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Biological complications in implant-supported oral rehabilitation: as the pendulum swings back towards endodontics and tooth preservation

The decision whether to retain a tooth by additional endodontic and restorative treatments or to extract it and replace it with an implant-supported restoration has been extensively debated, and the common approach to this clinical question has shifted back and forth many times. However, in recent years, it has become clear that implants are more prone to technical and biological ...

JANUS: A hypothesis-driven Bayesian approach for understanding edge formation in attributed multigraphs

Understanding edge formation represents a key question in network analysis. Various approaches have been postulated across disciplines ranging from network growth models to statistical (regression) methods. In this work, we extend this existing arsenal of methods with JANUS, a hypothesis-driven Bayesian approach that allows to intuitively compare hypotheses about edge formation in ...

Sparse matrix computations for dynamic network centrality

Time sliced networks describing human-human digital interactions are typically large and sparse. This is the case, for example, with pairwise connectivity describing social media, voice call or physical proximity, when measured over seconds, minutes or hours. However, if we wish to quantify and compare the overall time-dependent centrality of the network nodes, then we should ...

Optimal configuration analysis for a campus microgrid—a case study

The foremost issues of 21st century are challenging demand of electrical energy and to control the emission of Green House Gases (GHG) emissions. Renewable energy resources based sustainable microgrid emerges as one of the best feasible solution for future energy demand while considering zero carbon emission, fossil fuel independency, and enhanced reliability. In this paper, ...

The evidence for non-typeable Haemophilus influenzae as a causative agent of childhood pneumonia

Haemophilus influenzae type b (Hib) was a major cause of bacterial pneumonia in children prior to the introduction of Hib-conjugate vaccines. The widespread use of Hib-conjugate vaccines has resulted in a significant decline in the number of cases of invasive Hib disease, including bacteraemic pneumonia, in areas where the vaccine has been implemented. In many countries, ...

Microparticles in kidney diseases: focus on kidney transplantation

Background Microparticles are small (0.1–1 μm), extracellular vesicles that are used as diagnostic and prognostics markers of kidney diseases and kidney transplantation. They contain cytoplasm and surface markers of their cells of origin. The aim of this review is to describe the functional capabilities of microparticles in kidney diseases with focus on kidney transplantion. Main ...

Histomorphometric and immunohistochemical evaluation of collagen containing xenogeneic bone blocks used for lateral bone augmentation in staged implant placement

Background The osteoconductive properties of collagen containing xenogeneic bone blocks (CCXBB) remain unclear. The aim of this prospective single-arm clinical study was to assess the histological outcomes of CCXBB blocks used as bone replacement grafts for lateral bone augmentation procedures. Methods In 15 patients with severe horizontal alveolar ridge resorption, lateral ...

The effect of membrane exposure on lateral ridge augmentation: a case-controlled study

Background The effect of membrane exposure on guided bone regeneration (GBR) for lateral ridge augmentation has been poorly addressed. This case-controlled study aimed to investigate potential effect of membrane exposure lateral ridge augmentation and subsequent implant placement. Methods A total of 14 patients that did receive lateral ridge augmentation procedure using allogeneic ...

Theory-driven or process-driven prediction? Epistemological challenges of big data analytics

Most scientists are accustomed to make predictions based on consolidated and accepted theories pertaining to the domain of prediction. However, nowadays big data analytics (BDA) is able to deliver predictions based on executing a sequence of data processing while seemingly abstaining from being theoretically informed about the subject matter. This paper discusses how to deal with ...

Chemiluminescent immunoassay technology: what does it change in autoantibody detection?

Diagnostic technology is rapidly evolving, and over the last decade, substantial progress has been made even for the identification of antibodies, increasingly approaching this type of diagnostic to that of automated clinical chemistry laboratory. In this review, we describe the analytical and diagnostic characteristics of chemiluminescence technology in its strength and in its ...

How Adaptation Makes Low Firing Rates Robust

Low frequency firing is modeled by Type 1 neurons with a SNIC, but, because of the vertical slope of the square-root-like f–I curve, low f only occurs over a narrow range of I. When an adaptive current is added, however, the f–I curve is linearized, and low f occurs robustly over a large I range. Ermentrout (Neural Comput. 10(7):1721-1729, 1998) showed that this feature of ...

Assessing the effects of price regulation and freedom of choice on quality: evidence from the physiotherapy market

In health care, many aspects of the delivery of services are subject to regulation. Often the purpose of the regulated health care system is to encourage providers to keep costs down without skimping on quality. The purpose of this paper is to analyse the effect of price regulation and free choice on quality in physiotherapy organised by the Social Insurance Institution of Finland ...

Towards energy aware cloud computing application construction

The energy consumption of cloud computing continues to be an area of significant concern as data center growth continues to increase. This paper reports on an energy efficient interoperable cloud architecture realised as a cloud toolbox that focuses on reducing the energy consumption of cloud applications holistically across all deployment models. The architecture supports energy ...

IFNγ-producing CD4+ T lymphocytes: the double-edged swords in tuberculosis

IFNγ-producing CD4+ T cells (IFNγ+CD4+ T cells) are the key orchestrators of protective immunity against Mycobacterium tuberculosis (Mtb). Primarily, these cells act by enabling Mtb-infected macrophages to enforce phagosome-lysosome fusion, produce reactive nitrogen intermediates (RNIs), and activate autophagy pathways. However, TB is a heterogeneous disease and a host of clinical ...

Value-added disaggregated social accounting matrix for the Indian economy of the year 2007–2008

India is pioneer in constructing the social account matrices for its economy for various years, but limited efforts have been made to construct a SAM for India with detailed description about types labour input employed in various economic activities and subsequently the distribution of labour income across various households groups. To bridge this gap, we have constructed a ...

Vacation model for Markov machine repair problem with two heterogeneous unreliable servers and threshold recovery

Markov model of multi-component machining system comprising two unreliable heterogeneous servers and mixed type of standby support has been studied. The repair job of broken down machines is done on the basis of bi-level threshold policy for the activation of the servers. The server returns back to render repair job when the pre-specified workload of failed machines is build up. ...

How do work-family balance practices affect work-family conflict? The differential roles of work stress

This paper investigates the relationship between employees’ perception of work-family balance practices and work-family conflicts. It examines the role of challenge stress and hindrance stress as moderators. Based on survey data collected from 841 civil servants in Beijing, we found that perceived work-family balance practices may reduce work-family conflict, while challenge and ...

Complex spaces: global innovation networks & territorial innovation systems in information & communication technologies

This paper brings together two related bodies of theory that assist understanding of processes of socio-technical system change on the global scale. These are, first, the Global Value Chain perspective (GVC) that has now mutated into Global Production Networks (GPN) and, more recently, Global Innovation Networks (GIN). Examples of why this should be are exemplified (e.g. ...

Some aspects of research and practice for pile design in France

This paper summarises some aspects of the methods used in France for designing pile foundations under axial and transverse loadings. These methods mostly use the results of Ménard pressuremeter (MPM) tests and concern the determination of the bearing capacity, as well as the prediction of axial and transverse displacements. The prediction of the bearing capacity from CPT results is ...

Rail vehicle design optimization for operation in a mountainous railway track

The use of reliable computational tools and of validated vehicle and track models allow studying the railway vehicle performance in realistic operation conditions. The use of such advanced tools permits performing the so-called virtual homologation, which means that most of the criteria defined in the standards and regulations for vehicle acceptance can be verified numerically. ...