formation after Partial Hepatectomy

The metazoan liver exhibits a remarkable capacity to regenerate lost liver mass without leaving a scar following partial hepatectomy (PH). Whilst previous studies have identified components of several different signaling pathways that are essential for activation of hepatocyte proliferation during liver regeneration, the mechanisms that enable such regeneration to occur without...