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Functional interplay between NTP leaving group and base pair recognition during RNA polymerase II nucleotide incorporation revealed by methylene substitution

RNA polymerase II (pol II) utilizes a complex interaction network to select and incorporate correct nucleoside triphosphate (NTP) substrates with high efficiency and fidelity. Our previous ‘synthetic nucleic acid substitution’ strategy has been successfully applied in dissecting the function of nucleic acid moieties in pol II transcription. However, how the triphosphate moiety of ...

Mechanical Stretch Inhibits MicroRNA499 via p53 to Regulate Calcineurin-A Expression in Rat Cardiomyocytes

Background MicroRNAs play an important role in cardiac remodeling. MicroRNA 499 (miR499) is highly enriched in cardiomyocytes and targets the gene for Calcineurin A (CnA), which is associated with mitochondrial fission and apoptosis. The mechanism regulating miR499 in stretched cardiomyocytes and in volume overloaded heart is unclear. We sought to investigate the mechanism ...

Plate/shell topological optimization subjected to linear buckling constraints by adopting composite exponential filtering function

In this paper, a model of topology optimization with linear buckling constraints is established based on an independent and continuous mapping method to minimize the plate/shell structure weight. A composite exponential function (CEF) is selected as filtering functions for element weight, the element stiffness matrix and the element geometric stiffness matrix, which recognize the ...

Free Energy Landscape and Multiple Folding Pathways of an H-Type RNA Pseudoknot

How RNA sequences fold to specific tertiary structures is one of the key problems for understanding their dynamics and functions. Here, we study the folding process of an H-type RNA pseudoknot by performing a large-scale all-atom MD simulation and bias-exchange metadynamics. The folding free energy landscapes are obtained and several folding intermediates are identified. It is ...

Community Structure of Macrobiota and Environmental Parameters in Shallow Water Hydrothermal Vents off Kueishan Island, Taiwan

Hydrothermal vents represent a unique habitat in the marine ecosystem characterized with high water temperature and toxic acidic chemistry. Vents are distributed at depths ranging from a few meters to several thousand meters. The biological communities of shallow-water vents have, however, been insufficiently studied in most biogeographic areas. We attempted to characterize the ...

Metastatic EML4-ALK fusion detected by circulating DNA genotyping in an EGFR-mutated NSCLC patient and successful management by adding ALK inhibitors: a case report

Background Rebiopsy is highly recommended to identify the mechanism of acquired resistance to EGFR-TKIs in advanced lung cancer. Recent advances in multiplex genotyping based on circulating tumor DNA (ctDNA) provide a strong and non-invasive alternative for detection of the resistance mechanism. Case presentation Here we report a multiple metastatic NSCLC patient who was detected ...

MicroRNA profiling of the whitefly Bemisia tabaci Middle East-Aisa Minor I following the acquisition of Tomato yellow leaf curl China virus

Background The begomoviruses are the largest and most economically important group of plant viruses exclusively vectored by whitefly (Bemisia tabaci) in a circulative, persistent manner. During this process, begomoviruses and whitefly vectors have developed close relationships and complex interactions. However, the molecular mechanisms underlying these interactions remain largely ...

Clinicopathological characteristics and outcomes in stage I–III mucinous gastric adenocarcinoma: a retrospective study at a single medical center

Background The clinicopathological characteristics and outcomes of mucinous gastric adenocarcinoma (GC) remain unclear. We report the clinicopathological features and prognosis of patients with mucinous histology who underwent radical-intent gastrectomy. Methods We reviewed the medical records of 1470 patients with pathologically proven undifferentiated GC undergoing radical-intent ...

Traditional Chinese medicine and new concepts of predictive, preventive and personalized medicine in diagnosis and treatment of suboptimal health

Background The premise of disease-related phenotypes is the definition of the counterpart normality in medical sciences. Contrary to clinical practices that can be carefully planned according to clinical needs, heterogeneity and uncontrollability is the essence of humans in carrying out health studies. Full characterization of consistent phenotypes that define the general ...

A novel energy-efficient resource allocation algorithm based on immune clonal optimization for green cloud computing

Cloud computing is a style of computing in which dynamically scalable and other virtualized resources are provided as a service over the Internet. The energy consumption and makespan associated with the resources allocated should be taken into account. This paper proposes an improved clonal selection algorithm based on time cost and energy consumption models in cloud computing ...

Joint spectrum sensing and access for stable dynamic spectrum aggregation

Spectrum aggregation is an emerging technology to satisfy the data rate requirement of broadband services for next-generation wireless communication systems. In dynamic spectrum environment, in which the spectrum availability is time-varying, it is quite challenging to maintain the stability of spectrum aggregation. In this paper, we investigate the spectrum sensing and access ...

Distribution and geochemical significance of phenylphenanthrenes and their isomers in selected oils and rock extracts from the Tarim Basin, NW China

Twenty-two oil samples and eight source rock samples collected from the Tarim Basin, NW China were geochemically analyzed to investigate the occurrence and distribution of phenylphenanthrene (PhP), phenylanthracene (PhA), and binaphthyl (BiN) isomers and methylphenanthrene (MP) isomers in oils and rock extracts with different depositional environments. Phenylphenanthrenes are ...

A meta-analysis of the association between IL28B polymorphisms and infection susceptibility of hepatitis B virus in Asian population

Background Several association studies with small sample sizes of two SNPs in IL28BB (rs12979860 and rs8099917) showed inconsistent results, so in this study, we aim to evaluate the association between the two SNPs and infection susceptibility of Hepatitis B Virus (HBV) in Asian population, especially in Chinese population by meta-analysis. Methods Search the relevant published ...

Identification of single-stranded and double-stranded dna binding proteins based on protein structure

Wei Wang 0 Juan Liu 0 Xionghui Zhou 0 0 School of Computer, Wuhan University , Wuhan, Hubei 430072 , People's Republic of China Background: Protein-DNA interactions are essential for many

Re-Identification Risk versus Data Utility for Aggregated Mobility Research Using Mobile Phone Location Data

Mobile phone location data is a newly emerging data source of great potential to support human mobility research. However, recent studies have indicated that many users can be easily re-identified based on their unique activity patterns. Privacy protection procedures will usually change the original data and cause a loss of data utility for analysis purposes. Therefore, the need ...

High PHLPP expression is associated with better prognosis in patients with resected lung adenocarcinoma

Background PH domain Leucine-rich-repeats protein phosphatase (PHLPP) is a novel family of Ser/Thr protein dephosphatases that play a critical role in maintaining the balance in cell signaling. PHLPP negatively regulates PI3K/Akt and RAF/RAS/′ signaling activation, which is crucial in development, growth, and proliferation of lung cancer. The aim of this study was to investigate ...

Combined Intravitreal Anti-VEGF and Photodynamic Therapy versus Photodynamic Monotherapy for Polypoidal Choroidal Vasculopathy: A Systematic Review and Meta-Analysis of Comparative Studies

Purpose The aim of this study was to evaluate the efficacy and safety of photodynamic therapy (PDT) combined with intravitreal vascular endothelial growth factor (VEGF) inhibitors compared to those of PDT alone in the treatment of polypoidal choroidal vasculopathy (PCV). Methods A systematic search of Pubmed, Embase, and the Cochrane Library was performed to identify all ...

Long-term effect of respiratory training for chronic obstructive pulmonary disease patients at an outpatient clinic: a randomised controlled trial

Objective To assess the effect of respiratory training (RT) on lung function, activity tolerance and acute exacerbation frequency with chronic obstructive pulmonary disease (COPD). Design A randomised controlled trial. Setting Outpatient clinic and home of the COPD patients, Zhengzhou City, China. Subjects Sixty participants with COPD were randomised into two groups: an ...