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FastHap: fast and accurate single individual haplotype reconstruction using fuzzy conflict graphs

Motivation: Understanding exact structure of an individual’s haplotype plays a significant role in various fields of human genetics. Despite tremendous research effort in recent years, fast and accurate haplotype reconstruction remains as an active research topic, mainly owing to the computational challenges involved. Existing haplotype assembly algorithms focus primarily on ...

Regulation of flowering time by the miR156-mediated age pathway

Precise flowering time is critical to reproductive success. In response to diverse exogenous and endogenous cues including age, hormones, photoperiod, and temperature, the floral transition is controlled by a complex regulatory network, which involves extensive crosstalks, feedback, or feedforward loops between the components within flowering time pathways. The newly identified age ...

Fermentation of mixed substrates by Clostridium pasteurianum and its physiological, metabolic and proteomic characterizations

Background Clostridium pasteurianum is becoming increasingly attractive for the production of chemicals and fuels such as n-butanol and 1,3-propanediol. Previously we have shown that dual substrate fermentation using glucose and glycerol enhanced the cell growth and butanol production significantly. Although C. pasteurianum can grow efficiently with either glucose or glycerol ...

Design, synthesis, and biological evaluation of the novel glycyrrhetinic acid-cinnamoyl hybrids as anti-tumor agents

Background Glycyrrhetinic acid (GA) derivatives had shown not only cytotoxicity but also could trigger apoptosis in various human cancer cell lines. Moreover, cinnamic acid (CA) and its phenolic analogues as potent antitumor agents were employed in the design of anti-tumor drugs. To further improve the anti-tumor activity of GA and CA derivatives, a series of novel compounds were ...

4.4 Å Resolution Cryo-EM structure of human mTOR Complex 1

Jiawei Wang 5 Yanhui Xu 0 1 2 Hong-Wei Wang 5 0 State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University ... financial interests. COMPLIANCE WITH ETHICS GUIDELINES Huirong Yang, Jia Wang, Mengjie Liu, Xizi Chen, Min Huang, Dan Tan, Meng-Qiu Dong, Catherine C. L. Wong, Jiawei Wang, Yanhui Xu and Hong-Wei Wang

Analysis of opportunistic spectrum access in cognitive radio networks using hidden Markov model with state prediction

Jyu-Wei Wang 0 Ramzi Adriman 1 0 Department of Photonics and Comm. Engineering, Asia University , No. 500, Lioufong Rd., Wufong District, Taichung City , Taiwan 1 Department of Computer Science

First report of Rickettsia raoultii and R. slovaca in Melophagus ovinus, the sheep ked

Wang 4 Chang-Chun Tu 3 Chuang-Fu Chen 0 0 College of Animal Science and Technology, Shihezi University , Shihezi, Xinjiang Uygur Autonomous Region 832002 , China 1 Institute of Veterinary Medicine

Case-report: endovascular treatment of aortic pseudo-aneurysm caused by Fishbone

Aortic pseudo-aneurysm (APA) is a rare disease in clinic. Because of its relative rarity, we are far from making any conclusion regarding the natural history and appropriate therapeutic strategy for this condition. This study is to investigate the treatment effect of interventional therapy in aortic pseudo-aneurysm. A woman of 68 years old diagnosed with APA caused by fishbone was ...

Comparison of rabbit rib defect regeneration with and without graft

Rib segment, as one of the most widely used autologous boneresources for bone repair, is commonly isolated with an empty left in the defect. Although defective rib repair is thought to be unnecessary traditionally, it’s of vital importance actually to promote rib regeneration for patients with better postoperative recovery and higher life quality. Comparative investigations on ...

MicroRNAs in breast cancer: oncogene and tumor suppressors with clinical potential

cancers, may be the biggest challenges to be solved. Compliance with ethics guidelines Wei WANG and Yun-ping LUO declare that they have no conflict of interest. This article does not contain any studies

Induction of follicular luteinization by equine chorionic gonadotropin in cyclic guinea pigs

WisconsinMilwaukee, USA, for reading the revised manuscripts and offering valuable suggestions. Compliance with ethics guidelines Jun-rong LI, Wei WANG, and Fang-xiong SHI declare that they have no conflict of

The comparisons of phenotype and genotype between CADASIL and CADASIL-like patients and population-specific evaluation of CADASIL scale in China

Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common form of hereditary stroke disorder caused by mutations in the NOTCH3 gene. Although CADASIL scale is a widely used tool to screen clinically suspected CADASIL patients, the differential effects of this scale in various populations remain unknown. ...

Validation of standard operating procedures in a multicenter retrospective study to identify -omics biomarkers for chronic low back pain

Chronic low back pain (CLBP) is one of the most common medical conditions, ranking as the greatest contributor to global disability and accounting for huge societal costs based on the Global Burden of Disease 2010 study. Large genetic and -omics studies provide a promising avenue for the screening, development and validation of biomarkers useful for personalized diagnosis and ...

Metabolomic investigation of regional brain tissue dysfunctions induced by global cerebral ischemia

Background To get a broader view of global ischemia-induced cerebral disorders at the metabolic level, a nuclear magnetic resonance-based metabolomic study was performed to evaluate the metabolic profile changes on regional brain tissues of female and male mice upon bilateral common carotid arteries occlusion (BCCAO) operation. Results Significant metabolic disorders were observed ...

Meta-Analysis of Randomized Controlled Trials Comparing EX-PRESS Implantation with Trabeculectomy for Open-Angle Glaucoma

Purpose To evaluate the efficacy and safety of EX-PRESS implantation compared with trabeculectomy for uncontrolled open-angle glaucoma. Methods Pertinent randomized controlled trials were identified through systematic searches of the PubMed, EMBASE, and Cochrane Library. The efficacy measures utilized were the weighted mean differences (WMDs) for the intraocular pressure reduction ...

The Role of p-STAT3 as a Prognostic and Clinicopathological Marker in Colorectal Cancer: A Systematic Review and Meta-Analysis

Objective High expression of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) has been detected in a variety of human tumors. However, the association of positive p-STAT3 expression with clinicopathological parameters and the prognosis of colorectal cancer patients remain controversial. To identify the relationship between p-STAT3 expression and ...

RNA-Skim: a rapid method for RNA-Seq quantification at transcript level

Zhaojun Zhang 1 Wei Wang 0 0 Department of Computer Science, University of California , Los Angeles, CA, USA 1 Department of Computer Science, University of North Carolina at Chapel Hill , Chapel

Collapsing singletons may boost signal for associating rare variants in sequencing study

Advances in next-generation sequencing technology have made it possible to comprehensively interrogate the entire spectrum of genomic variations including rare variants. They may help capture the remaining genetic heritability which has not been fully explained by previous genome-wide association studies. Here we performed a gene-based genome-wide scan to identify hypertension ...

A novel histopathologic finding in the Descemet's membrane of a patient with Peters Anomaly: a case-report and literature review

Background Peters anomaly is a rare developmental abnormality of the anterior segment of the eye and is one of the main causes of congenital corneal opacities. Typically, histopathology of Peters anomaly shows immature or absent Descemet’s membrane and attenuated endothelial cells in the area of the corneal opacity, in addition to thinning or absence of Bowman’s membrane and ...

Overexpression of the Wheat Expansin Gene TaEXPA2 Improved Seed Production and Drought Tolerance in Transgenic Tobacco Plants

Expansins are cell wall proteins that are grouped into two main families, α-expansins and β-expansins, and they are implicated in the control of cell extension via the disruption of hydrogen bonds between cellulose and matrix glucans. TaEXPA2 is an α-expansin gene identified in wheat. Based on putative cis-regulatory elements in the TaEXPA2 promoter sequence and the expression ...